Bipolar Disorders最新文献

{"title":"Task Forces of the International Society for Bipolar Disorders: Reflections on the Past, Present, and Future","authors":"Ayal Schaffer, Holly A. Swartz, Mary G. Miller, Chad Daversa, Annemieke Dols, Kamilla Miskowiak, Lakshmi N. Yatham, Gin Malhi","doi":"10.1111/bdi.70123","DOIUrl":"10.1111/bdi.70123","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin Resistance as a Mediator of Suicide Risk in Bipolar Disorder: A Neurobiological and Imaging Study","authors":"Elena Mazza,&nbsp;Laura Raffaelli,&nbsp;Cristina Lorenzi,&nbsp;Rosa Decorato,&nbsp;Poletti Sara,&nbsp;Raffaella Zanardi,&nbsp;Cristina Colombo,&nbsp;Francesco Benedetti","doi":"10.1111/bdi.70121","DOIUrl":"10.1111/bdi.70121","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Major depressive disorder (MDD) and bipolar disorder (BD) are associated with increased suicide risk and commonly feature metabolic dysfunctions such as insulin resistance (IR) and obesity. These conditions are also linked to systemic inflammation and white matter (WM) alterations, which may underlie suicidal behaviors. This study explores how immune-metabolic markers affect WM integrity and suicidality in mood disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Inpatients with BD (<i>n</i> = 93) and MDD (<i>n</i> = 88) underwent diffusion tensor imaging to assess WM integrity. Blood samples were analyzed for insulin, glucose, and inflammatory markers. IR was assessed via HOMA-IR and QUICKI. Suicide risk was measured using the Beck Scale for Suicide Ideation (BSI) and the Hamilton Depression Rating Scale (HDRS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>BD patients showed higher IR, BMI, and inflammation compared to MDD patients. In BD, both insulin and HOMA-IR positively correlated with suicide risk and were associated with increased suicidal ideation. BMI indirectly predicted suicide risk through IR, but not via inflammation. WM analysis revealed that in high-suicide-risk BD patients, higher insulin and HOMA-IR were associated with reduced fractional anisotropy and increased mean and radial diffusivity—markers of axonal and myelin disruption. These effects were not observed in MDD or BD patients with lower suicide risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Insulin resistance emerges as a key contributor to suicidality in BD, possibly via its impact on WM integrity. Although BMI did not directly predict suicide risk, its effect through IR suggests metabolic health may be a modifiable target. Early intervention on IR and inflammation could benefit high-risk BD individuals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognition Assessment in Virtual Reality (CAVIR)—Spanish Version: Validation of a Novel Virtual Reality Test for Daily-Life Cognitive Skills in Bipolar Disorder","authors":"Natalia E. Fares-Otero,&nbsp;Brisa Solé,&nbsp;Andreas Elleby Jespersen,&nbsp;Natalia Roberto-Herrero,&nbsp;Sara Martin-Parra,&nbsp;Ricardo Lopez-Escribano,&nbsp;Anaid Pérez-Ramos,&nbsp;Flavia Piazza,&nbsp;Andrea Ruiz-Muñoz,&nbsp;Cristina Varo,&nbsp;Anders Morrison Lumbye,&nbsp;Eduard Vieta,&nbsp;Anabel Martinez-Aran,&nbsp;Kamilla Woznica Miskowiak","doi":"10.1111/bdi.70118","DOIUrl":"10.1111/bdi.70118","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;There is a need for ecologically valid measures of real-life cognitive functioning. We investigated: (I) the sensitivity of the Cognition Assessment in Virtual Reality (CAVIR) test, which assesses daily-life cognitive skills in an immersive virtual reality kitchen scenario, to capture cognitive impairments in a Spanish sample of patients with bipolar disorder (BD) compared to healthy controls (HCs); (II) the convergent validity of CAVIR against standard neuropsychological tests and functional measures.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Patients with BD in full/partial remission (&lt;i&gt;n&lt;/i&gt; = 40) and HCs (&lt;i&gt;n&lt;/i&gt; = 40) completed the CAVIR–Spanish version and standard neuropsychological tests; the Hamilton Depression Rating Scale (HRDS-17), the Young Mania Rating Scale (YMRS), the Functioning Assessment Short-Test (FAST) and the Brief University of California Performance-based Skills Assessment (UPSA-B). Between-group comparisons of CAVIR global and subtask scores were conducted, together with correlation and linear regression analyses adjusting for age and mood symptoms.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;CAVIR was sensitive to cognitive impairments in BD, with patients showing poorer performance than HCs on CAVIR global composite (BD = −1.09, 95% CI [−1.44, 0.74] vs. HCs = −0.19, 95% CI [−0.53, 0.15]) (&lt;i&gt;F&lt;/i&gt;&lt;sub&gt;(1,72)&lt;/sub&gt; = 9.52, &lt;i&gt;p&lt;/i&gt; = 0.003, &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msubsup&gt;\u0000 &lt;mi&gt;η&lt;/mi&gt;\u0000 &lt;mi&gt;p&lt;/mi&gt;\u0000 &lt;mn&gt;2&lt;/mn&gt;\u0000 &lt;/msubsup&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$$ {eta}_p^2 $$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt; = 0.12) and subtasks of sustained attention (BD = −1.25, 95% CI [−1.83, −0.70] vs. HCs = −0.14, 95% CI [−0.66, 0.37]) (&lt;i&gt;F&lt;/i&gt;&lt;sub&gt;(1,69)&lt;/sub&gt; = 6.12, &lt;i&gt;p&lt;/i&gt; = 0.016, &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msubsup&gt;\u0000 &lt;mi&gt;η&lt;/mi&gt;\u0000 &lt;mi&gt;p&lt;/mi&gt;\u0000 &lt;mn&gt;2&lt;/mn&gt;\u0000 &lt;/msubsup&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$$ {eta}_p^2 $$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt; = 0.08), processing speed (BD = −1.64, 95% CI [−2.11, −1.18] vs. HCs = −0.20, 95% CI [−0.66, 0.25]) (&lt;i&gt;F&lt;/i&gt;&lt;sub&gt;(1,68)&lt;/sub&gt; = 13.67, &lt;i&gt;p&lt;/i&gt; &lt; 0.001, &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 ","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.70118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Linkage for Bipolar Disorder to the Distal Region of Chromosome 19q: A Large Family Whole Genome Sequencing Study","authors":"Albert H. C. Wong,&nbsp;Andrew D. Paterson,&nbsp;Nicole M. Roslin,&nbsp;Elizabeth Tetzlaff,&nbsp;Andrew B. Sedrak,&nbsp;Young Zhou,&nbsp;Gaurav Sharma,&nbsp;Paul Grof,&nbsp;Anne Duffy","doi":"10.1111/bdi.70112","DOIUrl":"10.1111/bdi.70112","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Bipolar disorder (BD) is among the most heritable psychiatric disorders, with a genetic architecture likely consisting of both common genetic variants with small effects and rare variants with strong effects in certain families or populations. Genome-wide association studies (GWAS) with increasingly large sample sizes have identified many susceptibility genes, but common variants in these genes do not have a clear pathophysiological pathway to BD. Genetic linkage studies have the potential to identify rare causal variants in certain families.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aims&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We sought to determine the chromosomal regions linked with BD in a specific family that has many members affected by the lithium-responsive subtype of BD.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Materials and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We performed genome-wide genetic linkage analysis of a family identified through a lithium-responsive BD index patient with many relatives also affected with lithium-responsive BD-related mood disorders: three with BD I, four with BD II, and one with a major depressive episode.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;WGS (whole genome sequence) data were obtained for 12 members of the lithium-responsive BD pedigree including the eight affected subjects. Both parametric and nonparametric linkage analyses with the narrow BD phenotype and the broader phenotype including all eight with mood disorders provided evidence of linkage to the same region of chromosome 19. The maximum nonparametric linkage score was 3.89 for the broad phenotype, which exceeds typical thresholds for genome-wide significance.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Discussion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We identified a region of chromosome 19 that has not previously been linked to BD. Nor have significant GWAS variants been found in this region. It is possible that this family has different genetic origins for lithium-responsive BD than other patients studied previously. The family we analyzed is part of a larger cohort of BD patients and their family members, and genetic linkage analysis of additional families could be informative.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;These results provide a starting point for investigating genes in this chromosomal region that may be involved in the pathophysiology of the lithium-responsive subtype of BD.&lt;/p&gt;\u0000 ","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.70112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147962146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Elevated Body Mass Index, Inflammation, and Cognitive Performance in Individuals With Bipolar Disorder and Healthy Controls","authors":"Marzieh Majd,&nbsp;Jennifer Nicoloro-SantaBarbara,&nbsp;Maura De Laney,&nbsp;Katharine Burns,&nbsp;Emma V. Galante,&nbsp;Julia Lebovitz,&nbsp;Megan Shanahan,&nbsp;Katherine E. Burdick","doi":"10.1111/bdi.70111","DOIUrl":"10.1111/bdi.70111","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to investigate: (1) whether Body Mass Index (BMI) and peripheral inflammation are associated with cognitive performance in bipolar disorder (BD) and healthy controls (HCs), and (2) the potential mediating role of inflammation in the BMI-cognition link.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>As part of an ongoing study, 127 participants (79 BD, 48 HCs) completed the MATRICS Consensus Cognitive Battery. C-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor (TNF)-α levels were quantified in blood, and a composite inflammation index was created and utilized in primary analyses. Regression and mediation analyses were conducted using SAS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The BD group had higher inflammation compared to HCs (<i>p</i> &lt; 0.05). In the entire sample of BD individuals and HCs, higher BMI was associated with worse global cognitive performance, controlling for age, sex, diagnosis, education and medical comorbidity (beta = −0.22, <i>p</i> = 0.006). This association remained evident in the BD group, controlling for additional clinical factors (<i>p</i> &lt; 0.05). Higher inflammation was associated with worse global cognition, controlling for relevant covariates in the entire sample (beta = −0.19, <i>p</i> = 0.024); however, this association was no longer significant in the BD group after controlling for additional clinical factors (<i>p</i> = 0.09). The indirect effect of BMI on global cognition through IL-6 was statistically different from zero (ab: beta = −0.09, CI = −0.18, −0.01) in the entire sample, holding age and sex constant, suggesting that IL-6 partially accounts for the association between BMI and cognitive performance. However, this finding should be interpreted cautiously, given the modest sample size and exploratory analyses suggesting that the indirect effect may differ by diagnostic group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>BMI may serve as a potential biomarker and treatment target for obesity-related cognitive impairment in both BD and the general population, with IL-6 potentially contributing to this association.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing Hype and Hope: Are Third-Wave Cognitive Behavioral Therapies a Good Fit for Bipolar Disorder? An ISBD Psychological Interventions Taskforce Editorial Paper","authors":"Tatiana Cohab Khafif,&nbsp;Luisa de Siqueira Rotenberg,&nbsp;Emma Morton,&nbsp;Dahlia Mukherjee,&nbsp;Hailey Tremain,&nbsp;Thomas Richardson,&nbsp;Julieta Azevedo","doi":"10.1111/bdi.70110","DOIUrl":"10.1111/bdi.70110","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprogression in Bipolar Disorder: The Evidence Really Matters","authors":"Diego J. Martino","doi":"10.1111/bdi.70107","DOIUrl":"10.1111/bdi.70107","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 3","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Anxious Distress Specifier in Patients With a Major Depressive Episode—Influence of Overlapping Depressive Mixed State","authors":"Minoru Takeshima,&nbsp;Takeshi Inoue","doi":"10.1111/bdi.70106","DOIUrl":"10.1111/bdi.70106","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To examine the characteristics of major depressive episodes (MDEs) with underlying anxious distress (ANXD), specifically whether these characteristics are influenced by the presence of Benazzi's depressive mixed state (DMX) or are unique to ANXD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sociodemographic and clinical characteristics of patients with or without ANXD and of patients with ANXD with or without Benazzi's DMX were retrospectively examined in 160 patients with MDEs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 45.6% of patients met the criteria for ANXD. The mean Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) total score and frequencies of Benazzi's DMX, psychotic features, and psychiatric adverse events associated with antidepressants were significantly higher in patients with ANXD than in those without ANXD. Benazzi's DMX and male sex were independently associated with ANXD (odds ratio, 95% confidence interval: 4.95 [2.45–10.04], <i>p</i> &lt; 0.001 and 2.11 [1.04–4.27], <i>p</i> &lt; 0.038, respectively), regardless of depressive symptom severity or bipolar disorder diagnosis. In patients with ANXD with Benazzi's DMX, the rate of bipolar disorder diagnosis, QIDS-SR suicidal ideation score, and number of MDEs were significantly higher. The frequency of psychiatric adverse events associated with antidepressants and sociodemographic disadvantages in education and marital status were also numerically higher compared with patients with ANXD only.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although ANXD itself is not a defining feature of bipolarity, its coexistence with Benazzi's DMX suggests an underlying bipolar disorder. Furthermore, high suicidality, high frequency of psychiatric adverse events associated with antidepressants, and sociodemographic disadvantages may be influenced by Benazzi's DMX. Further studies are required to validate these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 3","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbid Schizophrenia and Psychotic Symptoms in Patients With Bipolar Disorder: A Meta-Analysis of the Global Literature","authors":"Wen Shao,&nbsp;Kangning Shao,&nbsp;Richard P. Bentall","doi":"10.1111/bdi.70093","DOIUrl":"10.1111/bdi.70093","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The boundary between bipolar disorder and schizophrenia has long been blurred by the shared psychopathology, genetic risk, and social factors. This study aims to examine the prevalence of psychosis and psychotic symptoms in bipolar patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Key words ‘bipolar’, ‘psychosis’, ‘schizophrenia’, and the variants were searched in titles and abstracts using Medline, Psych INFO and Web of Science and forward and backward citation searches were conducted; effects were computed using single proportion analysis with double arcsine transformation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The final analysis comprised 285 studies. The comorbidity of schizophrenia diagnoses in bipolar patients was low (8%). However, more broadly defined mood incongruent psychosis was quite prevalent (47%). Similarly, psychotic symptoms were common in bipolar patients, specifically those with a type I diagnosis or manic episode; delusions were more common than hallucinations and thought disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Significant overlap in phenomenology and psychopathology was observed between bipolar disorder and schizophrenia in this review. Future research should focus on comparing patients with similar symptoms and exploring the shared processes that contribute to these symptoms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 3","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Quality in Bipolar Disorder Compared to Unipolar Depression (Current and Remitted) and Healthy Controls: The Netherlands Study of Depression and Anxiety","authors":"M. A. Riedinger,&nbsp;M. Koenders,&nbsp;H. W. Jeuring,&nbsp;M. L. Molendijk,&nbsp;B. W. J. H. Penninx,&nbsp;N. J. A. van der Wee,&nbsp;M. de Leeuw,&nbsp;E. J. Giltay","doi":"10.1111/bdi.70104","DOIUrl":"10.1111/bdi.70104","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients with bipolar disorder (BD) have an increased risk to develop cardiovascular disease. Western diets have been hypothesized to increase the risk of cardiovascular disease in BD, but dietary habits in BD have not been extensively studied. We therefore assessed in a large cohort dietary quality in BD patients, in patients with current and remitted unipolar depression (UD), and healthy controls (HC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In total 1358 participants were included from the Netherlands Study of Depression and Anxiety (NESDA) and categorized into four groups: BD (<i>n</i> = 100, 48.0% male, mean age 50.9), current UD (<i>n</i> = 199, 28.0% male, mean age 52.4), remitted UD (<i>n</i> = 722, 29.8% male, mean age 52.4), and HC (<i>n</i> = 337, 40.7% male, mean age 51.2). Diet was assessed through the 238-item Food Frequency Questionnaire (FFQ), which yielded the ‘Mediterranean Diet Score’ (MDS). Dietary scores were compared using multivariate regression analyzes adjusting for sociodemographics, physical activity, and smoking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>BD patients scored significantly lower on the MDS than those with remitted UD (<i>p</i> = 0.01) and healthy controls (<i>p</i> = 0.02) but did not differ from those with current UD. Effect sizes were 0.24 for BD vs. remitted UD and 0.25 for BD vs. HC. Furthermore, BD patients had on average a higher waist circumference (<i>p</i> = 0.03) and BMI (<i>p</i> = 0.02) than healthy controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The average dietary quality of BD patients was of lesser quality compared to that in patients with remitted UD and HC. This may have contributed to the increased waist circumference and higher BMI we found among BD patients, with its adverse health consequences.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 3","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12994118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}