Multivariate brain-cognition associations in euthymic bipolar disorder

IF 5 2区医学 Q1 CLINICAL NEUROLOGY

Bipolar Disorders Pub Date : 2024-08-13 DOI:10.1111/bdi.13484

Bethany Little, Carly Flowers, Andrew Blamire, Peter Thelwall, John-Paul Taylor, Peter Gallagher, David Andrew Cousins, Yujiang Wang

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Abstract

Background

People with bipolar disorder (BD) tend to show widespread cognitive impairment compared to healthy controls. Impairments in processing speed (PS), attention and executive function (EF) may represent ‘core’ impairments that have a role in wider cognitive dysfunction. Cognitive impairments appear to relate to structural brain abnormalities in BD, but whether core deficits are related to particular brain regions is unclear and much of the research on brain-cognition associations is limited by univariate analysis and small samples.

Methods

Euthymic BD patients (n = 56) and matched healthy controls (n = 26) underwent T1-weighted MRI scans and completed neuropsychological tests of PS, attention and EF. We utilised public datasets to develop normative models of cortical thickness (n = 5977) to generate robust estimations of cortical abnormalities in patients. Canonical correlation analysis was used to assess multivariate brain-cognition associations in BD, controlling for age, sex and premorbid IQ.

Results

BD showed impairments on tests of PS, attention and EF, and abnormal cortical thickness in several brain regions compared to healthy controls. Impairments in tests of PS and EF were most strongly associated with cortical thickness in the left inferior temporal, right entorhinal and right temporal pole areas.

Conclusion

Impairments in PS, attention and EF can be observed in euthymic BD and may be related to abnormal cortical thickness in temporal regions. Future research should continue to leverage normative modelling and multivariate methods to examine complex brain-cognition associations in BD. Future research may benefit from exploring covariance between traditional brain structural morphological metrics such as cortical thickness, cortical volume and surface area.

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嗜睡型双相情感障碍的多变量大脑认知关联。

背景：与健康对照组相比，双相情感障碍（BD）患者往往表现出广泛的认知功能障碍。处理速度（PS）、注意力和执行功能（EF）的损伤可能代表了 "核心 "损伤，在更广泛的认知功能障碍中发挥作用。认知障碍似乎与 BD 患者的大脑结构异常有关，但核心缺陷是否与特定的大脑区域有关尚不清楚，而且许多关于大脑与认知关联的研究都受到单变量分析和小样本的限制：方法：接受T1加权磁共振成像扫描并完成PS、注意力和EF神经心理学测试的嗜睡性BD患者（56人）和匹配的健康对照组（26人）。我们利用公共数据集建立了皮质厚度的标准模型（n = 5977），从而对患者的皮质异常做出了可靠的估计。在控制年龄、性别和病前智商的情况下，我们使用卡农相关分析评估了BD患者大脑与认知的多变量关联：结果：与健康对照组相比，BD 在 PS、注意力和 EF 测试中表现出障碍，多个脑区的皮质厚度异常。PS和EF测试的损伤与左下颞叶、右内侧和右颞极区的皮质厚度关系最为密切：结论：在健康的 BD 患者中可以观察到 PS、注意力和 EF 的损伤，这可能与颞叶皮质厚度异常有关。未来的研究应继续利用常模和多变量方法来研究 BD 复杂的大脑认知关联。探索皮质厚度、皮质体积和表面积等传统脑结构形态学指标之间的协方差可能对未来研究有所裨益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bipolar Disorders 医学-精神病学

CiteScore

8.20

自引率

7.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas: biochemistry physiology neuropsychopharmacology neuroanatomy neuropathology genetics brain imaging epidemiology phenomenology clinical aspects and therapeutics of bipolar disorders Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders. The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.