Ulcers Pub Date : 2013-05-12 DOI: 10.1155/2013/625934

H. Trøstrup, T. Bjarnsholt, K. Kirketerp-Møller, N. Høiby, C. Moser

{"title":"What Is New in the Understanding of Non Healing Wounds Epidemiology, Pathophysiology, and Therapies","authors":"H. Trøstrup, T. Bjarnsholt, K. Kirketerp-Møller, N. Høiby, C. Moser","doi":"10.1155/2013/625934","DOIUrl":"https://doi.org/10.1155/2013/625934","url":null,"abstract":"Chronic wounds are a growing socioeconomic problem in the western world. Knowledge on recalcitrant wounds relies on in vitro studies or clinical observations, and there is emerging evidence on the clinical impact of bacterial biofilm on skin healing. Chronic wounds are locked in the inflammatory state of wound healing, and there are multiple explanations for this arrest with the theory of exaggerated proteolysis as the most commonly accepted. Previously, there has not been enough focus on the different etiologies of chronic wounds compared to acute, healing wounds. There is an urgent need to group chronic wounds by its cause when searching for possible diagnostic or therapeutic targets. Good wound management should therefore consist of recognition of basic wound etiology, irrigation, and debridement in order to reduce microbial and necrotic load, frequently changed dressings, and appropriate antimicrobial and antibiofilm strategies based on precise diagnosis. Representative sampling is required for diagnosis and antimicrobial treatment of wounds. The present review aims at describing the impact of biofilm infections on wounds in relation to diagnosing, treatment strategies, including experimentally adjuvant approaches and animal models.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"10 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2013-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81589494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Accumulation of Mast Cells in the Lesions and Effects of Antiallergic Drugs on the Patients with Inflammatory Bowel Disease 炎性肠病患者病变中肥大细胞的积累及抗过敏药物的作用

Ulcers Pub Date : 2013-05-09 DOI: 10.1155/2013/714807

M. Kurosawa, H. Nagai

引用次数: 3

Chronic Leg Ulcers: Epidemiology, Aetiopathogenesis, and Management 慢性腿部溃疡:流行病学、病原发生和管理

Ulcers Pub Date : 2013-04-22 DOI: 10.1155/2013/413604

S. Agale

引用次数: 241

Screening for Osteomyelitis Using Thermography in Patients with Diabetic Foot 利用热成像技术筛查糖尿病足患者的骨髓炎

Ulcers Pub Date : 2013-03-31 DOI: 10.1155/2013/284294

Makoto Oe, R. Yotsu, H. Sanada, T. Nagase, T. Tamaki

{"title":"Screening for Osteomyelitis Using Thermography in Patients with Diabetic Foot","authors":"Makoto Oe, R. Yotsu, H. Sanada, T. Nagase, T. Tamaki","doi":"10.1155/2013/284294","DOIUrl":"https://doi.org/10.1155/2013/284294","url":null,"abstract":"One of the most serious complications of diabetic foot (DF) is osteomyelitis, and early detection is important. To assess the validity of thermography to screen for osteomyelitis, we investigated thermographic findings in patients with both DF and osteomyelitis. The subjects were 18 diabetic patients with 20 occurrences of DF who visited a dermatology department at a hospital in Tokyo and underwent evaluation by magnetic resonance imaging (MRI) and thermography between June 2010 and July 2012. Osteomyelitis was identified by MRI. Thermographs were taken of the wounds and legs after bed rest of more than 15 minutes. Two wound management researchers evaluated the range of increased skin temperature. There were three types of distribution of increased skin temperature: the periwound, ankle, and knee patterns. Fisher’s exact test revealed that the ankle pattern was significantly more common in the group with osteomyelitis than in the group without osteomyelitis (). The positive predictive value was 100%, and the negative predictive value was 71.4%. Our results suggest that an area of increased skin temperature extending to the ankle can be a sign of osteomyelitis. Thermography might therefore be useful for screening for osteomyelitis in patients with DF.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"28 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2013-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87274898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Antioxidant Capacity, Cytoprotection, and Healing Actions of the Leaf Aqueous Extract of Ocimum suave in Rats Subjected to Chronic and Cold-Restraint Stress Ulcers 山楂叶水提物对慢性和冷抑制应激性溃疡大鼠的抗氧化能力、细胞保护和愈合作用

Ulcers Pub Date : 2013-03-31 DOI: 10.1155/2013/150780

P. V. Tan, C. Mezui, G. Enow-Orock, G. Agbor

{"title":"Antioxidant Capacity, Cytoprotection, and Healing Actions of the Leaf Aqueous Extract of Ocimum suave in Rats Subjected to Chronic and Cold-Restraint Stress Ulcers","authors":"P. V. Tan, C. Mezui, G. Enow-Orock, G. Agbor","doi":"10.1155/2013/150780","DOIUrl":"https://doi.org/10.1155/2013/150780","url":null,"abstract":"We evaluated the qualitative chemical composition and tested the antiulcer actions on cold/restraint stress ulcers, the healing effect on chronic acetic acid-induced gastric ulcers, and the in vivo and in vitro antioxidant capacity of Ocimum suave extract. Triterpenes, flavonoids, sugars, phenols, sterols, and multiple bonds were among the phytochemicals detected. The extract (250–500 mg/kg) dose-dependently inhibited the formation of gastric ulcers induced by cold/restraint stress (52.30%–83.10%). The prophylactic actions were associated with significant increases in gastric mucus production. There was significant histological healing of chronic ulcers following 14-day treatment with O. suave extract (250–500 mg/kg). We also evaluated the efficacy of O. suave extract in cold/restraint-induced oxidative stress in rat stomach tissue. O. suave (500 mg/kg) ameliorated the decreased levels of reduced glutathione from 0.85 (control group) to 2.08 nmol/g tissue. The levels of SOD and catalase were also improved in rats treated with O. suave extract. The extract had a high phenol content (899.87 mg phenol/g catechin equivalent), in vitro DPPH radical scavenging activity (89.29%), and FRAP (antioxidant capacity) (212.64 mg/g catechin equivalent). The cytoprotective and ulcer healing effects of the extract are attributed to enhanced mucus production and the antioxidant properties which may likely be associated with the high presence of flavonoids and polyphenols.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"43 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2013-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74700278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Chronic Nonhealing Wounds: Could Leg Ulcers Be Hereditary? 慢性不愈合伤口:腿部溃疡会遗传吗?

Ulcers Pub Date : 2013-03-10 DOI: 10.1155/2013/219257

N. Nagy, N. Nagy, G. Szabad, G. Szolnoky, Zsuzsanna Kiss-László, E. Dósa-Rácz, Z. Bata-Csörgő, Z. Bata-Csörgő, L. Kemény, L. Kemény, M. Széll, M. Széll

{"title":"Chronic Nonhealing Wounds: Could Leg Ulcers Be Hereditary?","authors":"N. Nagy, N. Nagy, G. Szabad, G. Szolnoky, Zsuzsanna Kiss-László, E. Dósa-Rácz, Z. Bata-Csörgő, Z. Bata-Csörgő, L. Kemény, L. Kemény, M. Széll, M. Széll","doi":"10.1155/2013/219257","DOIUrl":"https://doi.org/10.1155/2013/219257","url":null,"abstract":"Background. A number of well-known acquired and putative inherited etiological factors contribute to the development of venous leg ulcer (VLU). Aim. In this study we set out to perform a meta-analysis of putative genetic and acquired factors predisposing to VLU development. Methods. VLU patients () were divided into three subgroups in accordance with their acquired etiological factors. The frequencies of four genetic factors were determined: the R506Q (Leiden) mutation of the F5 gene, the G20210A mutation of the F2 (prothrombin) gene, the 2451 A/G SNP of the fibroblast growth factor receptor 2 (FGFR2) 3′ UTR, and the −308 G/A SNP of the tumor necrosis factor α (TNFA) promoter. Results. The −308 TNFA SNP exhibited a higher frequency among VLU patients without known acquired predisposing factor in their history, than among patients with thrombosis or soft tissue infection in their history (Fisher ). Conclusions. This study has demonstrated that the group of VLU patients is heterogeneous in their genetic predisposing factors. Further large-scale studies are needed to delineate the associations among genetic and acquired etiological factors with regard to VLU development and to integrate the consequences of the already known genetic factors to the management of VLU.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"10 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2013-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76399560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Ulcers in Thromboangiitis Obliterans (Buerger's Disease): Updating Epidemiology, Physiopathology, and Bosentan—A Novel Strategy of Therapy 血栓闭塞性脉管炎(伯格氏病)的慢性溃疡:最新流行病学，生理病理学和波生坦-一种新的治疗策略

Ulcers Pub Date : 2013-02-24 DOI: 10.1155/2013/230780

I. Maturana, J. Rodríguez, C. González, S. Bleda, J. Haro, F. Acín

引用次数: 2

Chronic Wounds, Biofilms and Use of Medicinal Larvae 慢性伤口、生物膜及药用幼虫的应用

Ulcers Pub Date : 2013-02-14 DOI: 10.1155/2013/487024

L. Cowan, J. Stechmiller, P. Phillips, Qingping Yang, G. Schultz

{"title":"Chronic Wounds, Biofilms and Use of Medicinal Larvae","authors":"L. Cowan, J. Stechmiller, P. Phillips, Qingping Yang, G. Schultz","doi":"10.1155/2013/487024","DOIUrl":"https://doi.org/10.1155/2013/487024","url":null,"abstract":"Chronic wounds are a significant health problem in the United States, with annual associated costs exceeding $20 billion annually. Traditional wound care consists of surgical debridement, manual irrigation, moisture retentive dressings, and topical and/or systemic antimicrobial therapy. However, despite progress in the science of wound healing, the prevalence and incidence of chronic wounds and their complications are escalating. The presence & complexity of bacterial biofilms in chronic wounds has recently been recognized as a key aspect of non-healing wounds. Bacterial biofilms are sessile colonies of polymicrobial organisms (bacteria, fungus, etc.) enclosed within a self-produced exopolymeric matrix that provides high levels of tolerance to host defenses, antibiotics and antiseptics. Thus, there is a need for alternative therapies to reduce biofilms in chronic wounds. In this report, we present initial findings from in vitro experiments which show that larval debridement therapy with disinfected blow fly larvae (Phaenicia sericata) reduced total CFUs (6-logs) of planktonic and mature biofilms of Pseudomonas aeruginosa or Staphylococcus aureus grown on dermal pig skin explants by 5-logs after 24 hours of exposure, and eliminated biofilms (no measurable CFUs) after 48 hours of exposure.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"192 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2013-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77516280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Compression Stockings for Treating Venous Leg Ulcers 治疗下肢静脉性溃疡的加压袜

Ulcers Pub Date : 2013-02-03 DOI: 10.1155/2013/686491

J. Benigni, A. Deman, J. Uhl

{"title":"Compression Stockings for Treating Venous Leg Ulcers","authors":"J. Benigni, A. Deman, J. Uhl","doi":"10.1155/2013/686491","DOIUrl":"https://doi.org/10.1155/2013/686491","url":null,"abstract":"Background. In order to treat venous leg ulcers, it is recommended to use high pressure compression (30–40 mmHg at the ankle). Compression stockings which are not operator dependant could be the best option because of their pressure control. However 30–40 mmHg compression stockings are often hard to put on. Putting two lower pressure compression stockings over each other could be a good therapeutic alternative. Objectives. To compare the in vitro pressures given by the manufacturers of 2 antiulcer kits with the in vivo interface pressures measured in healthy subjects and to evaluate the stiffness and friction indices from those kits based on the interface pressure in order to assess their clinical properties. Material and Methods. Using a Kikuhime pressure device, interface pressure was measured in 12 healthy subjects at the reference point B1. One stiffness index (Static Stiffness Index (SSI)) and a friction index have been calculated. Results. Mediven Ulcer kit gets the recommended pressures whereas Jobst’s Ulcer Care kit does not for treating a venous leg ulcer. Jobst’s Ulcer Care transmits entirely the pressure in relation to a friction index close to 1. Conclusion. This antiulcer kit study underlines that in vivo and in vitro pressures can be different (Jobst’s Ulcer Care kit and Mediven Ulcer kit). In order not to lose pressure, it is important to take into account the friction index when superimposing two stockings.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"86 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2013-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/686491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72501159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Acute Management of Nonvariceal Upper Gastrointestinal Bleeding 非静脉曲张性上消化道出血的急性治疗

Ulcers Pub Date : 2012-11-27 DOI: 10.1155/2012/361425

Hisham Al Dhahab, A. Barkun

{"title":"The Acute Management of Nonvariceal Upper Gastrointestinal Bleeding","authors":"Hisham Al Dhahab, A. Barkun","doi":"10.1155/2012/361425","DOIUrl":"https://doi.org/10.1155/2012/361425","url":null,"abstract":"Background. The mortality from nonvariceal upper gastrointestinal bleeding is still around 5%, despite the increased use of proton-pump inhibitors and the advancement of endoscopic therapeutic modalities. Aim. To review the state-of-the-art management of acute non variceal upper gastrointestinal bleeding from the presentation to the emergency department, risk stratification, endoscopic hemostasis, and postendoscopic consolidation management to reduce the risk of recurrent bleeding from peptic ulcers. Methods. A PubMed search was performed using the following key words acute management, non variceal upper gastrointestinal bleeding, and bleeding peptic ulcers. Results. Risk stratifying patients with acute non variceal upper gastrointestinal bleeding allows the categorization into low risk versus high risk of rebleeding, subsequently safely discharging low risk patients early from the emergency department, while achieving adequate hemostasis in high-risk lesions followed by continuous proton-pump inhibitors for 72 hours. Dual endoscopic therapy still remains the recommended choice in controlling bleeding from peptic ulcers despite the emergence of new endoscopic modalities such as the hemostatic powder. Conclusion. The management of nonvariceal upper gastrointestinal bleeding involves adequate resuscitation, preendoscopic risk assessment, endoscopic hemostasis, and post endoscopic pharmacological and nonpharmacological treatment.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"35 11 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2012-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89604106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

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