Bipolar Disorders最新文献

{"title":"Olanzapine-Induced Black Hairy Tongue: A Case Report.","authors":"Muhammed Fatih Tabara, Beyza Vatan, Mehmet Gurkan Gurok, Murad Atmaca","doi":"10.1111/bdi.70015","DOIUrl":"https://doi.org/10.1111/bdi.70015","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the Training and Educational Priorities of Bipolar Disorder-Focused Early and Mid-Career Researchers and Clinicians.","authors":"Norma Verdolini, Rebekah S Huber, Emma Morton, Tamsyn Van Rheenen, Gabriel Fries, Olivia Dean, Fabiano Gomes, Rachel Mitchell, Georgina M Hosang, Katie M Douglas","doi":"10.1111/bdi.70008","DOIUrl":"https://doi.org/10.1111/bdi.70008","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on Youth With and at Risk for Bipolar Disorder: A 5-Year Update.","authors":"Mikaela K Dimick, Xinyue Jiang, Katrin Kutlucinar, Kathryn Burrows, Benjamin I Goldstein","doi":"10.1111/bdi.70003","DOIUrl":"https://doi.org/10.1111/bdi.70003","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Acting Injectables: A Strategy to Mitigate Nonadherence in Bipolar Disorder","authors":"Justin Faden, Elina Maymind","doi":"10.1111/bdi.70005","DOIUrl":"10.1111/bdi.70005","url":null,"abstract":"<p>Despite our best efforts, partial or nonadherence to treatment is common in bipolar disorder. Varying definitions of nonadherence make a clear prevalence difficult to determine, but a recent nationwide bipolar disorder cohort study identified rates of nonadherence to treatment to be as high as 60%, with a mean prevalence of 40% [<span>1</span>]. The study included > 33,000 individuals with bipolar disorder, and approximately 60% were nonadherent at least once during the monitoring period. This begs the question, why? Nonadherence to pharmacologic treatment is not unique to bipolar disorder, but rates are notoriously high in mental health conditions. Reasons are multifactorial but include the number of comorbidities, young age, co-occurring substance use disorders, limited primary support system, psychotic symptoms, intensity of manic symptoms, and limited insight, amongst others [<span>1, 2</span>].</p><p>The consequence of nonadherence to treatment, especially in early disease bipolar disorder, can be dire. Manic exacerbations have been shown to result in brain damage, functional and cognitive impairment, and worse outcomes [<span>3, 4</span>]. Additionally, potentially due to increased impulsivity, bipolar disorder is strongly associated with increased loss of life due to suicide. The best way to prevent these exacerbations and deleterious outcomes is by maintaining adherence to efficacious treatment, thereby preserving brain function and quality of life.</p><p>In a recent article published in bipolar disorders, Vieta and colleagues expound on the landscape of long-acting injectable (LAI) antipsychotics for the treatment of bipolar disorder and provide expert consensus recommendations [<span>4</span>]. Key findings include moving past the preconceived notion that LAIs can be used only for bipolar disorder patients with severe disease, and utilizing LAIs as early as possible in the bipolar disease course, ideally during the first manic episode [<span>4</span>]. Historically, LAIs have been reserved for patients with chronic nonadherence to treatment and schizophrenia. However, robust evidence supports that LAIs can enhance fidelity to treatment, reduce psychotic and manic exacerbations, and reduce the risk of rehospitalization when compared to oral antipsychotics [<span>4</span>].</p><p>Bipolar 1 disorder can be difficult to treat, and individuals will often require multiple medications. However, polypharmacy has also been shown to reduce adherence [<span>1</span>]. LAIs can lower this burden by limiting the number of daily medications, providing consistent medication serum levels, and eliminating the guesswork about treatment adherence status. Using an LAI as the core treatment allows for rational polypharmacy and the utilization of other medications, such as lithium, in a synergistic manner. However, individuals are often not given the option of an LAI due to lack of healthcare provider awareness.</p><p>In recent years, there has been a ","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"27 2","pages":"152-153"},"PeriodicalIF":5.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacotherapy in Comorbid Bipolar Disorder and Post-Traumatic Stress Disorder From the STEP-BD Cohort","authors":"Samantha E. Russell,&nbsp;Anna L. Wrobel,&nbsp;David R. Skvarc,&nbsp;Mojtaba Lotfaliany,&nbsp;Olivia M. Dean,&nbsp;Melanie M. Ashton,&nbsp;Pedro V. S. Magalhães,&nbsp;Andrew Nierenberg,&nbsp;Michael Berk,&nbsp;Alyna Turner","doi":"10.1111/bdi.70002","DOIUrl":"10.1111/bdi.70002","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Post-traumatic stress disorder (PTSD) is more prevalent in those with bipolar disorder (BD) than in the general population, with rates of PTSD as high as 55% in some BD cohorts. Despite this, little research explores the effects of pharmacotherapy treatments in those with comorbid BD and PTSD. This study aims to explore patterns of pharmacotherapy use at baseline and their impact on symptoms in individuals with BD alone and comorbid BD and PTSD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Systematic Treatment Enhancement Program for BD (STEP-BD) cohort was utilised to examine and compare BD symptoms and pharmacotherapy treatments between those with BD alone (<i>n</i> = 3393) and those with comorbid BD and PTSD (<i>n</i> = 304). We conducted regression models to compare those with and without comorbid PTSD. Models included measures of depression, mania, functioning and quality of life over 24 months of the STEP-BD study. We included baseline pharmacotherapies (lithium, valproate, antidepressants, antipsychotics and benzodiazepines) as predictor outcome variables in all models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At baseline, reported use of lithium was lower in the comorbid BD and PTSD group, while the use of antidepressants, antipsychotics and benzodiazepines was significantly higher in the comorbid BD and PTSD than in the BD alone group. Benzodiazepine use was associated with a small improvement in depression symptom scores and poorer quality of life in those with comorbid BD and PTSD. Lastly, those with comorbid PTSD experienced higher levels of mania and depression symptoms and lower functioning and quality of life compared to BD alone, irrespective of pharmacotherapy treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Clinical trial participants with BD and PTSD reported worse symptoms and outcomes across 24 months of the STEP-BD study compared to those without comorbid PTSD, regardless of baseline medication use. These results highlight the importance of considering comorbidity in the treatment of mental health conditions, specifically BD, and the need for further exploration of effective treatment options.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"27 2","pages":"108-118"},"PeriodicalIF":5.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Workshopping Depression to Effect Better Recognition.","authors":"Gracie Meng-Cin Tsai, Ching-Wen Hung, Erica Bell, Gin Malhi, Chia-Yi Wu","doi":"10.1111/bdi.70004","DOIUrl":"https://doi.org/10.1111/bdi.70004","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moody Mood Moving Move","authors":"Zhaohui Su","doi":"10.1111/bdi.70001","DOIUrl":"10.1111/bdi.70001","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"27 2","pages":"156"},"PeriodicalIF":5.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Major Depression: A Need to Expand Behavioral Activation Research","authors":"Pedro Henrique Nunes Souto,&nbsp;Jainan Rodrigues Barretto,&nbsp;Ricardo Alberto Moreno,&nbsp;Adriana Munhoz Carneiro","doi":"10.1111/bdi.70000","DOIUrl":"10.1111/bdi.70000","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"27 2","pages":"154-155"},"PeriodicalIF":5.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobiological Mechanisms Link Bipolar Disorder to Cardiovascular Disease: A Retrospective Biobank Study of Adverse Event Risk and Contributory Mechanisms","authors":"Ji Hyun Baek,&nbsp;Simran S. Grewal,&nbsp;Krystel Abi Karam,&nbsp;Erin R. Hanlon,&nbsp;Shady Abohashem,&nbsp;Antonia V. Seligowski,&nbsp;Michael Henry,&nbsp;Michael T. Osborne,&nbsp;Andrew A. Nierenberg,&nbsp;Ahmed Tawakol","doi":"10.1111/bdi.13516","DOIUrl":"10.1111/bdi.13516","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Individuals with bipolar disorder are at greater risk of developing cardiovascular disease. However, the mechanisms underlying this association remain poorly understood. This study aimed to (1) determine the risk of major adverse cardiovascular events (MACE) after adjusting for important confounders and (2) evaluate the neural, autonomic, and immune mechanisms underlying the link between bipolar disorder and cardiovascular disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Leveraging the Mass General Brigham Biobank, bipolar disorder and incident MACE were identified using the International Classification of Disease (ICD) codes. Incident MACE events were assessed from enrollment to the date of data lock (December 2020); or to the 10-year period. Health behavior data were derived from optional surveys. Cox regression hazard models were applied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 118,827 Biobank participants, 6009 were diagnosed with bipolar disorder. Those with bipolar disorder (vs. without) demonstrated a higher risk of MACE after adjusting for cardiovascular risk factors (hazard ratio [95% confidence interval] = 1.29 [1.10–1.51], <i>p</i> = 0.002). The relationship remained significant over 10 years after adjustment for unhealthy lifestyle behaviors (1.29 [1.03, 1.61], <i>p</i> = 0.025). Furthermore, SNA, autonomic nervous system, and inflammatory markers each significantly associated with both bipolar disorder and MACE risk. Each of these measures mediated the association between bipolar disorder and MACE (accounting for 3.8%–17.8% of the relationship).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study demonstrates that bipolar disorder associates with heightened cardiovascular risk, even after accounting for cardiovascular risk. Moreover, the findings suggest that neurobiological pathways and perturbations in autonomic and inflammatory pathways may confer cardiovascular risk in bipolar disorder.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"27 1","pages":"57-66"},"PeriodicalIF":5.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to Reducing Stigmas in Serious Mental Illness Through Multidisciplinary Intersectional Patient Narratives and Digital Platforms","authors":"Anisha Narayan,&nbsp;Gregg F. Martin,&nbsp;Alex Leow","doi":"10.1111/bdi.13517","DOIUrl":"10.1111/bdi.13517","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"27 2","pages":"93-95"},"PeriodicalIF":5.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}