Bipolar Disorders最新文献

{"title":"Lithium and the American dream","authors":"Gin S. Malhi, Erica Bell","doi":"10.1111/bdi.13492","DOIUrl":"10.1111/bdi.13492","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 6","pages":"517-522"},"PeriodicalIF":5.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active components and mechanisms of action of psychological interventions in bipolar disorder: A systematic literature review","authors":"Duygu Serbetci,&nbsp;Zhao Hui Koh,&nbsp;Greg Murray,&nbsp;Hailey Tremain","doi":"10.1111/bdi.13464","DOIUrl":"10.1111/bdi.13464","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The efficacy of psychological interventions for bipolar disorder (BD) is well established, but much remains unknown about how change occurs. The primary objective of this exploratory study was to audit what is known about active components and mechanisms of action of psychological interventions for BD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We conducted a systematic review (PROSPERO CRD42022323276). Two independent reviewers screened references from four databases and extracted data from eligible studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included four component studies, six studies with mediation analyses and 26 studies presenting subjective experiences of how psychological interventions bring change. Ten mediators were examined across six studies, with only one putative mediator, medication adherence, tested in more than one study. Some initial support for mediation of varied outcomes by control over thoughts, positive non-verbal behaviour, self-esteem, post-trauma growth and medication adherence. Some preliminary support was found in two components, human support and IPT. Studies exploring participant experiences of therapeutic change enumerated a range of potential active components, mechanisms of action and contextual factors potentially warranting investigation in future research. However, the evidence base for active components and mechanisms of action in psychological interventions for BD is unsatisfactory. Findings were inconsistent, studies homogenous with significant methodological limitations and statistical approaches failed to meet quality criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Preliminary identification of potential components and mechanisms via qualitative analyses and the insights emerging from this review will inform future research aimed at investigating how psychological interventions work in BD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 7","pages":"661-683"},"PeriodicalIF":5.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CoDesign of a digital intervention for parents with bipolar disorder informed by integrated knowledge translation principles","authors":"Steven H. Jones,&nbsp;Stephanie Fortier,&nbsp;Christopher Lodge,&nbsp;Cathy Creswell,&nbsp;Fiona Lobban,&nbsp;Richard Morriss,&nbsp;Jasper Palmier Claus,&nbsp;Anne Duffy,&nbsp;Brian Green,&nbsp;Abigail Wells,&nbsp;Lucy Cryle","doi":"10.1111/bdi.13468","DOIUrl":"10.1111/bdi.13468","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To provide detailed information on the codesign of a digital intervention to support parents with bipolar disorder (BD) who have young children. Each step of this process is reported, as well as a detailed description of the final version of the intervention in line with the TIDieR framework.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Clinical experience and lived experience experts participated in online workshops, meetings, and remote feedback requests, informed by Integrated Knowledge Translation (IKT) principles. The IKT research group responded to each phase of recommendations from the knowledge users.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Five clinical experience experts and six lived experience experts engaged with the codesign process. Their recommendations for principles, content, look, and feel, and functionality of the digital intervention were structured over five iterative phases. This led to a final implemented design that was identified by the clinical and lived experience experts (referred to together as the knowledge users group) as genuinely reflecting their input.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The IKT principles offer an accessible structure for engaging with clinical and lived experience experts throughout a codesign process, in this case for a digital intervention for parents with BD. The resulting intervention is described in detail for transparency to aid further evaluation and development and to help other teams planning codesign approaches to intervention development.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 7","pages":"717-732"},"PeriodicalIF":5.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The second generation of psychological interventions research in bipolar disorder: Mapping the territory","authors":"Hailey Tremain,&nbsp;Greg Murray","doi":"10.1111/bdi.13488","DOIUrl":"10.1111/bdi.13488","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 7","pages":"643-645"},"PeriodicalIF":5.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariate brain-cognition associations in euthymic bipolar disorder","authors":"Bethany Little,&nbsp;Carly Flowers,&nbsp;Andrew Blamire,&nbsp;Peter Thelwall,&nbsp;John-Paul Taylor,&nbsp;Peter Gallagher,&nbsp;David Andrew Cousins,&nbsp;Yujiang Wang","doi":"10.1111/bdi.13484","DOIUrl":"10.1111/bdi.13484","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>People with bipolar disorder (BD) tend to show widespread cognitive impairment compared to healthy controls. Impairments in processing speed (PS), attention and executive function (EF) may represent ‘core’ impairments that have a role in wider cognitive dysfunction. Cognitive impairments appear to relate to structural brain abnormalities in BD, but whether core deficits are related to particular brain regions is unclear and much of the research on brain-cognition associations is limited by univariate analysis and small samples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Euthymic BD patients (<i>n</i> = 56) and matched healthy controls (<i>n</i> = 26) underwent T1-weighted MRI scans and completed neuropsychological tests of PS, attention and EF. We utilised public datasets to develop normative models of cortical thickness (<i>n</i> = 5977) to generate robust estimations of cortical abnormalities in patients. Canonical correlation analysis was used to assess multivariate brain-cognition associations in BD, controlling for age, sex and premorbid IQ.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>BD showed impairments on tests of PS, attention and EF, and abnormal cortical thickness in several brain regions compared to healthy controls. Impairments in tests of PS and EF were most strongly associated with cortical thickness in the left inferior temporal, right entorhinal and right temporal pole areas.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Impairments in PS, attention and EF can be observed in euthymic BD and may be related to abnormal cortical thickness in temporal regions. Future research should continue to leverage normative modelling and multivariate methods to examine complex brain-cognition associations in BD. Future research may benefit from exploring covariance between traditional brain structural morphological metrics such as cortical thickness, cortical volume and surface area.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 6","pages":"604-616"},"PeriodicalIF":5.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13484","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal temporal dynamics and spatial heterogeneity unveil vulnerability markers in the offspring of bipolar patients.","authors":"Luigi F Saccaro, Farnaz Delavari, Dimitri Van De Ville, Camille Piguet","doi":"10.1111/bdi.13487","DOIUrl":"https://doi.org/10.1111/bdi.13487","url":null,"abstract":"<p><strong>Objectives: </strong>Bipolar disorder (BD) is a highly heritable disorder characterized by emotion dysregulation and recurrent oscillations between mood states. Despite the proven efficacy of early interventions, vulnerability markers in high-risk individuals are still lacking. BD patients present structural alterations of the hippocampus, a pivotal hub of emotion regulation networks composed of multiple subregions with different projections. However, the hippocampal dynamic functional connectivity (dFC) in BD remains unclear. We aim to investigate whether the dFC of hippocampal subdivisions differentiates BD patients, offspring of BD patients (BDoff), and healthy controls (HC); and whether it correlates with symptoms differently between these groups.</p><p><strong>Methods: </strong>We studied for the first time the dFC of the hippocampus through a cutting-edge micro-co-activation patterns (μCAPs) analysis of resting-state functional MRI data of 97 subjects (26 BD, 18 BDoff, 53 HC). μCAPs allow a data-driven differentiation within the seed region.</p><p><strong>Results: </strong>dFC between the hippocampal body and a somatomotor-μCAP was lower both in BD patients (p-value_FDR:0.00015) and in BDoff (p-value_FDR:0.020) than in HC. Inversely, dFC between the hippocampal head and a limbic-μCAP was higher in BD patients than in HC (p-value_FDR: 0.005). Furthermore, the correlations between a frontoparietal-μCAP and both depression and emotion dysregulation symptoms were significantly higher in BD than HC (p-value_FDR <0.02).</p><p><strong>Conclusion: </strong>Overall, we observed alterations of large-scale functional brain networks associated with decreased cognitive control flexibility and disrupted somatomotor, saliency, and emotion processing in BD. Interestingly, BDoff presented an intermediate phenotype between BD and HC, suggesting that dFC of hippocampal subregions might represent a marker of vulnerability to BD.</p>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive predictors of response to interpersonal and social rhythm therapy in mood disorders","authors":"Samantha J. Groves,&nbsp;Katie M. Douglas,&nbsp;Marie T. Crowe,&nbsp;Maree Inder,&nbsp;Jenny Jordan,&nbsp;Dave Carlyle,&nbsp;Ben Beaglehole,&nbsp;Roger Mulder,&nbsp;Cameron Lacey,&nbsp;Sue Luty,&nbsp;Kate Eggleston,&nbsp;Chris Frampton,&nbsp;Christopher R. Bowie,&nbsp;Richard J. Porter","doi":"10.1111/bdi.13469","DOIUrl":"10.1111/bdi.13469","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>There has been increasing interest in examining the potential moderating effects that cognitive functioning has on treatment outcome in bipolar disorder (BD) and major depressive disorder (MDD). Therefore, the aim of this exploratory study was to examine the relationship between baseline cognitive function and treatment outcome in individuals with mood disorders who completed 12 months of interpersonal and social rhythm therapy (IPSRT), and were randomised to receive adjunctive cognitive remediation (CR) or no additional intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty-eight patients with mood disorders (BD, <i>n</i> = 36, MDD, <i>n</i> = 22), who were randomised to IPSRT-CR or IPSRT, underwent cognitive testing at baseline and completed follow-up mood measures after 12 months. General linear modelling was used to examine the relationship between baseline cognitive function (both objective and subjective) and change in mood symptom burden, and functioning, from baseline to treatment-end.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Poorer baseline attention/executive function was associated with less change in mood symptom burden, particularly depressive symptoms, at treatment-end. Additionally, slower psychomotor speed at baseline was associated with less improvement in mania symptom burden. Subjective cognitive function at baseline was not related to change in mood symptom burden at treatment-end, and neither objective nor subjective cognitive function was associated with functional outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Limitations</h3>\u0000 \u0000 <p>Due to the exploratory nature of the study, there was no correction for multiple comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Aspects of objective cognitive function were associated with treatment outcomes following psychotherapy. Further large-scale research is required to examine the role that cognitive function may have in determining various aspects of mood disorder recovery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 7","pages":"708-716"},"PeriodicalIF":5.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13469","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does BioAge identify accelerated aging in individuals with bipolar disorder? An exploratory study in the FACE-BD cohort","authors":"Bruno Etain,&nbsp;Cynthia Marie-Claire,&nbsp;Luana Spano,&nbsp;Frank Bellivier,&nbsp;Marion Leboyer,&nbsp;Sébastien Gard,&nbsp;Antoine Lefrere,&nbsp;Raoul Belzeaux,&nbsp;Philippe Courtet,&nbsp;Caroline Dubertret,&nbsp;Raymund Schwan,&nbsp;Valerie Aubin,&nbsp;Paul Roux,&nbsp;Mircea Polosan,&nbsp;Ludovic Samalin,&nbsp;Emmanuel Haffen,&nbsp;Emilie Olié,&nbsp;Ophelia Godin,&nbsp;FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators","doi":"10.1111/bdi.13480","DOIUrl":"10.1111/bdi.13480","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Individuals with bipolar disorders (BD) have an estimated loss of life expectancy around 10–15 years. Several laboratory-measured biomarkers of accelerated aging exist (e.g., telomere length), however with a questionable transferability to bedside. There is a need for easily and inexpensively measurable markers of aging, usable in routine practice, such as BioAge.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We calculated BioAge that estimates biological age based on routine blood tests and a physical exam, in a sample of 2220 outpatients with BD. We investigated associations between BioAge Acceleration (BioAgeAccel), which is an indicator of accelerated aging, and sociodemographic variables, clinical variables, and current psychotropic medication use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mean chronological age was 40.2 (±12.9). Mean BioAge was 39.1 (±12.4). Mean BioAgeAccel was 0.08 (±1.8). A minority of individuals (15%) had a BioAgeAccel above 2 years. Multivariable analyses suggested strong associations between a higher BioAgeAccel and younger age, male sex, overweight and sleep disturbances. Regarding current psychotropic medication use, discrepancies between univariate and multivariate analyses were observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A minority of individuals with BD had an accelerated aging as measured by BioAge. We identified associations with potentially modifiable factors, such as higher body mass index and sleep disturbances, that are however nonspecific to BD. These results require replications in independent samples of individuals with BD, and comparisons with a control group matched for age and gender. Longitudinal studies are also required to test whether any change in metabolic health, or sleep might decrease BioAgeAccel.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 6","pages":"595-603"},"PeriodicalIF":5.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13480","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical complexity of olanzapine use: Peripheral edema.","authors":"Vincent Zhang, Mary-Anne Hennen, Hector Lisboa, Najeeb Hussain","doi":"10.1111/bdi.13477","DOIUrl":"https://doi.org/10.1111/bdi.13477","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let us not forget postpartum manic or mixed episodes","authors":"Verinder Sharma","doi":"10.1111/bdi.13479","DOIUrl":"10.1111/bdi.13479","url":null,"abstract":"&lt;p&gt;In the nineteenth century, the estimated prevalence of puerperal mania varied from 1 in 80–800 deliveries.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; The literature from this era is replete with clinical accounts of puerperal mania and melancholia in women admitted to Victorian asylums. Changes in the nosology and interpretation of postpartum psychiatric disorder in the 20th century have produced lower rates of postpartum mania. For example, some cases of puerperal mania would be diagnosed as delirium or a toxic confusional state in today's terminology. Other factors have contributed to waning interest in puerperal mania. Coinciding with the deinstitutionalization process of replacing long-stay psychiatric hospitals with community mental health services, the research focus shifted from the study of severe psychopathology to commonly encountered conditions in the community such as baby blues and postpartum depression. The term third-day depression after childbirth, also known as the baby blues, was first described in 1952 but has a larger share of literature than postpartum mania. An ‘unofficial’ but popular nomenclature includes baby blues, postpartum depression, and postpartum psychosis but makes no direct mention of manic or mixed episodes. Postpartum psychosis denotes disparate conditions including brief psychotic disorder, manic or mixed episodes with or without psychotic features, and major depressive episodes with psychosis.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; The usurping of manic and mixed episodes by postpartum psychosis likely led to a lack of interest in the study of postpartum mania as shown in Figure 1.&lt;/p&gt;&lt;p&gt;Of mood and anxiety disorders, bipolar disorder carries the highest risk of recurrence in the postpartum period. Studies over the last few decades have demonstrated that postpartum bipolar disorder is common in community and clinical settings. A study of 10.000 women from the US found that approximately 14% of women screened positive for postpartum depression. Of those who screened positively, 23% had bipolar disorder, the most common type being bipolar I disorder (49.7%).&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; This means that approximately 1.6% of women in the community have a bipolar I mood episode after delivery. A recent study estimated that 39% of women with bipolar I disorder have a postpartum relapse. Of those with a postpartum relapse, 38% had a manic or mixed episode yielding an estimated prevalence of 14.82% among women with bipolar I disorder.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; This is likely an underestimate because mania can occur spontaneously in the absence of psychiatric illness. As a comparison, the global prevalence of postpartum psychosis is only 0.089 to 2.6 per 1000 births.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Detecting, diagnosing, and treating manic or mixed episodes in the postpartum period is challenging. Owing to their onset typically within the first few weeks following childbirth, and the lack of information about the timing of the onset of “postpartum” ep","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 6","pages":"529-531"},"PeriodicalIF":5.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13479","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}