益生菌在预防和治疗炎症性肠病中的潜在应用

Ulcers Pub Date : 2011-01-01 DOI:10.1155/2011/841651
S. D. Carmen, A. LeBlanc, A. Miyoshi, C. S. Rocha, V. Azevedo, J. Leblanc
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引用次数: 21

摘要

乳酸菌(LAB)是一种异质微生物,天然存在于许多食物中,具有广泛的治疗特性。本文的目的是概述目前正在扩大的关于LAB和其他益生菌微生物参与炎症性肠病预防和治疗的机制的知识。这些包括改变肠道菌群,刺激宿主免疫反应,以及由于其抗氧化特性而减少氧化应激。简要概述了基因工程LAB产生抗氧化酶(如过氧化氢酶和超氧化物歧化酶)或抗炎细胞因子(如IL-10)的用途。本文将表明益生菌在IBD的治疗方案中应该被考虑,因为它们提供了许多有益的效果,并且可以增强传统药物的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods and possess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledge of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment of inflammatory bowel diseases. These include changes in the gut microbiota, stimulation of the host immune responses, and reduction of the oxidative stress due to their antioxidant properties. A brief overview of the uses of genetically engineered LAB that produce either antioxidant enzymes (such as catalase and superoxide dismutase) or anti-inflammatory cytokines (such as IL-10) will also be discussed. This paper will show that probiotics should be considered in treatment protocols of IBD since they provide many beneficial effects and can enhance the effectiveness of traditional used medicines.
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