Bipolar Disorders最新文献

{"title":"Stable neural underpinnings of emotional cognition subgroups in patients newly diagnosed with bipolar disorder: A prospective fMRI study","authors":"Hanne Lie Kjærstad,&nbsp;Luisa de Siqueira Rotenberg,&nbsp;Julian Macoveanu,&nbsp;Klara Coello,&nbsp;Maria Faurholt-Jepsen,&nbsp;Anne Juul Bjertrup,&nbsp;Gitte M. Knudsen,&nbsp;Patrick M. Fisher,&nbsp;Maj Vinberg,&nbsp;Lars Vedel Kessing,&nbsp;Beny Lafer,&nbsp;Kamilla Woznica Miskowiak","doi":"10.1111/bdi.13444","DOIUrl":"10.1111/bdi.13444","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective<b>s</b></h3>\u0000 \u0000 <p>This study aimed to investigate the neural underpinnings of emotional cognition subgroups in recently diagnosed patients with bipolar disorder (BD) and change over time over a 15-month follow-up period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients and healthy controls (HC) underwent emotional and nonemotional cognitive assessments and functional magnetic resonance imaging (fMRI) at the baseline (BD <i>n</i> = 87; HC <i>n</i> = 65) and at 15-month follow-up (BD <i>n</i> = 44; HC <i>n</i> = 38). Neural activity during emotion reactivity and regulation in response to aversive pictures was assessed during fMRI. Patients were clustered into subgroups based on their emotional cognition and, with HC, were compared longitudinally on cognition and neural activity during emotion reactivity and regulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients were optimally clustered into two subgroups: Subgroup 1 (<i>n</i> = 40, 46%) was characterized by <i>heightened emotional reactivity</i> in negative social scenarios, which persisted over time, but were otherwise cognitively intact. This subgroup exhibited stable left amygdala <i>hyper</i>-activity over time during emotion reactivity compared to subgroup 2. Subgroup 2 (<i>n</i> = 47, 54%) was characterized by <i>global emotional cognitive impairments</i>, including stable difficulties with emotion regulation over time. During emotion regulation across both time points, this group exhibited <i>hypo</i>-activity in the left dorsolateral prefrontal cortex. Additionally, patients in subgroup 2 had poorer nonemotional cognition, had more psychiatric hospital admissions and history of psychotic episodes than those in subgroup 1.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Broad impairments in emotional cognition in approximately half of BD patients and associated nonemotional cognitive deficits may originate from insufficient recruitment of prefrontal resources, contributing to poorer clinical outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 6","pages":"556-569"},"PeriodicalIF":5.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140841372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring the exposome in bipolar disorder","authors":"Mete Ercis,&nbsp;Aysegul Ozerdem,&nbsp;Marin Veldic,&nbsp;Balwinder Singh,&nbsp;Brandon J. Coombes,&nbsp;Joanna M. Biernacka,&nbsp;Konstantinos N. Lazaridis,&nbsp;Mark A. Frye","doi":"10.1111/bdi.13443","DOIUrl":"10.1111/bdi.13443","url":null,"abstract":"&lt;p&gt;Although bipolar disorder is highly heritable, the identified genetic variants explain only a small portion of phenotypic variation and overall disease risk. Contemporaries of Kraepelin delineate environmental exposure to disease, in part, by developmental age and whether exposures are modifiable (i.e., diet, alcohol, and drug use) or non-modifiable (i.e., childhood maltreatment, head trauma, and infection-associated immune activation) risk factors.&lt;span&gt;&lt;sup&gt;1, 2&lt;/sup&gt;&lt;/span&gt; Exposures can be studied at the individual level and population level. For example, in comparison to age-matched controls, individuals with bipolar disorder, in particular those with a history of psychotic mania and non-early onset illness, had significantly increased long-term IgG antibody response to cytomegalovirus.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; In another study utilizing two large datasets from the United States and Denmark, air quality was identified as the strongest predictor of a bipolar disorder diagnosis among environmental quality indices.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; These examples provide a compelling illustration of how quantifying environmental exposure at both the individual and population levels has merit in enhancing our understanding of bipolar disorder and its putative subphenotypes. Achieving a more comprehensive and precise assessment of such environmental factors is critical for future clinical research initiatives.&lt;/p&gt;&lt;p&gt;Introduced in 2005, the exposome concept illustrated the need to assess environmental exposures more holistically.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; It encompasses all exposures an individual encounters, from conception to end of life. The exposome is broadly categorized into three interactive and potentially overlapping domains of general external exposures (geographic, social, and economic), specific external exposures (diet, tobacco, alcohol, substance use, pharmacotherapy, skin care products, pollutants, radiation, and contaminants), and internal exposures which include biological effects of external exposures (metabolism, hormones, gut microflora, inflammation, and oxidative stress). Importantly, these domains are not necessarily mutually exclusive and inevitably interact as exogenous factors influence internal factors. Advances in exposome research will likely facilitate greater breadth and depth of environmental risk quantification to disease and relapse.&lt;/p&gt;&lt;p&gt;Measuring the exposome is a challenging task due to the vast array and dynamic fluctuations of environmental exposures individuals encounter throughout their lives. Initial models for estimating the exposome score have been proposed for psychiatric disorders, particularly schizophrenia, with the potential to enhance risk prediction and stratification.&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; However, these models are currently limited to considering only external exposures and do not account for the internal biological response to environmental exposures, ultimately failing to capture the entirety of ","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 5","pages":"488-490"},"PeriodicalIF":5.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140841577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of the DSM-5 Mixed Features Specifier Interview","authors":"Mark Zimmerman,&nbsp;Daniel Mackin","doi":"10.1111/bdi.13436","DOIUrl":"10.1111/bdi.13436","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To examine the reliability and validity of a semi-structured interview assessing the features of the DSM-5 mixed features specifier. Our goal was to develop an instrument that could be used for both diagnostic and severity measurement purposes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Four hundred fifty-nine psychiatric patients in a depressive episode were interviewed by a trained diagnostic rater who administered semi-structured interviews including the DSM-5 Mixed Features Specifier Interview (DMSI). We examined the inter-rater reliability and psychometric properties of the DMSI. The patients were rated on clinician rating scales of depression, anxiety, and irritability, and measures of psychosocial functioning, suicidality, and family history of bipolar disorder.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The DMSI had excellent joint-interview interrater reliability. More than twice as many patients met the DSM-5 mixed features specifier criteria during the week before the assessment than for the majority of the episode (9.4% vs. 3.9%). DMSI total scores were more highly correlated with a clinician-rated measure of manic symptoms than with measures of depression and anxiety. More patients with bipolar depression met the mixed features specifier than patients with MDD. Amongst patients with MDD, those with mixed features more frequently had a family history of bipolar disorder, were more frequently diagnosed with anxiety disorders, attention deficit disorder, and borderline personality disorder, more frequently had attempted suicide, and were more severely depressed, anxious, and irritable.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The DMSI is a reliable and valid measure of the presence of the DSM-5 mixed features specifier in depressed patients as well as the severity of the features of the specifier.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 5","pages":"479-487"},"PeriodicalIF":5.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140841368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescribed psychostimulants and other pro-cognitive medications in bipolar disorder: A systematic review and meta-analysis of recurrence of manic symptoms","authors":"Andreea Chiorean,&nbsp;Brett D. M. Jones,&nbsp;Mijia Murong,&nbsp;Christina Gonzalez-Torres,&nbsp;Stefan Kloiber,&nbsp;Abigail Ortiz,&nbsp;Joshua D. Rosenblat,&nbsp;Benoit H. Mulsant,&nbsp;M. Ishrat Husain","doi":"10.1111/bdi.13440","DOIUrl":"10.1111/bdi.13440","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Clinicians are often hesitant to prescribe psychostimulants in bipolar disorder (BD) due to concerns of inducing (hypo)mania, despite limited published evidence on associations between prescribed psychostimulant use and recurrence of mood episodes in BD. The current systematic review and meta-analysis evaluated the emergence of (hypo)manic symptoms in patients with BD receiving prescribed psychostimulants or other pro-cognitive medications in euthymic or depressive states.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic search was performed of MEDLINE, Embase, and PsychINFO from inception to April 5, 2023 and search of Clinicaltrials.gov and Clinicaltrialsregister.eu for unpublished data. References of included studies were hand-searched. Randomized trials and prospective longitudinal studies that evaluated psychostimulants and non-stimulant medications recommended for the treatment of ADHD by the Canadian ADHD practice guidelines were included. The review was reported in line with PRISMA guidelines and was preregistered on PROSPERO (CRD42022358588).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After screening 414 unique records, we included 27 studies, of which five reported data that was quantitatively synthesized (<i>n</i> = 1653). The use of psychostimulants in BD was not associated with increased scores on the Young Mania Rating Scale in patients who were in a euthymic or depressed state (SMD IV −0.17; 95% CI, −0.40 to 0.06) compared to placebo. There was a high degree of study-level heterogeneity (<i>I</i>² = 80%). A qualitative synthesis of studies revealed a limited risk of medication-induced manic symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our review provides preliminary evidence to suggest psychostimulants and non-stimulant ADHD medications have a limited risk of precipitating (hypo)mania symptoms. More extensive studies evaluating the safety and efficacy of these medications are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 5","pages":"418-430"},"PeriodicalIF":5.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140803212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early intervention, relapse prevention, and neuroprogression in bipolar disorder: The evidence matters","authors":"Lakshmi N. Yatham,&nbsp;Ayal Schaffer,&nbsp;Lars V. Kessing,&nbsp;Kamilla Miskowiak,&nbsp;Flavio Kapczinski,&nbsp;Eduard Vieta,&nbsp;Robert M. Post,&nbsp;Michael Berk","doi":"10.1111/bdi.13435","DOIUrl":"10.1111/bdi.13435","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 4","pages":"313-316"},"PeriodicalIF":5.4,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140656701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential role of metformin cessation in bipolar mania relapse, with subsequent resolution upon re-initiation: A case report","authors":"Kimberly Choo,&nbsp;Han Lin Wan,&nbsp;Nisha Chandwani","doi":"10.1111/bdi.13437","DOIUrl":"10.1111/bdi.13437","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 5","pages":"496-499"},"PeriodicalIF":5.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the different sleep disturbances during the prodromal phase of depression and mania in bipolar disorders","authors":"Louise Basquin,&nbsp;Julia Maruani,&nbsp;Jeanne Leseur,&nbsp;Sibylle Mauries,&nbsp;Balthazar Bazin,&nbsp;Guillaume Pineau,&nbsp;Chantal Henry,&nbsp;Michel Lejoyeux,&nbsp;Pierre A. Geoffroy","doi":"10.1111/bdi.13429","DOIUrl":"10.1111/bdi.13429","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;One of the challenges in bipolar disorder (BD) lies in early detection of the illness and its recurrences, to improve prognosis. Sleep disturbances (SD) have been proposed as reliable predictive markers of conversion. While preliminary studies have explored the relationship between SD and the onset of mood episodes, the results remain heterogeneous and a few have specifically examined patients' perception of prodromal symptoms and their progression until the episode occurs. Identifying prodromes represents a crucial clinical challenge, as it enables early intervention, thereby reducing the severity of BD. Therefore, the objective of this study is to better characterize and evaluate the progressive nature of SD as prodromal symptoms of mood episodes, and patients' perception of it.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Patients diagnosed with BD, either hospitalized or seeking treatment for a (hypo)manic or depressive episode benefited from standardized questionnaires, structured interviews, and self-report questionnaires to evaluate SD prior to the current episode, as well as sociodemographic and clinical information.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Out of the 41 patients included, 59% spontaneously reported SD prior to the episode, appearing 90 days before depression and 35 days before mania (pre-indexed/spontaneous reports: 51.22% insomnia complaints, 4.88% hypersomnolence complaints, 7.32% parasomnias, 2.44% sleep movements). After inquiry about specific SD, the percentage of patients reporting prodromal SD increased significantly to 83%, appearing 210 days before depression and 112.5 days before mania (post-indexed reports: 75.61% presented with insomnia complaints appearing 150 days before depression and 20 days before mania, 46.34% had hypersomnolence complaints appearing 60 days before depression, 43.9% had parasomnias appearing 210 days before depression and 22.5 days before mania, 36.59% had sleep movements appearing 120 days before depression and 150 days before mania). Of note, bruxism appeared in 35% of patients before mania, and restless legs syndrome in 20% of patients before depression.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study highlights the very high prevalence of SD prior to a mood episode in patients with BD with differences between depressive and manic episodes. The more systematic screening of sleep alterations of the prodromal phase improved the recognition and characterization of different symptoms onset by patients. This underscores the need for ","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 5","pages":"454-467"},"PeriodicalIF":5.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13429","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140668714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faster than light: Ultrarapid cycling in bipolar disorder","authors":"Antonio Tejada-Alfonseca,&nbsp;Samuel Pampols-Perez,&nbsp;Roberto Palacios-Garrán","doi":"10.1111/bdi.13433","DOIUrl":"10.1111/bdi.13433","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 4","pages":"398-400"},"PeriodicalIF":5.4,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140674074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinguishing bipolar depression, bipolar mania, and major depressive disorder by gut microbial characteristics","authors":"Taipeng Sun,&nbsp;Gang Chen,&nbsp;Wenhao Jiang,&nbsp;Wei Xu,&nbsp;Linlin You,&nbsp;Chenguang Jiang,&nbsp;Suzhen Chen,&nbsp;Dan Wang,&nbsp;Xiao Zheng,&nbsp;Yonggui Yuan","doi":"10.1111/bdi.13439","DOIUrl":"10.1111/bdi.13439","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gut microbial disturbance has been widely confirmed in mood disorders. However, little is known about whether gut microbial characteristics can distinguish major depressive disorder (MDD), bipolar depression (BP-D), and bipolar mania (BP-M).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a prospective case–control study. The composition of gut microbiota was profiled using 16S ribosomal RNA (rRNA) gene sequencing of fecal samples and compared between healthy controls (HC; <i>n</i> = 46), MDD (<i>n</i> = 51), BP-D (<i>n</i> = 44), and patients with BP-M (<i>n</i> = 45).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Gut microbial compositions were remarkably changed in the patients with MDD, BP-D, and BP-M. Compared to HC, distinct gut microbiome signatures were found in MDD, BP-D, and BP-M, and some gut microbial changes were overlapping between the three mood disorders. Furthermore, we identified a signature of 7 <i>operational taxonomic units</i> (OUT; <i>Prevotellaceae</i>-related OUT22, <i>Prevotellaceae</i>-related OUT31, <i>Prevotellaceae</i>-related OTU770, <i>Ruminococcaceae</i>-related OUT70, <i>Bacteroidaceae</i>-related OTU1536, <i>Propionibacteriaceae</i>-related OTU97, <i>Acidaminococcaceae</i>-related OTU34) that can distinguish patients with MDD from those with BP-D, BP-M, or HC, with area under the curve (AUC) values ranging from 0.910 to 0.996.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results provide the clinical rationale for the discriminative diagnosis of MDD, BP-D, and BP-M by characteristic gut microbial features.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 6","pages":"584-594"},"PeriodicalIF":5.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140676528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manic episode associated with baclofen use: A case report","authors":"Merve Akkuş","doi":"10.1111/bdi.13431","DOIUrl":"10.1111/bdi.13431","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 6","pages":"633-636"},"PeriodicalIF":5.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140675552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}