Translational biomedicine最新文献

{"title":"Semen Culture a Diagnostic Tool in the Diagnosis of Bacterial Prostatitis","authors":"A. Panackal, A. Panackal","doi":"10.21767/2172-0479.100114","DOIUrl":"https://doi.org/10.21767/2172-0479.100114","url":null,"abstract":"","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68102033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Detection of Mycobacterium tuberculosis (MTB) and Rifampicin Resistant Strain among Subjects Accessing Health Care at Federal Medical Centre,Yenegoa, Bayelsa State; Nigeria","authors":"O. Azuonwu","doi":"10.21767/2172-0479.100120","DOIUrl":"https://doi.org/10.21767/2172-0479.100120","url":null,"abstract":"Background: An increasing global incidence of Mycobacterium Tuberculosis (MTB), and emergence of drug resistant strains of MTB, have critically promoted the urgent need to explore better effective methods that can rapidly detect MTB, and identify drug-resistant cases as recommended by World Health Organization report of 2008. Globally, multi-drug-resistant strains of MTB are increasingly becoming a huge public health issue, which has adversely affected the health care delivery of patients, especially in developing communities with limited functioning health care facility. Nonetheless, the aim and focus of the study is to evaluate the trend of rifampicin resistance strains of MTB among patients accessing care at the University of Port Harcourt Teaching Hospital. Methods: This observational cross-sectional study which utilized stratified proportionate random technique, was designed to evaluate the molecular detection, as well as the prevalence of MTB and multidrug resistant TB specifically RIF among the studied population. Results: The study population were 204 subjects recruited randomly, with a mean age of 37.23 ± 16.68 years and were categorized based on sex, 93 (45.6%) males and 111 (54.4%) females respectively. The MTB detected were 21 (10.3%) while 183 (89.7%) were negative. Also, drug resistant test was performed specifically for RIF to ascertain RIF resistant strain and the non-RIF resistant strains; only 6 (2.9%) were resistant to RIF while 197 (96.6%) were not resistant to RIF. Correlation analysis of MTB detected between sex, age and resistant to RIF showed nonsignificant association (p>0.05). The prevalence rates include: 2.9% and 7.4% for RIF Resistance and Non-RIF resistance respectively. Chi square result reported about 90% non-significance and 10% significance which occurred in the counts between RIF resistant and MTB detected (p<0.05). Conclusion: The use of dependable molecular detection of MTB method has been able to provide strong epidemiological impetus for an enhanced MTB diagnosis and management to be encouraged and should be sustained, especially in resources limited regions like Nigeria, with massive challenges of prompt and accurate diagnosis of the infection. However, it is strongly believed that continuous leveraging on the potency of the molecular diagnostic approach will help to uncover the rifampicin resistance strains, which obviously would have been a huge challenge with the routine microscopic smear method.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68102946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Herbal Remedy with Potent Anti-Inflammatory and Analgesic Properties","authors":"R. Hamidpour, L. Rashan","doi":"10.21767/2172-0479.100121","DOIUrl":"https://doi.org/10.21767/2172-0479.100121","url":null,"abstract":"","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68103021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective activity of Ethanolic Extractof Tinospora cordifolia on LPS inducedNeuroinflammation","authors":"R. Prakash, E. hya, N. Ramya, R. Dhivya, M. Priyadarshini, B. Sakthipriya","doi":"10.21767/2172-0479.100135","DOIUrl":"https://doi.org/10.21767/2172-0479.100135","url":null,"abstract":"Background: Neuroinflammation has been implicated in the pathogenesis or the progression of the variety of acute and chronic neurological and neurodegenerative disorders including Alzheimer’s disease. Aim: The present study is to investigate the ethanolic extract of Tinospora cordifolia on LPS induced behavioral alterations, oxidative stress and neuronal damage in rats. Methods: Adult male Wistar rats were divided into five groups six in each. Group I treated with normal saline (0.9% NaCl i.p.), group ii treated with normal saline + LPS (100 μg/kg i.p.), group iii treated with Aspirin (200 mg/kg) + LPS (100 μg/kg), Group IV treated with EETC (200 mg/kg) + LPS (100 μg/kg) and Group V treated with EETC (400 mg/kg) + LPS (100 μg/kg) for 14 days followed by single challenged of LPS to all the groups except control rats. On 15th day onwards, various behavioral assessment such as body weight, rectal temperature, locomotor activity, cognitive and memory assessment were carried out. Rats were sacrificed, and brain was isolated and estimated antioxidant levels (GSH, SOD, TBARS and CAT) and neuronal damage in the region of hippocampus were analyzed. Results: LPS treated rats significantly (P<0.001) decreased the body weight, locomotor activity, latency period in passive avoidance test and anti-oxidant levels in GSH, SOD and CAT and increased the rectal temperature and lipid peroxidase level (TBARS) compare to control rats. Pretreated with Aspirin 200 mg/kg rats and EETC (200 and 400 mg/kg) rats significantly attenuated the LPS induced behavioral alteration, oxidative damage and neuronal damage. Conclusion: The ethanolic extract of Tinospora cordifolia showed neuroprotective activity due to the presence of phytochemical constituents such as alkaloids, glycosides, diterpenoid lactones, berberine, flavonoids, saponins.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68105289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Self-Assembled Non-Viral vector as Potential Platform for mRNA-Based Vaccines","authors":"S. Persano","doi":"10.21767/2172-0479.100119","DOIUrl":"https://doi.org/10.21767/2172-0479.100119","url":null,"abstract":"Here, we show a universal anti-cancer vaccine, based on antigen-mRNA-loaded self-assembled polyplex nanocarrier. The establishment of antigen-specific T-cells, as consequence of the vaccination, performed following a subcutaneous route of administration, was confirmed by detection of IFN-γ/IL-2 producing T-cells in the spleen of the treated mice. Moreover, a high release of Th1-releated IgG isotypes (IgG2b and IgG2c) was observed, indicating a predominantly Th1 response. Finally, OVA-mRNA-based vaccine formulation has been employed for the treatment of melanoma lung metastasis of B16-OVA challenged mice, inducing a marked reduction of metastatic nodules up to 93%. Ascertained that any polypeptide-based antigen can be encoded as RNA, potentially our platform can represent a universal strategy suitable for the development of any mRNA-based vaccine.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68103447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lingering Binocular Vision Issues after a Suspected Concussion: A Case Study","authors":"Melissa Hunfalvay","doi":"10.21767/2172-0479.100115","DOIUrl":"https://doi.org/10.21767/2172-0479.100115","url":null,"abstract":"This case study examines long-term vision related issues after a suspected concussion. After assessments, it became apparent that the vision issues were widespread and ongoing vision therapy was conducted. A 12-month follow up revealed significant improvement in all oculomotor metrics, although the patient remained outside normative ranges.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68102099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Natural Gel That Relieves Muscle Spasms, Osteoarthritis and Back Pain","authors":"R. Hamidpour, L. Rashan","doi":"10.21767/2172-0479.100122","DOIUrl":"https://doi.org/10.21767/2172-0479.100122","url":null,"abstract":"Muscle spasms and sciatica can be extremely painful. Muscle spasms (or cramps) are sudden involuntary contractions of one or more muscles. While they are generally harmless, they can be temporarily debilitating. Osteoarthritis (OA) is the most chronic condition of the joint and the most common type of arthritis and is seen especially among old people. Sciatica, on the other hand, refers to much longer-lasting pain along the sciatic nerve, which branches from the lower back through the hips and down each leg. While self-treatment methods are often effective, severe cases of sciatica may require physical therapy or surgery. Both these conditions may also be treatable with forms of alternative medicine, such as herbal supplements. Emollient Gel is natural product whose anti-inflammatory and antirheumatic activities make it a promising treatment for muscle spasms, osteoarthritis and back pain. Pars Bioscience is pleased to be the first to make Emollient Gel commercially available.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68103412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Unique Natural Remedy that Alleviates Varicose Vein","authors":"R. Hamidpour, L. Rashan","doi":"10.21767/2172-0479.100127","DOIUrl":"https://doi.org/10.21767/2172-0479.100127","url":null,"abstract":"Varicose veins are swollen, twisted veins that become highly visible just underneath the surface of the skin. This common condition can occur in any part of the body, but varicose veins are usually found in the legs. Varicose veins are most commonly caused by a weakening of vein valves and vein walls. While varicose veins are usually not serious, common symptoms include mild to moderate pain, swelling, and itchy legs. A variety of treatments are available to patients. Lifestyle changes and different medical procedures can reduce pain and improve the appearance of the skin. Forms of alternative medicine are also known to help treat varicose veins. Chamomile 5 capsules and ointment are newly developed herbal remedies that have been shown to relieve symptoms of varicose veins. Pars Bioscience is pleased to be the first to make these novel remedies commercially available.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68104391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Comparison of Sucking Ice Bits With Plain Water and Ice Bits Containing of Mint Extract on Nausea and Vomiting During Chemotherapy in Patients Suffering from Breast Cancer","authors":"Hamid Robat Sarpooshi, Mohammd Haddadi, Maz, arani Ms, R. Borghabani","doi":"10.21767/2172-0479.100130","DOIUrl":"https://doi.org/10.21767/2172-0479.100130","url":null,"abstract":"Background and purpose: Breast cancer is known as the most widely recognized and lethal disease among women. Various strategies including surgery, radiotherapy, and chemotherapy are applied to cure cancer. Chemotherapy, as a typical helpful strategy, brings about various physical and mental symptoms. Nausea and vomiting are amongst the most common widely recognized symptoms of chemotherapy. Regardless of advancement in anti-nausea and anti-vomiting medicines, nausea and vomiting are yet the most widely recognized reactions of chemotherapy. In one hand, alternative and complementary medicines are among basic and safety measurements. This study has been accomplished to compare the effect of sucking ice bits with plain water and ice bits containing of mint concentrate on nausea and vomiting during chemotherapy. Materials and methodology: In this clinical study, 90 patients suffering from breast cancer with chemotherapy were placed into three groups of \"control\", \"ice bits with plain water\", and \"ice containing of mint extract\" randomly. Thirty ice bits in 1cc, 30 ice bits with mint extract in 1cc, and 30 cc of water were given to \"ice bits with plain water\", \"ice bits containing mint extract\", and \"control\" groups; respectively. Nausea was assessed by numerical scale of VAS, and vomiting was evaluated based on frequency. SPSS16 software was applied to analyze data. Findings: The findings showed that intervention group of \"ice bits with plain water\", \"ice bits containing of mint extract\", and \"control\" groups have got averages of 1.6, 1.96, and 2.9; respectively indicating to significance (P-value: 0.010), while in \"ice bits with plain water\" and in intervention group of \"ice containing of mint extract\" group there are 0.2, 0.233 vomiting cases, so that an average of 0.266 vomiting was observed in the control group indicating to a lack of significance (P-value: 0.835). Conclusion: According to the study results, sucking ice bits with plain water and ice bits containing of mint extract can take effect on nausea while they make no effect on vomiting resulted from chemotherapy.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68104454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence and Associated Factors of Toxoplasma gondii Infection among Pregnant Women Attending in Antenatal Clinic of Arba Minch Hospital, SouthEthiopia: Cross Sectional Study","authors":"T. Yohanes, Z. Zerdo, Nega Chufamo, Ashenafi Abossie","doi":"10.21767/2172-0479.1000105","DOIUrl":"https://doi.org/10.21767/2172-0479.1000105","url":null,"abstract":"Background: Toxoplasma gondii (T. gondii) is a ubiquitous, coccidian intracellular protozoan parasite that causes toxoplasmosis. T. gondii infection acquired during pregnancy may result in severe damage or death of the fetus and long-term sequelae in offspring. So far, no documented data concerning the seroprevalence of T. gondii infection among pregnant women is available in the study area. Therefore, this study was aimed at determining of T. gondii sero-prevalence and associated factors among pregnant women attending in ante natal clinic (ANC) of Arba Minch hospital, southern Ethiopia. Methods: A facility based cross sectional study design was employed. A total of 232 pregnant women visiting Arba Minch hospital ANC from February to April, 2015 were enrolled by using systematic sampling technique. Data regarding Socio-demographic and associated factors were gathered using pretest questionnaire. Approximately 2 milliliters of blood specimen was collected and serum samples were tested for anti-T. gondii IgG and IgM antibody using Enzyme Linked Immunosorbent Assay. Data were analyzed using SPSS version 20. Results: Out of the total 232 pregnant women tested, 184 were found to be seropositive, giving overall seroprevalence rate of T. gondii infection 79.3% (95%CI; 73.7-84.5). On multivariate analysis showed that consumption of raw meat (AOR=3.211; 95% CI: 1.592-6.477) and habit of eating raw vegetables or fruit (AOR=2.669; 95% CI: 1.264-5.639) were significantly associated with T. gondi infection. Conclusion: The overall seroprevalence of T. gondii infection among pregnant women was high and serological evidence of primary infection was observed. Therefore, screening of Toxoplasma infection should be considered during ANC follow up. Moreover, health information about ways to minimize exposure to the risk factors should be provided with main focus on not eats raw meat and raw vegetables.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.1000105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68088571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}