Bioarchitecture最新文献_第3页

Why does endocytosis in single cells care which side up? 为什么单细胞的内吞作用在意哪一面朝上?

Bioarchitecture Pub Date : 2014-03-01 Epub Date: 2014-04-09 DOI: 10.4161/bioa.28809

Kristine Schauer, Bruno Goud

{"title":"Why does endocytosis in single cells care which side up?","authors":"Kristine Schauer, Bruno Goud","doi":"10.4161/bioa.28809","DOIUrl":"https://doi.org/10.4161/bioa.28809","url":null,"abstract":"Eukaryotic cells display an asymmetric distribution of cellular compartments relying on their adhesion and the underlying anisotropy of the actin and microtubule cytoskeleton. Studies using a minimal cell culture system based on confined adhesion on micropatterns have illustrated that trafficking compartments are well organized at the single cell level in response to the geometry of cellular adhesion cues. Expanding our analysis on cellular uptake processes, we have found that cellular adhesion additionally defines the topology of endocytosis and signaling. During endocytosis, transferrin (Tfn) and epidermal growth factor (EGF) concentrate at distinct cellular sites in micropatterned cells. Tfn is enriched in adhesive sites during uptake, whereas EGF endocytosis is restricted to the dorsal cellular surface. This unexpected dorsal/ventral asymmetry is regulated by uptake mechanisms and actin dynamics. Interestingly, restricted EGF uptake leads to asymmetry of EGF receptor activation that is required to sustain downstream signaling. Based on our results, we propose that differential sorting begins at the plasma membrane leading to spatially distinct intracellular trafficking routes that are well defined in space. We speculate that the intracellular positioning of trafficking compartments sustains an important coupling between the endocytic and signaling systems that allows cells to sense their environment. ","PeriodicalId":89329,"journal":{"name":"Bioarchitecture","volume":"4 2","pages":"62-7"},"PeriodicalIF":0.0,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/bioa.28809","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32249105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo. 协调细胞骨架和胞吞作用以调节早期果蝇胚胎的质膜生长。

Bioarchitecture Pub Date : 2014-03-01 Epub Date: 2014-04-23 DOI: 10.4161/bioa.28949

Donghoon M Lee, Tony J C Harris

引用次数: 13

The marriage of quantitative genetics and cell biology: a novel screening approach reveals people have genetically encoded variation in microtubule stability. 定量遗传学和细胞生物学的结合:一种新的筛选方法揭示了人们在微管稳定性方面存在遗传编码变异。

Bioarchitecture Pub Date : 2014-03-01 Epub Date: 2014-03-11 DOI: 10.4161/bioa.28481

Dennis C Ko, Sarah L Jaslow

引用次数: 4

A membrane reservoir at the cell surface: unfolding the plasma membrane to fuel cell shape change. 细胞表面的膜储层:展开质膜，改变燃料电池的形状。

Bioarchitecture Pub Date : 2014-03-01 Epub Date: 2014-05-20 DOI: 10.4161/bioa.29069

Lauren Figard, Anna Marie Sokac

引用次数: 46

The special case of hepatocytes: unique tissue architecture calls for a distinct mode of cell division. 肝细胞的特殊情况:独特的组织结构需要独特的细胞分裂模式。

Bioarchitecture Pub Date : 2014-03-01 Epub Date: 2014-04-25 DOI: 10.4161/bioa.29012

Christiaan L Slim, Sven C D van IJzendoorn, Francisco Lázaro-Diéguez, Anne Müsch

{"title":"The special case of hepatocytes: unique tissue architecture calls for a distinct mode of cell division.","authors":"Christiaan L Slim, Sven C D van IJzendoorn, Francisco Lázaro-Diéguez, Anne Müsch","doi":"10.4161/bioa.29012","DOIUrl":"https://doi.org/10.4161/bioa.29012","url":null,"abstract":"Columnar epithelia (e.g., kidney, intestine) and hepatocytes embody the two major organizational phenotypes of non-stratified epithelial cells. Columnar epithelia establish their apical and basal domains at opposing poles and organize in monolayered cysts and tubules, in which their apical surfaces form a single continuous lumen whereas hepatocytes establish their apical domains in the midst of their basolateral domains and organize a highly branched capillary luminal network, the bile canaliculi, in which a single hepatocyte can engage in lumen formation with multiple neighbors. To maintain their distinct tissue architectures, columnar epithelial cells bisect their luminal domains during symmetric cell divisions, while the cleavage furrow in dividing hepatocytes avoids bisecting the bile canalicular domains. We discuss recently discovered molecular mechanisms that underlie the different cell division phenotypes in columnar and hepatocytic model cell lines. The serine/threonine kinase Par1b determines both the epithelial lumen polarity and cell division phenotype via cell adhesion signaling that converges on the small GTPase RhoA. ","PeriodicalId":89329,"journal":{"name":"Bioarchitecture","volume":"4 2","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/bioa.29012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32292984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The role of vertebrate nonmuscle Myosin II in development and human disease. 脊椎动物非肌肉肌球蛋白II在发育和人类疾病中的作用。

Bioarchitecture Pub Date : 2014-01-01 Epub Date: 2014-08-06 DOI: 10.4161/bioa.29766

Xuefei Ma, Robert S Adelstein

引用次数: 79

Emergent properties of composite semiflexible biopolymer networks. 复合半柔性生物聚合物网络的涌现特性。

Bioarchitecture Pub Date : 2014-01-01 DOI: 10.4161/19490992.2014.989035

Mikkel H Jensen, Eliza J Morris, Robert D Goldman, David A Weitz

引用次数: 30

Force-control at cellular membranes. 细胞膜上的力控制。

Bioarchitecture Pub Date : 2014-01-01 DOI: 10.1080/19490992.2015.1005524

Milos Galic, Isabell Begemann, Abhiyan Viplav, Maja Matis

{"title":"Force-control at cellular membranes.","authors":"Milos Galic, Isabell Begemann, Abhiyan Viplav, Maja Matis","doi":"10.1080/19490992.2015.1005524","DOIUrl":"https://doi.org/10.1080/19490992.2015.1005524","url":null,"abstract":"Force-regulation at cellular membranes relies on dynamic molecular platforms that integrate intra- and extracellular signals to control cell shape and function. To correctly respond to a continuously changing environment, activity of these platforms needs to be tightly controlled in space and time. Over the last few years, curvature-dependent mechano-chemical signal translation—a receptor-independent signaling mechanism where physical forces at the plasma membrane trigger nanoscale membrane deformations that are then translated into chemical signal transduction cascades—has emerged as a new signaling principle that cells use to regulate forces at the membrane. However, until recently, technical limitations have precluded studies of this force-induced curvature-dependent signaling at the physiological scale. Here, we comment on recent advancements that allow studying curvature-dependent signaling at membranes, and discuss processes where it may be involved in. Considering its general impact on cell function, a particular focus will be put on the curvature-dependence of feedback loops that control actin-based forces at cellular membranes.","PeriodicalId":89329,"journal":{"name":"Bioarchitecture","volume":"4 4-5","pages":"164-8"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19490992.2015.1005524","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33407908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Myosin light chains: Teaching old dogs new tricks. 肌球蛋白轻链:教老狗新把戏。

Bioarchitecture Pub Date : 2014-01-01 DOI: 10.1080/19490992.2015.1054092

Sarah M Heissler, James R Sellers

引用次数: 104

Stabilization of neuronal connections and the axonal cytoskeleton. 神经元连接和轴突细胞骨架的稳定。

Bioarchitecture Pub Date : 2014-01-01 Epub Date: 2014-02-03 DOI: 10.4161/bioa.28080

Yuyu Song, Scott T Brady

引用次数: 4