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Use of Lozenges Containing Lactobacillus brevis CD2 in Recurrent Aphthous Stomatitis: A Double-Blind Placebo-Controlled Trial 使用含有短乳杆菌CD2的含片治疗复发性口腔炎:一项双盲安慰剂对照试验
Ulcers Pub Date : 2011-05-24 DOI: 10.1155/2011/439425
V. Trinchieri, S. Carlo, M. Bossù, A. Polimeni
{"title":"Use of Lozenges Containing Lactobacillus brevis CD2 in Recurrent Aphthous Stomatitis: A Double-Blind Placebo-Controlled Trial","authors":"V. Trinchieri, S. Carlo, M. Bossù, A. Polimeni","doi":"10.1155/2011/439425","DOIUrl":"https://doi.org/10.1155/2011/439425","url":null,"abstract":"Recurrent aphthous stomatitis is a common disorder of the oral cavity, affecting mainly young people. It is characterized by small ulcers which can be very painful and generally heal spontaneously within 7–14 days. There is currently no therapy that can provide rapid healing. \u0000This study evaluated the efficacy and rapidity of response of a lozenge containing Lactobacillus brevis CD2. 30 patients were randomized to take 4 lozenges a day of active product or placebo for 7 days. Signs and symptoms as well as laboratory parameters in the saliva were assessed at the start of the study and after 7 days of treatment. \u0000The study demonstrated the efficacy and the rapidity of response of the Lactobacillus brevis CD2 lozenges in resolving the clinical signs and symptoms of aphthous stomatitis, with a significantly rapid improvement of pain. This is the first study confirming the efficacy of a probiotic product in this pathology.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"45 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2011-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77986939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Chronic Inflammation and Malignancy in Ulcerative Colitis 溃疡性结肠炎的慢性炎症和恶性肿瘤
Ulcers Pub Date : 2011-04-20 DOI: 10.1155/2011/714046
S. Sunkara, G. Swanson, C. Forsyth, A. Keshavarzian
{"title":"Chronic Inflammation and Malignancy in Ulcerative Colitis","authors":"S. Sunkara, G. Swanson, C. Forsyth, A. Keshavarzian","doi":"10.1155/2011/714046","DOIUrl":"https://doi.org/10.1155/2011/714046","url":null,"abstract":"Ulcerative colitis (UC) is a chronic inflammatory bowel disease \u0000(IBD) associated with multiple colonic and extraintestinal \u0000complications, the most severe being the development of colorectal \u0000cancer (CRC). Compared to the general population, there is an \u0000increased risk of CRC associated with UC. Although the \u0000pathogenesis of CRC in UC is unknown, most studies have linked it \u0000to long-standing inflammation as well as other risk factors such \u0000as duration of disease, extent of inflammation, family history of \u0000CRC, and coexisting conditions such as primary sclerosing \u0000cholangitis (PSC). UC is a life-long disease for which patients \u0000enter a vigilant screening program which includes surveillance \u0000colonoscopy to promote early detection of CRC yet some \u0000controversies exist regarding the cost effectiveness of \u0000surveillance colonoscopy and improving survival. Newer modalities \u0000such as chromoendoscopy, narrow band imaging, high definition \u0000colonoscopy, and confocal microscopy have aided in developing a \u0000more targeted approach for early detection of dysplasia in \u0000surveillance colonoscopy. This review focuses on the role of \u0000chronic colonic inflammation and dysplasia in development of \u0000UC-associated CRC and current methods of screening, detection, \u0000chemoprevention, and treatment of UC-associated CRC.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"36 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2011-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84180374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Cytokine Networks in Ulcerative Colitis 溃疡性结肠炎的细胞因子网络
Ulcers Pub Date : 2011-01-10 DOI: 10.1155/2011/391787
G. Roda, M. Marocchi, A. Sartini, E. Roda
{"title":"Cytokine Networks in Ulcerative Colitis","authors":"G. Roda, M. Marocchi, A. Sartini, E. Roda","doi":"10.1155/2011/391787","DOIUrl":"https://doi.org/10.1155/2011/391787","url":null,"abstract":"Ulcerative colitis (UC) is a relapsing inflammatory bowel disease whose pathogenesis has yet to be defined completely. A genetic predisposition is needed to develop the colitis, but environmental factors are necessary to trigger an exaggerated and aberrant immune response, which stands at the basis of the mucosal healing. Cytokines, small cell-signaling protein molecules secreted by various types of cells including immune and glia cells, are the main mediators of the mucosal healing in IBD; ulcerative colitis is characterized by a Th2 atypical immune response, since, beside the classical proinflammatory cytokines, such as IL-1, IL-6, and TNF-α, in the pathogenesis of UC, we find a complex network in which the Th2 cytokines, IL-10 and IL-13, play a key role, but little IL-4 was found. Our aim was to review the literature to point out the state of the art in terms of cytokines because the knowledge of cytokine network in UC could lead to the discovery of new therapeutical targets.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"79 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2011-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77215259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 49
Short-and Long-Term Clinical Outcomes of Infliximab in Fulminant Ulcerative Colitis 英夫利昔单抗治疗暴发性溃疡性结肠炎的短期和长期临床结果
Ulcers Pub Date : 2011-01-03 DOI: 10.1155/2011/156407
J. Florholmen, G. Øverland, Trine Olsen, Renathe Rismo, G. Cui, Ingrid Christiansen, E. Paulssen, R. Goll
{"title":"Short-and Long-Term Clinical Outcomes of Infliximab in Fulminant Ulcerative Colitis","authors":"J. Florholmen, G. Øverland, Trine Olsen, Renathe Rismo, G. Cui, Ingrid Christiansen, E. Paulssen, R. Goll","doi":"10.1155/2011/156407","DOIUrl":"https://doi.org/10.1155/2011/156407","url":null,"abstract":"The aim was to characterize short- and long-term clinical outcomes of infliximab in fulminant ulcerative colitis. Patients with severe ulcerative colitis meeting the criteria of fulminant colitis after 3 days of glucocorticosteroid treatment were randomized to control or additional induction therapy of infliximab followed by an on demand/maintenance therapy of infliximab. Twenty six patients with fulminant colitis were equally randomized. At Day 7, ten patients in the control group and none in the infliximab group were in the need of colectomy (𝑃<.001). Due to superior effect of infliximab, patients in the control group were of ethical reasons transformed to infliximab treatment instead of performing colectomy. The probability to avoid colectomy was 0.66 with a median observation time of 52 months and a maximal of 91 months. The addition of azathioprine reduced the risk of late colectomy. We conclude that infliximab is effective in preventing early and late colectomy in fulminant colitis.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"17 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2011-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90896865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Cytomegalovirus Reactivation in Ulcerative Colitis Patients. 溃疡性结肠炎患者巨细胞病毒的再激活。
Ulcers Pub Date : 2011-01-01 DOI: 10.1155/2011/282507
Minh Nguyen, Kara Bradford, Xiaolan Zhang, David Q Shih
{"title":"Cytomegalovirus Reactivation in Ulcerative Colitis Patients.","authors":"Minh Nguyen, Kara Bradford, Xiaolan Zhang, David Q Shih","doi":"10.1155/2011/282507","DOIUrl":"10.1155/2011/282507","url":null,"abstract":"<p><p>Ulcerative colitis (UC) patients are believed to have an increased risk for the colonic reactivation of cytomegalovirus (CMV) infection due to both inherent and iatrogenic factors. Numerous studies and case reports have described CMV infection as complicating the disease course of ulcerative colitis patients; the existing evidence suggests an association between the presence of CMV infection and increased colectomy and mortality rates in UC patients. Whether CMV is nonpathogenic with a tropism towards areas of dysplasia and inflammation in the colon of UC or plays an active role in pathogenesis is still debated. In this paper, we examine the existing evidence for the diagnosis and management of CMV infection in UC patients.</p>","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"2011 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124815/pdf/nihms262482.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29986028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis HB-EGF双胞内信号诱导的细胞增殖参与溃疡性结肠炎期间结肠炎相关癌症的发展
Ulcers Pub Date : 2011-01-01 DOI: 10.1155/2011/457637
S. Tanida, T. Mizoshita, Takashi Mizushima, T. Shimura, T. Kamiya, H. Kataoka, T. Joh
{"title":"Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis","authors":"S. Tanida, T. Mizoshita, Takashi Mizushima, T. Shimura, T. Kamiya, H. Kataoka, T. Joh","doi":"10.1155/2011/457637","DOIUrl":"https://doi.org/10.1155/2011/457637","url":null,"abstract":"In ulcerative colitis (UC), the duration and severity of inflammation are responsible for the development of colorectal cancer. Reactive oxygen species (ROS), reactive nitric metabolites (RNMs) and interleukin (IL)-8, released by epithelial and immune cells, are involved in the pathogenesis of colitis-associated cancer. Nitric oxide and peroxynitrite activate epidermal growth factor receptor (EGFR), and therapeutic agents targeted towards EGFR are currently used to treat advanced colorectal cancer. IL-8 (a G-protein coupled receptor (GPCR) agonist), which is involved in neutrophil recruitment and activation in persistent active colitis, also promotes cleavage of the proheparin-binding epidermal growth factor-like growth factor (proHB-EGF) through a disintegrin and metalloproteinase (ADAM). The cleaved HB-EGF and C-terminal fragments (intracellular CTF) regulate proliferation via EGFR activation and nuclear export of promyelocytic leukemia zinc finger, transcription repressor, respectively. Here, we focus on the mechanisms by which RNM- and IL-8-induced EGF signaling regulate cell proliferation during the development of colitis-associated cancer.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"39 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84044627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases 益生菌在预防和治疗炎症性肠病中的潜在应用
Ulcers Pub Date : 2011-01-01 DOI: 10.1155/2011/841651
S. D. Carmen, A. LeBlanc, A. Miyoshi, C. S. Rocha, V. Azevedo, J. Leblanc
{"title":"Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases","authors":"S. D. Carmen, A. LeBlanc, A. Miyoshi, C. S. Rocha, V. Azevedo, J. Leblanc","doi":"10.1155/2011/841651","DOIUrl":"https://doi.org/10.1155/2011/841651","url":null,"abstract":"Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods and possess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledge of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment of inflammatory bowel diseases. These include changes in the gut microbiota, stimulation of the host immune responses, and reduction of the oxidative stress due to their antioxidant properties. A brief overview of the uses of genetically engineered LAB that produce either antioxidant enzymes (such as catalase and superoxide dismutase) or anti-inflammatory cytokines (such as IL-10) will also be discussed. This paper will show that probiotics should be considered in treatment protocols of IBD since they provide many beneficial effects and can enhance the effectiveness of traditional used medicines.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"1 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76180249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Possible Association between Th1 Immune Polarization and Epithelial Permeability with Toll-Like Receptors 2 Dysfunction in the Pathogenesis of the Recurrent Aphthous Ulceration Th1免疫极化和上皮通透性与toll样受体2功能障碍在复发性口疮发病机制中的可能关联
Ulcers Pub Date : 2010-04-27 DOI: 10.1155/2010/163804
F. Barros, M. Lotufo, P. M. Andrade, C. França, R. Borra
{"title":"Possible Association between Th1 Immune Polarization and Epithelial Permeability with Toll-Like Receptors 2 Dysfunction in the Pathogenesis of the Recurrent Aphthous Ulceration","authors":"F. Barros, M. Lotufo, P. M. Andrade, C. França, R. Borra","doi":"10.1155/2010/163804","DOIUrl":"https://doi.org/10.1155/2010/163804","url":null,"abstract":"Recurrent Aphthous Ulceration (RAU) is a chronic oral inflammatory disease that affects approximately 25% of the general population. The etiology of the disease is unknown; however, factors that favor the onset of RAU have been correlated with a Th1 immune polarization, while factors that reduce RAU episodes have been associated with down regulation of immune reaction or stimulation of the peripheral tolerance. In this context, the integrity of the epithelial barrier is also fundamental for the prevention of the disease and conditions that augment its permeability or produce disruption are considered potential triggers. The key factor responsible for increased susceptibility is unclear, though a deficiency of Toll-like receptor (TLR) activity seems to be a good candidate. TLRs are a group of membrane proteins that recognize conserved molecules derived from bacterial, virus, fungal, or host tissues. Particularly, the TLR2 is involved in both immune regulation and control of epithelial barrier integrity. Thus, based on literature review, we showed evidences that correlate the TLR2 dysfunction and the diverse predisposing factors with the elements considered critical for disease pathogenesis: the Th1 immune reaction and the increased epithelial permeability.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"34 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2010-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85412208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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