Translational biomedicine最新文献

{"title":"Prevalence of Human ImmunodeficiencyVirus (HIV) Antibody among Subjects inOgba/Egbema/Ndoni Local GovernmentArea (LGA) of Rivers State of Nigeria","authors":"A. Obioma, Ihua Nnenna, Wokem, Gloria Ngozika, Igwe Chituru","doi":"10.21767/2172-0479.100118","DOIUrl":"https://doi.org/10.21767/2172-0479.100118","url":null,"abstract":"Background: The World Health Organization in approximation, reported that in 2007, about 33 million people were HIV infected globally, and approximately 2.5 million were newly infected, even as over 2 million died of AIDS despite all the huge prevention and intervention strategies in place. Although, there seems to be insufficient data regarding Human Immunodeficiency Virus infection prevalence in rural communities of Niger Delta as reported by many scholars in the region. The aim of this present study therefore, was to investigate the seroprevalence rate/prevalence of Human Immunodeficiency Virus infection in Ogba/Egbema/ Ndoni LGA of Rivers State. Methods: In this Cross-sectional study, a total of 1,484 subjects with age range of>15 years were screened for Human Immunodeficiency Virus infection in Omoku General Hospital and Erema General Hospital, all in Ogba/Egbema/Ndoni Local Government Area of Rivers State of Nigeria. Result. Results: The result of the study showed an overall prevalence rate of 10.6%. The highest Human Immunodeficiency Virus seropositive infection occurred in age group 21-26years (30.6%) with a prevalence rate of 3.23%. The female had the highest prevalence of 7.61% while the male stood at 2.96%. There was no statistical significant difference (X2=0.002; P>0.05) in prevalence based on marital status, even as the married had a prevalence of 5.73% while singles had 4.85% respectively. Conclusion: This study showed that inspite of the massive Human Immunodeficiency Virus campaign advocacies in the urban cities in the region, there is still much to be done especially in the rural villages in the region. This calls for intensified efforts on health education on the risk factors and strong awareness on attitudinal change program of the citizens. The need to strengthen the strategy of antiretroviral therapy provision in the rural villages would help to reduce Human Immunodeficiency Virus related mortality and morbidity in the infected persons in Niger Delta Communities.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68102413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Treatment of Oral Aphthous Ulcers: A Systematic Review","authors":"Atessa Pak Fetrat, M. Haddadi, Y. Setayesh, A. Shirazi, A. Moeintaghavi","doi":"10.21767/2172-0479.100138","DOIUrl":"https://doi.org/10.21767/2172-0479.100138","url":null,"abstract":"Background and purpose: Due to the large number of studies on traditional and herbal treatments for oral aphthous and lack of comprehensive studies on these cases, the purpose of this research was to study and careful analysis of the effectiveness of herbal medicines used in the treatment of these lesions and reported the final outcome that one of the best study methods in these cases is a systematic review. Methods: Five electronic databases (PubMed, ISI web of science, Scopus, Cochrane and OVID) by keywords based on the PICO were searched to identify all the clinical trials with topical and systemic therapeutic interventions aimed at treating or preventing recurrence published in Persian or English that related to the effects of drugs of natural herbal origin for the treatment of recurrent aphthous stomatitis from 2010 to 2015. A structured and standardized form has been used to extract data. Title, journal, year of publication and the field of the first author and corresponding author were recorded. Standard tools of risk of bias used in the systematic review studies that has been developed by the Cochrane (Last update 2011) was applied to investigate bias in the studies. Results: In the current study a total of 33 trials were analyzed. These studies were assessed the effectiveness of 29 different herbal drugs for RAS treatment. Only five studies were assessed as being at medium risk of bias. No study had a low risk of bias. There were insufficient evidences to support or refute the use of these interventions. Conclusion: In summary, current data suggested that there was a beneficial effect in using topical treatments with plant origin for RAS and no study did not report any side effects. Though due to very weak report and disparate studies, acknowledging the fact that which herbal treatment was the best and most effective treatment was not possible.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68105315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Erythropoietin Effect on Uterus Congestion after Uterine Ischemia Reperfusion","authors":"C. Tsompos, C. Panoulis, K. Toutouzas, A. Triantafyllou, G. Zografos, A. Papalois","doi":"10.21767/2172-0479.1000102","DOIUrl":"https://doi.org/10.21767/2172-0479.1000102","url":null,"abstract":"Objective: This experiment investigated the erythropoietin (Epo) effect after uterine ischemiareperfusion (IR) in rats. The effect of Epo was evaluated studying the mean uterine congestion (UC) lesions. Materials and methods: The mean weight of 40 rats used in the study was 247.7 g. The UC lesions were estimated for the groups A and C on 60 min and for the groups B and D on 120 min after reperfusion. Only the groups C and D were administered by Epo. Results: Epo administration non-significantly declined the UC lesions scores by (without lesions) 0.15 (-0.5595137-0.2595137) (p=0.4545). Reperfusion time non-significantly raised the UC lesions scores by (without lesions) 0.15 (-0.5676974-0.3676974) (P=0.5058). However, the combined Epo administration with reperfusion time non-significantly declined the UC lesions scores by (without lesions) 0.0090909 (-0.2577992-0.2396174) (p=0.9414). Conclusions: The Epo administration presented a nonsignificantly declining short-term effect on UC lesions scores. Perhaps, a higher Epo dosage and/or an experimental time lasting longer than 2 hours may reveal more significant efficacies.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.1000102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68088170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epileptic Seizure: A New Approach for Quantification of Autonomic Deregulation with Chaos Based Technique","authors":"D. Ghosh, Srimonti Dutta, S. Chakraborty, S. Samanta","doi":"10.21767/2172-0479.1000106","DOIUrl":"https://doi.org/10.21767/2172-0479.1000106","url":null,"abstract":"Background: Epileptic seizures can lead to changes in autonomic function affecting the sympathetic, parasympathetic and enteric nervous systems. Changes in cardiac signals are potential biomarkers that may provide an extracerebral indicator of ictal onset in some patients. Patients suffering from epilepsy experience some significant cardiac changes during seizure, causing some serious cardiac malfunctions which may lead to sudden unexpected death (SUDEP). The fluctuations observed in the heart rate during the process are non-linear and extremely complex. Chaos based non-linear methodology has become a very powerful tool in recent years in analysing such complex systems. Although a few papers on effect of seizure have been reported where study was done to assess the dynamics of cardiac systems for post-ictal patients not using non-linear technique, this paper reports the analysis of ECG signals of post-ictal patients using a modern and rigorous non-linear technique. Methods and findings: Multifractal detrended fluctuation analysis (MFDFA) technique has been applied here to determine the degree of multifractality of cardiac dynamics quantitatively of five women patients suffering from partial seizures. The analysis of the ECG clinical data obtained from ‘PhysioNet’ database shows that the degree of multifractality or complexity for each subject is different indicating the difference of severity of occurrences of seizure. Conclusion: The study reveals that the degree of autonomic deregulation can be quantified with the help of two parameters, the multifractal width and the autocorrelation exponent.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"464 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.1000106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68089378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Remedy for Irritable Bowel Syndrome","authors":"R. Hamidpour, L. Rashan","doi":"10.21767/2172-0479.100125","DOIUrl":"https://doi.org/10.21767/2172-0479.100125","url":null,"abstract":"Symptoms of irritable bowel syndrome are often uncomfortable and sometimes even debilitating, but IBS does not cause changes in bowel tissue or increase the risk of colorectal cancer. Only a small group of people with irritable bowel syndrome has severe signs and symptoms. Some patients can control their symptoms by managing diet, lifestyle, and stress, while others need more intensive treatment and medications [1]. Because many of these medications have potentially harmful side effects, Pars Bioscience is pleased to introduce EDS2, a novel herbal remedy designed to help patients overcome irritable bowel syndrome (Figure 1).","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68103220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumatosis Cystoides Intestinalis, Is theEmergency Surgery Inevitable: Case Report","authors":"R. Sharma, R. Chaudhary, Ramesh Bharti, Amar Verma, R. Verma, Bodh Negi Td","doi":"10.21767/2172-0479.100136","DOIUrl":"https://doi.org/10.21767/2172-0479.100136","url":null,"abstract":"Pneumatosis cystoides intestinalis is a rare clinical phenomenon in which there is presence of gas filled cysts in the gut wall. Its exact cause is not known but this condition is commonly associated with smoking and other factors leading to raised intra-abdominal pressure. Sometimes these gasses filled cysts may rupture on their own or secondary to some surgical intervention leading to presence of free gas in the abdomen or retroperitoneum. We present here a case report of the patient who presented to the emergency room with pain abdomen and a large amount of free gas in the abdomen seen on erect X-ray of the abdomen. Here comes the challenge to the surgeon, whether to operate or not. Contrast Enhanced Computerised Tomography (CECT) scan of the abdomen is a better modality for diagnosing Pneumatosis cystoides intestinalis (PCI) and it can prevent unnecessary surgeries. However, the management of this condition is mainly nonsurgical, and oxygen forms the mainstay of therapy.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68105340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wound Healing with Vitamin C","authors":"Hamid Robat Sarpooshi, Mohammd Haddadi, M. Siavoshi, R. Borghabani","doi":"10.21767/2172-0479.100139","DOIUrl":"https://doi.org/10.21767/2172-0479.100139","url":null,"abstract":"Introduction: Vitamin C, solvent in water, is necessary to synthesis and to keep collagen, and also is an intercellular surrounding material of body tissues, blood vessels, cartilages, bones, teeth, skins, and tendons. It is able to improve the protective mechanism of immune system, and wounds. Also, it is necessary to rehabilitate wounds and resistance against infection. This study makes an attempt to define the effect of topical vitamin C on improving second-degree burns. Materials and methods: In this clinical trial, 30 patients with second-degree burn referring to burn ward of Sabzevar Vasei Hospital were adopted. According to the defined volume, two groups were adopted on a patient in this study. The dressing of wounds was changed once a day and then the wound was washed. The parameters concerned with burn were considered in 1st, 3rd, 7th, and 14th days by applying Bates-Jensen tools of evaluating burn. SPSS-16 software and ANOVA test of repetitive measures were applied to analyze data. Findings: In this study, participants have got an age average of 43.03 ± 11.90, 60% of participants were composed of men, and the other 40% were women. The results of ANOVA Test showed repetitive measurements. The average of final score of burn between two types of cures was statistically significant (P=0.047). In other words, there was a significant difference on improving the burn between two groups, and Vitamin C takes a significant effect on improving the burn.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68105471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 49-Year-Old Man with Combined Myasthenia Gravis, Autoimmune Thyroiditis and IgG4 Orbitopathy","authors":"Shan-Han Chang, Y. Tsai, Ta-Fu Chen, Wan-Chen Wu, Pei-Lung Chen, Jinghao Lu","doi":"10.21767/2172-0479.100140","DOIUrl":"https://doi.org/10.21767/2172-0479.100140","url":null,"abstract":"Background: Patients with autoimmune thyroid disease have higher risk of myasthenia gravis, especially the ocular form of myasthenia gravis. IgG4-related disease and autoimmune thyroiditis have been reported to coexist; and IgG4- related thyroiditis pertain higher autoantibodies when compared with non-IgG4 thyroiditis. However, combined occurrence of myasthenia gravis, autoimmune thyroiditis, and IgG4-related disease has not been reported before. Methods: Here we report a case of ocular myasthenia gravis combined with autoimmune thyroiditis and elevated serum IgG4 that initially deteriorated to generalized myasthenia gravis after 3 days of intravenous (IV) pulse methylprednisolone treatment, but was rescued after plasma exchange therapy. The patient was placed on oral prednisolone, azathioprine, pentoxifylline, hydroxychloroquine, but the ocular symptoms relapsed occasionally when he felt tired. Another eight sessions of weekly IV pulse methylprednisolone were administered during outpatient clinic follow-ups. Findings: There was no more deterioration to generalized myasthenia gravis, and his ocular symptoms fully recovered after the treatment. He finally underwent thoracoscopic thymectomy, and pathology shows atrophic thymus. All immunosuppressants were tapered off after surgery, and he remained symptomfree on the last follow-up, about half a year after surgery. Conclusion: Since thyroid associated orbitopathy and IgG4-related orbitopathy respond well to steroid treatment, initial deterioration of concomittent ocular myasthenia gravis to generalized form after IV pulse steroid therapy can be rescued by plasmapheresis, and the follow-up IV pulse steroid therapy should not be precluded as the definitive treatment in this situation. Finally, all immunosuppressants were successfully discontinued and he remained symptomfree after surgical removal of the atrophic thymus.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68105065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Vistafin in Diabetes-Induced Impairment of Endothelial Repair System","authors":"A. Berezin","doi":"10.21767/2172-0479.1000104","DOIUrl":"https://doi.org/10.21767/2172-0479.1000104","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is considered a leading factor of cardiovascular (CV) events in general population. Impairment of endogenous endothelial repair system plays a pivotal role in T2DM-induced microangiopathy and macroangiopathy and, however, may contribute in CV risk and outcomes. Recent studies have shown that the nicotinamide phosphoribosyl transferase (NAMPT) currently known as visfatin has reported an integral adipocytokine with proinflammatory and immunomodulating properties. It is suggested that visfatin/NAMPT may act as multifunctional agent with undefined effect on several targets especially endothelial cells and progenitor cells depending of metabolical status of the patients. The short commentary is discussed a possible role of visfatin/NAMPT as a biomarker of nature evolution of T2DM and as a target for therapeutic strategy aimed to improve endothelial function in T2DM patients in future.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"139 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.1000104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68088461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Nutritional Statusand Soil-Transmitted Helminthes Re-Infection among School-Age Children in Chencha District, Southern Ethiopia: A Cross-Sectional Study","authors":"Z. Zerdo, T. Yohanes, B. Tariku, T. Teshome","doi":"10.21767/2172-0479.100111","DOIUrl":"https://doi.org/10.21767/2172-0479.100111","url":null,"abstract":"Background: Soil-transmitted helminthes infection and malnutrition are the major health threat of school-age children (SAC) in developing countries. Schoolbased mass-drug administration (MDA) is cost efficient and effective strategy in reducing the worm load of the parasites but re-infection is the main problem of this strategy. There is scarce data on the association of nutritional status of SAC and STH re-infection. Therefore, the present study was aimed at assessing the association of nutritional status and STH re-infection among SAC in Chencha district from April 20 to May 5, 2015. Methods: A cross-sectional study design was used to recruit 406 SAC from 10 randomly selected kebeles from the district. Structured questionnaire was used to collect background characteristics of SAC while Kato-Katz thick smear technique was used to quantify number of STH eggs per gram of stool specimen. Pearson chi square and logistic regressions were used to assess association between STH reinfection and nutritional status of SAC. Results and findings: The overall prevalence of malnutrition, stunting and underweight among SAC were 12.3% (95%CI=9.7% to 16.5%), 8.9% (95%CI 6.3% to 12.1%) and 4.2% (95%CI 2.5% to 6.6%) respectively. STH re-infection among stunted children was 25% (n=9) while it was 37.7% (n=139) among non-stunted children. However, this difference was not statistically significant with p-value equal to 0.132. In similar, the prevalence of STH re-infection among underweighted SAC was 52.9% (n=9) but it was by 7.1% lower among non-wasted children though it was not statistically not significant (P=0.151). Conclusions: we found low prevalence of malnutrition among SAC in Chencha district. In addition, malnutrition was not associated with STH re-infection among such population. Further prospective studies with long duration of follow-up shall be conducted in other parts in order to give more strong information about the association.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68100780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}