炎性肠病患者病变中肥大细胞的积累及抗过敏药物的作用

Ulcers Pub Date : 2013-05-09 DOI:10.1155/2013/714807
M. Kurosawa, H. Nagai
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引用次数: 3

摘要

炎症性肠病(IBD)的发病机制尚未得到充分证实。然而,众所周知,肥大细胞存在于胃肠道中,这表明肥大细胞可能参与其中。因此,我们对溃疡性结肠炎(UC)和嗜酸性结肠炎等IBD中肥大细胞的数量进行了研究,发现炎性病变中肥大细胞数量增加。我们也提出了一个病例UC是成功地治疗抗过敏药物,曲尼司特。此外,还介绍了包括超司他在内的免疫调节剂治疗该病的可能新方法。然而,我们的研究是在有限数量的IBD患者中进行的,需要进一步的研究来证实这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Accumulation of Mast Cells in the Lesions and Effects of Antiallergic Drugs on the Patients with Inflammatory Bowel Disease
The pathomechanism of inflammatory bowel disease (IBD) has not yet been fully demonstrated. However, it is well known that mast cells are present in the gastrointestinal tract, suggesting that mast cells may take part in it. So, we investigated the number of mast cells in IBD, such as ulcerative colitis (UC) and eosinophilic colitis, and showed that the number of mast cells was increased in the inflammatory lesions. We also presented a case of UC which was treated successfully with an antiallergic drug, tranilast. Furthermore, possible new approaches to treating the disease with immunomodulators including suplatast are introduced. However, our investigations were performed with a limited number of patients with IBD, and additional further studies are required to confirm the findings.
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