{"title":"Commentary on ‘Comorbidity of bipolar disorder and borderline personality disorder: Phenomenology, course and treatment considerations’ by Temes et al.","authors":"Roger T. Mulder","doi":"10.1111/bdi.13508","DOIUrl":"10.1111/bdi.13508","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 7","pages":"748-749"},"PeriodicalIF":5.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Holy Grail revisited: What works for whom?","authors":"Holly A. Swartz","doi":"10.1111/bdi.13507","DOIUrl":"10.1111/bdi.13507","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 7","pages":"744-745"},"PeriodicalIF":5.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jean Marrero-Polanco, Jeremiah B. Joyce, Caroline W. Grant, Paul E. Croarkin, Arjun P. Athreya, William V. Bobo
{"title":"Predicting remission after acute phase pharmacotherapy in patients with bipolar I depression: A machine learning approach with cross-trial and cross-drug replication","authors":"Jean Marrero-Polanco, Jeremiah B. Joyce, Caroline W. Grant, Paul E. Croarkin, Arjun P. Athreya, William V. Bobo","doi":"10.1111/bdi.13506","DOIUrl":"10.1111/bdi.13506","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Interpatient variability in bipolar I depression (BP-D) symptoms challenges the ability to predict pharmacotherapeutic outcomes. A machine learning workflow was developed to predict remission after 8 weeks of pharmacotherapy (total score of ≤8 on the Montgomery Åsberg Depression Rating Scale [MADRS]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Supervised machine learning models were trained on data from BP-D patients treated with olanzapine (<i>N</i> = 168) and were externally validated on patients treated with olanzapine/fluoxetine combination (OFC; <i>N</i> = 131) and lamotrigine (LTG; <i>N</i> = 126). Top predictors were used to develop a prognosis rule informing how many symptoms should change and by how much within 4 weeks to increase the odds of achieving remission.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>An AUC of 0.76 (NIR:0.59; <i>p</i> = 0.17) was established to predict remission in olanzapine-treated subjects. These trained models achieved AUCs of 0.70 with OFC (NIR:0.52; <i>p</i> < 0.03) and 0.73 with LTG (NIR:0.52; <i>p</i> < 0.003), demonstrating external replication of prediction performance. Week-4 changes in four MADRS symptoms (reported sadness, reduced sleep, reduced appetite, and concentration difficulties) were top predictors of remission. Across all pharmacotherapies, three or more of these symptoms needed to improve by ≥2 points at Week-4 to have a 65% chance of achieving remission at 8 weeks (OR: 3.74, 95% CI: 2.45–5.76; <i>p</i> < 9.3E-11).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Machine learning strategies achieved cross-trial and cross-drug replication in predicting remission after 8 weeks of pharmacotherapy for BP-D. Interpretable prognoses rules required only a limited number of depressive symptoms, providing a promising foundation for developing simple quantitative decision aids that may, in the future, serve as companions to clinical judgment at the point of care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"27 1","pages":"36-46"},"PeriodicalIF":5.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramzi Halabi, Khairatun Yusuff, Clara Park, Alexandra DeShaw, Christina Gonzalez-Torres, Muhammad I. Husain, Claire O'Donovan, Martin Alda, Benoit H. Mulsant, Abigail Ortiz
{"title":"Mood regulation in euthymic patients with a history of antidepressant-induced mania","authors":"Ramzi Halabi, Khairatun Yusuff, Clara Park, Alexandra DeShaw, Christina Gonzalez-Torres, Muhammad I. Husain, Claire O'Donovan, Martin Alda, Benoit H. Mulsant, Abigail Ortiz","doi":"10.1111/bdi.13504","DOIUrl":"10.1111/bdi.13504","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The use of antidepressants in bipolar disorder (BD) remains contentious, in part due to the risk of antidepressant-induced mania (AIM). However, there is no information on the architecture of mood regulation in patients who have experienced AIM. We compared the architecture of mood regulation in euthymic patients with and without a history of AIM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eighty-four euthymic participants were included. Participants rated their mood, anxiety and energy levels daily using an electronic (e-) visual analog scale, for a mean (SD) of 280.8(151.4) days. We analyzed their multivariate time series by computing each variable's auto-correlation, inter-variable cross-correlation, and composite multiscale entropy of mood, anxiety, and energy. Then, we compared the data features of participants with a history of AIM and those without AIM, using analysis of covariance, controlling for age, sex, and current treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Based on 18,103 daily observations, participants with AIM showed significantly stronger day-to-day auto-correlation and cross-correlation for mood, anxiety, and energy than those without AIM. The highest cross-correlation in participants with AIM was between mood and energy within the same day (median (IQR), 0.58 (0.27)). The strongest negative cross-correlation in participants with AIM was between mood and anxiety series within the same day (median (IQR), −0.52 (0.34)).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients with a history of AIM have a different underlying mood architecture compared to those without AIM. Their mood, anxiety and energy stay the same from day-to-day; and their anxiety is negatively correlated with their mood.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 8","pages":"810-819"},"PeriodicalIF":5.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concurrent State of the Art Abstracts","authors":"","doi":"10.1111/bdi.13474","DOIUrl":"https://doi.org/10.1111/bdi.13474","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 S1","pages":"10-44"},"PeriodicalIF":5.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13474","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Welcome Letter","authors":"","doi":"10.1111/bdi.13471","DOIUrl":"https://doi.org/10.1111/bdi.13471","url":null,"abstract":"<p>Welcome to the 26th Annual Conference of the International Society for Bipolar Disorders! The annual meeting brings together experts in bipolar disorders including researchers, educators, clinicians, and experts by experience. We are a global organization with representation from over 20 countries. Over three jam-packed days in Reykjavik, a first-time location for ISBD, we will share knowledge and wisdom about mood disorders. Through improved understanding of the causes and treatments for these conditions, we will be better prepared to support those we serve.</p><p>Meaningfully, 2024 marks the 30th anniversary of ISBD's inception. In 1994, Drs. David Kupfer and Ellen Frank hosted the first International Conference on Bipolar Disorders (ICBD), the precursor to ISBD, in Pittsburgh, Pennsylvania. An eager group of researchers and clinicians gathered on the University of Pittsburgh campus from June 23–24, 1994, for the latest updates on bipolar disorder. On June 17, 1999, ISBD was officially launched in Pittsburgh during the 3rd biennial ICBD meeting. Guided by Dr. Kupfer's vision for an international community of experts who gather regularly to share scientific advances and engage in advocacy for equitable research funding for bipolar disorders, ISBD was born. Thirty years later, ISBD is alive and well.</p><p>Selected from an outstanding pool of submissions, this year's program comprises 30 symposia, six workshops, 66 oral reports, and two poster sessions. We will also host the Women's Initiative to support gender diversity in our Society and an Early-Mid Career Committee networking session to advance the up-and-coming leaders in our field.</p><p>Among our truly exceptional line-up of presentations, I would like to highlight six invited plenary talks: <i>My Bipolar Journey</i> (Leah Charles-King), <i>Debate on Antidepressant Medication for Bipolar Disorder</i> (Ralph Kupka, Eduard Vieta, Lakshmi Yatham), <i>Genetic Architecture of Bipolar Disorder: Knowns and Unknowns</i> (Ole A. Andreassen), <i>From Speech to Emotion to Mood: Mental Health Modeling in Natural Environments</i> (Emily Mower Provost), <i>Older Age Bipolar Disorder: Cognitive and Somatic Comorbidities (</i>Annemiek Dols<i>), and Ongoing Bipolar Mood Instability: What Can, or Could, Psychological Interventions Offer?</i> (Kim Wright). Don't miss any of them!</p><p>Because of the large number of outstanding submissions this year, we expanded our oral report offerings. With 66 presentations, it is impossible to highlight all of them, but I wanted to call your attention to just a few offerings to give you a taste of the feast awaiting us: <i>Polygenic Scores and Mood Disorder Risk in Context of Family History and Developmental Psychopathology</i> (Rudolf Uher), <i>Elucidating Neurovascular Dynamics in Bipolar Disorder with Patient-Derived Vascularized Cerebral Organoids</i> (Annie Kathuria), <i>Fostering Network Opportunities and Creating a Community of Early and Mid-Career Members of t","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 S1","pages":"6"},"PeriodicalIF":5.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13471","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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