Bioarchitecture最新文献_第10页

The scaffolding protein IQGAP1 co-localizes with actin at the cytoplasmic face of the nuclear envelope: implications for cytoskeletal regulation. 脚手架蛋白IQGAP1与肌动蛋白共同定位于核膜的细胞质面:对细胞骨架调节的影响。

Bioarchitecture Pub Date : 2012-07-01 DOI: 10.4161/bioa.21182

Michael A Johnson, Beric R Henderson

引用次数: 14

TSPAN7: A new player in excitatory synapse maturation and function. TSPAN7:兴奋性突触成熟和功能的新参与者。

Bioarchitecture Pub Date : 2012-05-01 DOI: 10.4161/bioa.20829

Silvia Bassani, Maria Passafaro

引用次数: 17

Shaping muscle bioarchitecture for the fin to limb transition. 塑造鳍向肢过渡的肌肉生物结构。

Bioarchitecture Pub Date : 2012-05-01 DOI: 10.4161/bioa.20969

Nicholas J Cole, Peter Currie

引用次数: 0

The actin cytoskeleton as a sensor and mediator of apoptosis. 肌动蛋白细胞骨架作为细胞凋亡的传感器和介质。

Bioarchitecture Pub Date : 2012-05-01 DOI: 10.4161/bioa.20975

Melissa Desouza, Peter W Gunning, Justine R Stehn

引用次数: 217

Srf: A key factor controlling skeletal muscle hypertrophy by enhancing the recruitment of muscle stem cells. Srf:通过增强肌肉干细胞的募集来控制骨骼肌肥大的关键因素。

Bioarchitecture Pub Date : 2012-05-01 DOI: 10.4161/bioa.20699

Guerci Aline, Athanassia Sotiropoulos

{"title":"Srf: A key factor controlling skeletal muscle hypertrophy by enhancing the recruitment of muscle stem cells.","authors":"Guerci Aline, Athanassia Sotiropoulos","doi":"10.4161/bioa.20699","DOIUrl":"https://doi.org/10.4161/bioa.20699","url":null,"abstract":"Adult skeletal muscles adapt their fiber size to workload. We show that serum response factor (Srf) is required for satellite cell-mediated hypertrophic muscle growth. Deletion of Srf from myofibers, and not satellite cells, blunts overload-induced hypertrophy, and impairs satellite cell proliferation and recruitment to pre-existing fibers. We reveal a gene network in which Srf within myofibers modulates interleukin-6 and cyclooxygenase-2/interleukin-4 expressions and therefore exerts a paracrine control of satellite cell functions. In Srf-deleted muscles, in vivo overexpression of interleukin-6 is sufficient to restore satellite cell proliferation, but not satellite cell fusion and overall growth. In contrast, cyclooxygenase-2/interleukin-4 overexpression rescues satellite cell recruitment and muscle growth without affecting satellite cell proliferation, identifying altered fusion as the limiting cellular event. These findings unravel a role for Srf in the translation of mechanical cues applied to myofibers into paracrine signals, which in turn will modulate satellite cell functions and support muscle growth.","PeriodicalId":89329,"journal":{"name":"Bioarchitecture","volume":"2 3","pages":"88-90"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/bioa.20699","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30825071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The BAF60c-MyoD complex poises chromatin for rapid transcription. BAF60c-MyoD复合体为快速转录而调整染色质。

Bioarchitecture Pub Date : 2012-05-01 DOI: 10.4161/bioa.20970

Sonia-Vanina Forcales

{"title":"The BAF60c-MyoD complex poises chromatin for rapid transcription.","authors":"Sonia-Vanina Forcales","doi":"10.4161/bioa.20970","DOIUrl":"https://doi.org/10.4161/bioa.20970","url":null,"abstract":"Chromatin remodeling by the SWI/SNF complex is required to activate the transcription of myogenic-specific genes. Our work addressed the details of how SWI/SNF is recruited to myogenic regulatory regions in response to differentiation signals. Surprisingly, the muscle determination factor MyoD and the SWI/SNF subunit BAF60c form a complex on the regulatory elements of MyoD-targeted genes in myogenic precursor cells. This Brg1-devoid MyoD-BAF60c complex flags the chromatin of myogenic-differentiation genes before transcription is activated. On differentiation, BAF60c phosphorylation on a conserved threonine by p38 α kinase promotes the incorporation of MyoD-BAF60c into a Brg1-based SWI/SNF complex, which remodels the chromatin and activates transcription of MyoD-target genes. Downregulation of BAF60c expression prevents MyoD access to the chromatin and the proper loading of an active myogenic transcriptosome preventing the expression of hundreds of myogenic genes. Our data support an unprecedented two-step model by which (1) pre-assembled BAF60c-MyoD complex poises the chromatin of myogenic genes for rapid transcription; (2) chromatin-bound BAF60c \"senses\" the myogenic differentiation cues and recruits an active SWI/SNF complex to remodel the chromatin allowing transcriptional activation.","PeriodicalId":89329,"journal":{"name":"Bioarchitecture","volume":"2 3","pages":"104-109"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/bioa.20970","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30825549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Parvin-ILK: An intimate relationship. 一种亲密的关系。

Bioarchitecture Pub Date : 2012-05-01 DOI: 10.4161/bioa.20700

Katerina Vakaloglou, Christos Zervas

{"title":"Parvin-ILK: An intimate relationship.","authors":"Katerina Vakaloglou, Christos Zervas","doi":"10.4161/bioa.20700","DOIUrl":"https://doi.org/10.4161/bioa.20700","url":null,"abstract":"Integrin-linked kinase (ILK), PINCH and Parvin proteins form the IPP-complex that has been established as a core component of the integrin-actin link. Our recent genetic studies on Drosophila parvin, reveal that loss of function mutant defects phenocopy those observed upon loss of ILK or PINCH in the muscle and the wing, strengthening the notion that these proteins function together in the organism. Our work identified that ILK is necessary and sufficient for parvin subcellular localization, corroborating previous data indicating a direct association between these two proteins. Further genetic epistasis analysis of the IPP-complex assembly at integrin adhesion sites reveals that depending on the cell context each component is required differently. At the muscle attachment sites of the embryo, ILK is placed upstream in the hierarchy of genetic interactions required for the IPP-complex assembly. By contrast, in the wing epithelium the three proteins are mutually interdependent. Finally, we uncovered a novel property for the CH1-domain of parvin: its recruitment at the integrin-containing junctions in an ILK-dependent manner. Apparently, this ability of the CH1-domain is controlled by the inter-CH linker region. Thus, an intramolecular interaction within parvin could serve as a putative regulatory mechanism controlling the ILK-Parvin interaction.","PeriodicalId":89329,"journal":{"name":"Bioarchitecture","volume":"2 3","pages":"91-94"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/bioa.20700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30825073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A new role of multi scaffold protein Liprin-α: Liprin-α suppresses Rho-mDia mediated stress fiber formation. 多支架蛋白Liprin-α的新作用:Liprin-α抑制rho媒质介导的应激纤维形成。

Bioarchitecture Pub Date : 2012-02-01 DOI: 10.4161/bioa.20442

Satoko Sakamoto, Shuh Narumiya, Toshimasa Ishizaki

引用次数: 9

Scaffold remodeling in space and time controls synaptic transmission. 支架重构在空间和时间上控制突触传递。

Bioarchitecture Pub Date : 2012-02-01 DOI: 10.4161/bioa.20381

Julie Perroy, Enora Moutin

引用次数: 1

Axonemal radial spokes: 3D structure, function and assembly. 轴向径向辐条:三维结构、功能和装配。

Bioarchitecture Pub Date : 2012-02-01 DOI: 10.4161/bioa.20394

Gaia Pigino, Takashi Ishikawa

引用次数: 36