{"title":"Illnesses of Unknown Etiology.","authors":"F. Fumagalli","doi":"10.36648/2172-0479.21.12.189","DOIUrl":"https://doi.org/10.36648/2172-0479.21.12.189","url":null,"abstract":"A public health event (PHE) is defined as any occurrence that may have negative consequences for human health, including those that have not yet caused disease or illness but that have potential and those that may require a coordinated response . This framework focuses on PHEs of initially unknown etiology, which are PHEs for which the cause has not yet been determined. For such events, the One Health approach is recommended, where the ministry of health works in close collaboration with other ministries and multisectoral partners to enhance teamwork and improve efficiencies in preparedness, response, and monitoring and evaluation (M&E).","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"02 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69701777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Note on Laboratory and Clinical Medicine","authors":"A. Mahmoud","doi":"10.36648/2172-0479.21.12.E184","DOIUrl":"https://doi.org/10.36648/2172-0479.21.12.E184","url":null,"abstract":"A medical laboratory or clinical laboratory is a laboratory where tests are carried out on clinical specimens to obtain information about the health of a patient to aid in diagnosis, treatment, and prevention of disease. Clinical Medical laboratories are an example of applied science, as opposed to research laboratories that focus on basic science, such as found in some academic institutions.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69701805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Brief Note on Blood Banking and Serology","authors":"B. Vainer","doi":"10.36648/2172-0479.21.12.E185","DOIUrl":"https://doi.org/10.36648/2172-0479.21.12.E185","url":null,"abstract":"Blood banking is the process that takes place in the lab to make sure that donated blood, or blood products, are safe before they are used in blood transfusions and other medical procedures. Blood banking includes typing the blood for transfusion and testing for infectious diseases. Most blood donors are volunteers. However, sometimes, a patient may want to donate blood a couple of weeks before undergoing surgery, so that his or her blood is available in case of a blood transfusion","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69702243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CAR (Chimeric Antigen Receptor) T-Cell Therapy: Immuno-Oncology, Immunomodulation, and Immunotherapy in Cancer","authors":"V. Maurya","doi":"10.36648/2172-0479.21.12.164","DOIUrl":"https://doi.org/10.36648/2172-0479.21.12.164","url":null,"abstract":"Background: Cancer is one of the main sources of death around the world. Throughout the long term, several traditional cytotoxic methodologies for neoplastic illnesses have been created. Notwithstanding, because of their restricted adequacy as per the heterogeneity of malignant growth cells, there is a steady quest for helpful methodologies with the improved result, for example, an immunotherapy that uses furthermore, improves the ordinary limit of the patient's resistant malignancy. Strategies: Chimeric Antigen Receptor (CAR) T-cell treatment includes Genetic modification of patient's autologous T-cells to communicate a CAR specific for a tumor antigen, following by ex vivo cell development furthermore, re-implantation back to the patient. This T-cell Genetic modification may happen either through viralbased quality exchange strategies or nonviral techniques, for example, DNA-based transposons, CRISPR/Cas9 innovation, or a direct exchange of in vitro deciphered mRNA by electroporation. Results: Clinical trials have indicated exceptionally encouraging outcomes in end-stage patients with a full recuperation of up to 92% in Acute Lymphocytic Leukemia. Notwithstanding such outcomes in hematological diseases, the powerful interpretation of CAR T-cell treatment to solid tumors and the comparing clinical experience is restricted because of helpful boundaries, similar to CAR T-cell development, diligence, dealing, and destiny inside tumors. Conclusion: In this project, the clinical outcome of CARs, the principle Genetic change techniques, the safety matters just as the underlying clinical manifestations in CAR T-cells; are elaborated.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69701012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global Economic and Social Progress of Medicine","authors":"Pinki Chowdhury","doi":"10.36648/2172-0479.21.12.E183","DOIUrl":"https://doi.org/10.36648/2172-0479.21.12.E183","url":null,"abstract":"The resources and knowledge for achieving improved global health exist, a new, critical paradigm on health as an aspect of human development, human security, and human rights is needed. Such a shift is required to sufficiently modify and credibly reduce the present dominance of perverse market forces on global health. New scientific discoveries can make wide-ranging contributions to improved health. Despite impressive scientific advances and massive economic growth over the past 60 years, disparities in wealth and health have persisted and, in many places, widened. As a result, the hope of achieving significantly improved health for a greater proportion of the world's people-one of the most pressing problems of our time-has become an ever more distant prospect.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69701796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Research on Clinical Translation","authors":"Run-zhi Lai","doi":"10.36648/2172-0479.21.12.187","DOIUrl":"https://doi.org/10.36648/2172-0479.21.12.187","url":null,"abstract":"","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69701664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unravelling the Role of Stem Cells in Chronic Myeloid Leukaemia and Potential Treatments","authors":"Jeevan Francis","doi":"10.36648/2172-0479.11.3.2","DOIUrl":"https://doi.org/10.36648/2172-0479.11.3.2","url":null,"abstract":"Chronic Myeloid Leukaemia (CML) is a disorder of the haematopoietic system characterised by the malignant clonal growth of bone marrow cells, specifically haematopoietic stem cells (HSCs), which are capable of giving rise to all lineages of blood cells. In essence, CML is a condition where transformed HSCs give rise to cells of myeloid lineage, e.g. platelets, neutrophils etc, causing them to accumulate in the circulating blood. The aim of this paper was to understand and review the role of stem cells (SCs) and Cancer Stem Cells (CSCs) in CML, current strategies for targeting CSCs, potential targets for CML CSC treatment such as histone deacetylase inhibition, autophagy inhibitors, p53 activation by SIRT1 inhibitors, HIF inhibition, and the regulation of c-myc.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69701209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial note for Translational Medicine","authors":"J. Sriharika","doi":"10.36648/2172-0479.11.3.169","DOIUrl":"https://doi.org/10.36648/2172-0479.11.3.169","url":null,"abstract":"I am pleased to introduce Translational Biomedicine (IPTB) Translational Biomedicine is an international open access*, peer-reviewed academic journal with Journal Impact Factor 1.12. The Journal publishes original science-based research that advances communication between the scientific discovery and health improvement. I am pleased to announce that, all issues of volume 10 were published online well within the time and the print issues were also brought out and dispatched within 30 days of publishing the issue online during the year of 2019. mp3download.link Best YouTube to MP3 converter. Download MP3 from YouTube for Free. one would honestly have expected more on the track Youtube to mp3 Download Mp3 songs for free Given the legendary pedigree of the man behind the sound downloadmp3-gratis.biz Download mp3 songs online at Mp3 Converter, watch high quality online music videos download-mp3gratis.me watch and download free songs of the highest quality. Listen to songs online here comfortably without any annoying advertisements. metrolagu.site Easy to use and free MP3 downloader. YouTube To MP3 download in seconds using the best YouTube to MP3 converter. YouTube To Mp3 Get the latest song by simply typing the latest artist or song title in the Search menu. Mp3 file format with 128 - 320 Kbps bitrate converted from YouTube videos. read at this blog All those artist performances are still available on YouTube today find more here","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69700712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In-silico Study to elucidate corona Virus by plant phytoderivatives that hits as a fusion inhibitors targeting HR1 domain in spike protein which conformational Changes efficiently inhibit entry COVID-19","authors":"M. N. Khan","doi":"10.36648/2172-0479.11.3.1","DOIUrl":"https://doi.org/10.36648/2172-0479.11.3.1","url":null,"abstract":"Introduction: COVID-19 could be a human beta corona virus that have potential source of severe widespread respiratory and asymptomatic multiple pathophysiological conditions and is belonging to the SARS and MERS β-corona viruses linage that have inflated mortality rates and acute potential of pandemic. The viral envelope surface spike glycoprotein (S) binding with host cell receptor angiotensin-converting enzyme 2 (ACE2) and conciliate fuse the virus particle inside the host cell membranes, promising spike protein substantially important to endocytosis and host species an involuntary orienting response. Methods: Within the present in-silico study, two plant bioactive compounds namely ALS-1 and ALS-2 (from Alangium salvifolium) were analyzed for his or her inhibitory role on fusion peptide region or S2 HR-1 domain and efficiently block virus entry into host cell by applying the molecular simulation, docking studies. Other parameters viz. determination of molecular interaction-based binding affinity values, protein-ligand interactions, Lipinski rule of 5, functional properties and biological activities for the above compounds were also calculated by employing the acceptable bioinformatics tools. Results: The results of docking analysis clearly showed that ALS-1 has highest binding affinity with trimeric Spike glycoprotein (-11.6 kcal/mole) and ALS-2 (-10.8 kcal/mole). Based on protein interaction analysis both phytoderivatives bind HR-1 (fusion peptide) domain. Other parametric results showed good absorption activity and not violated Lipinski score of drug-likeness. Conclusion: Therefore studied plant derivatives may have the potential to play a big role as 2019 n-CoV fusion peptide inhibitor, revealing influential inhibitory activity against S-participated endocytosis and 2019 n-CoV viral infection, suggesting further optimizations (3-DQASR) and pharmaceutical development of both derivatives, respectively, to stop and treat novel COVID-19 infection.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69700525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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