Protein post-translational modifications: Novel molecular switches and strategies for targeted therapy in ischemic heart disease

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomedicine & Pharmacotherapy Pub Date : 2025-07-19 DOI:10.1016/j.biopha.2025.118357

Yuanyuan Chen , Gaojie Xin , Xiaoshan Cui , Jiaming Gao , Huiyu Zhang , Fan Guo , Zixin Liu , Shujuan Xu , Ce Cao , Lanlan Li , Hao Guo , Jianhua Fu

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Abstract

Protein post-translational modifications (PTMs), serving as crucial molecular switches regulating protein function and signaling pathways, have emerged as a research hotspot for elucidating the pathogenesis of Ischemic heart disease (IHD) and devising targeted therapeutic approaches. This review provides a comprehensive overview of the principal PTM types associated with IHD, encompassing phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, lactylation and succinylation. It also delves into the molecular mechanisms and key targets of PTMs in IHD pathology, primarily involving myocardial energy metabolism, calcium homeostasis, inflammatory responses, cell death, and myocardial fibrosis. Additionally, this paper evaluates the prospective applications of specific kinase modulators, PTM-targeting modifiers, and gene editing technologies in the treatment of IHD, and proposes a “modificatomics”-oriented precision intervention strategy, which offers a novel perspective for the management of IHD.

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蛋白质翻译后修饰：缺血性心脏病靶向治疗的新分子开关和策略

蛋白质翻译后修饰（Protein post-translational修饰，PTMs）作为调节蛋白质功能和信号通路的关键分子开关，已成为阐明缺血性心脏病（IHD）发病机制和制定靶向治疗方法的研究热点。本文综述了与IHD相关的主要PTM类型，包括磷酸化、乙酰化、泛素化、sumo化、糖基化、乳酸化和琥珀化。它还深入研究了ptm在IHD病理中的分子机制和关键靶点，主要涉及心肌能量代谢、钙稳态、炎症反应、细胞死亡和心肌纤维化。此外，本文还对特异性激酶调节剂、ptm靶向修饰剂和基因编辑技术在IHD治疗中的应用前景进行了评价，并提出了以“修饰原子”为导向的精准干预策略，为IHD的治疗提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.