International journal of molecular imaging最新文献

The Value of F18-FDG PET/CT in Medullary Thyroid Cancer Patients with Persistent Elevated Calcitonin Levels F18-FDG PET/CT在降钙素持续升高的甲状腺髓样癌患者中的价值

International journal of molecular imaging Pub Date : 2020-01-01 DOI: 10.4172/2155-9937.1000149

Ş. Alçiçek, B. Yazıcı, A. Oral, I. Şimşir, S. Tatlıdil, A. Akgün

{"title":"The Value of F18-FDG PET/CT in Medullary Thyroid Cancer Patients with Persistent Elevated Calcitonin Levels","authors":"Ş. Alçiçek, B. Yazıcı, A. Oral, I. Şimşir, S. Tatlıdil, A. Akgün","doi":"10.4172/2155-9937.1000149","DOIUrl":"https://doi.org/10.4172/2155-9937.1000149","url":null,"abstract":"Purpose of the Study In this retrospective study, we reported our experience with FDG-PET/CT in evaluation of medullary thyroid cancer (MTC) patients with persistent elevated calcitonin levels. Materials and Methods A total of 33 F-18 FDG PET/CT scans and 9 somatostatin receptor imaging (SRI) (6 In-111 octreotide and 3 Ga-68 DOTATATE PET/CT) of 25 MTC patients with persistently elevated calcitonin levels, performed for staging and restaging, were analyzed retrospectively. The scans were compared lesion by lesion with histopathological data and other imaging methods. Because all patients had abnormally high calcitonin levels defined as persistent disease, negative F-18 FDG PET/CT scans accepted as false negative. Because there was no true-negative study, only sensitivity and positive predictive value (PPV) were calculated. Calcitonin levels and SUVmax values were assessed by Mann- Whitney U test and the ROC curve analysis. Results There were 11 true-positive, 11 false-positive and 11 false-negative F-18 FDG PET/CT scans. Sensitivity and PPV were 50% and 50% respectively. Difference of mean calcitonin level between true-positive cases and the others was nonsignificant. SUVmax of true-positive lesions were significantly higher than of the others. All 9 SRIs were negative. Conclusions FDG PET/CT scan appeared to be less sensitive. However, it should be considered that F-18 FDG PET/CT was performed to the patients with only no lesion had been detected by the other imaging modalities in this group. Because F-18 FDG PET/CT was not performed when a residual or recurrent lesion had clearly been detected before, sensitivity of 50% was considered to be acceptable.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"41 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81181394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Verification of Endotracheal Intubation with Ultrasonography in Emergency Medicine Clinic 急诊临床超声对气管插管的验证

International journal of molecular imaging Pub Date : 2018-05-04 DOI: 10.4172/2155-9937.1000141

K. Mustafa, Y. Gokhan, S. Suha, C. Bahadır, P. Ismet

{"title":"Verification of Endotracheal Intubation with Ultrasonography in Emergency Medicine Clinic","authors":"K. Mustafa, Y. Gokhan, S. Suha, C. Bahadır, P. Ismet","doi":"10.4172/2155-9937.1000141","DOIUrl":"https://doi.org/10.4172/2155-9937.1000141","url":null,"abstract":"Introduction and Aim: Endotracheal intubation (EI) is vital in emergency medicine where airway management is critical. In literature haven't got any gold standard method for endotracheal tube (ET) confirmation. Aim of our study is to compare sensitivity and specificity of ultrasonography (USG) that has become widespread in emergency medicine, in confirmation of ET with other methods. Materials and Methods: This study is a clinical observational prospective single-centered and conducted at Emergency Department of A°zmir Bozyaka Training and Research Hospital in September – November 2014. All the patient above 18 years old who had been intubated because of medical indications and cardiac arrest are included. End-tidal waveform capnograph and oscultation were used. We used Ultrasonography (USG) just after incubation for confirmation of tube placement. During ventilation, both hemithorax and epigastric area were auscultated. Simultaneously, we used USG for lung sliding bilaterally. After six ventilations, we recorded value of partial pressure of carbon dioxide (pCO2) on capnograph and whether waveform was present, or not. Results: 37 patients were included to the study. 19 (51.4%) were men. 21 (56.8%) of the patient were intubated due to cardiac arrest, 2 (5.4%) of them due to low Glasgow coma scale (GCS), 12 (32.4%) of them too difficult intubation, 1 (2.7%) of them due to low partial pressure of oxygen (pO2), 1 (2.7%) of them to change ET. Sensitivity of USG for confirmation of tube placement is 100% (CI 95%; 40.23-100%), specificity is 96.97% (95%CI; 84.18-99.49%), positive predictive value (PPV) 80% (CI 95%; 28.81-96.70%), negative predictive value (NPV) 100% (CI 95%; 89.01-100%). Kappa value of USG is 0,87. Conclusion: USG is being largely used in emergency departments and shows high sensitivity and specificity to confirm ET placement. USG can be used to confirm endotracheal tube placement; so, complications of esophageal intubation can be avoided.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"56 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87179665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computed Tomography: A Reliable Modality for the Assessment of Bowel Wall Thickening to Categorize Benign and Malignant Lesions of Bowel Wall 计算机断层扫描:评估肠壁增厚以区分肠壁良恶性病变的可靠方法

International journal of molecular imaging Pub Date : 2018-01-01 DOI: 10.4172/2155-9937.1000145

Kasmika Ghimire Kasmika, P. Peng, Min Guo, Delin Zhong

引用次数: 1

Preliminary Study of the Location of the Her2 Proteins by Molecular Imaging (MALDI-IMS) in a Histological Section of the Breast 乳腺组织切片中Her2蛋白分子成像(MALDI-IMS)定位的初步研究

International journal of molecular imaging Pub Date : 2018-01-01 DOI: 10.4172/2155-9937.1000i111

L. Cantero, L. Valero, M. S. D. Pino, L. Bernet

引用次数: 0

Complex Sigmoid Diverticulitis Presenting as Tubo-Ovarian Abscess and Developed Iliopsoas Abscess as Complications 复杂乙状结肠憩室炎表现为输卵管卵巢脓肿和发展为髂腰肌脓肿的并发症

International journal of molecular imaging Pub Date : 2018-01-01 DOI: 10.4172/2155-9937.1000146

P. Balaji

引用次数: 0

In Silico Study of miR-132 with mRNA of Acetylcholinesterase to Investigate the Binding Affinity for Interaction miR-132与乙酰胆碱酯酶mRNA的结合性研究

International journal of molecular imaging Pub Date : 2018-01-01 DOI: 10.4172/2155-9937.1000144

Sabahat Sohail

{"title":"In Silico Study of miR-132 with mRNA of Acetylcholinesterase to Investigate the Binding Affinity for Interaction","authors":"Sabahat Sohail","doi":"10.4172/2155-9937.1000144","DOIUrl":"https://doi.org/10.4172/2155-9937.1000144","url":null,"abstract":"Acetylcholinesterase (AChE) is a key enzyme in central nervous system which hydrolaze neurotransmitter acetylcholine (ACh) at cholinergic brain synapses. High expression of AChE in brain and muscles is responsible for diverse neurological conditions leading from neuromuscular, neurodegenerative and neuropsychological diseases. miRNA-132 is a non-coding RNA molecule which help to regulate the expression level of number of genes involved in neurological development, angiogenesis and synaptic transmission. However, miR-132 is the only miR so far that has been experimentally validated as targeting AChE, with consequences on inflammatory responses. Various bioinformatics tools like MODELLER, I-Tasser, ModeRNA, 3D-Dart, ERRAT, ProSA and Rampage were employed for AChE, miR-132 and mRNA model building and their validations. The binding affinities of these macromolecules were also investigated. The results revealed that the miR-132 binds to 3'-UTR region of AChE. The catalytic triad Ser-203, His-447 and Glu-334 found in active site gorge of protein binds to the ligand. Thus, the models of proteinligand and mRNA-miR-132 complexes proved miR-132 as an inhibitor of Acetylcholinesterase. Therefore miR-132 can be a potent inhibitor for Acetylcholinesterase and further analysis of this inhibitor could be helpful for exploration of ligand binding pockets and designing of a novel therapeutic target to cure central nervous system disorders.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"9 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81893774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Terrifying Drug Threats the Streets: Flakka - A Case Report 一种可怕的毒品威胁着街道:Flakka -一个案例报告

International journal of molecular imaging Pub Date : 2018-01-01 DOI: 10.4172/2155-9937.1000142

Ş. Atiş, G. Yilmaz, Oner Bozan, B. Çekmen

引用次数: 0

The Role of PET/CT in the Diagnosis of Kikuchi-Fujimoto Disease: A Case Series and Review of the Literature PET/CT在菊池-藤本病诊断中的作用:一个病例系列和文献综述

International journal of molecular imaging Pub Date : 2017-12-11 DOI: 10.4172/2155-9937.1000139

F. P. Mghanga, K. Bakari, H. Mayala

{"title":"The Role of PET/CT in the Diagnosis of Kikuchi-Fujimoto Disease: A Case Series and Review of the Literature","authors":"F. P. Mghanga, K. Bakari, H. Mayala","doi":"10.4172/2155-9937.1000139","DOIUrl":"https://doi.org/10.4172/2155-9937.1000139","url":null,"abstract":"Introduction: Kikuchi-Fujimoto disease (KFD), also known as Kikuchi’s disease or histiocytic necrotizing lymphadenitis, is a self-limiting case of non-cancerous lymphadenopathy. Although previous reports have demonstrated its physical findings and traditional imaging characteristics, few studies mentioned the application of 18fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) imaging in the diagnosis and follow-up of this disease. Here, we present three cases of KFD, describe the findings from PET/CT images and review the relevant literature to improve the diagnosis of this rare disease. \u0000Case presentation: Three patients, two females (15 and 16 years old) and one male (28 years old), with KFD were diagnosed by biopsy. All patients presented with bilateral cervical lymph nodes and no history of fever, and underwent multiple physical examinations, conventional imaging (Ultrasonography, CT and MRI) and 18F-FDG PET/CT. The images from 18F-FDG PET/CT revealed increased FDG uptake in all three patients. We also observed that the maximum standardized uptake value (SUVmax) in the affected lymph nodes in our patients ranged from 4.85 to 21.1 (mean ± SD, 10.53 ± 3.02) and the mean of SUVmax values ranged from 3.5 to 17.3 (mean ± SD, 7.35 ± 4.13), while 12 out of 16 large nodes with the maximum values of SUVmax were located in the cervical region. All patients presented with splenomegal which showed low affinity to FDG. \u0000Conclusion: Our study showed that 18F-FDG PET/CT imaging of KFD was mainly characterized by mild-tomoderate FDG uptake on the affected lymph nodes with maximum diameter of less than 35 cm and no or mild lymph node fusion and rarely extra-nodal infiltration. Moreover, 18F-FDG PET/CT may be a useful tool in the diagnosis of KFD prior to biopsy; where location, size and the response to FDG may be the important and useful factors for making clinical decision for biopsy.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"18 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80710831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Case of Severe Nephroptosis with Complete Tracer Retention at Standing Position Nuclear Renal Scan 重度肾下垂伴站立位核肾扫描示踪剂完全滞留1例

International journal of molecular imaging Pub Date : 2017-12-05 DOI: 10.4172/2155-9937.1000i108

R. Bertolo, F. Porpiglia, T. Angusti

引用次数: 0

The Efficiency of Applying the Radiology Technologist of the Radiation Dose Monitoring Technique During the Fluoroscopy Procedures for Oncology in Paediatrics Care Aged Between 4 to 7 Years 4 ~ 7岁儿科肿瘤透视检查中放射技师应用放射剂量监测技术的效果

International journal of molecular imaging Pub Date : 2017-10-18 DOI: 10.4172/2155-9937.1000140

Hissa Mohammed

{"title":"The Efficiency of Applying the Radiology Technologist of the Radiation Dose Monitoring Technique During the Fluoroscopy Procedures for Oncology in Paediatrics Care Aged Between 4 to 7 Years","authors":"Hissa Mohammed","doi":"10.4172/2155-9937.1000140","DOIUrl":"https://doi.org/10.4172/2155-9937.1000140","url":null,"abstract":"Fluoroscopy is one of the radiation sources used in diagnostic processes in radiology. Owing to the diagnostic approach that entails observation of the affected anatomy using radiation in real time, harmful effects may potentially occur. Therefore, safety measures in the radiographer's use of equipment and effective monitoring and management are essential in diagnostic processes. Additionally, patients in the age group of four to seven years have less anatomy and tissue development, which presents higher levels of health risks. The study will focus on analyzing the pre-procedure requirements and the set of guidelines, which enable the enforcement of the safety of the concerned patients within the paediatric practice. For example, the study will observe the potency of undertaking the reduction of the fluoroscopic times and improving the communications between the health specialists. The study will also evaluate methods and techniques employed in achieving efficiency in fluoroscopy radiation dose management. Direct and indirect methods will be employed to monitor the dosage effects. Direct methods would entail performing a skin dose test on the target area of fluoroscopic radiation. Detectors would be employed, for example the photographic films and thermo-luminescent dosimeters. The indirect methods will employ the use of the dose area product meter to ascertain the effects of radiation on the patients. Some of the dose reduction techniques involve the manipulation of equipment operation, for example beam quality adjustment, dose level setting, and dose spreading. The results used to evaluate the dosage level will entail analyzing measurements of the skin exposure unit of the fluoroscopic equipment. These results will be achieved through the use of different operational voltage levels on the fluoroscopic equipment. Skin dose will be determined through a combination of several measurable factors in fluoroscopic equipment operation.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"25 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80988643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0