与青少年双相情感障碍相关的冠状动脉疾病多基因风险的神经结构相关性

IF 4.5 2区 医学 Q1 CLINICAL NEUROLOGY
Nidhi P Kulkarni, Clement C Zai, Kody G Kennedy, Megan Mio, L Trevor Young, Bradley J MacIntosh, Benjamin I Goldstein
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引用次数: 0

摘要

导读:双相情感障碍(BD)以异常的神经结构表型为特征,也与心血管疾病密切相关。在这里,我们研究了与青年BD灰质结构相关的冠状动脉疾病(CAD)的多基因风险。方法:青年参与者(平均年龄17.1岁;n = 66 BD, n = 45健康对照[HC])进行了t1加权磁共振成像。CAD多基因风险评分(CAD- prs)采用独立的成人全基因组汇总统计计算。协变量调整的顶点分析检验了CAD-PRS与整个样本以及BD组和HC组中皮质体积、厚度和表面积(SA)的关系。额外的兴趣区(ROI)分析被用于检查前扣带皮层(ACC)、杏仁核和海马。还进行了探索性的性别分层分析。结果:在整个样本中,较高的CAD-PRS与右下颞回体积相关(β = -0.32, p = 0.03)。CAD-PRS与BD(5个皮质厚度簇)和HC(1个SA簇)的脑结构也呈负相关。在双相障碍组中,性别分层分析显示女性有显著的发现,但男性没有。ROI分析显示,BD组较高的CAD-PRS与较低的ACC厚度存在名义关联(β = -0.31, puncorrected = 0.05, pcorrected = 0.20)。结论:较高的CAD-PRS与青年中与双相障碍相关的区域灰质结构降低有关。这一发现在双相障碍组中更为明显,尤其是在女性中,并且与皮层厚度有关。未来的纵向研究需要检查CAD-PRS与神经发育变化的关系,并辨别观察到的发现背后的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neurostructural Correlates of Polygenic Risk for Coronary Artery Disease in Relation to Youth Bipolar Disorder.

Introduction: Bipolar disorder (BD), characterized by anomalous neurostructural phenotypes, is also strongly associated with cardiovascular disease. Here we examined polygenic risk for coronary artery disease (CAD) in relation to gray matter structure in youth BD.

Methods: Youth participants (mean age 17.1 years; n = 66 BD, n = 45 healthy controls [HC]) underwent T1-weighted magnetic resonance imaging. CAD polygenic risk scores (CAD-PRS) were calculated using independent, adult genome-wide summary statistics. Covariate-adjusted vertex-wise analyses examined the association of CAD-PRS with cortical volume, thickness, and surface area (SA) in the overall sample, and within BD and HC groups. Additional region-of-interest (ROI) analyses were conducted to examine the anterior cingulate cortex (ACC), amygdala, and hippocampus. Exploratory sex-stratified analyses were also undertaken.

Results: In the overall sample, higher CAD-PRS was associated with lower right inferior temporal gyrus volume (β = -0.32, p = 0.03). There were also negative associations between CAD-PRS and brain structure within BD (5 cortical thickness clusters) and HC (1 SA cluster). Within the BD group, sex-stratified analyses revealed significant findings for females, but not for males. ROI analyses revealed a nominal association of higher CAD-PRS with lower ACC thickness in the BD group (β = -0.31, puncorrected = 0.05, pcorrected = 0.20).

Conclusion: Higher CAD-PRS was associated with lower regional gray matter structure in youth, in regions implicated in BD. Findings were more pronounced in the BD group, particularly among females, and related to cortical thickness specifically. Future longitudinal studies are needed to examine the association of CAD-PRS with neurodevelopmental changes over time and to discern mechanisms underlying the observed findings.

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来源期刊
Bipolar Disorders
Bipolar Disorders 医学-精神病学
CiteScore
8.20
自引率
7.40%
发文量
90
审稿时长
6-12 weeks
期刊介绍: Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas: biochemistry physiology neuropsychopharmacology neuroanatomy neuropathology genetics brain imaging epidemiology phenomenology clinical aspects and therapeutics of bipolar disorders Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders. The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.
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