Bipolar Disorders最新文献

{"title":"Longer Sleep Duration Predicts Progression to Bipolar or Psychotic Disorders in Youth Accessing Early Intervention Mental Health Services","authors":"Joanne S. Carpenter,&nbsp;Jacob J. Crouse,&nbsp;Mathew Varidel,&nbsp;Emiliana Tonini,&nbsp;Mirim Shin,&nbsp;Natalia Zmicerevska,&nbsp;Alissa Nichles,&nbsp;Daniel F. Hermens,&nbsp;Kathleen R. Merikangas,&nbsp;Elizabeth M. Scott,&nbsp;Ian B. Hickie,&nbsp;Frank Iorfino","doi":"10.1111/bdi.70183","DOIUrl":"10.1111/bdi.70183","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>While growing evidence implicates sleep-wake and circadian rhythm disturbances (SCRDs) in the onset and course of mood and psychotic disorders, longitudinal studies using objective measures are limited. This clinical cohort study examined whether actigraphy-derived SCRDs (sleep duration, timing, and efficiency) predicted transition to (i) any full-threshold mental disorders; and then specifically; (ii) full-threshold bipolar or psychotic disorders; or (iii) other full-threshold (i.e., depressive or anxiety) disorders, in youth accessing mental health care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Actigraphy monitoring was completed for 5–23 days in 250 participants (aged 12–30) presenting to youth-focused early intervention services in Sydney, Australia. Participants were followed longitudinally as part of the Optymise cohort for at least 6+ months (up to 8 years; median 2.5 years). Logistic regression and Cox proportional hazards models estimated associations between SCRDs and illness progression, after controlling for relevant baseline clinical and demographic covariates (e.g., age, sex, social and occupational functioning, mania-like and psychotic-like experiences, medication use).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Longer sleep duration at baseline predicted higher odds of transition (OR = 2.23 [95% CI = 1.38–3.74]), and shorter time-to-transition (HR = 2.05 [95% CI = 1.23–3.40]) to full-threshold bipolar or psychotic disorders. This effect remained significant after controlling for clinical covariates. Later sleep midpoint predicted transition to any full-threshold mental disorder (OR = 1.46 [95% CI = 1.02–2.17]) at the uncorrected significance level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Excessive sleep duration may represent an early marker of vulnerability for progression to severe mental illness. Findings support the prognostic utility of objective measures of SCRDs to guide indicated prevention and early intervention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.70183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Assessment of Adherence to Treatment in Bipolar Disorders Should Take Into Consideration All Demographic and Clinical Variables","authors":"Ana Zélia Abreu Pires de Sousa,&nbsp;Tainá Conrado Ferreira,&nbsp;Lia Mesquita de Abreu,&nbsp;Fabio Gomes de Matos e Souza,&nbsp;Luísa Weber Bisol","doi":"10.1111/bdi.70173","DOIUrl":"https://doi.org/10.1111/bdi.70173","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148909821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Lithium Use and Suicide-Related Behaviors in Bipolar Disorder: A Multicenter Study","authors":"Xin Guan,&nbsp;Xin-yue Wang,&nbsp;Chun-hui Qu,&nbsp;Yi-chen Li,&nbsp;Li-na Wang,&nbsp;Yan-chi Zhang,&nbsp;Zhong-hua Su,&nbsp;Zhi-jian Yao,&nbsp;Cui-xia An,&nbsp;Yan-bin Jia,&nbsp;Zuo-wei Wang,&nbsp;Han Rong,&nbsp;Kang-guang Lin,&nbsp;Zong-ling He,&nbsp;Shao-hua Hu,&nbsp;Chuan-sheng Wang,&nbsp;Jia-qi Bao,&nbsp;Xiang-yang Xu,&nbsp;Xin Yu,&nbsp;Li-gang Wang,&nbsp;Ping Sun","doi":"10.1111/bdi.70180","DOIUrl":"https://doi.org/10.1111/bdi.70180","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real-world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this multicenter cross-sectional study, 616 individuals aged 12–45 years with bipolar disorder were recruited from 14 psychiatric centers, of whom 585 had complete data for the present analyses. Lithium exposure within the past year was determined from clinical records. The primary outcome was a composite of suicide-related behaviors, including suicidal ideation, suicide attempts, and non-suicidal self-injury. A pre-specified analytical framework was applied, with multivariable logistic regression as the primary analysis and propensity score matching (PSM) as the principal approach to improve covariate balance. Regression-based decomposition analyses were conducted to examine whether aggression was statistically associated with the exposure-outcome relationship, and restricted cubic spline models were used to characterize the dose–response association between aggression and suicide-related behaviors. Robustness analyses included inverse probability of treatment weighting (IPTW), alternative matching specifications, &lt;i&gt;E&lt;/i&gt;-value analyses, cluster-robust standard errors, and exploratory age-stratified analyses.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Lithium exposure was associated with lower odds of suicide-related behaviors in both the fully adjusted model (OR = 0.55, 95% CI: 0.34–0.89) and the propensity score-matched sample (OR = 0.53, 95% CI: 0.33–0.86). Higher aggression scores were linearly associated with increased suicide-related risk. Exploratory regression-based decomposition analyses indicated that approximately 20.93% of the observed lithium-outcome association was statistically accounted for by aggression. Results from robustness analyses were directionally consistent with the primary findings.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this multicenter clinical sample, lithium exposure was consistently associated with lower odds of suicide-related behaviors across multiple analytic approaches. Aggression was independently associated with suicide-related risk and statistically accounted for part of the observed association between lithium exposure and suicide-related outcomes. However, causal inference is limited by the cross-sectional design, and residual confounding—particularly confounding by indication—remains a key concern. Prospective longitudinal studies ","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148909822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Polygenic Risk Score for Suicidal Behavior With Ventral Prefrontal Morphology in Bipolar Disorder","authors":"Noa Katz Shroitman,&nbsp;Daniel F. Levey,&nbsp;Brian Pittman,&nbsp;Suchen Zheng,&nbsp;Susan Quatrano,&nbsp;Anjali Sankar,&nbsp;Lejla Colic,&nbsp;Joel Gelernter,&nbsp;Virginia L. Willour,&nbsp;Hilary P. Blumberg","doi":"10.1111/bdi.70172","DOIUrl":"https://doi.org/10.1111/bdi.70172","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Bipolar disorder (BD) studies consistently implicate the ventral prefrontal cortex (VPFC) in association with suicidal behaviors. A suicidal behavior polygenic risk score (PRS) can now be computed to test whether elevated genetic risk for suicidal behavior is associated with variation in VPFC gray matter and/or suicidal behavior history.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We explored relationships among a PRS previously associated with suicidal behavior, VPFC morphology, and suicidal behavior in 376 individuals of European ancestry (mean age 30y; 57% female): 225 with BD (76 suicide attempters (SAs), 149 non-suicide attempters (NSAs)) and 151 healthy control individuals (HCs). We calculated PRS and performed magnetic resonance imaging to assess VPFC (inferior frontal gyrus (IFG) and orbitofrontal cortex) cortical thickness and surface area. Associations were examined among PRS, diagnosis, suicide attempt history, and brain measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among individuals with BD, those with higher PRS showed decreased right VPFC surface area, primarily due to IFG reductions (<i>p</i> &lt; 0.01). A significant group (SA, NSA, HC)–by-PRS interaction was observed for right IFG cortical surface area (<i>p</i> &lt; 0.05); NSAs with high vs. low PRS had significantly smaller right IFG surface area. The mean PRS was highest for SAs, then NSAs, and lowest for HCs; however, differences did not reach significance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings suggest this suicide PRS may reflect genetic mechanisms influencing IFG differences in BD. Given the modest sample size, replication of these preliminary findings in large-scale diverse cohorts is required to determine whether including this PRS and/or the corresponding IFG values could improve multimodal BD suicidal behavior prediction algorithms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148909823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties of the Turkish Version of the Rapid Mood Screener for Bipolar Disorder (RMS-T): A Validity and Reliability Study","authors":"Yasan Bilge Sair,&nbsp;Roger S. McIntyre,&nbsp;Burkay Karadag,&nbsp;Mevlut Ture,&nbsp;Bilge Dogan,&nbsp;Beliz Tural,&nbsp;Tutku Demir Ok,&nbsp;Hande Akbal,&nbsp;Sena Merve Kırmacı,&nbsp;Ceyhan Akkeyik","doi":"10.1111/bdi.70181","DOIUrl":"10.1111/bdi.70181","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The Rapid Mood Screener (RMS) is a reliable and validated brief, point-of-care, patient-administered screening tool for bipolar disorders. Herein we aim to evaluate the reliability and validity of the RMS in Turkish adults with bipolar I disorder (BD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Forward and backward translation was conducted for the English version of the RMS to the Turkish version of RMS (RMS-T). We conducted a ROC analysis for both the Mood Disorder Questionnaire (MDQ) and RMS-T in adults with major depressive disorder (MDD) or BD. The maximum sensitivity and specificity were also calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We recruited 128 participants (<i>n</i> = 63 BD-I, <i>n</i> = 65 MDD). Participants who responded 4 or more “yes” out of six items on the RMS-T were adjudicated as a positive screen for BD-I. The sensitivity of the RMS-T was 79.4% and the specificity was 84.6%. The RMS-T was determined to be of higher discriminative power in discriminating BD relative to the MDQ (AUC = 0.865, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The RMS-T is a valid and easy-to-use self-administer tool for the identification of BD-I in individuals with depression. The RMS has many advantages over the MDQ in clinical settings by having fewer items, a simpler scoring system, and shorter completion time. Early screening and detection of BD is critical for appropriate treatment selection to achieve the goal of overall improving health outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing Sleep in Bipolar Disorder: An Overview of Pharmacological and Non-Pharmacological Interventions","authors":"Valentina Baldini,&nbsp;Francesco Pasquino,&nbsp;Francesca Iannucci,&nbsp;Noemi Venezia,&nbsp;Diana De Ronchi,&nbsp;Giuseppe Plazzi,&nbsp;Lorenzo Pelizza,&nbsp;Marco Menchetti","doi":"10.1111/bdi.70179","DOIUrl":"10.1111/bdi.70179","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Sleep disturbances are common in individuals with bipolar disorder (BD) and are linked to greater symptom severity, higher relapse risk, and increased suicidality. Despite their clinical relevance, sleep problems in BD are frequently underdiagnosed and inadequately treated. This systematic review aimed to evaluate the efficacy and safety of pharmacological and non-pharmacological interventions specifically targeting sleep disturbances in BD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We systematically searched PubMed, Embase, Web of Science, and PsycINFO for studies published until May 2025. Inclusion criteria encompassed randomized controlled trials and observational studies assessing interventions specifically targeting sleep disturbances in individuals with BD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eleven studies met the inclusion criteria. Non-pharmacological interventions, particularly cognitive behavioral therapy for insomnia adapted for bipolar disorder (CBTI-BD), consistently improved sleep efficiency, latency, and total sleep time and were associated with reductions in depressive symptoms. Bright light therapy yielded mixed results, whereas the Benson Relaxation Technique showed improvements in sleep quality and emotional regulation. Among pharmacological approaches, melatonin improved circadian alignment and sleep parameters without mood destabilization. Suvorexant showed limited efficacy. Antidepressants were linked to poorer sleep quality and greater impulsivity during euthymia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Sleep-focused interventions, especially behavioral strategies such as CBTI-BD, appear effective and well tolerated for managing sleep disturbances in BD, primarily in euthymic and interepisode samples where they have been tested. Pharmacological interventions show more variable effects and require careful attention to tolerability and clinical stability. Because each intervention was evaluated in a single clinical phase, the available evidence cannot determine whether clinical phase or chronotype moderates treatment response; trials designed to detect such moderation are needed before individualized, phase-specific recommendations can be made.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 6","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13538971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New and Trending Oral Sessions","authors":"","doi":"10.1111/bdi.70162","DOIUrl":"https://doi.org/10.1111/bdi.70162","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 S1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2026 ISBD Keynote Abstracts","authors":"","doi":"10.1111/bdi.70160","DOIUrl":"https://doi.org/10.1111/bdi.70160","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 S1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent Symposium Sessions","authors":"","doi":"10.1111/bdi.70161","DOIUrl":"https://doi.org/10.1111/bdi.70161","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 S1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conference Chairs","authors":"","doi":"10.1111/bdi.70159","DOIUrl":"https://doi.org/10.1111/bdi.70159","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 S1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}