Bipolar Disorders最新文献

{"title":"Mood regulation in euthymic patients with a history of antidepressant-induced mania","authors":"Ramzi Halabi,&nbsp;Khairatun Yusuff,&nbsp;Clara Park,&nbsp;Alexandra DeShaw,&nbsp;Christina Gonzalez-Torres,&nbsp;Muhammad I. Husain,&nbsp;Claire O'Donovan,&nbsp;Martin Alda,&nbsp;Benoit H. Mulsant,&nbsp;Abigail Ortiz","doi":"10.1111/bdi.13504","DOIUrl":"10.1111/bdi.13504","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The use of antidepressants in bipolar disorder (BD) remains contentious, in part due to the risk of antidepressant-induced mania (AIM). However, there is no information on the architecture of mood regulation in patients who have experienced AIM. We compared the architecture of mood regulation in euthymic patients with and without a history of AIM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eighty-four euthymic participants were included. Participants rated their mood, anxiety and energy levels daily using an electronic (e-) visual analog scale, for a mean (SD) of 280.8(151.4) days. We analyzed their multivariate time series by computing each variable's auto-correlation, inter-variable cross-correlation, and composite multiscale entropy of mood, anxiety, and energy. Then, we compared the data features of participants with a history of AIM and those without AIM, using analysis of covariance, controlling for age, sex, and current treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Based on 18,103 daily observations, participants with AIM showed significantly stronger day-to-day auto-correlation and cross-correlation for mood, anxiety, and energy than those without AIM. The highest cross-correlation in participants with AIM was between mood and energy within the same day (median (IQR), 0.58 (0.27)). The strongest negative cross-correlation in participants with AIM was between mood and anxiety series within the same day (median (IQR), −0.52 (0.34)).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients with a history of AIM have a different underlying mood architecture compared to those without AIM. Their mood, anxiety and energy stay the same from day-to-day; and their anxiety is negatively correlated with their mood.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 8","pages":"810-819"},"PeriodicalIF":5.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Abstracts","authors":"","doi":"10.1111/bdi.13475","DOIUrl":"https://doi.org/10.1111/bdi.13475","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 S1","pages":"45-71"},"PeriodicalIF":5.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13475","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISBD Keynote Abstracts","authors":"","doi":"10.1111/bdi.13473","DOIUrl":"https://doi.org/10.1111/bdi.13473","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 S1","pages":"8-9"},"PeriodicalIF":5.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent State of the Art Abstracts","authors":"","doi":"10.1111/bdi.13474","DOIUrl":"https://doi.org/10.1111/bdi.13474","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 S1","pages":"10-44"},"PeriodicalIF":5.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13474","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Abstracts","authors":"","doi":"10.1111/bdi.13476","DOIUrl":"https://doi.org/10.1111/bdi.13476","url":null,"abstract":"","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 S1","pages":"72-150"},"PeriodicalIF":5.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome Letter","authors":"","doi":"10.1111/bdi.13471","DOIUrl":"https://doi.org/10.1111/bdi.13471","url":null,"abstract":"&lt;p&gt;Welcome to the 26th Annual Conference of the International Society for Bipolar Disorders! The annual meeting brings together experts in bipolar disorders including researchers, educators, clinicians, and experts by experience. We are a global organization with representation from over 20 countries. Over three jam-packed days in Reykjavik, a first-time location for ISBD, we will share knowledge and wisdom about mood disorders. Through improved understanding of the causes and treatments for these conditions, we will be better prepared to support those we serve.&lt;/p&gt;&lt;p&gt;Meaningfully, 2024 marks the 30th anniversary of ISBD's inception. In 1994, Drs. David Kupfer and Ellen Frank hosted the first International Conference on Bipolar Disorders (ICBD), the precursor to ISBD, in Pittsburgh, Pennsylvania. An eager group of researchers and clinicians gathered on the University of Pittsburgh campus from June 23–24, 1994, for the latest updates on bipolar disorder. On June 17, 1999, ISBD was officially launched in Pittsburgh during the 3rd biennial ICBD meeting. Guided by Dr. Kupfer's vision for an international community of experts who gather regularly to share scientific advances and engage in advocacy for equitable research funding for bipolar disorders, ISBD was born. Thirty years later, ISBD is alive and well.&lt;/p&gt;&lt;p&gt;Selected from an outstanding pool of submissions, this year's program comprises 30 symposia, six workshops, 66 oral reports, and two poster sessions. We will also host the Women's Initiative to support gender diversity in our Society and an Early-Mid Career Committee networking session to advance the up-and-coming leaders in our field.&lt;/p&gt;&lt;p&gt;Among our truly exceptional line-up of presentations, I would like to highlight six invited plenary talks: &lt;i&gt;My Bipolar Journey&lt;/i&gt; (Leah Charles-King), &lt;i&gt;Debate on Antidepressant Medication for Bipolar Disorder&lt;/i&gt; (Ralph Kupka, Eduard Vieta, Lakshmi Yatham), &lt;i&gt;Genetic Architecture of Bipolar Disorder: Knowns and Unknowns&lt;/i&gt; (Ole A. Andreassen), &lt;i&gt;From Speech to Emotion to Mood: Mental Health Modeling in Natural Environments&lt;/i&gt; (Emily Mower Provost), &lt;i&gt;Older Age Bipolar Disorder: Cognitive and Somatic Comorbidities (&lt;/i&gt;Annemiek Dols&lt;i&gt;), and Ongoing Bipolar Mood Instability: What Can, or Could, Psychological Interventions Offer?&lt;/i&gt; (Kim Wright). Don't miss any of them!&lt;/p&gt;&lt;p&gt;Because of the large number of outstanding submissions this year, we expanded our oral report offerings. With 66 presentations, it is impossible to highlight all of them, but I wanted to call your attention to just a few offerings to give you a taste of the feast awaiting us: &lt;i&gt;Polygenic Scores and Mood Disorder Risk in Context of Family History and Developmental Psychopathology&lt;/i&gt; (Rudolf Uher), &lt;i&gt;Elucidating Neurovascular Dynamics in Bipolar Disorder with Patient-Derived Vascularized Cerebral Organoids&lt;/i&gt; (Annie Kathuria), &lt;i&gt;Fostering Network Opportunities and Creating a Community of Early and Mid-Career Members of t","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 S1","pages":"6"},"PeriodicalIF":5.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13471","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISBD Conference Steering Committee Listing","authors":"","doi":"10.1111/bdi.13472","DOIUrl":"https://doi.org/10.1111/bdi.13472","url":null,"abstract":"<p>\u0000 <b>CONFERENCE CHAIRS</b>\u0000 </p><p>\u0000 <b>Holly Swartz, MD (US)</b>\u0000 </p><p>Steering Committee Co-Chair</p><p>ISBD President</p><p>\u0000 <b>Ralph Kupka, MD, PhD (Netherlands)</b>\u0000 </p><p>Steering Committee Co-Chair</p><p>Vice-President of Education</p><p>\u0000 <b>STEERING COMMITTEE</b>\u0000 </p><p>Holly Swartz, MD (US)</p><p>Ralph Kupka, MD, PhD (Netherlands)</p><p>Gin S. Malhi, FRCPsych, FRANZCP, MD (Australia)</p><p>Andrew A. Nierenberg, MD (US)</p><p>Melvin McInnis, FRCPsych, MD (US)</p><p>Kamilla Miskowiak, Dr Med Sc (Denmark)</p><p>Michael Bauer, MD, PhD (Germany)</p><p>Ayal Schaffer, FRCPC (Canada)</p><p>Jair Soares, MD, PhD (US)</p>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 S1","pages":"7"},"PeriodicalIF":5.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.13472","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of long-term lithium therapy on kidney functioning in mood disorders: A population-based historical cohort study","authors":"Ajay K. Parsaik,&nbsp;Aanchal Chaudhary,&nbsp;Shivy Sharma,&nbsp;Brooke Ellen Delgoffe,&nbsp;Rachel Gabor,&nbsp;Balwinder Singh","doi":"10.1111/bdi.13501","DOIUrl":"10.1111/bdi.13501","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Lithium is Food and Drug Administration-approved for bipolar disorder (BD) and is also used in depressive disorders but is underutilized due to concerns about chronic kidney disease (CKD). We explored clinical and demographic profiles of patients on long-term lithium therapy (LTLT) and assessed kidney function. Our aims were to identify the predictors for CKD stage ≥3 and the impact of lithium discontinuation post-CKD diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a population-based historical cohort study of adult patients with mood disorders on LTLT at the Marshfield Clinical Health System from 1990 to 2019. Data on lithium therapy and kidney-related information (estimated glomerular filtration rate and CKD) were extracted from electronic medical records.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 1603 patients with mood disorders (mean age 42.1 years, 60% females), 15.3% (<i>n</i> = 246) developed CKD stage ≥3. Patients without CKD were on lithium for 4.5 years, compared to 6.6 years for those with CKD. Hypertension, age, and BD were significant CKD risk factors. Kidney function declined linearly with lithium duration, returning to pre-treatment trajectory in patients without CKD but showed no improvement in those with CKD after lithium discontinuation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings suggest that CKD occurs in 15% of patients with mood disorder receiving LTLT, with its progression potentially influenced by existing comorbidities rather than lithium alone. These results underscore the importance of monitoring kidney function in patients on LTLT and considering individual risk factors for CKD development. In patients who developed CKD, Li discontinuation did not impact change in kidney function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"27 1","pages":"28-35"},"PeriodicalIF":5.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent trends in hospital admission due to bipolar disorder in 10–19-year-olds in Spain: A nationwide population-based study","authors":"Teresa López-Cuadrado,&nbsp;Ezra Susser,&nbsp;Gonzalo Martínez-Alés","doi":"10.1111/bdi.13500","DOIUrl":"10.1111/bdi.13500","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Bipolar disorder (BD) hospitalization rates in children and adolescents vary greatly across place and over time. There are no population-based studies on youth BD hospitalizations in Spain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We identified all patients aged 10–19 hospitalized due to BD in Spain between 2000 and 2021, examined their demographic and clinical characteristics, and assessed temporal trends in hospitalizations – overall and stratified by age and presence of additional psychiatric comorbidity. We used Joinpoint regressions to identify inflection points and quantify whole-period and annual percentage changes (APCs) in trends.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 4770 BD hospitalizations in 10–19-year-olds between 2000 and 2021 (average annual rate: 4.8 per 100,000), over half indicated an additional psychiatric comorbidity, most frequently substance abuse (62.2%), mostly due to cannabis (72.4%). During the study period, admissions increased twofold with an inflection point: Rates increased annually only between 2000 and 2008, for APCs 34.0% (95% confidence interval: 20.0%, 71.1%) among 10–14-year-olds, 10.3% (6.4%, 14.3%) among 15–19-year-olds, and 15.5% (11.5%, 22.7%) among patients with additional psychiatric comorbidity. Between 2009 and 2021, rates decreased moderately among 10–14-year-olds – APC: −8.3% (−14.1%, −4.4%) and slightly among 15–19-year-olds without additional psychiatric comorbidity – APC: −2.6(−5.7, −1.0), remaining largely stable among 15–19-year-olds overall.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Recent trends in hospitalization due to BD in 10–19-year-olds in Spain indicate salient increases in the early 2000s – especially among (i) patients aged 10–14 (decreasing moderately after 2009 among 10–14-year-olds and plateauing among 15–19-year-olds) and (ii) patients with additional psychiatric comorbidity (i.e., cannabis use disorder). These findings suggest links with recent changes in clinical practices for children and recent trends in substance use among Spanish youth.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 8","pages":"801-809"},"PeriodicalIF":5.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 6-month, prospective, randomized controlled trial of customized adherence enhancement versus a bipolar-specific educational control in poorly adherent adolescents and young adults living with bipolar disorder","authors":"Jennifer B. Levin,&nbsp;Melissa DelBello,&nbsp;Avani C. Modi,&nbsp;Farren Briggs,&nbsp;Larry F. Forthun,&nbsp;Molly McVoy,&nbsp;Joy Yala,&nbsp;Raechel Cooley,&nbsp;Jessica Black,&nbsp;Carla Conroy,&nbsp;Martha Sajatovic","doi":"10.1111/bdi.13489","DOIUrl":"10.1111/bdi.13489","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Few studies have addressed medication adherence in adolescents and young adults (AYAs) with bipolar disorder (BD). This 6-month prospective randomized-controlled trial (RCT) tested customized adherence enhancement for adolescents and young adults (CAE-AYA), a behavioral intervention for AYAs versus enhanced treatment as usual (ETAU).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Inclusion criteria were AYAs age 13–21 with BD type I or II with suboptimal adherence defined as missing ≥20% of medications. Assessments were conducted at Screening, Baseline, and weeks 8, 12 and 24. Primary outcome was past 7 day self-reported Tablets Routine Questionnaire (TRQ) validated by electronic pillbox monitoring (SimpleMed). Symptom measures included the Hamilton Depression Rating Scale (HAM-D) and Young Mania Rating Scale (YMRS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean sample age (<i>N</i> = 36) was 19.1 years (SD = 2.0); 66.7% (<i>N</i> = 24) female, BD Type I (81%). The mean missed medication on TRQ for the total sample was 35.4% (SD = 28.8) at screening and 30.4% (SD = 30.5) at baseline. Both CAE-AYA and ETAU improved on TRQ from screening to baseline. Baseline mean missed medication using SimpleMed was 51.6% (SD = 38.5). Baseline HAM-D and YMRS means were 7.1 (SD = 4.7) and 6.0 (SD = 7.3), respectively. Attrition rate at week 24 was 36%. Baseline to 24-week change on TRQ, adjusting for age, gender, educational level, living situation, family history, race, and ethnicity, showed improvement favoring CAE-AYA versus ETAU of 15%. SimpleMed interpretation was limited due to substantial missing data. There was a significant reduction in depression favoring CAE-AYA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CAE-AYA may improve adherence in AYAs with BD, although conclusions need to be made cautiously given study limitations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Trials Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NCT04348604.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8959,"journal":{"name":"Bipolar Disorders","volume":"26 7","pages":"696-707"},"PeriodicalIF":5.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}