易患双相情感障碍的因素：一项30年的纵向研究。

IF 5 2区医学 Q1 CLINICAL NEUROLOGY

Bipolar Disorders Pub Date : 2025-03-28 DOI:10.1111/bdi.70026

Peter Tyrer, Min Yang, Helen Tyrer, Gin Malhi

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引用次数: 0

摘要

目的：探讨在以焦虑和抑郁障碍为表现的人群中预测双相情感障碍发展的因素。方法：在一项为期30年的研究中，诺丁汉神经症研究招募了一项随机对照试验，比较了患有双相情感障碍病理的患者和没有双相情感障碍症状的患者的人格状态、生活事件、服务数据和早期病程。结果：30多年来，基线评估的200名患者中有5名（2.5%）发展为明确的双相情感障碍，1名在研究的前10周内，3名（1.5%）患有双相情感障碍II型病理。对这些数据的分析表明，那些患有某种程度双相情感障碍的患者在焦虑和抑郁症状以及一般精神病理方面有所增加，在研究的第二年最为明显，而没有双相情感障碍的患者则没有发现这一点。结论：接受焦虑和抑郁障碍治疗的患者在初始治疗后仍然不适，其发展为双相情感障碍的风险高于其他患者。

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Factors Predisposing to the Onset of Bipolar Disorder: A 30-Year Longitudinal Study.

Objective: To examine the factors that predict the development of bipolar disorder in a population presenting with anxiety and depressive disorders.

Method: In a 30-year study, the Nottingham Study of Neurotic Disorder, the personality status, life events, service data, and early course of patients recruited to a randomised controlled trial were compared in patients who developed bipolar pathology and those who had no bipolar symptoms.

Results: Over 30 years, 5 (2.5%) of 200 patients assessed at baseline developed unequivocal bipolar disorder, one within the first 10 weeks of the study, and three (1.5%) had bipolar II pathology. Analysis of these data showed that those patients who had some degree of bipolarity had an increase in anxiety and depressive symptoms and general psychopathology, most pronounced in the second year of the study, that was not found with patients who had no bipolar pathology.

Conclusions: Patients treated for anxiety and depressive disorders who remain unwell after initial treatment are more at risk of developing bipolar disorder than others.

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来源期刊

Bipolar Disorders 医学-精神病学

CiteScore

8.20

自引率

7.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas: biochemistry physiology neuropsychopharmacology neuroanatomy neuropathology genetics brain imaging epidemiology phenomenology clinical aspects and therapeutics of bipolar disorders Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders. The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.