{"title":"Yet Why Not Say What Happened?","authors":"Jacqueline W, Ayal Schaffer","doi":"10.1111/bdi.13515","DOIUrl":"https://doi.org/10.1111/bdi.13515","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Stefana, Paolo Fusar-Poli, Pierluigi Politi, Eduard Vieta, Eric A Youngstrom
{"title":"Sexual Feelings in the Psychotherapy Room: Comparing Their Occurrence in Patients With Unipolar Depression, Bipolar Disorder, and Neither of These.","authors":"Alberto Stefana, Paolo Fusar-Poli, Pierluigi Politi, Eduard Vieta, Eric A Youngstrom","doi":"10.1111/bdi.13511","DOIUrl":"https://doi.org/10.1111/bdi.13511","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chronic Serotonin Syndrome Masquerading as Anxiety and Agitation in a Patient With Mood Disorder: A Clinical Dilemma!","authors":"Nicola Keeth, Jonathan G Leung, Balwinder Singh","doi":"10.1111/bdi.13513","DOIUrl":"https://doi.org/10.1111/bdi.13513","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Susan K Service, Juan F De La Hoz, Ana M Diaz-Zuluaga, Alejandro Arias, Aditya Pimplaskar, Chuc Luu, Laura Mena, Johanna Valencia-Echeverry, Mauricio Castaño Ramírez, Carrie E Bearden, Chiara Sabatti, Victor I Reus, Carlos López-Jaramillo, Nelson B Freimer, Loes M Olde Loohuis
{"title":"Predicting Diagnostic Conversion From Major Depressive Disorder to Bipolar Disorder: An EHR Based Study From Colombia.","authors":"Susan K Service, Juan F De La Hoz, Ana M Diaz-Zuluaga, Alejandro Arias, Aditya Pimplaskar, Chuc Luu, Laura Mena, Johanna Valencia-Echeverry, Mauricio Castaño Ramírez, Carrie E Bearden, Chiara Sabatti, Victor I Reus, Carlos López-Jaramillo, Nelson B Freimer, Loes M Olde Loohuis","doi":"10.1111/bdi.13512","DOIUrl":"10.1111/bdi.13512","url":null,"abstract":"<p><strong>Objectives: </strong>Most bipolar disorder (BD) patients initially present with depressive symptoms, resulting in a delayed diagnosis of BD and poor clinical outcomes. This study aims to identify features predictive of the conversion from Major Depressive Disorder (MDD) to BD by leveraging electronic health record (EHR) data from the Clínica San Juan de Dios Manizales in Colombia.</p><p><strong>Methods: </strong>We employed a multivariable Cox regression model to identify important predictors of conversion from MDD to BD.</p><p><strong>Results: </strong>Analyzing 15 years of EHR data from 13,607 patients diagnosed with MDD, a total of 1610 (11.8%) transitioned to BD. Predictive features of the conversion to BD included severity of the initial MDD episode, presence of psychosis and hospitalization at first episode, family history of BD, and female gender. Additionally, we observed associations with medication classes (positive associations with prescriptions of mood stabilizers, antipsychotics, and negative associations with antidepressants) and a positive association with suicidality, a feature derived from natural language processing (NLP) of clinical notes. Together, these risk factors predicted BD conversion within 5 years of the initial MDD diagnosis, with a recall of 72% and a precision of 38%.</p><p><strong>Conclusions: </strong>Our study confirms previously identified risk factors identified through registry-based studies (female gender and psychotic depression at the index MDD episode) and identifies novel ones (suicidality extracted from clinical notes). These results simultaneously demonstrate the validity of using EHR data for predicting BD conversion and underscore its potential for the identification of novel risk factors, thereby improving early diagnosis.</p>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patients' Perspectives on the Consequences of Eliminating Prepubertal-Pediatric Bipolar Disorder as a Valid Diagnosis.","authors":"Katrin I Kutlucinar, Kathryn Burrows","doi":"10.1111/bdi.13510","DOIUrl":"https://doi.org/10.1111/bdi.13510","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bipolar DisordersPub Date : 2024-12-01Epub Date: 2024-09-02DOI: 10.1111/bdi.13495
Ming Chen, Yi Tang, Gang Li, Ming-Zhi Xu, Cai-Lan Hou
{"title":"Case report: Manic-like symptoms mimicking early-onset bipolar disorder in a case of neuropsychiatric lupus.","authors":"Ming Chen, Yi Tang, Gang Li, Ming-Zhi Xu, Cai-Lan Hou","doi":"10.1111/bdi.13495","DOIUrl":"10.1111/bdi.13495","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":"835-838"},"PeriodicalIF":5.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bipolar DisordersPub Date : 2024-12-01Epub Date: 2024-08-26DOI: 10.1111/bdi.13491
Matthew Tennant, Richard Porter, Ben Beaglehole
{"title":"Mapping review of register-based cohort studies of bipolar disorder.","authors":"Matthew Tennant, Richard Porter, Ben Beaglehole","doi":"10.1111/bdi.13491","DOIUrl":"10.1111/bdi.13491","url":null,"abstract":"<p><strong>Objectives: </strong>Register-based cohorts allow us to better understand bipolar disorder over a life course. They are inclusive and their long-term data collection provides a longer scope than most clinical trials. This mapping review provides an overview of register-based cohort studies of bipolar disorder to inform researchers of the strengths and limitations to this body of research and identify gaps for future research.</p><p><strong>Methods: </strong>A systematic search was performed of Medline, EMBASE, and PsycINFO databases. Cohort studies were included if they focused on bipolar disorder and had a minimum of 1 year of longitudinal data. Studies needed to be from databases that monitor the whole state or national population. A descriptive analysis of the studies' populations and methodology provides an overview of this field of study and identifies evidence gaps.</p><p><strong>Results: </strong>A hundred and forty-six studies were included. The majority were from databases in Taiwan (n = 63), Denmark (n = 38), Sweden (n = 23), and Finland (n = 11). Forty-eight studies focused on aetiological questions. Sixty prognostic studies identified cohorts with bipolar disorder and described the impact of the illness by considering comorbidity, prescribing patterns, social functioning, and mortality. Thirty-six treatment studies focused on the efficacy and adverse effects of pharmaceuticals and ECT. No studies focused on psychological treatments.</p><p><strong>Conclusion: </strong>Bipolar disorder research should include register-based cohorts with greater geopolitical and cultural diversity. Custodians of health registers should consider how non-pharmaceutical interventions such as psychotherapy are captured. Register-based cohorts investigating treatments of bipolar disorder should consider long-term social outcomes alongside the usual clinical outcomes.</p>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":"764-771"},"PeriodicalIF":5.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bipolar DisordersPub Date : 2024-12-01Epub Date: 2024-08-12DOI: 10.1111/bdi.13486
Anna Repo, Riittakerttu Kaltiala, Timo Holttinen
{"title":"Hospital-treated bipolar disorder in adolescence in Finland 1980-2010: Rehospitalizations, diagnostic stability, and mortality.","authors":"Anna Repo, Riittakerttu Kaltiala, Timo Holttinen","doi":"10.1111/bdi.13486","DOIUrl":"10.1111/bdi.13486","url":null,"abstract":"<p><strong>Aims: </strong>Estimates of the occurrence of bipolar disorder among adolescents vary from country to country and from time to time. Long delays from first symptoms to diagnosis of bipolar disorder have been suggested. Studies among adults suggest increased mortality, particularly due to suicide and cardiovascular diseases. We set out to study the prognosis of adolescent onset bipolar disorder in terms of rehospitalizations, diagnostic stability, and mortality.</p><p><strong>Methods: </strong>The study comprised a register-based follow-up of all adolescents admitted to psychiatric inpatient care for the first time in their lives at age 13-17 during the period 1980-2010. They were followed up in the National Care Register for Health Care and Causes of death registers until 31 December 2014.</p><p><strong>Results: </strong>Incidence of bipolar disorder among 13- to 17-year-old adolescents over the whole study period was 2.8 per 100, 000 same aged adolescents, and across decades, the incidence increased six-fold. Patients with bipolar disorder during their first-ever inpatient treatment were rehospitalized more often than those treated for other reasons. Conversion from bipolar disorder to other diagnoses was far more common than the opposite. Mortality did not differ between those firstdiagnosed with bipolar disorder and those treated for other reasons.</p><p><strong>Conclusion: </strong>The incidence of adolescent onset bipolar disorder has increased across decades. The present study does not call for attention to delayed diagnosis of bipolar disorder. Adolescent onset bipolar disorders are severe disorders that often require rehospitalization, but diagnostic stability is modest. Mortality is comparable to that in other equally serious disorders.</p>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":"793-800"},"PeriodicalIF":5.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bipolar DisordersPub Date : 2024-12-01Epub Date: 2024-09-01DOI: 10.1111/bdi.13494
Irem Hacisalihoglu Aydin, Rif S El-Mallakh
{"title":"Concept article: Antidepressant-induced destabilization in bipolar illness mediated by serotonin 3 receptor (5HT3).","authors":"Irem Hacisalihoglu Aydin, Rif S El-Mallakh","doi":"10.1111/bdi.13494","DOIUrl":"10.1111/bdi.13494","url":null,"abstract":"<p><strong>Objectives: </strong>Antidepressants used by patients with bipolar disorder have been associated with destabilization with an increase in mania, depression, and cycling. The most commonly proposed mechanism, that antidepressants 'overshoot' their antidepressant effect to create a manic or mixed state, is unlikely since antidepressants have actually been found to be ineffective in treating bipolar depression. Beginning with known bipolar-specific pathophysiologic abnormalities provides the greatest likelihood of insight.</p><p><strong>Methods: </strong>PubMed was queried with 'bipolar', 'sodium', 'intracellular sodium', 'serotonin 3', '5HT<sub>3</sub>', '5-hydroxytryptamine type 3 receptors', and 'antidepressant' either individually or in combination.</p><p><strong>Results: </strong>Pathologic mood states (both mania and depression) are associated with increased intracellular sodium (Na) concentrations that depolarize the resting membrane potential to increase cellular excitability (mania) or cause depolarization block (depression). Stimulation of the serotonin (5HT) receptors depolarizes the post-synaptic neuron. Stimulation of 5HT<sub>3</sub> may be of particular importance since it is coupled to a cation channel that directly depolarizes the membrane. These effects directly impact the physiology of patients with bipolar disorder to alter neuronal excitability in a fashion that worsens both mania and depression.</p><p><strong>Proposed concept: </strong>The most consistently observed biological abnormality in individuals going through mania or bipolar depression involves a decline in Na pump activity, with consequent elevation of intracellular Na levels. Antidepressant treatment potentiates this, particularly by activation of 5HT<sub>3</sub>. This hypothesis can be tested by coadministering a 5HT<sub>3</sub> antagonist (e.g., vortioxetine or ondansetron) to achieve blockade of that receptor while treating bipolar depression with a serotoninergic antidepressant.</p>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":"772-778"},"PeriodicalIF":5.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}