Ulcers最新文献_第3页

Ulcerative Lesions in Behcet's Disease 白塞氏病的溃疡性病变

Ulcers Pub Date : 2012-11-12 DOI: 10.1155/2012/146797

Ü. Türsen, B. Türsen

引用次数: 3

Update on Peptic Ulcers in the Pediatric Age 儿科消化性溃疡最新进展

Ulcers Pub Date : 2012-11-05 DOI: 10.1155/2012/896509

G. Guariso, M. Gasparetto

{"title":"Update on Peptic Ulcers in the Pediatric Age","authors":"G. Guariso, M. Gasparetto","doi":"10.1155/2012/896509","DOIUrl":"https://doi.org/10.1155/2012/896509","url":null,"abstract":"Background. Peptic ulcer disease (PUD) in children is reported worldwide, although it is relatively rare as compared with adults. Helicobacter pylori (HP) infection is a common cause of PUD in the pediatric age. Other risk factors include the use of nonsteroidal anti-inflammatory agents (NSAIDs), steroids, immunosuppressive drugs, and stressful events. Aim. To critically review the evidence on epidemiology, diagnostic management, and available treatments for PUD in the pediatric age. Methods. A MEDLINE search was performed indicating keywords as “Peptic Ulcer Disease,” “Epidemiology,” “Pediatric,” “Helicobacter pylori,” “Gastric ulcer,” “Bulbar Ulcer,” and “Upper Gastrointestinal Bleeding.” A selection of clinical trials, systematic reviews, and meta-analyses within the time period 2002–2012 was performed. Results. PUD in children is reported worldwide with an estimated frequency of 8.1% in Europe and of 17.4% in the US. When the underlying cause of PUD is addressed, the prognosis is excellent. Standard triple therapy, bismuth-based quadruple therapy, and the sequential therapy represent the current recommended treatments for HP related ulcers. NSAIDs related ulcers are treated by stopping the causative medications and by administration of proton-pump inhibitors or antisecretory drugs. Conclusions. PUD still represents a major concern in the paediatric age. A careful differential diagnosis and an adequate treatment constitute an excellent prognosis.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"5 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2012-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78282787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Stratification of Highest-Risk Patients with Chronic Skin Ulcers in a Stanford Retrospective Cohort Includes Diabetes, Need for Systemic Antibiotics, and Albumin Levels 在斯坦福回顾性队列中，慢性皮肤溃疡高危患者的分层包括糖尿病、需要全身性抗生素和白蛋白水平

Ulcers Pub Date : 2012-10-09 DOI: 10.1155/2012/767861

O. Amir, Andy Liu, A. Chang

{"title":"Stratification of Highest-Risk Patients with Chronic Skin Ulcers in a Stanford Retrospective Cohort Includes Diabetes, Need for Systemic Antibiotics, and Albumin Levels","authors":"O. Amir, Andy Liu, A. Chang","doi":"10.1155/2012/767861","DOIUrl":"https://doi.org/10.1155/2012/767861","url":null,"abstract":"Chronic nonsurgical skin wounds such as venous stasis and diabetic ulcers have been associated with a number of comorbid conditions; however, the strength of these associations has not been compared. We utilized the Stanford Translational Research Integrated Database Environment (STRIDE) system to identify a cohort of 637 patients with chronic skin ulcers. Preliminary analysis () showed that 49.7% of the patients had a poor prognosis such as amputation or a nonhealing ulcer for at least a year. Factors significantly associated () with these outcomes included diabetes mellitus, chronic kidney disease, peripheral neuropathy, peripheral arterial disease, and need for systemic antibiotics. Patients with poor outcomes also tended to have lower hemoglobin levels (), higher WBC levels (), and lower albumin levels (). On multivariate analysis, however, only diabetes mellitus (OR 5.87, 1.36–25.3), need for systemic antibiotics (OR 3.88, 1.06–14.2), and albumin levels (0.20 per unit, 0.07–0.60) remained significant independent predictors of poor wound-healing outcomes. These data identify patients at the highest risk for poor wound-healing and who may benefit the most from more aggressive wound care and treatment.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"83 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2012-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90630035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

In-Hospital Nonvariceal Upper Gastrointestinal Bleeding following Cardiac Surgery: Patient Characteristics, Endoscopic Lesions and Prognosis 心脏手术后住院非静脉曲张上消化道出血:患者特征、内镜病变和预后

Ulcers Pub Date : 2012-08-28 DOI: 10.1155/2012/196982

Marcos Amorim, A. Barkun, Martin Larocque, K. Herba, B. Devarennes, M. Martel

{"title":"In-Hospital Nonvariceal Upper Gastrointestinal Bleeding following Cardiac Surgery: Patient Characteristics, Endoscopic Lesions and Prognosis","authors":"Marcos Amorim, A. Barkun, Martin Larocque, K. Herba, B. Devarennes, M. Martel","doi":"10.1155/2012/196982","DOIUrl":"https://doi.org/10.1155/2012/196982","url":null,"abstract":"Background. Nonvariceal upper gastrointestinal bleeding (NVUGIB) can occur following cardiac surgery, with sparse contemporary data on patient characteristics and predictors of outcome in this setting. Aim. To describe the clinical and endoscopic characteristics of patients with NVUGIB following cardiac surgery and characterize predictors of outcome. Methods. Retrospective review of 131 consecutive patients with NVUGIB following cardiac surgery from 2002 to 2005. Demographic characteristics, therapeutic management, and predictors of outcomes were determined. Results. 69.5% were male, mean age: 68.8 ± 10.2 yrs, mean Parsonnet score: 24.6 ± 14.2. Commonest symptoms included melena (59.4%) or coffee ground emesis (25.8%). In-hospital medications included ASA (88.5%), heparin (95.4%, low molecular weight 6.9%), coumadin (48.1%), clopidogrel (22.9%), and NSAIDS (42%). Initial hemodynamic instability was noted in 47.1%. Associated laboratory results included hematocrit 26 ± 6, platelets 243 ± 133 109/L, INR 1.7 ± 1.6, and PTT 53.3 ± 35.6 s. Endoscopic evaluation (122 patients) yielded ulcers (85.5%) with high-risk lesions in 45.5%. Ulcers were located principally in the stomach (22.5%) or duodenum (45.9%). Many patients had more than one lesion, including esophagitis (28.7%) or erosions (26.8%). 48.8% received endoscopic therapy. Mean lengths of intensive care unit and overall stays were 10.4 ± 18.4 and 39.4 ± 46.9 days, respectively. Overall mortality was 19.1%. Only mechanical ventilation under 48 hours predicted mortality (O.R = 0.11; 95% CI = 0.04−0.34). Conclusions. This contemporary cohort of consecutive patients with NVUGIB following cardiac surgery bled most often from ulcers or esophagitis; many had multiple lesions. ICU and total hospital stays as well as mortality were significant. Mechanical ventilation for under 48 hours was associated with improved survival.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"1 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2012-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85072521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Gastroprotective Efficacy of Coenzyme Q10 in Indomethacin-Induced Gastropathy: Other Potential Mechanisms 辅酶Q10在吲哚美辛诱导的胃病中的胃保护作用:其他潜在机制

Ulcers Pub Date : 2012-02-06 DOI: 10.1155/2012/957898

Asmaa M. Malash, D. Abdallah, A. Agha, S. A. Kenawy

{"title":"Gastroprotective Efficacy of Coenzyme Q10 in Indomethacin-Induced Gastropathy: Other Potential Mechanisms","authors":"Asmaa M. Malash, D. Abdallah, A. Agha, S. A. Kenawy","doi":"10.1155/2012/957898","DOIUrl":"https://doi.org/10.1155/2012/957898","url":null,"abstract":"Though recently the mitochondrial bioenergetic coenzyme (Co)Q10 has been shown to protect against indomethacin-induced gastric ulceration, yet the full mechanistic cassettes have not been investigated. Therefore, the current investigation assessed further gastroprotective mechanisms of CoQ10 using the indomethacin-induced gastropathy model. While CoQ10 was administered at 3 dose levels to male Wistar rats, the proton pump inhibitor, pantoprazole, was given at 4 dose levels ahead of pyloric ligation and indomethacin administration. Indomethacin evoked gastric ulcerations that were associated by decreased gastric mucosal nitric oxide and glutathione levels. The NSAID reduced gastric volume and mucin content, but increased titratable acidity, acid output, and peptic activity. CoQ10, especially at the higher dose levels, as well as pantoprazole pretreatments reverted almost all diversions induced by the NSAID to different extends. Moreover, preadministration with the nonselective nitric oxide synthase inhibitor, L-NAME, boosted ulcer formation that was associated by suppression of gastric mucosal nitric oxide in CoQ10 and pantoprazole-treated groups. The current investigation shows that CoQ10 guards against gastric ulceration via its partial inhibition of titratable acidity and peptic activity, as well as enhancement of mucin secretion due to both gastric mucosal nitric oxide and glutathione replenishment, especially at the higher dose levels.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"14 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2012-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75973639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Cytoprotective Effect of Morinda tinctoria Roxb. against Surgical and Chemical Factor Induced Gastric and Duodenal Ulcers in Rats 巴戟天的细胞保护作用。对大鼠外科及化学因素所致胃、十二指肠溃疡的影响

Ulcers Pub Date : 2011-12-25 DOI: 10.1155/2011/142719

D. Sivaraman, P. Muralidharan

引用次数: 17

Fat Restriction Is Associated with Impaired Quality of Life in Patients with Ulcerative Colitis and Crohn's Disease 脂肪限制与溃疡性结肠炎和克罗恩病患者的生活质量受损有关

Ulcers Pub Date : 2011-11-30 DOI: 10.1155/2011/594532

A. Kuwabara, H. Nakase, Hidemi Tsuji, K. Shide, T. Chiba, N. Inagaki, Kiyoshi Tanaka

引用次数: 4

Influence of Cord Blood Fraction (below 5 kDa) on Reparative Processes during Subchronic Ulcerative Gastropathy 脐带血分数(低于5kda)对亚慢性溃疡性胃病修复过程的影响

Ulcers Pub Date : 2011-09-05 DOI: 10.1155/2011/214124

A. K. Gulevsky, Yelena Sergeevna Abakumova, N. Moiseyeva, Yevgeniy Ivanov

引用次数: 8

The Human Gastric Pathogen Helicobacter pylori and Its Association with Gastric Cancer and Ulcer Disease 人胃致病菌幽门螺杆菌及其与胃癌和溃疡疾病的关系

Ulcers Pub Date : 2011-07-18 DOI: 10.1155/2011/340157

B. Bauer, T. Meyer

{"title":"The Human Gastric Pathogen Helicobacter pylori and Its Association with Gastric Cancer and Ulcer Disease","authors":"B. Bauer, T. Meyer","doi":"10.1155/2011/340157","DOIUrl":"https://doi.org/10.1155/2011/340157","url":null,"abstract":"With the momentous discovery in the 1980's that a bacterium, Helicobacter pylori, can cause peptic ulcer disease and gastric cancer, antibiotic therapies and prophylactic measures have been successful, only in part, in reducing the global burden of these diseases. To date, ~700,000 deaths worldwide are still attributable annually to gastric cancer alone. Here, we review H. pylori's contribution to the epidemiology and histopathology of both gastric cancer and peptic ulcer disease. Furthermore, we examine the host-pathogen relationship and H. pylori biology in context of these diseases, focusing on strain differences, virulence factors (CagA and VacA), immune activation and the challenges posed by resistance to existing therapies. We consider also the important role of host-genetic variants, for example, in inflammatory response genes, in determining infection outcome and the role of H. pylori in other pathologies—some accepted, for example, MALT lymphoma, and others more controversial, for example, idiopathic thrombocytic purpura. More recently, intriguing suggestions that H. pylori has protective effects in GERD and autoimmune diseases, such as asthma, have gained momentum. Therefore, we consider the basis for these suggestions and discuss the potential impact for future therapeutic rationales.","PeriodicalId":89514,"journal":{"name":"Ulcers","volume":"1 1","pages":"1-23"},"PeriodicalIF":0.0,"publicationDate":"2011-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79159595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 119

Novel Techniques in Endoscopy Are Useful in Evaluating Patients with Ulcerative Colitis 内窥镜新技术在评估溃疡性结肠炎患者中是有用的

Ulcers Pub Date : 2011-06-22 DOI: 10.1155/2011/398785

T. Ando, O. Watanabe, Y. Nishio, K. Ishiguro, O. Maeda, Masanao Nakamura, R. Miyahara, N. Ohmiya, H. Goto

引用次数: 0