Bioelectromagnetics最新文献

{"title":"Effects of Whole-Body Exposure to Pulsed Electromagnetic Field at Different Frequencies on Knee Osteoarthritis","authors":"Xiaotian Yang,&nbsp;Xuqing Li,&nbsp;Haixin Song,&nbsp;Tao Wu,&nbsp;Jianhua Li,&nbsp;Chengqi He","doi":"10.1002/bem.70016","DOIUrl":"https://doi.org/10.1002/bem.70016","url":null,"abstract":"<div>\u0000 \u0000 <p>This study aimed to investigate the efficacy of pulsed electromagnetic field (PEMF) at different frequencies during knee osteoarthritis (OA) progression. Ten-week-old male wild-type (WT) mice undergoing the destabilization of the medial meniscus (DMM) surgery were randomly divided into four groups (<i>n</i> = 10 each) respectively: DMM, DMM with three PEMF exposure (8, 50, or 75 Hz). PEMF (3.8 mT, 1 h/day) at different frequencies was applied for 4 weeks. Von Frey test, histological assessment, RT-PCR, immunohistochemical staining, and microcomputed tomography (CT) were performed. PEMF at three frequencies (8, 50, and 75 Hz) decreased the Osteoarthritis Research Society International (OARSI) scores to different extents compared to the DMM group. The mRNA and protein expressions of MMP13 and aggrecan (Acan) in cartilage were improved in three PEMF groups; PEMF at 50 and 75 Hz had better positive effects than PEMF at 8 Hz. The increased synovitis was attenuated by 75 Hz PEMF. 75 and 50 Hz PEMF groups had a beneficial effect on increasing 50% paw withdrawal threshold (PWT) compared with the DMM group. Micro-CT analysis showed that 75 Hz PEMF group, compared with DMM group, increased trabecular thickness (Tb.Th) of femur and bone volume/total volume (BV/TV) of femoral condyle and femur, and decreased bone surface/bone volume (BS/BV) of tibia. The study demonstrated that PEMF at 75 Hz could attenuate symptomatic and structural knee OA progression. Bioelectromagnetics. 00:00–00, 2025. © 2025 Bioelectromagnetics Society.</p></div>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"46 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144716881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Radiofrequency Electromagnetic Fields on Cardiac Activity at Rest: A Systematic Review of Healthy Human Studies","authors":"Lisa Michelant,&nbsp;Brahim Selmaoui","doi":"10.1002/bem.70014","DOIUrl":"https://doi.org/10.1002/bem.70014","url":null,"abstract":"<p>Radiofrequency electromagnetic fields (RF-EMF) exposure is increasingly prevalent, raising concerns about potential non-thermal health effects. This systematic review synthesizes current evidence regarding RF exposure effects on cardiac activity, focusing on heart rate (HR) and heart rate variability (HRV). Studies on healthy individuals were selected based on strict methodological criteria, including experimental design, control for confounding variables, and sufficient details on exposure parameters. Articles were included if they compared healthy subjects with and without exposure and provided cardiac measurements, specific absorption rate, or exposure measurement. A total of 28 articles were analyzed. This review included studies with RF exposure ranging from 100 to 110,000 MHz and exposure durations varying from short periods to 7 nights, with most studies lasting between 5 and 50 min. Most studies demonstrated no significant effects of RF exposure on HR, regardless of the exposure system, frequency, duration, age, sex, distance, or subject position. Findings for HRV were more nuanced, with most studies indicating no significant impact on key HRV parameters. However, some position-dependent variations emerged, particularly in antenna-based studies. Additionally, our analysis suggests that RF exposure may particularly interfere with cardiac regulatory mechanisms when the cardiovascular system is challenged and required to adapt, such as during postural changes or physiological maneuvers, although there are insufficient comparable studies to validate this hypothesis. Importantly, all included studies were conducted under resting or non-stressful conditions and involved only healthy participants. Therefore, our conclusions cannot be generalized to stressed states or clinical populations. Moreover, methodological harmonization is needed to improve comparability across future studies. The main limitation of the current evidence being the heterogeneity of experimental protocols, highlighting the need for methodological standardization in future studies. To address current heterogeneity, we propose specific methodological recommendations, including systematic blinding, accurate exposure measurement and detailed exposure, to improve comparability and reproducibility in future studies. Bioelectromagnetics. 00:00–00, 2025. © 2025 Bioelectromagnetics Society.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"46 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Situ Measurements of Radiofrequency Electromagnetic Fields Measurements Around 5G Macro Base Stations in the UK","authors":"Carolina Calderon,&nbsp;Darren Addison,&nbsp;Azadeh Peyman","doi":"10.1002/bem.70012","DOIUrl":"https://doi.org/10.1002/bem.70012","url":null,"abstract":"<p>Radiofrequency (RF) electromagnetic field spot measurements were performed in line-of-sight to 56 active 5G macro base stations across 30 publicly accessible locations in the United Kingdom (UK). Four different exposure scenarios were assessed: background (no traffic instigation), streaming videos, downlink speed test, and extrapolation of SS-RSRP decoder measurements. Power density measurements across the 420 MHz–6 GHz frequency range were also performed at each site to assess the total exposure from various RF sources in the environment. Both total RF and 5G specific power density levels were found to be well within the 1998 ICNIRP public reference levels, even when extrapolating to worst-case scenario (≤ 5%). 4G downlink was the dominant contributor to total RF exposure, with 5G contributing on average less than 10%. No statistically significant difference was observed between beamforming and non-beamforming sites. Streaming did not seem to contribute materially to exposure levels, suggesting that background measurements are a good representation of typical downlink exposure at current urban and suburban 5G sites.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"46 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the Core Temperature Response of Free-Moving Rats to 1.95 GHz Electromagnetic Fields","authors":"Nathan Bala,&nbsp;Rodney J. Croft,&nbsp;Robert L. McIntosh,&nbsp;Steve Iskra,&nbsp;John V. Frankland,&nbsp;Raymond J. McKenzie,&nbsp;Chao Deng","doi":"10.1002/bem.70013","DOIUrl":"https://doi.org/10.1002/bem.70013","url":null,"abstract":"<p>The present study investigated the core body temperature (CBT) response of free-moving adult male and female Sprague Dawley rats, during and following a 3-h exposure to 1.95 GHz radiofrequency electromagnetic fields (RF-EMFs) within custom-built reverberation chambers, using temperature capsules implanted within the intraperitoneal cavity and data transmitted via radiotelemetry. Comparing RF-EMF exposures (at Whole-Body Average-Specific Absorption Rate [WBA-SAR] levels of 0.1, 0.4, and 4 W/kg) to the sham exposed condition, we identified a statistically significant peak increase in CBT after 26 min of RF-EMF exposure at 4 W/kg (+0.49°C), but not in the 0.1 or 0.4 W/kg conditions at the same timepoint. In the last 30 min of the RF-EMF exposure, temperature was significantly increased in both the 4 W/kg (0.62°C) and 0.4 W/kg (0.14°C) conditions, but not 0.1 W/kg, when compared to sham. After 20 min following cessation of exposure, post temperature was still significantly higher in the 4 W/kg condition when compared to the sham (0.37°C), but not in either 0.1 or 0.4 W/kg. Based on our findings, it is apparent that rats can effectively compensate for increased thermal loads of up to 4 W/kg as the maximum temperature rise was substantially lower than 1°C. In addition, the elevated CBT during exposure in the 4 W/kg condition was significantly reduced immediately after exposure cessation, indicating that measures of CBT following RF-EMF exposure cessation may not reflect maximum RF-EMF-mediated changes in the CBT of rats. Bioelectromagnetics. 00:00–00, 2025. © 2025 Bioelectromagnetics Society.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"46 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Electromagnetic Field on Seed Germination, β-Amylase Activity, Total Protein Content, Water Uptake, and Growth of Wheat Seedlings (Triticum aestivum)","authors":"Enerelt Urnukhsaikhan,&nbsp;Bum-Erdene Bold,&nbsp;Luvsanbat Khurelbaatar,&nbsp;Altanzul Bazarvaani,&nbsp;Tsogbadrakh Mishig-Ochir","doi":"10.1002/bem.70011","DOIUrl":"https://doi.org/10.1002/bem.70011","url":null,"abstract":"<div>\u0000 \u0000 <p>This study investigated the effects of electromagnetic field (EMF) treatment on wheat seeds' germination, <i>β</i>-amylase activity, total protein content, water uptake and seedling growth under laboratory conditions. Wheat seeds were exposed to a 10 Hz EMF of 7.5 mT for 5 h over 3 days, with untreated seeds as controls. Results showed significant increases in overall biomass (8.68-fold), above-ground biomass (AGB) (49.47%), and below-ground biomass (BGB) (39.18%) after 48 h of imbibition. EMF treatment enhanced total protein content by fourfold and amylase activity by 4.5-fold compared to controls after 24 h of imbibition. The experimental group also exhibited accelerated germination by 36 h compared to controls. Notably, <i>β</i>-amylase activity in leaf tissue increased fivefold, which is crucial for seed germination. The study concludes that EMF application in early development activates biochemical reactions, accelerating germination and potentially improving crop tolerance to abiotic stresses and promoting seedling emergence in/. Bioelectromagnetics. 00:00–00, 2025. © 2025 © 2025 Bioelectromagnetics Society.</p></div>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"46 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Dipole Sensor Response Linearization Through Physics-Informed Neural Networks","authors":"Alessandro Fasse,&nbsp;Romain Meyer,&nbsp;Esra Neufeld,&nbsp;Maxim Haas,&nbsp;Nicolas Chavannes,&nbsp;Niels Kuster","doi":"10.1002/bem.70010","DOIUrl":"https://doi.org/10.1002/bem.70010","url":null,"abstract":"<p>Short-dipole diode sensors loaded with highly resistive lines are commonly used to measure the time-averaged square of the high-frequency electromagnetic field amplitude directly. Their precision, simplicity, broadband, high dynamic range capability, and minimal scattering make them ideal for application in the near-field of sources, particularly for demonstrating compliance with exposure limits. However, the usage of these sensors to cover multiple orders of magnitude of field amplitude requires signal-specific linearization of the sensor response. Traditionally, linearization had been performed for each signal or modulation by measurement and, more recently, by simulations based on a calibrated sensor model. These approaches have become prohibitively expensive with the launch of the fifth generation of mobile communication (5G), which added thousands of diverse and complex modulation schemes. In response to these challenges, we first developed an innovative approach to accelerate sensor model simulations with an enhancement of accuracy, which allows us to subsequently establish a data set comprising a large number of probe parameters and signal characteristic configurations. Subsequently, a physics-informed neural network (PINN) was trained with readily accessible signal characteristics to obtain on-the-fly linearization parameters with acceptable uncertainties across the relevant dynamic range. In contrast to traditional artificial intelligence (AI) models that predominantly rely on pattern recognition from precomputed data, our approach ensures that the model captures the intrinsic relationships and system dynamics inherent to the physical phenomena under study. Our AI-based approach achieves an error below 0.4 dB at peak specific absorption rate (SAR) values of up to <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>&gt;</mo>\u0000 <mspace></mspace>\u0000 <mn>200</mn>\u0000 <mspace></mspace>\u0000 <msup>\u0000 <mstyle>\u0000 <mspace></mspace>\u0000 <mtext>W kg</mtext>\u0000 <mspace></mspace>\u0000 </mstyle>\u0000 <mrow>\u0000 <mo>−</mo>\u0000 <mn>1</mn>\u0000 </mrow>\u0000 </msup>\u0000 </mrow>\u0000 <annotation> $gt ,200,{text{W kg}}^{-1}$</annotation>\u0000 </semantics></math>. In addition, AI accelerates the determination of linearization parameters by a factor <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>&gt;</mo>\u0000 </mrow>\u0000 <annotation> $gt $</annotation>\u0000 </semantics></math> 34,000<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>×</mo>\u0000 </mrow>\u0000 ","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"46 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.70010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caspase-Dependent Cell Death and HDAC4 Translocation Following Microsecond Pulsed Electric Field (μsPEF) Exposure in MCF-7 Breast Cancer Cells","authors":"Zahra Safaei,&nbsp;Gary L. Thompson","doi":"10.1002/bem.70009","DOIUrl":"https://doi.org/10.1002/bem.70009","url":null,"abstract":"<div>\u0000 \u0000 <p>Breast cancer is the second-leading cancer-related death among women. Survival rates decrease from 99% for localized stages of breast tumors to only 27% when distant metastases develop. Increased invasiveness and proliferation of breast cancer cells correlate with overexpression of an enzymatic coregulator of gene expression, histone deacetylase-4 (HDAC4). If HDAC4 is cleaved into two halves by another enzyme called caspase, one-half of HDAC4 goes into the nucleus of the cell where it promotes a highly regulated form of cellular self-destruction known as apoptosis. Caspases are activated by fast rises in calcium ion (Ca²⁺) concentrations inside cells, which can be initiated via plasma membrane electropermeabilization induced by microsecond pulsed electric fields (µsPEFs) applied to cells positioned between electrodes. However, the MCF-7 breast cancer cell line is deficient in caspase-3, which is the type of caspase predominantly responsible for cleavage of HDAC4. In this in vitro study, we demonstrate µsPEF exposure elicits HDAC4 translocation independently of caspase activity in MCF-7 cells. Yet, µsPEF-induced MCF-7 cell death remains dependent on Ca²⁺ electropermeabilization and caspase activity. Bioelectromagnetics. 00:00–00, 2025. © 2025 © 2025 Bioelectromagnetics Society.</p></div>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"46 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5G EMF Exposure at 3.6 GHz in Greece Using Data From Frequency-Selective Monitoring Sensors","authors":"Serafeim Iakovidis,&nbsp;Athanasios Manassas,&nbsp;Christos Apostolidis,&nbsp;Theodoros Samaras","doi":"10.1002/bem.70008","DOIUrl":"https://doi.org/10.1002/bem.70008","url":null,"abstract":"<p>The introduction of 5G networks has raised public concerns about potential changes in environmental electromagnetic field (EMF) exposure. This study analyzes continuous monitoring data collected over 2 years (August 2022–October 2024) from 13 frequency-selective monitoring sensors located in Greece's five largest cities. Focusing on the 3.6 GHz band, we evaluated trends and weekly variations in EMF levels. Results indicated a gradual increase in EMF exposure at 3.6 GHz, driven by the growing penetration of 5G infrastructure and devices. Notably, this band exhibited higher maximum-to-median power density ratios compared to other frequency bands, attributable to active antenna systems' characteristics and traffic variations. Applying the ICNIRP 2020 guidelines, we found that 30-min averaged values significantly reduced these variations. All measured EMF levels, including maximum values, remained well below Greek and international safety limits. These findings, especially the increasing trend identified for the EMF levels, underscore the importance of continuous monitoring networks for assessing EMF exposure to existing and emerging telecommunications networks and ensuring compliance with safety standards.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"46 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Electromagnetic Hypersensitivity (EHS) From Mobile Phone Radiofrequency Radiation (RFR) Exposure: A Mixed-Method Study Protocol","authors":"Nur Syarah Zulaikha Mohd Razak,&nbsp;Anita Abd Rahman,&nbsp;Halimatus Sakdiah Minhat,&nbsp;Fatimah Ahmad Fauzi","doi":"10.1002/bem.70007","DOIUrl":"https://doi.org/10.1002/bem.70007","url":null,"abstract":"<div>\u0000 \u0000 <p>More than 7 billion mobile phone users were recorded worldwide in 2022. Radiofrequency radiation (RFR) from mobile phones can produce radiobiological effects, which may lead to electromagnetic hypersensitivity (EHS) in humans. This study employs a mixed-method approach: the quantitative component identifies predictors of EHS from mobile phone RFR using the biopsychosocial model, whereas the qualitative component explores individual experiences that contribute to EHS. Quantitative analysis is conducted using the Statistical Package for the Social Sciences (SPSS) version 25.0 for descriptive and analytical statistics, whereas qualitative analysis is carried out with NVivo version 14 for thematic analysis. Findings from both analyses are compared and discussed to highlight similarities and differences, providing a richer, in-depth understanding of EHS resulting from mobile phone RFR exposure among undergraduate students. The study sample consists of 351 undergraduate students aged 18–25 from Universiti Putra Malaysia (UPM), conducted between April 2023 and December 2023. Approval was obtained from the Ethics Committee for Research Involving Human Subjects at UPM before the study. The quantitative component uses a proportionate simple random sampling method with a validated questionnaire, whereas the qualitative component utilizes purposive sampling through in-depth interviews. Enhancing understanding of EHS may contribute to new knowledge and raise awareness of its potential effects on the population. Bioelectromagnetics. 00:00–00, 2025. © 2025 Bioelectromagnetics Society.</p></div>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"46 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Deployment of 5G Wireless Communication and Risk Assessment on Human Health: Quid Novi?","authors":"Brahim Selmaoui,&nbsp;Layla Jamal,&nbsp;Lisa Michelant","doi":"10.1002/bem.70005","DOIUrl":"https://doi.org/10.1002/bem.70005","url":null,"abstract":"<p>The rapid deployment of 5G wireless communication has amazingly accelerated global connectivity, marking a significant milestone in how we interact with technology and with each other. This next-generation network promises to revolutionize industries by delivering faster data speeds, drastically reducing latency, and providing the capacity to support a vast and growing ecosystem of interconnected devices. From smart cities and autonomous vehicles to advanced healthcare applications and immersive virtual reality experiences, 5G is poised to be the backbone of a hyper-connected world.</p><p>However, the swift and widespread rollout of 5G has not been without controversy. Alongside the excitement over its potential, significant concerns have emerged regarding its potential impact on human health. These concerns stem from the increased exposure to electromagnetic fields (EMFs) associated with 5G technology, particularly as it operates on higher frequency bands, including millimeter waves. Consequently, given the lack of publications concerning the effects of frequencies implemented for 5G (3.5–26 GHz) for the general public, more in-depth studies need to be established due to the increased debates and inconclusive reports about the subject.</p><p>Given that 5G is a relatively new technology, short- and long-term studies are still in progress to assess its health implications comprehensively. For this purpose, the European Union Commission via their institutions has launched a call for proposals in the environmental health topic (HORIZON-HL-TH-2021-ENVHLTH-02). This program was implemented to answer to the public concern about the health effect of 5G exposure. The total amount of funding was 30 million euros from Horizon Europe 2021–2027. The results should fill the current knowledge gaps on the effects of wireless technologies on health and the environment. Four projects funded by Horizon Europe have been brought together under the CLUE-H network, involving more than 60 European research organizations across four research consortia: ETAIN, GOLIAT, NextGEM, and SEAWave. Additionally, scientists from outside Europe, including the USA, Korea, and Japan, are also collaborating on these projects.</p><p>The rapid deployment of 5G brings unprecedented opportunities for technological innovation but also necessitates thorough and ongoing risk assessment regarding its potential health impacts. While current scientific consensus generally supports the safety of 5G under existing guidelines, the evolving nature of the technology, coupled with the long-term uncertainty, underscores the importance of continued research, transparent communication, and adaptive regulatory frameworks. As 5G becomes more ubiquitous, balancing its benefits with precautionary health measures will be crucial to ensuring public trust and safety.</p><p>The authors declare no conflicts of interest.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"46 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}