International journal of molecular imaging最新文献_第6页

(99m)Technetium Sestamibi-(123)Iodine Scintigraphy Is More Accurate Than (99m)Technetium Sestamibi Alone before Surgery for Primary Hyperparathyroidism. (99m)锝Sestamibi-(123)碘显像术比(99m)锝Sestamibi在原发性甲状旁腺功能亢进术前更准确。

International journal of molecular imaging Pub Date : 2015-01-01 Epub Date: 2015-02-01 DOI: 10.1155/2015/391625

Eeva M Ryhänen, Jukka Schildt, Ilkka Heiskanen, Mika Väisänen, Aapo Ahonen, Eliisa Löyttyniemi, Camilla Schalin-Jäntti, Matti J Välimäki

{"title":"(99m)Technetium Sestamibi-(123)Iodine Scintigraphy Is More Accurate Than (99m)Technetium Sestamibi Alone before Surgery for Primary Hyperparathyroidism.","authors":"Eeva M Ryhänen, Jukka Schildt, Ilkka Heiskanen, Mika Väisänen, Aapo Ahonen, Eliisa Löyttyniemi, Camilla Schalin-Jäntti, Matti J Välimäki","doi":"10.1155/2015/391625","DOIUrl":"https://doi.org/10.1155/2015/391625","url":null,"abstract":"Objectives. Studies comparing outcome of single-(99m)Tc-methoxyisobutylisonitrile ((99m)Tc-sestamibi) and dual-tracer (99m)Tc-sestamibi scintigraphy in combination with (123)I before primary surgery of primary hyperparathyroidism (PHPT) are scarce. Methods. We compared (99m)Tc-sestamibi/(123)I and (99m)Tc-sestamibi in a single-centre retrospective series of 269 PHPT patients. The results were related to laboratory, surgical and histological findings. Results. (99m)Tc-sestamibi/(123)I and (99m)Tc-sestamibi were positive in 206 (76.6%) and 111 (41.3%) of 269 patients, respectively (P < 0.001). Accuracies for (99m)Tc-sestamibi/(123)I and (99m)Tc-sestamibi were 63.4% and 34.9%, respectively (96% CI, P < 0.001). Prevalence of multiglandular disease was 15.2%. In multiglandular disease, (99m)Tc-sestamibi/(123)I and (99m)Tc-sestamibi revealed 43.8 and 22.1% of pathological glands, respectively (P < 0.001). Cure rate was similar for patients with (191/206; 92.7%) and without (59 of 63; 93.7%) a positive (99m)Tc-sestamibi/(123)I finding. Duration of targeted surgery (one or two quadrants) was 21 and 15 minutes shorter than bilateral neck exploration, respectively (both P < 0.001). Higher serum calcium (P = 0.014) and PTH (P = 0.055) concentrations and larger tumours (P < 0.001) characterized the 206 patients with a positive preoperative scan who were cured by removal of a single adenoma. Conclusions. (99m)Tc-sestamibi/(123)I scintigraphy is more accurate than (99m)Tc-sestamibi before surgery of PHPT. However, outcome of surgery is not determined by scintigraphy alone. ","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2015 ","pages":"391625"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/391625","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33088693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Psychosocial Effect of Malocclusion among Sudanese University DentalStudents 苏丹大学牙科学生错牙合的心理社会效应

International journal of molecular imaging Pub Date : 2015-01-01 DOI: 10.4172/2155-9937.1000122

A. Abuaffan

引用次数: 0

Radionuclide Theranostics in Cancer 放射性核素治疗癌症

International journal of molecular imaging Pub Date : 2014-12-12 DOI: 10.4172/2155-9937.1000E104

D. Denoyer, Pouliot

引用次数: 2

Speeding up the Analysis of Neuron Morphology using Parallel Processing 利用并行处理加速神经元形态分析

International journal of molecular imaging Pub Date : 2014-10-10 DOI: 10.4172/2155-9937.1000115

Dong Wang, D. Bourke, L. Domanski, P. Vallotton

引用次数: 0

Chromatographic Separation and Utilization of Labeled 99m Tc-Valsartan for Cardiac Imaging 99m tc -缬沙坦在心脏成像中的色谱分离与应用

International journal of molecular imaging Pub Date : 2014-08-05 DOI: 10.4172/2155-9937.1000114

Sanad Mh, Borai Eh

引用次数: 6

Ex Vivo Characterization of a Novel Iodine-123-Labelled Aminomethylchroman as a Potential Agonist Ligand for SPECT Imaging of Dopamine D2/3 Receptors. 一种新的碘-123标记的氨基甲基染色质作为多巴胺D2/3受体SPECT成像的潜在激动剂配体的体外表征。

International journal of molecular imaging Pub Date : 2014-01-01 Epub Date: 2014-12-25 DOI: 10.1155/2014/507012

Jan-Peter van Wieringen, Kora de Bruin, Henk M Janssen, P Michel Fransen, Anton G M Janssen, Peter A van Doremalen, Martin C Michel, Philip H Elsinga, Jan Booij

{"title":"Ex Vivo Characterization of a Novel Iodine-123-Labelled Aminomethylchroman as a Potential Agonist Ligand for SPECT Imaging of Dopamine D2/3 Receptors.","authors":"Jan-Peter van Wieringen, Kora de Bruin, Henk M Janssen, P Michel Fransen, Anton G M Janssen, Peter A van Doremalen, Martin C Michel, Philip H Elsinga, Jan Booij","doi":"10.1155/2014/507012","DOIUrl":"https://doi.org/10.1155/2014/507012","url":null,"abstract":"For imaging of dopamine D2/3 receptors, agonist tracers are favoured over antagonists because they are more sensitive to detection of dopamine release and because they may selectively label the high-affinity receptor state. We have developed novel D2/3 receptor selective agonists that can be radiolabelled with [(123)I], which label is advantageous over most other labels, such as carbon-11, as it has a longer half-life. Particularly, we considered (R) N-[7-hydroxychroman-2-yl]-methyl 4-iodobenzyl amine (compound 1) as an attractive candidate for development as it shows high binding affinity to D2/3 receptors in vitro, and here we report on the characterization of this first [(123)I]-labelled D2/3 receptor agonist radiopharmaceutical intended for SPECT imaging. The appropriate tin precursor for [(123)I]-1 was developed and was successfully radiolabelled with iodine-123 giving a moderate yield (30-35%) and a good purity (>95%) for [(123)I]-1. In biodistribution experiments in Wistar rats intravenous injection of [(123)I]-1 resulted in a fast brain uptake, where the observed binding in the D2/3 receptor-rich striatum was slightly higher than that in the cerebellum 30 min to 4 h p.i. Storage phosphor imaging experiments, however, did not show specific D2/3 receptor binding. In conclusion, despite promising in vitro data for 1, neither specific ex vivo binding nor high signal-to-noise ratios were found in rodents for [(123)I]-1. ","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2014 ","pages":"507012"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/507012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32993870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Longitudinal imaging of cancer cell metastases in two preclinical models: a correlation of noninvasive imaging to histopathology. 两种临床前模型中癌细胞转移的纵向成像：无创成像与组织病理学的关联。

International journal of molecular imaging Pub Date : 2014-01-01 Epub Date: 2014-03-03 DOI: 10.1155/2014/102702

Pavan P Adiseshaiah, Nimit L Patel, Lilia V Ileva, Joseph D Kalen, Diana C Haines, Scott E McNeil

{"title":"Longitudinal imaging of cancer cell metastases in two preclinical models: a correlation of noninvasive imaging to histopathology.","authors":"Pavan P Adiseshaiah, Nimit L Patel, Lilia V Ileva, Joseph D Kalen, Diana C Haines, Scott E McNeil","doi":"10.1155/2014/102702","DOIUrl":"10.1155/2014/102702","url":null,"abstract":"Metastatic spread is the leading cause of death from cancer. Early detection of cancer at primary and metastatic sites by noninvasive imaging modalities would be beneficial for both therapeutic intervention and disease management. Noninvasive imaging modalities such as bioluminescence (optical), positron emission tomography (PET)/X-ray computed tomography (CT), and magnetic resonance imaging (MRI) can provide complementary information and accurately measure tumor growth as confirmed by histopathology. Methods. We validated two metastatic tumor models, MDA-MD-231-Luc and B16-F10-Luc intravenously injected, and 4T1-Luc cells orthotopically implanted into the mammary fat pad. Longitudinal whole body bioluminescence imaging (BLI) evaluated metastasis, and tumor burden of the melanoma cell line (B16-F10-Luc) was correlated with (PET)/CT and MRI. In addition, ex vivo imaging evaluated metastasis in relevant organs and histopathological analysis was used to confirm imaging. Results. BLI revealed successful colonization of cancer cells in both metastatic tumor models over a 4-week period. Furthermore, lung metastasis of B16-F10-Luc cells imaged by PET/CT at week four showed a strong correlation (R (2) = 0.9) with histopathology. The presence and degree of metastasis as determined by imaging correlated (R (2) = 0.7) well with histopathology findings. Conclusions. We validated two metastatic tumor models by longitudinal noninvasive imaging with good histopathology correlation. ","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2014 ","pages":"102702"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32255332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of (99m)tc-tetrofosmin and (99m)tc-sestamibi uptake in glioma cell lines: the role of p-glycoprotein expression. 胶质瘤细胞系(99m)tc-tetrofosmin和(99m)tc-sestamibi摄取的比较:p-糖蛋白表达的作用。

International journal of molecular imaging Pub Date : 2014-01-01 Epub Date: 2014-11-10 DOI: 10.1155/2014/471032

George A Alexiou, Xanthi Xourgia, Evrysthenis Vartholomatos, Spyridon Tsiouris, John A Kalef-Ezra, Andreas D Fotopoulos, Athanasios P Kyritsis

{"title":"Comparison of (99m)tc-tetrofosmin and (99m)tc-sestamibi uptake in glioma cell lines: the role of p-glycoprotein expression.","authors":"George A Alexiou, Xanthi Xourgia, Evrysthenis Vartholomatos, Spyridon Tsiouris, John A Kalef-Ezra, Andreas D Fotopoulos, Athanasios P Kyritsis","doi":"10.1155/2014/471032","DOIUrl":"https://doi.org/10.1155/2014/471032","url":null,"abstract":"(99m)Tc-Tetrofosmin ((99m)Tc-TF) and (99m)Tc-Sestamibi ((99m)Tc-MIBI) are SPECT tracers that have been used for brain tumor imaging. Tumor's multidrug resistance phenotype, namely, P-glycoprotein (p-gp), and the multidrug resistance related proteins (MRPs) expression have been suggested to influence both tracers' uptake. In the present study we set out to compare (99m)Tc-TF and (99m)Tc-MIBI uptake in high-grade glioma cell lines and to investigate the influence of gliomas p-gp expression on both tracers' uptake. We used four glioma cell lines (U251MG, A172, U87MG, and T98G). The expression of p-gp protein was evaluated by flow cytometry. Twenty μCi (7.4·10(5) Bq) of (99m)Tc-TF and (99m)Tc-MIBI were used. The radioactivity in the cellular lysate was measured with a dose calibrator. P-gp was significantly expressed only in the U251MG cell line (P < 0.001). In all gliomas cell lines (U251MG, U87MG, A172, and T98G) the (99m)Tc-TF uptake was significantly higher than (99m)Tc-sestamibi. The U251MG cell line, in which significant p-gp expression was documented, exhibited the strongest uptake difference. (99m)Tc-TF uptake was higher than (99m)Tc-MIBI in all studied high-grade glioma cell lines. Thus, (99m)Tc-TF may be superior to (99m)Tc-MIBI for glioma imaging in vivo. ","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2014 ","pages":"471032"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/471032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32848778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Lyophilized Kit for the Preparation of the PET Perfusion Agent [(68)Ga]-MAA. PET灌注剂[(68)Ga]-MAA制备冻干试剂盒。

International journal of molecular imaging Pub Date : 2014-01-01 Epub Date: 2014-03-31 DOI: 10.1155/2014/269365

Alejandro Amor-Coarasa, Andrew Milera, Denny Carvajal, Seza Gulec, Anthony J McGoron

{"title":"Lyophilized Kit for the Preparation of the PET Perfusion Agent [(68)Ga]-MAA.","authors":"Alejandro Amor-Coarasa, Andrew Milera, Denny Carvajal, Seza Gulec, Anthony J McGoron","doi":"10.1155/2014/269365","DOIUrl":"https://doi.org/10.1155/2014/269365","url":null,"abstract":"Rapid developments in the field of medical imaging have opened new avenues for the use of positron emitting labeled microparticles. The radioisotope used in our research was (68)Ga, which is easy to obtain from a generator and has good nuclear properties for PET imaging. Methods. Commercially available macroaggregated albumin (MAA) microparticles were suspended in sterile saline, centrifuged to remove the free albumin and stannous chloride, relyophilized, and stored for later labeling with (68)Ga. Labeling was performed at different temperatures and times. (68)Ga purification settings were also tested and optimized. Labeling yield and purity of relyophilized MAA microparticles were compared with those that were not relyophilized. Results. MAA particles kept their original size distribution after relyophilization. Labeling yield was 98% at 75°C when a (68)Ga purification system was used, compared to 80% with unpurified (68)Ga. Radiochemical purity was over 97% up to 4 hours after the labeling. The relyophilized MAA and labeling method eliminate the need for centrifugation purification of the final product and simplify the labeling process. Animal experiments demonstrated the high in vivo stability of the obtained PET agent with more than 95% of the activity remaining in the lungs after 4 hours. ","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2014 ","pages":"269365"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/269365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32318078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Beneficial Effect of Glucose Control on Atherosclerosis Progression in Diabetic ApoE(-/-) Mice: Shown by Rage Directed Imaging. 血糖控制对糖尿病ApoE(-/-)小鼠动脉粥样硬化进展的有益作用:Rage定向成像显示

International journal of molecular imaging Pub Date : 2014-01-01 Epub Date: 2014-04-14 DOI: 10.1155/2014/695391

Yared Tekabe, Maria Kollaros, Qing Li, Geping Zhang, Chong Li, Ann Marie Schmidt, Lynne L Johnson

{"title":"Beneficial Effect of Glucose Control on Atherosclerosis Progression in Diabetic ApoE(-/-) Mice: Shown by Rage Directed Imaging.","authors":"Yared Tekabe, Maria Kollaros, Qing Li, Geping Zhang, Chong Li, Ann Marie Schmidt, Lynne L Johnson","doi":"10.1155/2014/695391","DOIUrl":"10.1155/2014/695391","url":null,"abstract":"Objective. Receptor for advanced glycated endproducts (RAGE) plays an important role in atherogenesis in diabetes. We imaged RAGE to investigate the effect of glucose control to suppress RAGE and reduce atherosclerosis in apolipoprotein E null (apoE(-/-)) diabetic mice. Methods and Results. Thirty-three apoE(-/-) mice received streptozotocin and 6 weeks later 15 began treatment with insulin implants. Blood glucose measurements during study averaged: 140 ± 23 mg/dL (treated) and 354 ± 14 mg/dL (untreated). After 15 wk 30 mice were injected with (99m)Tc-anti-RAGE F(ab')2, 3 with (99m)Tc-nonimmune IgG F(ab')2, and all with CT contrast agent and underwent SPECT/CT imaging. At necropsy, the proximal aorta was weighed, counted, and sectioned and the % injected dose per gram (%ID/g) was calculated. From the merged SPECT/CT scans, tracer uptake localized to arteries was lower in the treated mice: 3.15 ± 1.82 × 10(-3) versus 8.69 ± 4.58 × 10(-3)%ID (P = 0.001). Percent cross-sectional lesion area was smaller in the treated (14.3 ± 7.8% versus 29.5 ± 10.9%) (P = 0.03). RAGE uptake on scans (%ID) correlated with quantitative RAGE staining in the atheroma and with %ID/g (R = 0.6887; P = 0.01). Lesion size as percent cross-sectional area was smaller in the treated (14.3 ± 7.8% versus 29.5 ± 10.9%) (P = 0.03). RAGE uptake on scans (%ID) correlated with quantitative RAGE staining in the atheroma and with %ID/g (R = 0.6887; P = 0.01). Conclusions. These results support the importance of suppressing RAGE to reduce atherosclerotic complications of diabetes and value of molecular imaging to assess treatment effect. ","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2014 ","pages":"695391"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/695391","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32341516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3