Bipolar Disorders最新文献

{"title":"Research on Youth With and at Risk for Bipolar Disorder: A 5-Year Update.","authors":"Mikaela K Dimick, Xinyue Jiang, Katrin Kutlucinar, Kathryn Burrows, Benjamin I Goldstein","doi":"10.1111/bdi.70003","DOIUrl":"https://doi.org/10.1111/bdi.70003","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Acting Injectables: A Strategy to Mitigate Nonadherence in Bipolar Disorder.","authors":"Justin Faden, Elina Maymind","doi":"10.1111/bdi.70005","DOIUrl":"https://doi.org/10.1111/bdi.70005","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacotherapy in Comorbid Bipolar Disorder and Post-Traumatic Stress Disorder From the STEP-BD Cohort.","authors":"Samantha E Russell, Anna L Wrobel, David R Skvarc, Mojtaba Lotfaliany, Olivia M Dean, Melanie M Ashton, Pedro V S Magalhães, Andrew Nierenberg, Michael Berk, Alyna Turner","doi":"10.1111/bdi.70002","DOIUrl":"https://doi.org/10.1111/bdi.70002","url":null,"abstract":"<p><strong>Introduction: </strong>Post-traumatic stress disorder (PTSD) is more prevalent in those with bipolar disorder (BD) than in the general population, with rates of PTSD as high as 55% in some BD cohorts. Despite this, little research explores the effects of pharmacotherapy treatments in those with comorbid BD and PTSD. This study aims to explore patterns of pharmacotherapy use at baseline and their impact on symptoms in individuals with BD alone and comorbid BD and PTSD.</p><p><strong>Methods: </strong>The Systematic Treatment Enhancement Program for BD (STEP-BD) cohort was utilised to examine and compare BD symptoms and pharmacotherapy treatments between those with BD alone (n = 3393) and those with comorbid BD and PTSD (n = 304). We conducted regression models to compare those with and without comorbid PTSD. Models included measures of depression, mania, functioning and quality of life over 24 months of the STEP-BD study. We included baseline pharmacotherapies (lithium, valproate, antidepressants, antipsychotics and benzodiazepines) as predictor outcome variables in all models.</p><p><strong>Results: </strong>At baseline, reported use of lithium was lower in the comorbid BD and PTSD group, while the use of antidepressants, antipsychotics and benzodiazepines was significantly higher in the comorbid BD and PTSD than in the BD alone group. Benzodiazepine use was associated with a small improvement in depression symptom scores and poorer quality of life in those with comorbid BD and PTSD. Lastly, those with comorbid PTSD experienced higher levels of mania and depression symptoms and lower functioning and quality of life compared to BD alone, irrespective of pharmacotherapy treatment.</p><p><strong>Conclusion: </strong>Clinical trial participants with BD and PTSD reported worse symptoms and outcomes across 24 months of the STEP-BD study compared to those without comorbid PTSD, regardless of baseline medication use. These results highlight the importance of considering comorbidity in the treatment of mental health conditions, specifically BD, and the need for further exploration of effective treatment options.</p>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Workshopping Depression to Effect Better Recognition.","authors":"Gracie Meng-Cin Tsai, Ching-Wen Hung, Erica Bell, Gin Malhi, Chia-Yi Wu","doi":"10.1111/bdi.70004","DOIUrl":"https://doi.org/10.1111/bdi.70004","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moody Mood Moving Move.","authors":"Zhaohui Su","doi":"10.1111/bdi.70001","DOIUrl":"https://doi.org/10.1111/bdi.70001","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Major Depression: A Need to Expand Behavioral Activation Research.","authors":"Pedro Henrique Nunes Souto, Jainan Rodrigues Barretto, Ricardo Alberto Moreno, Adriana Munhoz Carneiro","doi":"10.1111/bdi.70000","DOIUrl":"https://doi.org/10.1111/bdi.70000","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobiological Mechanisms Link Bipolar Disorder to Cardiovascular Disease: A Retrospective Biobank Study of Adverse Event Risk and Contributory Mechanisms","authors":"Ji Hyun Baek,&nbsp;Simran S. Grewal,&nbsp;Krystel Abi Karam,&nbsp;Erin R. Hanlon,&nbsp;Shady Abohashem,&nbsp;Antonia V. Seligowski,&nbsp;Michael Henry,&nbsp;Michael T. Osborne,&nbsp;Andrew A. Nierenberg,&nbsp;Ahmed Tawakol","doi":"10.1111/bdi.13516","DOIUrl":"10.1111/bdi.13516","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Individuals with bipolar disorder are at greater risk of developing cardiovascular disease. However, the mechanisms underlying this association remain poorly understood. This study aimed to (1) determine the risk of major adverse cardiovascular events (MACE) after adjusting for important confounders and (2) evaluate the neural, autonomic, and immune mechanisms underlying the link between bipolar disorder and cardiovascular disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Leveraging the Mass General Brigham Biobank, bipolar disorder and incident MACE were identified using the International Classification of Disease (ICD) codes. Incident MACE events were assessed from enrollment to the date of data lock (December 2020); or to the 10-year period. Health behavior data were derived from optional surveys. Cox regression hazard models were applied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 118,827 Biobank participants, 6009 were diagnosed with bipolar disorder. Those with bipolar disorder (vs. without) demonstrated a higher risk of MACE after adjusting for cardiovascular risk factors (hazard ratio [95% confidence interval] = 1.29 [1.10–1.51], <i>p</i> = 0.002). The relationship remained significant over 10 years after adjustment for unhealthy lifestyle behaviors (1.29 [1.03, 1.61], <i>p</i> = 0.025). Furthermore, SNA, autonomic nervous system, and inflammatory markers each significantly associated with both bipolar disorder and MACE risk. Each of these measures mediated the association between bipolar disorder and MACE (accounting for 3.8%–17.8% of the relationship).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study demonstrates that bipolar disorder associates with heightened cardiovascular risk, even after accounting for cardiovascular risk. Moreover, the findings suggest that neurobiological pathways and perturbations in autonomic and inflammatory pathways may confer cardiovascular risk in bipolar disorder.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"27 1","pages":"57-66"},"PeriodicalIF":5.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to Reducing Stigmas in Serious Mental Illness Through Multidisciplinary Intersectional Patient Narratives and Digital Platforms.","authors":"Anisha Narayan, Gregg F Martin, Alex Leow","doi":"10.1111/bdi.13517","DOIUrl":"https://doi.org/10.1111/bdi.13517","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yet Why Not Say What Happened?","authors":"Jacqueline W, Ayal Schaffer","doi":"10.1111/bdi.13515","DOIUrl":"https://doi.org/10.1111/bdi.13515","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual Feelings in the Psychotherapy Room: Comparing Their Occurrence in Patients With Unipolar Depression, Bipolar Disorder, and Neither of These","authors":"Alberto Stefana,&nbsp;Paolo Fusar-Poli,&nbsp;Pierluigi Politi,&nbsp;Eduard Vieta,&nbsp;Eric A. Youngstrom","doi":"10.1111/bdi.13511","DOIUrl":"10.1111/bdi.13511","url":null,"abstract":"&lt;p&gt;We read with interest the paper by Yaghmaei et al. [&lt;span&gt;1&lt;/span&gt;], which highlights the significant impact of sexual challenges faced by individuals with bipolar disorder on their quality of life, as well as on their families. Their research underscores the need for early family-tailored sexual health interventions and the importance of recognizing these issues in both diagnostic and therapeutic contexts.&lt;/p&gt;&lt;p&gt;We agree with Yaghmaei et al. and wish to extend the discussion to another crucial aspect of the lives of these patients: the psychotherapeutic context.&lt;/p&gt;&lt;p&gt;Changes in the sexual patterns of psychiatric patients are evident not only within their families but also profoundly influence the therapeutic environment and dynamic. For example, behaviors such as innuendo, unsolicited sexual advances, changes in couture and make-up, and even sexual exhibitionism are notable, particularly during certain stages of bipolar illnesses. From its very beginning, the realm of psychotherapy is not immune to these erotic undertones. Most psychotherapists, at various points in their career, will experience romantic or sexual overtures from their patients. In certain situations, these advances can even evoke reciprocal feelings in the therapist. When not properly managed, such dynamics can jeopardize the therapeutic relationship, hinder treatment progress, and, in extreme cases, result in breaches of professional conduct. Although the literature suggests is it not the most common ethical violation providers are sanctioned for [&lt;span&gt;2&lt;/span&gt;], sexual misconduct is a serious and recognized issue in the field. Herbert Strean's 1994 publication, “Therapists who have sex with their patients,” continues to be an enlightening read. Pooled data indicate that more than 4% of surveyed mental health professionals surveyed have admitted to crossing sexual boundaries with one or more of their patients [&lt;span&gt;3&lt;/span&gt;]. Furthermore, it is crucial to acknowledge that the prevalence and types of ethical violations can vary significantly by region, cultural context, therapist's unresolved personal problems, and the specific group of mental health professionals studied [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;A pressing question remains: Are erotic behaviors in therapy sessions more prevalent among patients with bipolar disorder compared to those with other diagnoses? The forthcoming, original data seek to shed some light on this pivotal issue.&lt;/p&gt;&lt;p&gt;The data presented herein are from a secondary analysis of a cross-sectional study aimed at developing and preliminarily validating a self-report inventory that assesses patients' perceptions and affective reactions to their therapists during psychotherapy sessions [&lt;span&gt;5&lt;/span&gt;]. The sample comprised 701 adults diagnosed with psychiatric disorders, all of whom underwent individual psychotherapy and resided in the United States. Participants were recruited from March through April 2022 through two national registers for clinical research ","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"27 1","pages":"69-71"},"PeriodicalIF":5.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13511","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}