Translational biomedicine最新文献_第3页

The Effect of Intravitreal Injection of Avastin for Neovascular Age related Macular Degeneration 玻璃体内注射阿瓦斯丁治疗新生血管性年龄相关性黄斑变性的疗效观察

Translational biomedicine Pub Date : 2020-01-01 DOI: 10.36648/2172-0479.11.3.168

A. Asadollah, E. Shahverdi

引用次数: 1

Prevalence of Low Birth Weight andAssociated Factor among neonate Born atJimma Medical Center (JMC), Jimma, SouthWestern Ethiopia 埃塞俄比亚西南部吉马医疗中心(JMC)新生儿低出生体重患病率及相关因素

Translational biomedicine Pub Date : 2019-01-01 DOI: 10.21767/2172-0479.100156

Seidmortaz Ss, T. Tolosa, D. Adugna

{"title":"Prevalence of Low Birth Weight andAssociated Factor among neonate Born atJimma Medical Center (JMC), Jimma, SouthWestern Ethiopia","authors":"Seidmortaz Ss, T. Tolosa, D. Adugna","doi":"10.21767/2172-0479.100156","DOIUrl":"https://doi.org/10.21767/2172-0479.100156","url":null,"abstract":"Background: Low Birth Weight continues to remain key public health concern related to poverty, social factors such as lower status of women, lack of nutrition and Antenatal care. Objective: To determine the prevalence of Low Birth Weight and associated factor, among the neonates born in Jimma medical center from May 1, 2015 GC- April 30, 2017 G.C. Methods: A facility based cross sectional descriptive study was carried out on birth weight distribution. Data was collected from delivery registration book of obstetrics department by using structured data collection format and analysis was done manually. Finally the finding was presented by using tables, frequency, percentage, x2-test was used to determine association between variables. Results: A total of 3546 live birth new-born were observed among which more than half 54% were male and 46% were female. The mean birth weight was 3200 g and the prevalence of low birth weight was 7.8%. with regard to factor associated with birth weight Antenatal care follow up, parity, gestational age, sex of new born and maternal age during the last pregnancy had significant association with low birth weight with the p value <0.05. Conclusion: The prevalence of low birth weight in the study area was comparatively lower than that of countrywide figure. Maternal related factors like, maternal age, parity, and Antenatal care follow up as well as new-born related factors like sex of the neonate and gestational age were significantly associated with low birth weight. Therefore Further Large scale study with a representative sample size is recommended to be conducted in the future..","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68107860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

A Xeno-Free, Serum-Free Expansion Medium for Ex-vivo Expansion and Maintenance of Major Human Tissue-Derived Mesenchymal Stromal Cells 一种无xeno、无血清的体外培养和维持主要人组织源性间充质基质细胞的培养基

Translational biomedicine Pub Date : 2018-01-01 DOI: 10.21767/2172-0479.100146

Lopes, A. Ngo, H. Ni

{"title":"A Xeno-Free, Serum-Free Expansion Medium for Ex-vivo Expansion and Maintenance of Major Human Tissue-Derived Mesenchymal Stromal Cells","authors":"Lopes, A. Ngo, H. Ni","doi":"10.21767/2172-0479.100146","DOIUrl":"https://doi.org/10.21767/2172-0479.100146","url":null,"abstract":"Introduction: MSCs, one of the most useful stem cell type for clinical applications, can be derived from various adult tissues. While sharing the same basic properties, there are however differences in their proliferative capacity, degree of potency and level of multipotent marker expression and immunosuppression ability. As the cell media industry continues to develop effective serum-free cell culture media, an understanding of the potential effect on MSCs profile and functionality is needed. Methods and Findings: MSCs derived from adipose tissue, bone marrow and umbilical cord were grown in FBS containing media, or a newly-developed XSFM and characterized by flow cytometry, immunomodulation and differentiation assays. In this study we have found that each source of MSCs had a different cell expansion profile, but cells grown in XSFM reach higher cumulative cell numbers. No significant difference was noted in the expression profile of CD45, CD105 and CD90 and cells retained their differentiation and their immunomodulatory potential. BM-derived MCSs had a relatively weaker immunomodulatory potential, but this could be improved when cells were cultured in XSFM. Conclusion: In conclusion, the developed XSFM for human MSCs provides a superior alternative for clinical applications with multiple cell origins, by eliminating the drawbacks of sera usage, while leading to higher cumulative cell numbers and maintaining the cell characteristics.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68106232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Mice with the Heart-Specific Overexpression of Prothrombin- Do Not Show Cardiac Insufficiency 心脏特异性凝血酶原-过表达的小鼠不表现出心功能不全

Translational biomedicine Pub Date : 2018-01-01 DOI: 10.21767/2172-0479.100148

I. Keiichi, Hongo Kenichi, D. Tarò, Morimoto Satoshi, Y. Akira, K. Haruka, T. Yoshiro, Nagoshi Tomohisa, Kusakari Yoichiro, Akaike Toru, M. Susumu, Ogawa Kazuo, Minai Kosuke, Kawai Makoto, M. Seiichiro, Y. Teiichi, Yoshimura Michihiro

引用次数: 0

Predictive Value of Major Inflammatory Markers in Complete Blood Count for Short-Term Prognosis in Patients with Acute Carbon-monoxide Poisoning 全血细胞计数中主要炎症标志物对急性一氧化碳中毒患者短期预后的预测价值

Translational biomedicine Pub Date : 2018-01-01 DOI: 10.21767/2172-0479.100154

Weiqiang Wang, Jincheng Cheng, Kai Wang, Jun Zhang

{"title":"Predictive Value of Major Inflammatory Markers in Complete Blood Count for Short-Term Prognosis in Patients with Acute Carbon-monoxide Poisoning","authors":"Weiqiang Wang, Jincheng Cheng, Kai Wang, Jun Zhang","doi":"10.21767/2172-0479.100154","DOIUrl":"https://doi.org/10.21767/2172-0479.100154","url":null,"abstract":"Background: Acute carbon monoxide poisoning (ACOP) has high morbidity and mortality. The best inflammatory markers or indices can be identified by retrospective analysis the associations of inflammatory indices in completed blood count and short-term prognosis in ACOP patients and the indices can be used to guide in clinical diagnosis and treatment. Method: There were 256 ACOP patients who admitted into No. 123 Hospital from Jan 2008 to Dec 2017 were enrolled into this study. According to the health condition of ACOP patients after 2 months, the patients were divided into poor (n=21) and good (n=235) prognosis groups. The inflammatory indices, age, Glasgow coma scale (GCS) and other parameters were compared between the groups. Receiver operating characteristic (ROC) curves were used to evaluate the predictive values of various indicators towards prognosis of patients with ACOP. Results: The count of white blood cells, neutrophil, red blood cell distribution width, age and hypertension morbidity rate were significantly higher in poor prognosis group than that of the good prognosis group while the GCS was significant lower in the poor prognosis group compared to the good prognosis group. Multifactor analysis showed that neutrophil, age and GCS were risk factors for poor prognosis in patients with ACOP. Thus the results of combination of neutrophil count with age and GSC can be best in predicting the prognosis of ACOP. Conclusion: Neutrophil count is the indicator in predicting the short-term prognosis of ACOP and its predictive value can be increased by combining the parameters like age and GCS.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"09 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68107629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Obstetric Simulation in the Learning of Skills Related to Birthing Care in Medical Students, Medellin-Colombia 产科模拟在医科学生分娩护理技能学习中的效果，哥伦比亚麦德林

Translational biomedicine Pub Date : 2018-01-01 DOI: 10.21767/2172-0479.100152

JA Cardona-Arias, J. Córdoba, A. Ibarra

{"title":"Efficacy of Obstetric Simulation in the Learning of Skills Related to Birthing Care in Medical Students, Medellin-Colombia","authors":"JA Cardona-Arias, J. Córdoba, A. Ibarra","doi":"10.21767/2172-0479.100152","DOIUrl":"https://doi.org/10.21767/2172-0479.100152","url":null,"abstract":"Introduction: In Colombia, studies regarding the effectiveness of simulation-based medical training programmes are scarce. Objective: To evaluate the effectiveness of a simulationbased obstetric educational intervention in the learning of skills related to birthing care in medical students in Medellin (Colombia). Methods: A randomized experimental study of 28 students who received the intervention and 21 students who did not receive the intervention and served as the control group. A scale was constructed and psychometrically evaluated to measure competencies in three domains, Being, Knowing, and Doing, in birthing care; this scale was applied before and after the intervention, generating a rating between 0 (poorest) and 100 (best). The effectiveness of the educational intervention was evaluated using differences-indifferences and linear regression analysis. Results: The scale showed excellent psychometric properties in the domains of knowing and doing, with Cronbach’s α-value greater than 0.80; furthermore, 100% success in internal consistency, discriminant power, and content validity added to the high explained variance. The intervention did not generate significant changes in the competency in the being domain and was effective in improving competencies in the Knowing and Doing domains, with increases of 23.9 and 27.2 points, respectively. Conclusion: The simulation-based birth-related skills learning programme was effective in increasing the competencies of knowing and doing in medical students.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68107507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prevalence of Thyroid Disorders in an Institution Providing Health Services in Medellin-Colombia 哥伦比亚麦德林一家提供保健服务的机构中甲状腺疾病的患病率

Translational biomedicine Pub Date : 2018-01-01 DOI: 10.21767/2172-0479.100149

Carmona Carmona Ca, Bedoya Pa, A. Jb, Cardona Arias Ja

{"title":"Prevalence of Thyroid Disorders in an Institution Providing Health Services in Medellin-Colombia","authors":"Carmona Carmona Ca, Bedoya Pa, A. Jb, Cardona Arias Ja","doi":"10.21767/2172-0479.100149","DOIUrl":"https://doi.org/10.21767/2172-0479.100149","url":null,"abstract":"Introduction: Thyroid hormones regulate numerous metabolic processes. Therefore, any alteration in their synthesis or function has important health implications. Despite the importance of thyroid disorders, there are few studies in Colombia about the prevalence of these diseases. Objective: To determine the prevalence of thyroid function alterations in a health care institution in Medellin-Colombia, and their distribution according to sex and age. Methods: Cross-sectional descriptive study in a population of 5.962 subjects, using secondary information. Summary and frequency measurements were done. Associations between the variables were evaluated with chi-square and t-student´s tests, while the magnitude of the association was determined with prevalence ratios and a confidence interval of 95%. Result: The prevalence of thyroid-stimulating hormone (TSH) alterations was 24.5%, 19% of people had a high concentration of this hormone, being statistically higher in women. The prevalence of alterations in thyroid profile T3 (triiodothyronine) and T4 (thyroxine) was 8%, from which 5.1% corresponded to subclinical hypothyroidism, 1.3% to subclinical hyperthyroidism, 0.7% to primary hyperthyroidism and 0.1% to central hyperthyroidism. Conclusion: The population studied had a high prevalence of alterations in TSH concentrations, being higher in women than in men. It is important that health care institutions design strategies for the control and monitoring of these alterations. Moreover, it is necessary to study thyroid profile alterations in the general population.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68106697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The Synergism of Somatostatin, Melatonin, Vitamins Prolactin and Estrogen Inhibitors Increased Survival, Objective Response and Performance Status In 297 Cases of Breast Cancer 生长抑素、褪黑素、维生素催乳素和雌激素抑制剂的协同作用提高297例乳腺癌患者的生存、客观反应和运动状态

Translational biomedicine Pub Date : 2018-01-01 DOI: 10.21767/2172-0479.100144

G. D. Bella, B. Colori, R. Scanferlato

{"title":"The Synergism of Somatostatin, Melatonin, Vitamins Prolactin and Estrogen Inhibitors Increased Survival, Objective Response and Performance Status In 297 Cases of Breast Cancer","authors":"G. D. Bella, B. Colori, R. Scanferlato","doi":"10.21767/2172-0479.100144","DOIUrl":"https://doi.org/10.21767/2172-0479.100144","url":null,"abstract":"Background: Breast cancer is still the leading cause of death in women worldwide. Study question: Our purpose is to improve survival, objective response and quality of life with a non-toxic biological therapy. Study design: The DBM (Di Bella Method) with MLT (Melatonin), Retinoids, solubilized in vitamin E, D3, and C, Folates, proteoglycans and calcium, has a differentiating, cytostatic, anti-angiogenic, immune-modulating, factorially synergic effect, simultaneously reinforcing the functions which physiology considers to be essential for life. With Somatostatin/Octreotide, prolactin and estrogen inhibitors, DBM has an antiproliferative, antiangiogenic and antimetastatic effect. These molecules govern negatively pituitary secretions like GH-PRL, whose mitogenic properties are enhanced by the combination of ovarian hormones such as estrogen. The negative regulation of GH extends to IGF-1, EGF (Epidermal Growth Factor), VEGF (Vascular Endothelial Growth Factor), and GHdependent growth factors. The DBM (Di Bella Method) uses minimal metronomic apoptotic, non-cytotoxic and non-mutagenic doses of cyclophosphamide. The tolerability of which is enhanced by MLT and by the vitamins included in the DBM. We report a retrospective observational study with 5-year follow-up, carried out on 297 patients affected by breast cancer and treated with the Di Bella Method biological therapy. Results and conclusion: complete and stable objective responses without cytolytic chemotherapy, in some cases even without surgery or radiotherapy, with a generalized improvement in quality of life and no significant and/or prolonged toxicity. The most important 5-year survival rate was 69.4% at stage IV cancer versus 26.3% reported by the National Cancer Institute.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68106720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Effectiveness of Tens (Transcutaneous Electrical Nerve Stimulation) in Reducing Pain during Replacing the Dressing in Hospitalized Patients in Burn Center of Sabzevar 经皮神经电刺激减轻Sabzevar烧伤中心住院患者换药时疼痛的效果

Translational biomedicine Pub Date : 2018-01-01 DOI: 10.21767/2172-0479.100142

M. Siavoshi, R. Bordbar, Sabzevar Av, Nik Mj, B. Payvar, M. Khosravani, Moghadam Ag

{"title":"The Effectiveness of Tens (Transcutaneous Electrical Nerve Stimulation) in Reducing Pain during Replacing the Dressing in Hospitalized Patients in Burn Center of Sabzevar","authors":"M. Siavoshi, R. Bordbar, Sabzevar Av, Nik Mj, B. Payvar, M. Khosravani, Moghadam Ag","doi":"10.21767/2172-0479.100142","DOIUrl":"https://doi.org/10.21767/2172-0479.100142","url":null,"abstract":"Background and aim: A burning pain is considered among the most painful conditions experienced by burn patients, specifically, during changing the wound dressing. By using complementary therapies such as aromatherapy, hypnosis, music therapy, acupressure, TENS is considered as nurses’ serious tasks and has special importance in pain controlling of patients. This study was accomplished to consider the effect of electrical nerve stimulation (TENS) through skin during replacing the wound dressing in hospitalized burn patients in burn ward of Sabzevar Vasee hospital. Materials and methods: This is a clinical trial study performed on 40 hospitalized burn patients of Sabzevar Vasee hospital in 2014. The patients were divided randomly into two groups, including control category (20 individuals) and case one (20 individuals). Before changing the wound dressing, morphine was injected to the patient, and in the second days after referral, the members of control group received placebo TENS with morphine, and TENS was received in the members of test group while replacing the dressing. Finally, after replacing the dressing, the pain of patient was measured according to pain numeric scale 0-10. The data was analyzed with Mann-Whitney tests by SPSS software (ver. 20). The significance level (p-value) in statistical tests used in this study is considered 5%. Results: The average of pain in second day was 7.00 ± 0.56 and 5.00 ± 0.48 in control and test groups, respectively. There was a significant difference in reduction of the pain between two groups (P=0.013). It means that TENS can alleviate the pain 2.3 units more than placebo TENS. Conclusion: Supplementary TENS and morphine are effective in reducing the pain in burn patients during replacing the bandage.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68106398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detailed Clinician Updates are Critical to Educational Success for Pediatric Patients With ME/CFS 详细的临床医生更新对ME/CFS患儿的教育成功至关重要

Translational biomedicine Pub Date : 2018-01-01 DOI: 10.21767/2172-0479.100143

Faith R. Newton

引用次数: 0