Bipolar Disorders最新文献

{"title":"Cognitive predictors of response to interpersonal and social rhythm therapy in mood disorders","authors":"Samantha J. Groves,&nbsp;Katie M. Douglas,&nbsp;Marie T. Crowe,&nbsp;Maree Inder,&nbsp;Jenny Jordan,&nbsp;Dave Carlyle,&nbsp;Ben Beaglehole,&nbsp;Roger Mulder,&nbsp;Cameron Lacey,&nbsp;Sue Luty,&nbsp;Kate Eggleston,&nbsp;Chris Frampton,&nbsp;Christopher R. Bowie,&nbsp;Richard J. Porter","doi":"10.1111/bdi.13469","DOIUrl":"10.1111/bdi.13469","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>There has been increasing interest in examining the potential moderating effects that cognitive functioning has on treatment outcome in bipolar disorder (BD) and major depressive disorder (MDD). Therefore, the aim of this exploratory study was to examine the relationship between baseline cognitive function and treatment outcome in individuals with mood disorders who completed 12 months of interpersonal and social rhythm therapy (IPSRT), and were randomised to receive adjunctive cognitive remediation (CR) or no additional intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty-eight patients with mood disorders (BD, <i>n</i> = 36, MDD, <i>n</i> = 22), who were randomised to IPSRT-CR or IPSRT, underwent cognitive testing at baseline and completed follow-up mood measures after 12 months. General linear modelling was used to examine the relationship between baseline cognitive function (both objective and subjective) and change in mood symptom burden, and functioning, from baseline to treatment-end.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Poorer baseline attention/executive function was associated with less change in mood symptom burden, particularly depressive symptoms, at treatment-end. Additionally, slower psychomotor speed at baseline was associated with less improvement in mania symptom burden. Subjective cognitive function at baseline was not related to change in mood symptom burden at treatment-end, and neither objective nor subjective cognitive function was associated with functional outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Limitations</h3>\u0000 \u0000 <p>Due to the exploratory nature of the study, there was no correction for multiple comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Aspects of objective cognitive function were associated with treatment outcomes following psychotherapy. Further large-scale research is required to examine the role that cognitive function may have in determining various aspects of mood disorder recovery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 7","pages":"708-716"},"PeriodicalIF":5.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13469","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does BioAge identify accelerated aging in individuals with bipolar disorder? An exploratory study in the FACE-BD cohort","authors":"Bruno Etain,&nbsp;Cynthia Marie-Claire,&nbsp;Luana Spano,&nbsp;Frank Bellivier,&nbsp;Marion Leboyer,&nbsp;Sébastien Gard,&nbsp;Antoine Lefrere,&nbsp;Raoul Belzeaux,&nbsp;Philippe Courtet,&nbsp;Caroline Dubertret,&nbsp;Raymund Schwan,&nbsp;Valerie Aubin,&nbsp;Paul Roux,&nbsp;Mircea Polosan,&nbsp;Ludovic Samalin,&nbsp;Emmanuel Haffen,&nbsp;Emilie Olié,&nbsp;Ophelia Godin,&nbsp;FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators","doi":"10.1111/bdi.13480","DOIUrl":"10.1111/bdi.13480","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Individuals with bipolar disorders (BD) have an estimated loss of life expectancy around 10–15 years. Several laboratory-measured biomarkers of accelerated aging exist (e.g., telomere length), however with a questionable transferability to bedside. There is a need for easily and inexpensively measurable markers of aging, usable in routine practice, such as BioAge.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We calculated BioAge that estimates biological age based on routine blood tests and a physical exam, in a sample of 2220 outpatients with BD. We investigated associations between BioAge Acceleration (BioAgeAccel), which is an indicator of accelerated aging, and sociodemographic variables, clinical variables, and current psychotropic medication use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mean chronological age was 40.2 (±12.9). Mean BioAge was 39.1 (±12.4). Mean BioAgeAccel was 0.08 (±1.8). A minority of individuals (15%) had a BioAgeAccel above 2 years. Multivariable analyses suggested strong associations between a higher BioAgeAccel and younger age, male sex, overweight and sleep disturbances. Regarding current psychotropic medication use, discrepancies between univariate and multivariate analyses were observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A minority of individuals with BD had an accelerated aging as measured by BioAge. We identified associations with potentially modifiable factors, such as higher body mass index and sleep disturbances, that are however nonspecific to BD. These results require replications in independent samples of individuals with BD, and comparisons with a control group matched for age and gender. Longitudinal studies are also required to test whether any change in metabolic health, or sleep might decrease BioAgeAccel.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 6","pages":"595-603"},"PeriodicalIF":5.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13480","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical complexity of olanzapine use: Peripheral edema","authors":"Vincent Zhang,&nbsp;Mary-Anne Hennen,&nbsp;Hector Lisboa,&nbsp;Najeeb Hussain","doi":"10.1111/bdi.13477","DOIUrl":"10.1111/bdi.13477","url":null,"abstract":"&lt;p&gt;The patient is a 19-year old boy with a past medical history of bipolar I disorder, benzodiazepine use, and marijuana use disorder who presents after threatening his mother with a knife following an argument with both his parents. At home, he was not taking any prescribed medications. Upon admission to the inpatient psychiatry unit for mood dysregulation, he was started on paliperidone and divalproex sodium and clonazepam daily. Previous trials of risperidone and divalproex sodium were unsuccessful in the past without any side effects. After being admitted, he denied any audiovisual hallucinations/suicidal or homicidal ideation but was superficially cooperative, and his behavior was still erratic, labile, and violent. Indeed, the following day, he punched another patient in the face unprovoked, necessitating the addition of PRN medications (ziprasidone, diphenhydramine, and lorazepam) and being brought to the quiet room. Olanzapine was added and increased due to continued violence (banging his head against a wall and attacking a staff member). In spite of these various medications, the patient expressed poor insight into his condition, in addition to his need for medications and further treatments.&lt;/p&gt;&lt;p&gt;Just over a month following the arrival to the unit, the patient developed bilateral upper and lower extremity swelling along with redness. Per the patient, he had noticed such swelling days after he was first given medication in the hospital—however, he did not mention this, nor was it noticed or documented. This swelling manifested as bilateral pitting edema primarily in the lower extremities up to the knee, alongside additional redness of the fingers. The patient denied any associated shortness of breath, rash, pruritus, wheezing, history of allergies/urticaria/asthma and any other medical conditions (cardiac, renal, etc.). Medical workup was initiated, and laboratories were unremarkable besides a mild normocytic anemia. Cardiac and pulmonary physical examinations (and echocardiogram) revealed no pertinent positives, and the patient saturated well on room air throughout.&lt;/p&gt;&lt;p&gt;The development of edema can be attributed to the introduction of olanzapine, as seen by its onset a few days after initiation and disappearance following discontinuing the medication. All additional potential causes of the edema including cardiovascular, pulmonary, and allergic were ruled out as shown above. Furthermore, some of the other medications (divalproex sodium, paliperidone) the patient was taking at the time rarely cause edema, and the patient has no past history of such symptoms despite taking them before. Olanzapine was thereafter discontinued and replaced with chlorpromazine, and the patient's legs were elevated, and a trial of compression socks was started. And a week later, the patient's edema had all but subsided and his behavior and mentation were much improved without any aggression or violence. He was thus discharged following a verbal commitment t","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"27 1","pages":"74-76"},"PeriodicalIF":5.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13477","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should we combine antipsychotics in patients with bipolar disorder?","authors":"Vanessa Gnielka,&nbsp;Thiago Henrique Roza,&nbsp;Ives Cavalcante Passos","doi":"10.1111/bdi.13482","DOIUrl":"10.1111/bdi.13482","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 8","pages":"761-763"},"PeriodicalIF":5.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let us not forget postpartum manic or mixed episodes","authors":"Verinder Sharma","doi":"10.1111/bdi.13479","DOIUrl":"10.1111/bdi.13479","url":null,"abstract":"&lt;p&gt;In the nineteenth century, the estimated prevalence of puerperal mania varied from 1 in 80–800 deliveries.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; The literature from this era is replete with clinical accounts of puerperal mania and melancholia in women admitted to Victorian asylums. Changes in the nosology and interpretation of postpartum psychiatric disorder in the 20th century have produced lower rates of postpartum mania. For example, some cases of puerperal mania would be diagnosed as delirium or a toxic confusional state in today's terminology. Other factors have contributed to waning interest in puerperal mania. Coinciding with the deinstitutionalization process of replacing long-stay psychiatric hospitals with community mental health services, the research focus shifted from the study of severe psychopathology to commonly encountered conditions in the community such as baby blues and postpartum depression. The term third-day depression after childbirth, also known as the baby blues, was first described in 1952 but has a larger share of literature than postpartum mania. An ‘unofficial’ but popular nomenclature includes baby blues, postpartum depression, and postpartum psychosis but makes no direct mention of manic or mixed episodes. Postpartum psychosis denotes disparate conditions including brief psychotic disorder, manic or mixed episodes with or without psychotic features, and major depressive episodes with psychosis.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; The usurping of manic and mixed episodes by postpartum psychosis likely led to a lack of interest in the study of postpartum mania as shown in Figure 1.&lt;/p&gt;&lt;p&gt;Of mood and anxiety disorders, bipolar disorder carries the highest risk of recurrence in the postpartum period. Studies over the last few decades have demonstrated that postpartum bipolar disorder is common in community and clinical settings. A study of 10.000 women from the US found that approximately 14% of women screened positive for postpartum depression. Of those who screened positively, 23% had bipolar disorder, the most common type being bipolar I disorder (49.7%).&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; This means that approximately 1.6% of women in the community have a bipolar I mood episode after delivery. A recent study estimated that 39% of women with bipolar I disorder have a postpartum relapse. Of those with a postpartum relapse, 38% had a manic or mixed episode yielding an estimated prevalence of 14.82% among women with bipolar I disorder.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; This is likely an underestimate because mania can occur spontaneously in the absence of psychiatric illness. As a comparison, the global prevalence of postpartum psychosis is only 0.089 to 2.6 per 1000 births.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Detecting, diagnosing, and treating manic or mixed episodes in the postpartum period is challenging. Owing to their onset typically within the first few weeks following childbirth, and the lack of information about the timing of the onset of “postpartum” ep","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 6","pages":"529-531"},"PeriodicalIF":5.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13479","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine and lamotrigine combination in mood disorders—A call for real-world evidence reporting","authors":"Alina Wilkowska,&nbsp;Mariusz S. Wiglusz,&nbsp;Wiesław J. Cubała","doi":"10.1111/bdi.13478","DOIUrl":"10.1111/bdi.13478","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 8","pages":"820"},"PeriodicalIF":5.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral skill practice as a predictor of mood and family functioning in adolescents with bipolar and depressive mood disorders: Results of a 6-month randomized trial of family-focused therapy","authors":"Marc J. Weintraub,&nbsp;John A. Merranko,&nbsp;Megan C. Ichinose,&nbsp;Danielle M. Denenny,&nbsp;Patricia D. Walshaw,&nbsp;Georga Morgan-Fleming,&nbsp;Robin D. Brown,&nbsp;Armen C. Arevian,&nbsp;David J. Miklowitz","doi":"10.1111/bdi.13466","DOIUrl":"10.1111/bdi.13466","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Behavioral interventions require considerable practice of treatment skills in between therapy sessions. The effects of these treatments may vary with the degree to which patients are able to implement these practices. In offspring of parents with bipolar and major depressive disorders, we examined whether youth who frequently practiced communication and problem-solving skills between family-focused therapy (FFT) sessions had less severe mood symptoms and better psychosocial functioning over 6 months than youth who practiced less frequently.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We randomly assigned offspring (ages 12–19) of parents with mood disorders to 12 sessions of FFT plus a mobile app that encouraged the practice of communication, problem-solving and mood management skills (FFT-MyCoachConnect [MCC] condition) or 12 sessions of FFT with an app that only allowed for tracking of symptoms and stress (FFT-Track condition). Independent evaluators assessed youths' mood and psychosocial functioning at 9-week intervals over 27 weeks. Clinicians rated participants' between-session skill practice at each FFT session.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>FFT-MCC was associated with more frequent skill practice than FFT-Track over 18 weeks of treatment. Skill practice was associated with reductions in youths' mood instability and perceptions of family conflict over 27 weeks in both app conditions. Skill practice mediated the effects of app condition on youths' mood instability and family functioning.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Mobile applications as adjuncts to family therapy for youth with mood disorders can help increase skill practice. These findings provide preliminary causal evidence for behavioral skill practice improving mood symptoms and family functioning among youth with mood disorders.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 7","pages":"733-743"},"PeriodicalIF":5.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who benefits from digital interventions for bipolar disorder? Stage of illness characteristics as predictors of changes in quality of life","authors":"Hailey Tremain,&nbsp;Kathryn Fletcher,&nbsp;Denny Meyer,&nbsp;Greg Murray","doi":"10.1111/bdi.13462","DOIUrl":"10.1111/bdi.13462","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study explored the potential role of stage-related variables in intervention outcomes in bipolar disorder (BD). Specifically, we aimed to identify which subgroups of individuals were most likely to experience improved quality of life following digitally delivered psychosocial interventions for BD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study involved a secondary analysis of combined data from two randomised control trials (RCTs). Each trial assessed the effectiveness of digitally delivered interventions for improving quality of life, in late-stage (ORBIT RCT) or early-stage (BETTER RCT) BD. Three iterations of cluster analyses were performed, identifying subgroups of individuals based on (i) current phenomenology, (ii) course of illness and (iii) medication response. The resultant subgroups were compared with regard to changes in quality of life pre-post intervention, via repeated measures ANOVAs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In each cluster analysis, two clusters were found. The current phenomenology clusters reflected two impairment levels, ‘moderate impairment’ and ‘low impairment’. The course of illness clusters reflected ‘more chronicity’ and ‘less chronicity’ and the medication response clusters reflected ‘good medication response’ and ‘poor medication response’. Differences in changes in quality of life over time were observed between the two current phenomenology clusters and between the medication response clusters, while the course of illness subgroups did not respond differently.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There are at least two distinct groups of treatment-seeking individuals with established BD, based on illness features with previously established links to different illness stages. Clusters within the current phenomenology and medication response domains demonstrated significantly different trajectories of QoL change over time in the context of our interventions, highlighting potential implications for treatment selection aligned with precision psychiatry.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 7","pages":"684-695"},"PeriodicalIF":5.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Need for further exploring at the intersection of ADHD medications and bipolar disorder","authors":"U. Volpe","doi":"10.1111/bdi.13467","DOIUrl":"10.1111/bdi.13467","url":null,"abstract":"&lt;p&gt;Bipolar disorder (BD) and attention-deficit hyperactivity disorder (ADHD) may copresent and manifest as complex clinical presentations, often accompanied by further comorbidities such as anxiety and substance use disorders. ADHD/BD comorbidity not only relies on a widely reported symptomatological and neurobiological overlap, but it also creates an intricate interplay between ADHD, affective and other psychiatric conditions, requiring a more nuanced understanding of their comorbid nature. Moreover, clinical and nosological perspectives on the nature of the ADHD/BD comorbidity may significantly vary across developmental stages, ranging from an overestimated comorbidity (possibly due to the confound role of greater symptoms' overlap in childhood, adolescence and youth cases) to a prodromal developmental pattern (i.e., from ADHD to BD) or a separate nosological entity (“ADHD-BD”).&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; In younger patients, in particular, recent literature also suggests a possible specific role of emotional dysregulation, a common key feature of ADHD and bipolar spectrum disorders, acting as a confound variable that may enhance the misconception of ADHD/BD comorbidity and favor the misdiagnosis of ADHD as a BD spectrum disorder.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Clearly, the emphasis on the need to disentangle the complex relationship between juvenile ADHD and BD highlights the challenges in delineating these disorders for better diagnostic characterization and therapeutic indications.&lt;/p&gt;&lt;p&gt;The systematic review by Miskowiak et al.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; addresses a highly relevant clinical topic, reporting on the available evidence on the efficacy and safety of ADHD pharmacotherapies to treat cognitive impairment and ADHD symptoms in juvenile and adult BD. Shared neurobiological dysregulations, particularly involving dopamine and norepinephrine signalling pathways, may significantly contribute to the symptomatic overlap between BD and ADHD. However, pharmacological interventions targeting dopamine and noradrenaline pathways (such as stimulants and alpha-2-adrenergic agonists) long held promise to ameliorate cognitive deficits and ADHD symptoms in individuals with BD. Indeed, the evidence relative to dysfunctions of the dopamine transporter (DAT) gene and catechol-O-methyltransferase (COMT) gene variants underscores the intricate interplay between these disorders and prompts for therapeutic implications.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Miskowiak et al.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; also report preliminary favorable evidence of efficacy of ADHD drugs in treating ADHD symptoms in BD, with a current lack of evidence for psychostimulants to trigger or exacerbate mania and insufficient evidence to conclude on their role in improving cognitive symptoms in BD.&lt;/p&gt;&lt;p&gt;Also in our previous work,&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; we underscored the potential benefits of adjunctive therapy in alleviating ADHD symptoms in BD patients. Indeed, while mood stabilization should remain th","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 6","pages":"622-623"},"PeriodicalIF":5.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13467","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to study psychological mechanisms of mania? A systematic review on the methodology of experimental studies on manic mood dysregulation of leading theories on bipolar disorder","authors":"V. F. J. Glas,&nbsp;M. A. Koenders,&nbsp;R. W. Kupka,&nbsp;E. J. Regeer","doi":"10.1111/bdi.13463","DOIUrl":"10.1111/bdi.13463","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Although there are several psychological theories on bipolar disorders (BD), the empirical evidence on these theories through experimental studies is still limited. The current study systematically reviews experimental methods used in studies on the main theories of BD: Reward Hypersensitivity Theory (RST) or Behavioral Activation System (BAS), Integrative Cognitive Model (ICM), Positive Emotion Persistence (PEP), Manic Defense theory (MD), and Mental Imagery (MI). The primary aim is to provide an overview of the used methods and to identify limitations and suggest areas of improvement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic search of six databases until October 2023 was conducted. Study selection involved two independent reviewers extracting data on experimental study design and methodology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 84 experimental studies were reviewed. BAS and RST were the most frequently studied theories. The majority of these experimental studies focus on mechanisms of reward sensitivity. Other important elements of the reviewed theories, such as goal setting and—attainment, situation selection (avoidance or approach), activation, affective/emotional reactivity, and regulatory strategies, are understudied. Self-report and neuropsychological tasks are most often used, while mood induction and physiological measures are rarely used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There is a need for more consensus on the operationalization of psychological theories of mania. Standardization of test batteries could improve comparability among studies and foster a more systematic approach to experimental research. Research on affective (activated) states is still underrepresented in comparison with studies on trait vulnerabilities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 7","pages":"646-660"},"PeriodicalIF":5.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}