Translational biomedicine最新文献

{"title":"Preparedness for Global Dengue Resurgence: An Urgent Need","authors":"Shyamapada Mandal","doi":"10.21767/2172-0479.100150","DOIUrl":"https://doi.org/10.21767/2172-0479.100150","url":null,"abstract":"Dengue virus (DENV: Genus Flavivirus; family Flaviviridae), which is vectored by female Aedes aegypti (in endemic regions principally in urban areas) as well as female Aedes albopictus (mostly in rural areas) mosquitoes, cause dengue in humans (with the infection of its all four serotypes [1-3]: DENV1, DENV2, DENV3 and DENV4) that arrays from self-limiting mild feverish illness: DF (dengue fever), to severe life-threatening forms, DHF (dengue hemorrhagic fever) and DSS (dengue shock syndrome) leading to death (Figure 1). The disease has been recognized as a major public health problem in developing tropics and subtropics, but is now spreading rapidly globally with worldwide transportation of infective vectors of DENVs [4,5], due to:","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68106750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Cosolvents and Surfactants on the Rate Constant (Log K) of Sparfloxacin","authors":"Ruth Eg, Chika Mj","doi":"10.21767/2172-0479.100155","DOIUrl":"https://doi.org/10.21767/2172-0479.100155","url":null,"abstract":"Sparfloxacin, a difluoroquinolone antibacterial agent is clinically used in the treatment of streptococci and community-acquired lower respiratory tract infections. The aim of the present study was to investigate to what extent cosolvents and surfactants could affect sparfloxacin degradation kinetics under acidic condition. The degradation of sparfloxacin in acidic aqueous solution of cosolvents and surfactants at 60 ± 0.2°C was studied. The degradation was determined by UV spectrometry. The degradation was observed to follow apparent first-order rate kinetics and the rate constants for the decomposition were obtained from plots of logarithm percent drug concentration remaining versus time. The reaction was shown to be hydrogen ion catalysed. Significant increase in the stability of sparfloxacin was observed with the cosolvents and surfactants investigated. The study suggests that cosolvents or surfactants at non-toxic concentrations could be incorporated into liquid pharmaceutical dosage forms of sparfloxacin to stabilize the preparations under acidic conditions.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68107692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlamydia Trachomatis in Rheumatoid Arthritis-A Novel Risk Factor of Secondary Amyloidosis?","authors":"Nickolay Fs, Anastasiya Kt","doi":"10.21767/2172-0479.100147","DOIUrl":"https://doi.org/10.21767/2172-0479.100147","url":null,"abstract":"Renal involvement is considered to be one of the most severe complications, defining clinical course and prognosis of rheumatoid arthritis (RA). Secondary amyloidosis often leads to renal failure and fatal outcome in patients with RA. Progressive renal function decline in secondary amyloidosis makes extremely important revealing possible predictors. Since effective treatment of secondary amyloidosis has not been developed yet, slowing down the progression of chronic kidney disease by impact on risk factors becomes extremely important. A causal relationship between chronic infection and secondary amyloidosis development have been well known for a long time, but main attention was attached to chronic purulent diseases, such as osteomyelitis, multiple bronchiectasis, etc. Special attention was drawn to such longstanding infection as tuberculosis. Meanwhile there are a number of other cases describing secondary amyloidosis development when chronic infection plays critical role, for example in Reiter's syndrome.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68106429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Effect of Nanosilver Spray and 1% Silver Sulfadiazine Cream on the Healing of Second-Degree Burn Wound","authors":"A. D. Abadi, Mojtaba Vaheb, Rakhshani Mh, T. Tofighian","doi":"10.21767/2172-0479.100141","DOIUrl":"https://doi.org/10.21767/2172-0479.100141","url":null,"abstract":"Introduction: Recent scientific advances have led to the availability of silver nanoparticles which can kill microbial agents with their higher power of penetration into them. The present study aimed to compare the effect of nanosilver spray and silver sulfadiazine cream on the healing of second-degree burn wounds. Materials and methods: A clinical trial was conducted in Vasei Hospital of Sabzevar in 2016. For this purpose, 21 patients with a second-degree burn wound of the same depth and size in one or two organs were selected as the sample based on the convenient sampling method. Wounds of patients were divided into two parts; one part was dressed with silver sulfadiazine cream and the other one was dressed with nanosilver spray. The wound dressing was changed every day after washing the wound with normal saline. Wound parameters including size, depth, edges, undermining, necrotic tissue type, necrotic tissue amount, exudate type, exudate amount, skin color surrounding wound, peripheral tissue edema and induration, granulation tissue, and epithelialization were measured on the first, third, seventh, fourteenth, and twenty-first days using Bates-Jensen Wound Assessment Tool. The obtained data were statistically analyzed using the generalized linear model test in SPSS-16. Findings: The mean recovery status at the beginning of the study and on the twenty-first day was 32.05 ± 2.13 and 13.95 ± 1.68 in the nanosilver spray group and 32.24 ± 2.77 and 14.52 ± 2.46 in the silver sulfadiazine group. However, no significant difference was observed between the two groups (p=0.87). Conclusion: Both types of dressing improved the wound and had the same effect on the wound healing. However, since the cost of treatment and pain were lower in dressing with nanosilver, it is more recommended to be used for burn wounds.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68106531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Over-Expression of GH/GHR in Breast Cancer and Oncosuppressor Role of Somatostatin as a Physiological Inhibitor","authors":"G. D. Bella, R. Scanferlato, B. Colori","doi":"10.21767/2172-0479.100151","DOIUrl":"https://doi.org/10.21767/2172-0479.100151","url":null,"abstract":"Background: The interaction between pituitary hormones (Growth Hormone-Prolactin), ovarian hormones (Estradiol) and growth factors forms the basis of the mechanisms underlying the growth of tumors of the breast. The literature contains reports of the increased expression of the mitogenic GH (Growth Hormone)/IGF1 (Insulin-Like Growth Factor) axis in tumor tissues compared to healthy tissues, with a directly proportional dose-dependent relationship between GH/IGF1, proliferative index and invasive ability in numerous types of tumors. Methods and Findings: We carried out this experimental research on the mitogenic role of GH and consequently on the rationale of the anticancer use of its inhibition. The levels of expression of several genes, GH and GHR, were evaluated in 39 cases of breast cancer, divided according to different risk levels on the basis of immunohistochemical and histological tests with nuclear grade. Conclusion: Research showed that breast cancers with a high and intermediate risk of recurrence are characterized by over-expression of GH and of its receptor (GHR). The expression was limited in cases with a low risk. The overexpression of GH-GHR in breast cancer with a ratio proportional to the level of aggressiveness is a rationale that can encourage a therapeutic intervention with inhibition of the mitogenic GH-IGF1-PRL axis and estrogen.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68106245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Growth/Differentiation Factor-15 in Chronic Heart Failure: New Challenge in Biomarker-Guided Therapy?","authors":"A. Berezin","doi":"10.21767/2172-0479.1000103","DOIUrl":"https://doi.org/10.21767/2172-0479.1000103","url":null,"abstract":"Heart failure (HF) biomarker-guided therapy is promising method, which directs to improving of clinical status, attenuation of admission/readmission to the hospital and reduces of mortality rate. Many biological markers, i.e. inflammatory cytokines, are under consideration as a surrogate target for HF treatment, while there is known biomarkers with established predictive value, such as natriuretic peptides. However, discovery of new biomarkers reflecting various underlying mechanisms of HF and appearing to be surrogate targets for biomarkerguided therapy is promising. Nowadays, growth differentiation factor 15 (GDF-15) is suggested a target biomarker for HF treatment. Although elevated level of GDF-15 associated with HF development, progression, and prognosis, there is not represented evidence regarding direct comparison of this biomarker with other clinical risk predictors and biomarkers. Moreover, GDF-15 might serve as a contributor to endothelial progenitor cells (EPC) dysfunction by inducing EPC death/autophagy and limiting their response to angiopoetic and reparative effects. The short communication is discussed whether GDF-15 is good molecular target for HF guided therapy.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.1000103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68088343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Perspective on Diverse Phenotypic Expression of Two Siblings Affected by Cystic Fibrosis with Homozygous F508del Genotype","authors":"Beth Harknes, H. Fanous","doi":"10.21767/2172-0479.100113","DOIUrl":"https://doi.org/10.21767/2172-0479.100113","url":null,"abstract":"Cystic Fibrosis (CF) is a single gene recessive genetic disorder caused by mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and has been estimated to have a prevalence of 1/25000 live births in Caucasians [1,2]. Recently, there has been substantial progress in the knowledge of CF as well as identification of more than 1,800 mutations in the CFTR gene that play a role in the phenotypic characterization of the disease. We describe a case of 2 Cystic Fibrosis siblings have markedly different clinical courses throughout their life. To objectively measure differences in their clinical courses, we reviewed clinical data points, chest x-rays and lung function tests [3].","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68102198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Herbal Preparation Useful in Weight Loss","authors":"R. Hamidpour, L. Rashan","doi":"10.21767/2172-0479.100134","DOIUrl":"https://doi.org/10.21767/2172-0479.100134","url":null,"abstract":"Overweight and obesity are serious health issues in the United States. Defined by the National Institutes of Health, “overweight” refers to an excess amount of body weight resulting from muscles, bones, fat, and water. “Obesity,” meanwhile, describes an excess amount of body fat. While no single treatment method is effective against all cases of overweight and obesity, patients do have a variety of options. Diet, exercise, weight-loss drugs, and, in extreme cases, weight-loss surgery can all alleviate overweight and obesity. Less traditional treatments can also be effective. Humerus 3, a novel herbal preparation, is one such treatment. By safely and naturally decreasing hunger and increased feeling of fullness and therefore aid to suppress appetite among overweight individuals 3-7. Humerus 3 has been shown to promote a gradual decrease in body weight. This new form of treatment may be particularly helpful for those struggling with overweight or obesity. Pars Bioscience is pleased to be the first to make this novel remedy commercially available.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68105232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Herbal Preparation that Relieves Symptoms of Premenstrual Syndrome","authors":"R. Hamidpour, L. Rashan","doi":"10.21767/2172-0479.100126","DOIUrl":"https://doi.org/10.21767/2172-0479.100126","url":null,"abstract":"Premenstrual syndrome (PMS) refers to a wide range of symptoms that commonly effect women one to two weeks before their period (menstruation) begins. The specific causes of PMS are unknown, but fluctuating hormone levels during the menstrual cycle appear to play an important role. PMS can lead to both physical and mental complications; anxiety, depression, mood swings, irritability, insomnia, muscle pain, headache, fatigue, weight gain, and breast tenderness are just some of the many possible symptoms. While all these symptoms are associated with PMS, most women only experience one or a few of them. The severity of premenstrual syndrome varies from woman to woman. For some PMS is merely a minor nuisance; for others, the physical pain and emotional stress is overwhelming. Women with these disabling symptoms suffer from the most severe form of PMS – premenstrual dysphoric disorder (PMDD).","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68103336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Molecular Weight Components from Various Sources Eliminate Oxidative Stress and Restore Physiological Characteristic of Animals at Early Stages of Cu-Induced Liver Fibrosis Development","authors":"Bozhkov Ai, Nikitchenko YuV, Lebid Km, E. G. Ivanov, Kurguzova Ni, Gayevoy Ss, Sharko Mo, Alsardia Mohammad Ma, Alaaddin Ay","doi":"10.21767/2172-0479.1000107","DOIUrl":"https://doi.org/10.21767/2172-0479.1000107","url":null,"abstract":"Background: Low molecular weight components (proteins and peptides with a molecular weight less than 45 kDa), were isolated from bovine colostrum and Sacharomyces cerevisue and Pleurotus osteatus cell components. It has been determined their effects on physiological characteristics (weight change, body temperature, work capacity) and biochemical parameters (cholesterol, triacylglycerols, creatinine and albumin) and lipid hydroperoxides (figure prooxidant activity) activity of glutathione peroxidase (a measure of antioxidant system) on the model of Cu-induced liver fibrosis. It is shown that irrespective of the method and the source of the LMWCC and the Mix-factor its components eliminated the loss of body weight, the body temperature normalized, and partially restored working capacity of animals with Cu-induced fibrosis. Methods: A three-fold serial intraperitoneal administration of copper sulfate to animals at the dose of 33% of the lethal dose with an interval of 48 hours between injections was accompanied with development of liver fibrosis. Doses of \"Mix-factor\" and LMWCC were chosen for the removed of influence of experimental animal’s fibrosis. In the investigation were used the methods of definition of content of cholesterol, triacylglycerols, creatinine and albumin. Besides, it has been activity of glutathione peroxidase and content of lipid hydroperoxides. Results: Content of cholesterol, triacylglycerols, creatinine and albumin remained unchanged in animals with Cuinduced liver fibrosis, a lipid hydroperoxides have increased by 90% in blood serum and 83% in liver mitochondria and activity of glutathione peroxidase was reduced. Introduction of LMWCC and mix-factor increases the activity of glutathione peroxidase and normalize lipid hydroperoxides content. It has been identified S-shaped dose dependence of LMWCC on indicators of proantioxidant system. Conclusion: The results showed that LMWCC obtained from various sources (from cow colostrum or from Pleurotus ostreatus fungi, or from yeast) activated antioxidant defense enzymes (glutathione peroxidase), eliminated oxidative stress in animals with Cu-induced liver fibrosis. These biochemical changes in the body of animals with fibrosis were accompanied by normalization of physiological characteristics (body temperature, growth rate of animals).","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.1000107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68089468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}