Bipolar Disorders最新文献

{"title":"Smoking Initiation, Age at Onset of Symptoms and Suicide Attempts Among Patients With Bipolar Disorder: Comparisons With Non-Psychiatric Adults.","authors":"Manuel Gurpegui, Luis Gutiérrez-Rojas, José M Martínez-Ortega, Jesús García-Jiménez, Sara Jiménez-Fernández, Pablo J González-Domenech, Lucía Pérez-Costillas","doi":"10.1111/bdi.70149","DOIUrl":"10.1111/bdi.70149","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of tobacco smoking and high nicotine dependence (ND) in bipolar disorder (BD) is higher than in the general population but lower than in schizophrenia. This study aims to analyse the relationship of smoking behaviours, including age at onset of daily smoking (AODS), with age at onset of BD and course-of-illness variables -particularly recurrent suicide attempt- in a community sample of BD patients, also compared in their smoking behaviour variables with a sample of non-psychiatric adults.</p><p><strong>Methods: </strong>Samples of 108 patients with BD and 290 non-psychiatric adults were compared in their smoking habit. High ND was defined by a score of ≥ 6 on the Fagerström Test for Nicotine Dependence. Logistic regression analyses were employed to identify factors associated with daily smoking and high ND. Hazard curves were used to compare AODS between patients and controls and, among patients, age of BD onset between smokers and non-smokers. Within-subject survival times -AODS and the age at onset of BD symptoms- were compared with a multi-state illness-death model.</p><p><strong>Results: </strong>Compared with controls, BD patients showed higher prevalences of current daily smoking (44% vs. 34%) and high ND (25% vs. 9%); and lower smoking cessation rates (23% vs. 38%). Among BD patients, recurrent suicide attempt showed a strong independent association with both daily smoking and high ND. AODS was later in BD patients than the control group. Among patients, illness onset was earlier in smokers and AODS was earlier than illness onset.</p><p><strong>Conclusion: </strong>Addressing tobacco consumption should be an integral component of BD prevention and treatment strategies.</p>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 5","pages":"e70149"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13373819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to [A High-Accuracy and Easy-Use Differential Diagnosis Method of Bipolar Disorder Depressive Phase and Major Depressive Disorder Using a Wearable Near-Infrared Spectroscopy].","authors":"","doi":"10.1111/bdi.70144","DOIUrl":"10.1111/bdi.70144","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 5","pages":"e70144"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Toll-Like Receptor Signalling Pathway Is Altered in iPSC-Derived Cortical Networks From People With Bipolar Disorder.","authors":"Bruna Panizzutti, Chiara Cristina Bortolasci, Megan Ellis, Briana Spolding, Courtney Swinton, Trang T T Truong, Cassie Field, Zoe Shih-Jung Liu, Damián Hernández, Greg Roebuck, Ajeet B Singh, Bruno Agustini, Robson Zazula, Ana C Andreazza, Dana El Soufi El Sabbagh, Hyunjin Jeong, Olivia M Dean, Jee Hyun Kim, Michael Berk, Ken Walder","doi":"10.1111/bdi.70169","DOIUrl":"10.1111/bdi.70169","url":null,"abstract":"<p><strong>Background: </strong>Induced pluripotent stem cell (iPSC)-derived brain cells are widely utilised as in vitro models for several neuropsychiatric disorders, as they retain the donor's genetic profile, offering a unique opportunity to study living human brain cells and perform controlled experimental manipulations. In this study, we conducted whole transcriptome sequencing of cortical networks (co-cultures of neurons and astrocytes) derived from 12 participants with bipolar disorder (BD) and 12 participants without a history of mental health disorders. Aiming to identify new molecular mechanisms underlying the pathophysiology of bipolar disorder.</p><p><strong>Methods: </strong>iPSCs were generated by reprogramming peripheral blood mononuclear cells (PBMCs) using episomal vectors. iPSCs were then differentiated into neural progenitor cells (NPCs) and matured into cortical networks (CNs) that express markers of neurons and astrocytes. Whole transcriptome data were obtained using the Illumina NovaSeq X sequencing platform. Differential expression analysis was performed using DESeq2 in R.</p><p><strong>Results: </strong>Gene set enrichment analysis identified 191 enriched pathways in BD, 171 were downregulated, and around 10% were associated with the immune system. Of these, the toll-like signalling pathway, which is downregulated in BD, was further investigated.</p><p><strong>Conclusion: </strong>Our results suggest a profound immune dysregulation in BD, with downregulation of the sensing innate immune system, particularly highlighting the immune system's role as a complex signalling network.</p>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 5","pages":"e70169"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Volumetric Changes in the Thalamus in Adolescent First Episode of Mania and Cannabis Use: A Preliminary Study.","authors":"Gi Jung Shin, Jesse D Hinckley, Amanda E Guyer, Manpreet K Singh","doi":"10.1111/bdi.70157","DOIUrl":"10.1111/bdi.70157","url":null,"abstract":"<p><strong>Background: </strong>Aberrant thalamic structure has been documented in youth with bipolar disorder (BD) and linked with cannabis use, which commonly co-occurs with BD. However, the timeline of when these associations evolve remains unclear. This study aimed to longitudinally compare thalamic volume among youth with and without first episode mania who do or do not use cannabis and other substances.</p><p><strong>Methods: </strong>Demographic and magnetic resonance imaging (MRI) data from youth (13-18 years old) with BD (n = 22) were compared to similarly aged healthy youth (n = 23) at baseline and 12-month follow-up. Clinical group status, including BD and substance misuse and dependence, was evaluated using semistructured interviews. Multivariate analyses accounting for total brain volume and baseline age were conducted to evaluate baseline and longitudinal group differences in thalamic volume.</p><p><strong>Results: </strong>At 12 months, BD youth had significantly smaller left thalamus volumes compared to healthy youth (p = 0.009). Lifetime cannabis use was associated with smaller left thalamus volumes for all youth (p < 0.001) and for youth with BD compared to healthy controls (p < 0.001) across time. Among BD youth, co-occurring lifetime substance use was associated with significant volumetric reductions in the left thalamus from baseline to follow-up (p = 0.004), but not among healthy youth (p = 0.517). No significant group differences or changes were observed in the right thalamus.</p><p><strong>Conclusions: </strong>BD is associated with smaller left thalamic volume after the first manic episode. Cannabis use may compound thalamic volume reductions in youth with BD. Investigations with larger sample sizes are needed to replicate these findings and examine clinical correlates of cannabis use alongside long-term thalamic trajectories.</p>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 5","pages":"e70157"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13378242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Defining Treatment-Resistant Bipolar Depression: Recommendations From the ISBD Task Force\".","authors":"","doi":"10.1111/bdi.70165","DOIUrl":"10.1111/bdi.70165","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 5","pages":"e70165"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13386787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Partum Psychosis With Catatonic Features: A Case Report.","authors":"Fábio Argollo, Rodrigo Alves, Samuel Cunha, Igor Studart","doi":"10.1111/bdi.70153","DOIUrl":"10.1111/bdi.70153","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 5","pages":"e70153"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Rapid Cycling Bipolar Disorder With Lurasidone, Clozapine, and Valproate: A Case Report.","authors":"Petr Potměšil, Miloslav Kopeček, Veronika Andrashko","doi":"10.1111/bdi.70155","DOIUrl":"10.1111/bdi.70155","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 5","pages":"e70155"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Essential Information About Chronobiology and Chronotherapy for the Optimal Care of People With Bipolar Disorders: An Expert Consensus.","authors":"Jacob J Crouse, Victoria Loblay, Anthony Jorm, Timothy R Wong, Zsofi de Haan, Carla Gorban, Mirim Shin, Emiliana Tonini, Chris Aiken, Lauren B Alloy, Kürşat Altinbaş, Serge Beaulieu, Joanne S Carpenter, Bruno Etain, Yuichi Esaki, Jess G Fiedorowicz, Corrado Garbazza, Pierre A Geoffroy, Bartholomeus C M Haarman, Tone E G Henriksen, Maria Paz Hidalgo, Maree L Inder, Raymond W Lam, Helle Ø Madsen, Colleen A McClung, Gunnar Morken, Laura Palagini, James Phelps, Richard J Porter, Aswin Ratheesh, Rixt F Riemersma-Van der Lek, Janusz K Rybakowski, Erika F H Saunders, Peter F J Schulte, Daniel J Smith, Holly A Swartz, Bryan K Tolliver, Anna Wirz-Justice, Ian B Hickie, John F Gottlieb","doi":"10.1111/bdi.70141","DOIUrl":"10.1111/bdi.70141","url":null,"abstract":"<p><strong>Introduction: </strong>Circadian dysfunction is involved in the pathophysiology of bipolar disorders (BD), and circadian-based interventions are gaining recognition in their management. Moreover, basic and epidemiologic research has generated findings inspiring circadian-informed self- and clinician-management strategies. Despite these gains, many Clinical Practice Guidelines and clinical training programs have not incorporated this evidence in their recommendations and curricula. This International Society for Bipolar Disorders (ISBD) Chronobiology and Chronotherapy Task Force position paper reports a Delphi-based expert consensus on what is essential for mental health clinicians to know about the chronobiology and chronotherapy of BD.</p><p><strong>Methods: </strong>An initial pool of statements was extracted from academic and grey literature, and experts could suggest additional statements. Statements were rated on a 5-point scale ('essential'; 'important'; 'don't know/depends'; 'unimportant'; 'should not be included'). Consensus was reached when statements were rated as essential or important by ≥ 80% of experts.</p><p><strong>Results: </strong>Thirty experts from 15 countries in Europe, North and South America, and the Asia Pacific participated (mean age of 55.3 years [SD = 11.8]; 40% female; 83% psychiatrists; mean clinical experience of 26 years [SD = 10.8]). Eight-hundred-and-thirty-seven statements were rated across three rounds. Consensus was reached on 342 statements spanning four major themes: basic circadian science; circadian health and disruption; chronobiology of BD; and six chronotherapies (e.g., protocols, outcomes, risks/contraindications).</p><p><strong>Conclusions: </strong>An expert consensus was obtained on the essential information about the chronobiology and chronotherapy of BD, intended to help clinicians optimise their management of BD. Dissemination of this knowledge is expected to enhance the training and efficacy of clinicians.</p>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 5","pages":"e70141"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13352581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pursuing, Protecting and Publishing the Truth: The Three Benjamins From a Personal Perspective.","authors":"Anne Naylor","doi":"10.1111/bdi.70130","DOIUrl":"10.1111/bdi.70130","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 5","pages":"e70130"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13353242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a Safe and Effective Lithium Therapeutic Range for Older Adults With Bipolar Disorder: An ISBD Task Force Systematic Review.","authors":"Paula V Nunes, Andrew T Olagunju, Debbie Zittema, Astha Dhyani, Lei Fu, Peijun Chen, Laura Montejo, Gabriel R Fries, Lars V Kessing, Eduard Vieta, Orestes V Forlenza, Annemieke Dols, Hilary P Blumberg, Lisa T Eyler, Kenneth I Shulman","doi":"10.1111/bdi.70151","DOIUrl":"10.1111/bdi.70151","url":null,"abstract":"<p><strong>Objectives: </strong>Lithium is recommended as the first-line maintenance treatment for older adults with bipolar disorder (OABD). However, age-related reduction in renal clearance, heightened sensitivity to adverse effects, and drug interactions increase the risk of toxicity and necessitate lower therapeutic serum levels in this population. Despite expert consensus supporting age-adjusted targets, most clinical laboratories still do not report age-specific therapeutic ranges. We conducted a systematic review on recommended serum lithium levels in OABD to update evidence supporting age-specific therapeutic ranges for safe and effective lithium management.</p><p><strong>Methods: </strong>We searched Medline, PsycINFO, Embase, and Cochrane Central Register of Controlled Trials since 2017 for studies analyzing lithium serum levels in individuals with bipolar disorder ≥ 60 years. Two reviewers independently screened titles, abstracts, and full texts. We used the National Institutes of Health Quality Assessment Tool to assess methodological quality.</p><p><strong>Results: </strong>Fourteen studies, including 8808 older adults using lithium, met inclusion criteria. All studies were observational with cross-sectional or cohort designs. Mean or median lithium levels ranged from 0.47-0.67 mmol/L. Levels of 0.82-1.00 mmol/L were associated with increased side effects or early toxicity signs, while levels of 1.20-1.25 mmol/L were overtly toxic. Impaired renal function and concomitant use of diuretics, ACE inhibitors, and NSAIDs required closer monitoring for toxicity.</p><p><strong>Conclusions: </strong>These findings are consistent with age-adjusted lithium therapeutic targets in older adults and provide additional observational support for clinical laboratories to adopt age-specific therapeutic ranges. Clinicians should consider individualized monitoring accounting for age-related physiological changes and medication interactions to ensure safer and effective lithium therapy.</p>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"28 5","pages":"e70151"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13373820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}