Anna Manelis, Hang Hu, Rachel Miceli, Skye Satz, Rachel Lau, Satish Iyengar, Holly A. Swartz
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The BD group consisted of individuals with BD Type I (<i>n</i> = 11) and BD Type II (<i>n</i> = 27), while the DD group consisted of individuals with major depressive disorder (MDD, <i>n</i> = 38) and persistent depressive disorder (PDD, <i>n</i> = 19) Cortical myelin content was calculated using the T1w/T2w ratio. Elastic net regularized regression identified brain regions whose myelin content was associated with ventricular size and asymmetry. A post hoc linear regression examined how participants' diagnosis, illness duration, and current level of depression moderated the relationship between the size and asymmetry of the lateral ventricles and levels of cortical myelin in the selected brain regions.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Individuals with BD and DD had larger lateral ventricles than HC. Larger ventricles and lower asymmetry were observed in individuals with BD who had longer lifetime illness duration and more severe current depressive symptoms. A greater left asymmetry was observed in participants with DD than in those with BD (<i>p</i> < 0.01). Elastic net revealed that both ventricular enlargement and asymmetry were associated with altered myelin content in cingulate, frontal, and sensorimotor cortices. 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引用次数: 0
摘要
背景：在双相情感障碍（BD）和抑郁症（DD）患者中，脑室增大和不对称性与其他脑结构指标之间的联系尚不清楚。我们的研究比较了BD患者、DD患者和健康对照（HC）的侧室大小、心室不对称性和皮质髓磷脂含量。方法：对149例患者（年龄27.7 （SD = 6.1）岁，78%为女性，BD = 38, DD = 57, HC = 54）进行磁共振成像（MRI），获取T1w和T2w图像。BD组由BD I型（n = 11）和BD II型（n = 27）组成，DD组由重度抑郁症（MDD, n = 38）和持续性抑郁症（PDD, n = 19）组成，采用T1w/T2w比值计算皮质髓磷脂含量。弹性网正则化回归识别髓磷脂含量与心室大小和不对称性相关的脑区。事后线性回归检验了参与者的诊断、疾病持续时间和当前抑郁水平如何调节侧脑室的大小和不对称性与选定脑区域皮质髓鞘水平之间的关系。结果：BD和DD患者侧脑室比HC大。在终生病程较长和当前抑郁症状较严重的双相障碍患者中，观察到更大的心室和更低的不对称性。与BD患者相比，DD患者的左脑不对称性更大(p)。结论：侧脑室增大和不对称性与髓磷脂含量失衡有关，因此可能导致情绪障碍患者的情绪和认知功能障碍。
Lateral Ventricular Enlargement and Asymmetry and Myelin Content Imbalance in Individuals With Bipolar and Depressive Disorders: Clinical and Research Implications
Background
The link between ventricular enlargement and asymmetry with other indices of brain structure remains underexplored in individuals with bipolar (BD) and depressive (DD) disorders. Our study compared the lateral ventricular size, ventricular asymmetry, and cortical myelin content in individuals with BD versus those with DD versus healthy controls (HC).
Methods
We obtained T1w and T2w images from 149 individuals (age = 27.7 (SD = 6.1) years, 78% female, BD = 38, DD = 57, HC = 54) using Magnetic Resonance Imaging (MRI). The BD group consisted of individuals with BD Type I (n = 11) and BD Type II (n = 27), while the DD group consisted of individuals with major depressive disorder (MDD, n = 38) and persistent depressive disorder (PDD, n = 19) Cortical myelin content was calculated using the T1w/T2w ratio. Elastic net regularized regression identified brain regions whose myelin content was associated with ventricular size and asymmetry. A post hoc linear regression examined how participants' diagnosis, illness duration, and current level of depression moderated the relationship between the size and asymmetry of the lateral ventricles and levels of cortical myelin in the selected brain regions.
Results
Individuals with BD and DD had larger lateral ventricles than HC. Larger ventricles and lower asymmetry were observed in individuals with BD who had longer lifetime illness duration and more severe current depressive symptoms. A greater left asymmetry was observed in participants with DD than in those with BD (p < 0.01). Elastic net revealed that both ventricular enlargement and asymmetry were associated with altered myelin content in cingulate, frontal, and sensorimotor cortices. In BD, but not in other groups, ventricular enlargement was related to altered myelin content in the right insular regions.
Conclusions
Lateral ventricular enlargement and asymmetry are linked to myelin content imbalance, thus potentially leading to emotional and cognitive dysfunction in mood disorders.
期刊介绍：
Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas:
biochemistry
physiology
neuropsychopharmacology
neuroanatomy
neuropathology
genetics
brain imaging
epidemiology
phenomenology
clinical aspects
and therapeutics of bipolar disorders
Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders.
The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.
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