Ulcers最新文献 - Book学术

To Evaluate Antimicrobial Properties of Platelet Rich Plasma and Source of Colonization in Pressure Ulcers in Spinal Injury Patients 评价脊髓损伤患者压疮中富血小板血浆的抗菌特性及其定植来源

Ulcers Pub Date : 2015-01-28 DOI: 10.1155/2015/749585

Roop Singh, R. K. Dhayal, P. Sehgal, R. Rohilla

{"title":"To Evaluate Antimicrobial Properties of Platelet Rich Plasma and Source of Colonization in Pressure Ulcers in Spinal Injury Patients","authors":"Roop Singh, R. K. Dhayal, P. Sehgal, R. Rohilla","doi":"10.1155/2015/749585","DOIUrl":"https://doi.org/10.1155/2015/749585","url":null,"abstract":"Background. Exposure of pressure ulcers (PrUs), particularly to urine and feces, leads to increased colonization of wounds. The aim of the present study was to evaluate the source of microbial colonization and antimicrobial properties of autologous platelet rich plasma (PRP) in controlling it in PrUs. Methods. Twenty-five patients of spinal cord injury (SCI) with at least two PrUs were taken for the study. Local application of autologous PRP on one PrU (case) was compared with saline dressing on the other PrU (control). Urine cultures, urethral meatus, PrUs, and perineal swabs were taken at weekly interval for five weeks. Result. Colonization rate of PrUs (case) decreased from 92% at enrollment to 24% at the 5th week but did not significantly decrease in PrUs (control) from enrollment (84%) to the 5th week (76%). Association between PrU (case) and perineal cultures was observed for Staphylococcus aureus at enrollment 41% (, ) and at the 2nd week 47% (, ). 47% association between PrU (control) and perineal cultures at enrollment (, ) and 29% association at the 2nd week (, ) were observed for Staphylococcus aureus. There was association between bacteria present in perineum/urine and those colonizing PrUs. Conclusion. There is a significant association between PrUs colonization and bacteria present in local environment (urine and feces). Local application of autologous PRP changes the “biological milieu” of the PrUs through its antimicrobial properties leading to reduction in bacterial colonization.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"78 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2015-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80076707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Anti-Inflammatory and Gastroprotective Evaluation of Prodrugs of Piroxicam 吡罗昔康前药的抗炎和胃保护作用评价

Ulcers Pub Date : 2014-08-26 DOI: 10.1155/2014/729754

V. Redasani, Amol Shinde, S. Surana

引用次数: 6

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing 草药疗法:非甾体抗炎药诱导胃溃疡愈合的替代疗法

Ulcers Pub Date : 2014-05-06 DOI: 10.1155/2014/361586

A. Chatterjee, S. Bandyopadhyay

引用次数: 18

Giant Prepyloric Ulcer Haemorrhage: Patient Characteristics, Treatment, and Outcome in 2003–2012 巨大的幽门前溃疡出血:2003-2012年的患者特征、治疗和结果

Ulcers Pub Date : 2014-04-10 DOI: 10.1155/2014/326065

M. Peetsalu, Ü. Kirsimägi, A. Peetsalu

引用次数: 0

Urease Inhibitory Activity of Aerial Parts of Artemisia scoparia: Exploration in an In Vitro Study 猪角蒿地上部分脲酶抑制活性的体外研究

Ulcers Pub Date : 2014-01-16 DOI: 10.1155/2014/184736

M. Khan, H. Khan, S. Tariq, Samreen Pervez

引用次数: 22

Antiulcerogenic Activity of 1-Hydroxy-3,7,8-trimethoxyxanthone Isolated from the Methanol Extract of Anthocleista vogelii PLANCH. in Rats 花青菜甲醇提取物中1-羟基-3,7,8-三甲氧基山酮的抗溃疡活性。在老鼠身上

Ulcers Pub Date : 2014-01-02 DOI: 10.1155/2014/172096

G. Ateufack, T. B. Nguelefack, H. K. Wabo, P. Tane, A. Kamanyi

引用次数: 14

Crossectomy and Foam Sclerotherapy of the Great Saphenous Vein versus Stripping of Great Saphenous Vein and Varicectomy in the Treatment of the Legs Ulcers 大隐静脉切开术和泡沫硬化治疗与大隐静脉剥脱和静脉曲张切除术治疗下肢溃疡的比较

Ulcers Pub Date : 2013-12-16 DOI: 10.1155/2013/734859

Alvaro Delgado-Beltran

引用次数: 0

Profile, Bacteriology, and Risk Factors for Foot Ulcers among Diabetics in a Tertiary Hospital in Calabar, Nigeria 尼日利亚卡拉巴一家三级医院糖尿病患者足部溃疡的概况、细菌学和危险因素

Ulcers Pub Date : 2013-09-08 DOI: 10.1155/2013/820468

A. Otu, V. Umoh, O. Essien, O. Enang, H. Okpa, P. Mbu

{"title":"Profile, Bacteriology, and Risk Factors for Foot Ulcers among Diabetics in a Tertiary Hospital in Calabar, Nigeria","authors":"A. Otu, V. Umoh, O. Essien, O. Enang, H. Okpa, P. Mbu","doi":"10.1155/2013/820468","DOIUrl":"https://doi.org/10.1155/2013/820468","url":null,"abstract":"Diabetic foot disease is a major medical, social, and economic problem. This retrospective study assessed the profile of diabetes mellitus patients with foot ulcers in the University of Calabar Teaching Hospital (UCTH), Nigeria. Admission records of all patients admitted unto the medical wards of UCTH over a 5 year period were analysed. The records of diabetic patients were retrieved. Data on patient characteristics and possible risk factors for diabetes mellitus foot ulcers was extracted. Of the 3,882 patients admitted, 297 (7%) were on account of complications of diabetes mellitus. Foot ulcers accounted for 63 (21.2%) of all diabetic admissions. The elderly constituted the majority of patients admitted with foot ulcers. The average duration of stay of diabetics with foot ulcers was 38.5 days. Diabetics admitted for other conditions had average duration of admission of 15.8 days. Staphylococcus aureus was the commonest organism isolated from swabs of foot ulcers. Most of the organisms identified from ulcer swab cultures were sensitive to quinolones and resistant to penicillins. These diabetic foot ulcers were significantly associated with peripheral sensory neuropathy, peripheral vascular disease, intermittent claudication, and walking barefoot. An effective diabetes foot programme is required to address these risk factors and reverse the current trend.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"17 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2013-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87984194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Chronic Ulcers: Updating Epidemiology, Physiopathology, and Therapies 慢性溃疡:最新流行病学、生理病理学和治疗

Ulcers Pub Date : 2013-08-01 DOI: 10.1155/2013/964826

M. Frade, P. K. Das

引用次数: 5

In Vivo Models Used for Evaluation of Potential Antigastroduodenal Ulcer Agents 用于评估潜在抗胃十二指肠溃疡药物的体内模型

Ulcers Pub Date : 2013-06-25 DOI: 10.1155/2013/796405

M. B. Adinortey, C. Ansah, I. Galyuon, A. Nyarko

{"title":"In Vivo Models Used for Evaluation of Potential Antigastroduodenal Ulcer Agents","authors":"M. B. Adinortey, C. Ansah, I. Galyuon, A. Nyarko","doi":"10.1155/2013/796405","DOIUrl":"https://doi.org/10.1155/2013/796405","url":null,"abstract":"Peptic ulcer is among the most serious gastrointestinal diseases in the world. Several orthodox drugs are employed for the treatment of the disease. Although these drugs are effective, they produce many adverse effects thus limiting their use. In recent years, there has been a growing interest in alternative therapies, especially those from plants due to their perceived relative lower side effects, ease of accessibility, and affordability. Plant medicines with ethnomedicinal use in peptic ulcer management need to be screened for their effectiveness and possible isolation of lead compounds. This requires use of appropriate animal models of various ulcers. The limited number of antiulcer models for drug development against gastric and duodenal ulcer studies has hindered the progress of targeted therapy in this field. It is, therefore, necessary to review the literature on experimental models used to screen agents with potential antigastroduodenal ulcer activity and explain their biochemical basis in order to facilitate their use in the development of new preventive and curative antiulcer drugs. Clinical trials can then be carried out on agents/drugs that show promise. In this paper, current in vivo animal models of ulcers and the pathophysiological mechanisms underlying their induction, their limitations, as well as the challenges associated with their use have been discussed.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"56 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2013-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81583958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 157