International journal of molecular imaging最新文献_第10页

Contribution of (18)F-Fluoro-ethyl-tyrosine Positron Emission Tomography to Target Volume Delineation in Stereotactic Radiotherapy of Malignant Cranial Base Tumours: First Clinical Experience. (18) f -氟乙基酪氨酸正电子发射断层扫描对恶性颅底肿瘤立体定向放疗靶体积描绘的贡献:首次临床经验。

International journal of molecular imaging Pub Date : 2012-01-01 Epub Date: 2012-10-08 DOI: 10.1155/2012/412585

Reinhold Graf, Michail Plotkin, Fonyuy Nyuyki, Peter Wust, Reinhard Wurm, Volker Budach, Winfried Brenner, Daniel Fahdt

{"title":"Contribution of (18)F-Fluoro-ethyl-tyrosine Positron Emission Tomography to Target Volume Delineation in Stereotactic Radiotherapy of Malignant Cranial Base Tumours: First Clinical Experience.","authors":"Reinhold Graf, Michail Plotkin, Fonyuy Nyuyki, Peter Wust, Reinhard Wurm, Volker Budach, Winfried Brenner, Daniel Fahdt","doi":"10.1155/2012/412585","DOIUrl":"https://doi.org/10.1155/2012/412585","url":null,"abstract":"Increased amino acid uptake has been demonstrated in intracerebral tumours and head and neck carcinomas of squamous cell origin. We investigated the potential impact of using (18)F-fluoro-ethyl-tyrosine ((18)F-FET)-PET/CT in addition to conventional imaging for gross tumour volume (GTV) delineation in stereotactic radiotherapy of skull base tumours. The study population consisted of 14 consecutive patients with cranial base tumours (10 with squamous cell histology, 4 others). All patients underwent a FET-PET/CT examination in addition to contrast-enhanced CT and 11 patients underwent MRI. All tumours and histologic types showed increased FET uptake. The GTV was defined by all voxels showing hyperintensity in MRI or CT (GTV(MRI/CT)) or enhancement in PET (GTV(PET)), forming a GTV(composite) that was used for the initial treatment fields. An additional volume of infiltrative growth outside the GTV(MRI/CT) of about 1.0 ± 2 cm(3) (5% of the conventional volume) was demonstrated by FET-PET only (GTV(PETplus)) with significant enlargement (>10% of GTV(MRI/CT)) in three patients. From existing data, we found correlation between cellular density and the standardized uptake value (SUV) of FET. We were able to substantially reduce the volume of escalated radiation dose (GTV(boost)) by 11 ± 2 cm(3) (24%) of the conventional volume.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2012 ","pages":"412585"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/412585","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31096585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

PET Imaging in Recurrent Medullary Thyroid Carcinoma. 复发性甲状腺髓样癌的PET显像。

International journal of molecular imaging Pub Date : 2012-01-01 Epub Date: 2012-07-18 DOI: 10.1155/2012/324686

Giorgio Treglia, Vittoria Rufini, Massimo Salvatori, Alessandro Giordano, Luca Giovanella

{"title":"PET Imaging in Recurrent Medullary Thyroid Carcinoma.","authors":"Giorgio Treglia, Vittoria Rufini, Massimo Salvatori, Alessandro Giordano, Luca Giovanella","doi":"10.1155/2012/324686","DOIUrl":"https://doi.org/10.1155/2012/324686","url":null,"abstract":"Purpose. To perform an overview about the role of positron emission tomography (PET) or PET/computed tomography (PET/CT) using different radiopharmaceuticals in recurrent medullary thyroid carcinoma (MTC) based on biochemical findings (increased tumor marker levels after primary surgery). Methods. A comprehensive literature search of studies published in PubMed/MEDLINE, Scopus, and Embase databases through February 2012 regarding PET or PET/CT in patients with recurrent MTC was performed. Results. Twenty-nine studies comprising 714 patients with suspected recurrent MTC were retrieved. Twenty-seven articles evaluated the role of fluorine-18-fluorodeoxyglucose (FDG) PET or PET/CT in recurrent MTC with conflicting results. Diagnostic accuracy of FDG-PET and PET/CT increased in MTC patients with higher calcitonin and carcinoembryonic antigen values, suggesting that these imaging methods could be very useful in patients with more advanced and aggressive disease. Eight articles evaluated the role of fluorine-18-dihydroxyphenylalanine (FDOPA) PET or PET/CT in recurrent MTC reporting promising results. Overall, FDOPA seems to be superior but complementary compared to FDG in detecting recurrent MTC. Few studies evaluating other PET tracers are also discussed. Conclusions. PET radiopharmaceuticals reflect different metabolic pathways in MTC. FDOPA seems to be the most useful PET tracer in detecting recurrent MTC based on rising levels of tumor markers. FDG may complement FDOPA in patients with more aggressive MTC.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2012 ","pages":"324686"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/324686","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30803618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Renal Function in Relation to Cardiac (123)I-MIBG Scintigraphy in Patients with Chronic Heart Failure. 慢性心力衰竭患者肾功能与心脏(123)I-MIBG闪烁成像的关系。

International journal of molecular imaging Pub Date : 2012-01-01 Epub Date: 2012-05-14 DOI: 10.1155/2012/434790

Derk O Verschure, G Aernout Somsen, Berthe L F van Eck-Smit, Hein J Verberne

{"title":"Renal Function in Relation to Cardiac (123)I-MIBG Scintigraphy in Patients with Chronic Heart Failure.","authors":"Derk O Verschure, G Aernout Somsen, Berthe L F van Eck-Smit, Hein J Verberne","doi":"10.1155/2012/434790","DOIUrl":"https://doi.org/10.1155/2012/434790","url":null,"abstract":"The aim of this study was to explore if estimates of renal function could explain variability of (123)I-metaiodobenzylguanidine ((123)I-MIBG) assessed myocardial sympathetic activity. Furthermore estimates of renal function were compared to (123)I-MIBG as predictors of cardiac death in chronic heart failure (CHF). Semi-quantitative parameters of (123)I-MIBG myocardial uptake and washout were calculated using early heart/mediastinum ratio (H/M), late H/M and washout. Renal function was calculated as estimated Creatinine Clearance (e-CC) and as estimated Glomerular Filtration Rate (e-GFR). Thirty-nine patients with CHF (24 males; age: 64.4 ± 10.5 years; NYHA II/III/IV: 17/20/2; LVEF: 24.0 ± 11.5%) were studied. Variability in any of the semi-quantitative (123)I-MIBG myocardial parameters could not be explained by e-CC or e-GFR. During follow-up (60 ± 37 months) there were 6 cardiac deaths. Cox proportional hazard regression analysis showed that late H/M was the only independent predictor for cardiac death (Chi-square 3.2, regression coefficient: -4.095; standard error: 2.063; hazard ratio: 0.17 [95% CI: 0.000-0.950]). Addition of estimates of renal function did not significantly change the Chi-square of the model. Semi-quantitative (123)I-MIBG myocardial parameters are independent of estimates of renal function. In addition, cardiac sympathetic innervation assessed by (123)I-MIBG scintigraphy seems to be superior to renal function in the prediction of cardiac death in CHF patients.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2012 ","pages":"434790"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/434790","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30665949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

(123)I-MIBG Scintigraphy as a Powerful Tool to Plan an Implantable Cardioverter Defibrillator and to Assess Cardiac Resynchronization Therapy in Heart Failure Patients. (12)I-MIBG闪烁成像作为植入式心律转复除颤器计划和评估心衰患者心脏再同步化治疗的有力工具。

International journal of molecular imaging Pub Date : 2012-01-01 Epub Date: 2012-09-26 DOI: 10.1155/2012/690468

Antonella Stefanelli, Giorgio Treglia, Alessandro Giordano

{"title":"(123)I-MIBG Scintigraphy as a Powerful Tool to Plan an Implantable Cardioverter Defibrillator and to Assess Cardiac Resynchronization Therapy in Heart Failure Patients.","authors":"Antonella Stefanelli, Giorgio Treglia, Alessandro Giordano","doi":"10.1155/2012/690468","DOIUrl":"https://doi.org/10.1155/2012/690468","url":null,"abstract":"Iodine-123-metaiodobenzylguanidine ((123)I-MIBG) scintigraphy is a nuclear medicine technique which describes the functional status of the cardiac sympathetic nervous system. It is well known that an autonomic dysfunction is present in heart failure setting as a neuronal uptake of norepinephrine is impaired in the failing myocardium. Reduction in sympathetic nervous function in the heart, measured by reduced myocardial uptake of (123)I-MIBG, is an indicator of poor prognosis for heart failure patients. The aim of this paper was to investigate the role of (123)I-MIBG scintigraphy in evaluating the need of implantable cardioverter defibrillator (ICD) and the response to cardiac resynchronization therapy (CRT) in heart failure patients. For this purpose scientific literature data on these topics were reviewed. Based on literature data, (123)I-MIBG scintigraphy seems to be a useful tool to assess which patients may benefit most from an ICD implantation to reduce the risk of ventricular arrhythmia or sudden cardiac death. Furthermore, (123)I-MIBG scintigraphy seems to predict which patients will response to CRT with an improvement in left ventricular function.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2012 ","pages":"690468"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/690468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30969659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

(111)Indium Labelling of Recombinant Activated Coagulation Factor VII: In Vitro and Preliminary In Vivo Studies in Healthy Rats. (111)重组活化凝血因子VII的铟标记:体外和健康大鼠体内初步研究。

International journal of molecular imaging Pub Date : 2012-01-01 Epub Date: 2012-02-12 DOI: 10.1155/2012/464810

Amarnadh Nalla, Inge Buch, Maibritt Sigvardt, Rasmus Poul Bodholdt, Andreas Kjaer, Birger Hesse

{"title":"(111)Indium Labelling of Recombinant Activated Coagulation Factor VII: In Vitro and Preliminary In Vivo Studies in Healthy Rats.","authors":"Amarnadh Nalla, Inge Buch, Maibritt Sigvardt, Rasmus Poul Bodholdt, Andreas Kjaer, Birger Hesse","doi":"10.1155/2012/464810","DOIUrl":"https://doi.org/10.1155/2012/464810","url":null,"abstract":"The aim of this study is to investigate whether (111)Indium-labelled recombinant FVIIa (rFVIIa) could be a potential radiopharmaceutical for localization of bleeding sources. DTPA-conjugated rFVIIa was radiolabelled with (111)In chloride. In vitro binding efficiency of (111)In-DTPA-rFVIIa to F1A2-Mab-sepharose was 99% in buffer, while it was 88-82% in serum. The binding efficiency of (111)In-DTPA-rFVIIa to TF (1-209)-sepharose was 48% in buffer whereas 39%-36% in serum, respectively. In vivo experiment was conducted in healthy rats, and gamma camera images were taken immediately after iv. administration of 1.6-1.8 MBq (111)In-DTPA-rFVIIa up to 120-130 min. Five min after administration of (111)In-DTPA-rFVIIa, percentage of (111)In activity was 6.0% in the cardiac region and 24.5% in the liver region. After 2 hours activity was decreased to 3.3% in heart while it had increased to 42.0% in the liver. The (111)In-DTPA-rFVIIa might be a potential radiopharmaceutical for visualisation of tissues with significant TF expression such as acute bleeding lesions in the gastrointestinal tract.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":" ","pages":"464810"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/464810","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40169109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group. 神经母细胞瘤中去甲肾上腺素转运蛋白表达和间氧苄基胍亲和力的评估:来自儿童肿瘤组的报告。

International journal of molecular imaging Pub Date : 2012-01-01 Epub Date: 2012-09-25 DOI: 10.1155/2012/250834

Steven G Dubois, Ethan Geier, Vandana Batra, Sook Wah Yee, John Neuhaus, Mark Segal, Daniel Martinez, Bruce Pawel, Greg Yanik, Arlene Naranjo, Wendy B London, Susan Kreissman, David Baker, Edward Attiyeh, Michael D Hogarty, John M Maris, Kathleen Giacomini, Katherine K Matthay

{"title":"Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group.","authors":"Steven G Dubois, Ethan Geier, Vandana Batra, Sook Wah Yee, John Neuhaus, Mark Segal, Daniel Martinez, Bruce Pawel, Greg Yanik, Arlene Naranjo, Wendy B London, Susan Kreissman, David Baker, Edward Attiyeh, Michael D Hogarty, John M Maris, Kathleen Giacomini, Katherine K Matthay","doi":"10.1155/2012/250834","DOIUrl":"https://doi.org/10.1155/2012/250834","url":null,"abstract":"Purpose. (123)I-metaiodobenzylguanidine (MIBG) is used for the diagnostic evaluation of neuroblastoma. We evaluated the relationship between norepinephrine transporter (NET) expression and clinical MIBG uptake. Methods. Quantitative reverse transcription PCR (N = 82) and immunohistochemistry (IHC; N = 61) were performed for neuroblastoma NET mRNA and protein expression and correlated with MIBG avidity on diagnostic scans. The correlation of NET expression with clinical features was also performed. Results. Median NET mRNA expression level for the 19 MIBG avid patients was 12.9% (range 1.6-73.7%) versus 5.9% (range 0.6-110.0%) for the 8 nonavid patients (P = 0.31). Median percent NET protein expression was 50% (range 0-100%) in MIBG avid patients compared to 10% (range 0-80%) in nonavid patients (P = 0.027). MYCN amplified tumors had lower NET protein expression compared to nonamplified tumors (10% versus 50%; P = 0.0002). Conclusions. NET protein expression in neuroblastoma correlates with MIBG avidity. MYCN amplified tumors have lower NET protein expression.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2012 ","pages":"250834"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/250834","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30964654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46

(64)Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer: Correlation between Tumor Uptake and Integrin α(V)β(3) Expression in Human Neuroendocrine Tumor Xenografts. (64)Cu-NODAGA-c(RGDyK)是一种新的血管生成PET示踪剂:肿瘤摄取与整合素α(V)β(3)在人神经内分泌肿瘤异种移植中的表达相关。

International journal of molecular imaging Pub Date : 2012-01-01 Epub Date: 2012-10-02 DOI: 10.1155/2012/379807

Jytte Oxboel, Christina Schjoeth-Eskesen, Henrik H El-Ali, Jacob Madsen, Andreas Kjaer

{"title":"(64)Cu-NODAGA-c(RGDyK) Is a Promising New Angiogenesis PET Tracer: Correlation between Tumor Uptake and Integrin α(V)β(3) Expression in Human Neuroendocrine Tumor Xenografts.","authors":"Jytte Oxboel, Christina Schjoeth-Eskesen, Henrik H El-Ali, Jacob Madsen, Andreas Kjaer","doi":"10.1155/2012/379807","DOIUrl":"https://doi.org/10.1155/2012/379807","url":null,"abstract":"Purpose. The purpose of this paper is to evaluate a new PET tracer (64)Cu-NODAGA-c(RGDyK) for imaging of tumor angiogenesis using gene expression of angiogenesis markers as reference and to estimate radiation dosimetry for humans. Procedures. Nude mice with human neuroendocrine tumor xenografts (H727) were administered (64)Cu-NODAGA-c(RGDyK) i.v. for study of biodistribution as well as for dynamic PET. Gene expression of angiogenesis markers integrin α(V), integrin β(3), and VEGF-A were analyzed using QPCR and correlated to the tracer uptake in the tumors (%ID/g). From biodistribution data human radiation-absorbed doses were estimated using OLINDA/EXM. Results. Tumor uptake was 1.2%ID/g with strong correlations between gene expression and tracer uptake, for integrin α(V) R = 0.76, integrin β(3) R = 0.75 and VEGF-A R = 0.81 (all P < 0.05). The whole body effective dose for humans was estimated to be 0.038 and 0.029 mSv/MBq for females and males, respectively, with highest absorbed dose in bladder wall. Conclusion. (64)Cu-NODAGA-c(RGDyK) is a promising new angiogenesis PET tracer with potential for human use.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2012 ","pages":"379807"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/379807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30997888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Fluorine-18-fluorodeoxyglucose positron emission tomography in assessing retroperitoneal fibrosis: a literature review. 氟-18-氟脱氧葡萄糖正电子发射断层扫描评估腹膜后纤维化:文献综述。

International journal of molecular imaging Pub Date : 2012-01-01 Epub Date: 2012-09-25 DOI: 10.1155/2012/484052

Giorgio Treglia, Maria Vittoria Mattoli, Francesco Bertagna

引用次数: 2

Feasibility evaluation of radioimmunoguided surgery of breast cancer. 放射免疫引导乳腺癌手术的可行性评价。

International journal of molecular imaging Pub Date : 2012-01-01 Epub Date: 2012-02-20 DOI: 10.1155/2012/545034

Ananth Ravi, Raymond M Reilly, Claire M B Holloway, Curtis B Caldwell

{"title":"Feasibility evaluation of radioimmunoguided surgery of breast cancer.","authors":"Ananth Ravi, Raymond M Reilly, Claire M B Holloway, Curtis B Caldwell","doi":"10.1155/2012/545034","DOIUrl":"https://doi.org/10.1155/2012/545034","url":null,"abstract":"Breast-conserving surgery involves completely excising the tumour while limiting the amount of normal tissue removed, which is technically challenging to achieve, especially given the limited intraoperative guidance available to the surgeon. This study evaluates the feasibility of radioimmunoguided surgery (RIGS) to guide the detection and delineation of tumours intraoperatively. The 3D point-response function of a commercial gamma-ray-detecting probe (GDP) was determined as a function of radionuclide ((131)I, (111)In,( 99m)Tc), energy-window threshold, and collimator length (0.0-3.0-cm). This function was used to calculate the minimum detectable tumour volumes (MDTVs) and the minimum tumour-to-background activity concentration ratio (T:B) for effective delineation of a breast tumour model. The GDP had larger MDTVs and a higher minimum required T:B for tumour delineation with (131)I than with (111)In or (99m)Tc. It was shown that for (111)In there was a benefit to using a collimator length of 0.5-cm. For the model used, the minimum required T:B required for effective tumour delineation was 5.2 ± 0.4. RIGS has the potential to significantly improve the accuracy of breast-conserving surgery; however, before these benefits can be realized, novel radiopharmaceuticals need to be developed that have a higher specificity for cancerous tissue in vivo than what is currently available.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":" ","pages":"545034"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/545034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40169110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Differential short-term repeated forearm hyperaemic reactivity in coronary artery disease patients compared to healthy low risk participants. 冠状动脉疾病患者与健康低风险参与者短期重复前臂充血反应的差异

International journal of molecular imaging Pub Date : 2012-01-01 Epub Date: 2012-10-24 DOI: 10.1155/2012/578504

Simon L Bacon, Bernard Meloche, Kim L Lavoie, André Arsenault

{"title":"Differential short-term repeated forearm hyperaemic reactivity in coronary artery disease patients compared to healthy low risk participants.","authors":"Simon L Bacon, Bernard Meloche, Kim L Lavoie, André Arsenault","doi":"10.1155/2012/578504","DOIUrl":"https://doi.org/10.1155/2012/578504","url":null,"abstract":"The hyperaemic response of the forearm is a widely used technique to assess the vascular reactivity. Little is known about the short-term reproducibility and the possible exhaustion of this response in normal or diseased states. As such, the current study was conducted to assess this phenomenon using a unique nuclear medicine- (NM-) based technique. 19 patients with coronary artery disease (CAD) undergoing NM exercise stress tests and 15 low risk (LR) participants completed 2 reactive hyperaemia tests, using a SPECT-based technique, separated by 15 min. Analyses revealed that CAD patients had lower hyperaemic responses than LR participants (P < .001), and that there was a significant group × time interaction (P < .005), such that LR participants showed a larger decrease in the reactivity (5.2 ± 0.4 to 3.6 ± 0.4) than the CAD patients (2.9 ± 0.3 to 2.6 ± 0.3). These results suggest that there is a variability, due to disease states, in the reproducibility of the hypaeremic reactivity. This needs to be taken into account in short-term repeated measure studies.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2012 ","pages":"578504"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/578504","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31096587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1