Bipolar Disorders最新文献_第5页

Case report: Manic-like symptoms mimicking early-onset bipolar disorder in a case of neuropsychiatric lupus 病例报告：一例神经精神红斑狼疮患者模仿早发躁郁症状的躁狂症状。

IF 5 2区医学

Bipolar Disorders Pub Date : 2024-09-02 DOI: 10.1111/bdi.13495

Ming Chen, Yi Tang, Gang Li, Ming-Zhi Xu, Cai-Lan Hou

引用次数: 0

A case of delirious mania in the context of concurrent cardiac comorbidities and autonomic instability 并发心脏病和自律神经不稳定的谵妄性躁狂症病例。

IF 5 2区医学

Bipolar Disorders Pub Date : 2024-09-02 DOI: 10.1111/bdi.13502

Cathy Daichang, Eric Rutkowski, Zeshawn Ali

引用次数: 0

Postpartum rage attacks in a female with bipolar II disorder and obsessive-compulsive disorder: Diagnostic and treatment challenges 一名患有双相情感障碍 II 和强迫症的女性产后愤怒发作：诊断和治疗难题。

IF 5 2区医学

Bipolar Disorders Pub Date : 2024-09-02 DOI: 10.1111/bdi.13499

Verinder Sharma

{"title":"Postpartum rage attacks in a female with bipolar II disorder and obsessive-compulsive disorder: Diagnostic and treatment challenges","authors":"Verinder Sharma","doi":"10.1111/bdi.13499","DOIUrl":"10.1111/bdi.13499","url":null,"abstract":"<p>A 26-year-old first-time mother was referred for assessment and management of postpartum depression. A few weeks before her first visit to the clinic, she was prescribed sertraline which she had previously taken with for treatment of non-puerperal episodes of depression. Within 2 weeks of the retrial of sertraline 75 mg daily, there was a marked improvement in symptoms of depression and anxiety. She also had obsessions and compulsions, but these were not severe enough to reach the diagnostic criteria of obsessive-compulsive disorder (OCD). The diagnosis of major depressive disorder was confirmed due to the history of at least 10 episodes over as many years (see Figure 1). She had made two suicide attempts including a drug overdose following which she was hospitalized. She denied hypo/manic symptoms; however, she reported a history of bipolar I disorder in a sibling. Due to the history of sustained response to sertraline, we recommended continuation of the current dose (75 mg daily). She took it for several months before discontinuing it during her subsequent pregnancy. She remained well after stopping it but had a recurrence of depression immediately following her delivery. She was prescribed sertraline by her family physician, and after a few weeks, quetiapine 25 mg was added. She was also taking lorazepam 0.5 mg/daily, as needed.</p><p>She was referred to our clinic again 8 months after giving birth to her second child for evaluation of intrusive thoughts of harm coming to her children. She had become increasingly worried about their safety since the abrupt cessation of breastfeeding 4 months earlier. In particular, she was afraid of them dying in a motor vehicle accident, or a fire at home. She had spent thousands of dollars on car seats, strollers, mattresses, baby monitors, car window breakers, and fire alarms to safeguard her children. She also reported a history of compulsive skin-picking and hair-pulling. She had become overly sensitive to noises in the house, such as the dishwasher, breathing sounds, and chewing. On the Mood Disorder Questionnaire, she endorsed all items with co-occurrence and moderate functional impairment. She reported having had brief hypomanic and mixed episodes lasting up to a week since her last delivery. She did not have psychotic features and denied abusing alcohol or using illicit drugs.</p><p>Of her extant symptoms, she was particularly concerned about the daily occurrences of episodes of intense anger toward her husband and children. These episodes lasted 45–60 min and were accompanied by yelling, and destruction of property. There were no acts of violence, but she was afraid that she might harm others. She experienced anger attacks after her first delivery, but these were less intense, and less frequent than her rage attacks over the last few months. Her diagnosis was revised to bipolar II disorder and OCD. The sertraline dose was tapered off over 2 weeks due to lack of effectiveness and concerns about ind","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"27 1","pages":"84-86"},"PeriodicalIF":5.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13499","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concept article: Antidepressant-induced destabilization in bipolar illness mediated by serotonin 3 receptor (5HT3) 概念文章：血清素 3 受体（5HT3）介导的抗抑郁药诱导的双相情感障碍疾病的不稳定性。

IF 5 2区医学

Bipolar Disorders Pub Date : 2024-09-01 DOI: 10.1111/bdi.13494

Irem Hacisalihoglu Aydin, Rif S. El-Mallakh

{"title":"Concept article: Antidepressant-induced destabilization in bipolar illness mediated by serotonin 3 receptor (5HT3)","authors":"Irem Hacisalihoglu Aydin, Rif S. El-Mallakh","doi":"10.1111/bdi.13494","DOIUrl":"10.1111/bdi.13494","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Antidepressants used by patients with bipolar disorder have been associated with destabilization with an increase in mania, depression, and cycling. The most commonly proposed mechanism, that antidepressants ‘overshoot’ their antidepressant effect to create a manic or mixed state, is unlikely since antidepressants have actually been found to be ineffective in treating bipolar depression. Beginning with known bipolar-specific pathophysiologic abnormalities provides the greatest likelihood of insight.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PubMed was queried with ‘bipolar’, ‘sodium’, ‘intracellular sodium’, ‘serotonin 3’, ‘5HT<sub>3</sub>’, ‘5-hydroxytryptamine type 3 receptors’, and ‘antidepressant’ either individually or in combination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pathologic mood states (both mania and depression) are associated with increased intracellular sodium (Na) concentrations that depolarize the resting membrane potential to increase cellular excitability (mania) or cause depolarization block (depression). Stimulation of the serotonin (5HT) receptors depolarizes the post-synaptic neuron. Stimulation of 5HT<sub>3</sub> may be of particular importance since it is coupled to a cation channel that directly depolarizes the membrane. These effects <i>directly</i> impact the physiology of patients with bipolar disorder to alter neuronal excitability in a fashion that worsens both mania and depression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Proposed Concept</h3>\u0000 \u0000 <p>The most consistently observed biological abnormality in individuals going through mania or bipolar depression involves a decline in Na pump activity, with consequent elevation of intracellular Na levels. Antidepressant treatment potentiates this, particularly by activation of 5HT<sub>3</sub>. This hypothesis can be tested by coadministering a 5HT<sub>3</sub> antagonist (e.g., vortioxetine or ondansetron) to achieve blockade of that receptor while treating bipolar depression with a serotoninergic antidepressant.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 8","pages":"772-778"},"PeriodicalIF":5.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NMDA antagonists use in bipolar depression: A case report NMDA 拮抗剂用于双相抑郁症：病例报告。

IF 5 2区医学

Bipolar Disorders Pub Date : 2024-09-01 DOI: 10.1111/bdi.13496

Kirolos Ibrahim, Sara Abell, Rif El-Mallakh

引用次数: 0

Conceptualizing the relationship between synthetic cannabinoid use and neuroleptic malignant syndrome. 合成大麻素的使用与神经性恶性综合征之间关系的概念化。

IF 5 2区医学

Bipolar Disorders Pub Date : 2024-09-01 DOI: 10.1111/bdi.13503

Vincent Zhang, Alexis June Wirtz, Anmol Dhingra, Ashar Zahid, Najeeb Hussain

引用次数: 0

Utilizing long-acting injectables to address noncompliance among adolescents diagnosed with bipolar disorder 利用长效注射剂解决被诊断出患有躁郁症的青少年不遵医嘱的问题。