International journal of molecular imaging最新文献

{"title":"A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma.","authors":"Danny L Costantini,&nbsp;Reza Vali,&nbsp;Susan McQuattie,&nbsp;Jeffrey Chan,&nbsp;Angela Punnett,&nbsp;Shiela Weitzman,&nbsp;Amer Shammas,&nbsp;Martin Charron","doi":"10.1155/2016/6045894","DOIUrl":"https://doi.org/10.1155/2016/6045894","url":null,"abstract":"<p><p>We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow and liver (18F-FLT SUV 8.6 ± 0.6 and 5.0 ± 0.3, versus 18F-FDG SUV 1.9 ± 0.1 and 3.4 ± 0.7, resp., p < 0.05). In total, 15 lesions were evaluated with average 18F-FDG and 18F-FLT SUVs of 2.6 ± 0.1 and 2.0 ± 0.4, respectively. Nonspecific uptake in reactive lymph nodes and thymus was observed. Future studies to assess the clinical utility of 18F-FLT PET/CT in pediatric lymphoma are planned. </p>","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2016 ","pages":"6045894"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6045894","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34585623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal Temperature Changes Do Not Affect Cardiac Glucose Metabolism","authors":"J. Schildt, A. Loimaala, E. Hippeläinen, P. Nikkinen, A. Ahonen","doi":"10.1155/2015/916016","DOIUrl":"https://doi.org/10.1155/2015/916016","url":null,"abstract":"FDG-PET/CT is widely used to diagnose cardiac inflammation such as cardiac sarcoidosis. Physiological myocardial FDG uptake often creates a problem when assessing the possible pathological glucose metabolism of the heart. Several factors, such as fasting, blood glucose, and hormone levels, influence normal myocardial glucose metabolism. The effect of outdoor temperature on myocardial FDG uptake has not been reported before. We retrospectively reviewed 29 cancer patients who underwent PET scans in warm summer months and again in cold winter months. We obtained myocardial, liver, and mediastinal standardized uptake values (SUVs) as well as quantitative cardiac heterogeneity and the myocardial FDG uptake pattern. We also compared age and body mass index to other variables. The mean myocardial FDG uptake showed no significant difference between summer and winter months. Average outdoor temperature did not correlate significantly with myocardial SUVmax in either summer or winter. The heterogeneity of myocardial FDG uptake did not differ significantly between seasons. Outdoor temperature seems to have no significant effect on myocardial FDG uptake or heterogeneity. Therefore, warming the patients prior to attending cardiac PET studies in order to reduce physiological myocardial FDG uptake seems to be unnecessary.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/916016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64159284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Sickle Cell Disease and Dental Caries among Sudanese Children","authors":"A. Abuaffan","doi":"10.4172/2155-9937.1000120","DOIUrl":"https://doi.org/10.4172/2155-9937.1000120","url":null,"abstract":"Background: Sickle cell disease is an autosomal recessive hemoglobinopathy predominant among Afro-descendants, and has been categorized as a public health issue as it affects a significant percentage of the world’s population. The aim of this study is to determine the association of dental caries among Sudanese sickle cell disease children in relation to healthy controls children. \u0000Methods: dmft and DMFT were recorded for 212 sickle cell disease children aged 3-15 years old, matched with 212 control healthy children in Khartoum, Sudan. Statistical analysis was done using statistical software SPSS 17.5 version. Chi square test was used for the comparison of study and control groups, the level of significance was set at p \u0000Results: dmft was significant among age group 4-6 and 7-11 years old while DMFT was only significant among group 12-14 years old sickle cell disease. There is highly significant association exists in dmft and DMF. Sickle cell disease group is 1.115 likely to have present component in dmft when compared to control group and 1.82 likely to have present component of DMFT when compared to control group. \u0000Conclusion: Sudanese sickle cell disease children had high prevalence of dental caries than the healthy children. Establishment of frequent dental examination schedule for sickle cell disease children, including preventive dental care and promoting oral hygiene practices with toothbrushes, toothpaste, and mouthwash are recommended.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"11641 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2015-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88648039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Bio-evaluation of 99mTc-carbonyl Complex of Ursodeoxycholic Acid for Heptobiliary Imaging","authors":"Sanad Mh","doi":"10.4172/2155-9937.1000119","DOIUrl":"https://doi.org/10.4172/2155-9937.1000119","url":null,"abstract":"A method on the development of hepatobiliary imaging can be occurred by using 99mTc-tricarbonyl [99m Tc(CO)3(H2O)3]+ core with Ursodeoxycholic Acid (UDCA) under 30 min heating at 100oC. Hepatobiliary imaging is also used to help diagnose symptoms such as: Abdominal pain that may be caused by a sudden inflammation of the gallbladder called cholecystitis, pain or fever following surgery on the gallbladder or the upper gastrointestinal tract. Biliary atresia in newborns, a blockage in the ducts that carry bile from the liver to the gall bladder. Labeling yield and stability were analyzed by high performance liquid chromatography (labeling yield>98% and stability for 6 h) at pH 9 and 3 mg substrate. RP-HPLC was used to evaluate the radiochemical yield and purity of the labeled product. Biodistribution studies were carried out in Albino Swiss mice at different time intervals after administration of 99mTc-tricarbonyl [99mTc(CO)3(H2O)3]+ (UDCA).The uptake of complex in the liver gave the chance to diagnose it. The results indicate that the labeled compound cleared from the systematic circulation within 2 h after administration and majority of organs showed significant decrease in uptake of it. These results introduce 99mTc-tricarbonyl UDCA as a novel potential radiopharmaceutical for hepatobiliary imaging.A method on the development of hepatobiliary imaging can be occurred by using 99mTc-tricarbonyl [99m Tc(CO)3(H2O)3]+ core with Ursodeoxycholic Acid (UDCA) under 30 min heating at 100oC. Hepatobiliary imaging is also used to help diagnose symptoms such as: Abdominal pain that may be caused by a sudden inflammation of the gallbladder called cholecystitis, pain or fever following surgery on the gallbladder or the upper gastrointestinal tract. Biliary atresia in newborns, a blockage in the ducts that carry bile from the liver to the gall bladder. Labeling yield and stability were analyzed by high performance liquid chromatography (labeling yield>98% and stability for 6 h) at pH 9 and 3 mg substrate. RP-HPLC was used to evaluate the radiochemical yield and purity of the labeled product. Biodistribution studies were carried out in Albino Swiss mice at different time intervals after administration of 99mTc-tricarbonyl [99mTc(CO)3(H2O)3]+ (UDCA).The uptake of complex in the liver gave the chance to diagnose it. The results indicate that the labeled compound cleared from the systematic circulation within 2 h after administration and majority of organs showed significant decrease in uptake of it. These results introduce 99mTc-tricarbonyl UDCA as a novel potential radiopharmaceutical for hepatobiliary imaging.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"27 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2015-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83238799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Diabetic Maculopathy Stages using Fundus Images","authors":"K. Nishanth","doi":"10.4172/2155-9937.1000118","DOIUrl":"https://doi.org/10.4172/2155-9937.1000118","url":null,"abstract":"The impairment and blindness are caused due to Diabetes mellitus. Most of sick person are suffering with impairment diabetes and fifty to sixty percent of ill persons are suffering due to blindness diabetes. Present paper concentrated the identification process of diabetes mellitus using a computer-based intelligent system. The method consists of non-clinically and clinically significant maculopathy and usual eye images. With the help of morphological image processing techniques the fundus are extracted from the usual eye images. Later for comparison the extracted data is applied to classifiers named as (i) feed-forward ANN and (ii) (PNN) probabilistic neural network.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"08 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2015-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86030464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"F-18 FDG Brain PET in a Para-Neoplastric Syndrome Patient with Anti NMDA Receptor Encephalitis","authors":"Ming-Kai Chen","doi":"10.4172/2155-9937.1000117","DOIUrl":"https://doi.org/10.4172/2155-9937.1000117","url":null,"abstract":"The encephalitis associated with antibodies (Ab) against the N-Methyl-D-Aspartate Receptor (NMDAR) was first discovered in 2007 [1]. Since then, there have been several reports on clinical features and diagnostic tools for better understanding the pathophysiology of this disease. Magnetic Resonance Imaging (MRI), Magnetic Resonance Spectroscopy (MRS), Electroencephalogram (EEG), Fluoro-2-Deoxy- D-Glucose Positron Emission Tomography (FDG PET), and Single Photon Emission Computed Tomography (SPECT) with 99mtc-D,LHexamethyl- Propyleneamine Oxime (HMPAO) have shown a variety of abnormal findings but with no conclusion of characteristic features. High serum Ab titer for NMDA receptor and abnormal Cerebrospinal Fluid (CSF) evaluation are present in majority of the patients [2] and have been considered the diagnostic standard. However, noninvasive imaging diagnostic evaluation of this syndrome has not been established yet.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"25 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2015-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74563580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial Experience of Monitoring Response of Breast Cancer to Bevacizumab-containing Chemotherapy using A New Integrin Specific PET Imaging Tracer (F-18)RGD-K5","authors":"S. Bahri","doi":"10.4172/2155-9937.1000116","DOIUrl":"https://doi.org/10.4172/2155-9937.1000116","url":null,"abstract":"This study investigates the use of [F-18]RGD-K5, an integrin αvβ3 targeting PET tracer, in breast cancer patients receiving chemotherapy with bevacizumab (Avastin®). Two patients were analyzed: Subject-1 had metastatic breast cancers and Subject-2 had a primary cancer in the breast. The therapy regimen was weekly paclitaxel and carboplatin combined with bi-weekly bevacizumab. Each subject received 5 PET-CT scans: pre-treatment [F-18]RGD-K5 and [F-18]FDG, one [F-18]RGD-K5 F/U scan after 2 doses of bevacizumab, and another [F-18]RGD-K5 and [F-18] FDG F/U after 4 doses of bevacizumab. Many lesions in Subject-1 showed a high [F-18]RGD-K5 baseline uptake. The two most [F-18]RGD-K5 avid lesions had SUVs of 10.8 and 10.1, and the corresponding [F-18]FDG uptakes were much lower (SUV of 1.0 and 3.5). The [F-18]RGD-K5 SUVs in all analyzed lesions decreased during treatment, showing a mean of 34% reduction after 2 doses, and 47% reduction after 4 doses of bevacizumab. The changes in the [F-18]FDG SUVs were much smaller, with a mean reduction of 24%. In contrast to the patient with metastatic cancer, the primary tumor in Subject-2 showed a low [F-18]RGD-K5 uptake (SUV=1.8), but a high [F-18]FDG uptake (SUV=8.7). The [F-18]FDG SUV decreased to 2.4 (72% reduction) after 4 doses of bevacizumab, while the [F-18] RGD-K5 uptake remained unchanged. The results that [F-18]RGD-K5 avid lesions show a great SUV reduction after bevacizumab treatment suggest that the [F-18]RGD-K5 tracer may be potentially used for selecting candidate patient for receiving bevacizumab, as well as in monitoring of the early treatment changes.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"94 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2015-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82757193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle enhanced MRI scanning to detect cellular inflammation in experimental chronic renal allograft rejection.","authors":"S R Alam, G H Tse, C Stirrat, T J MacGillivray, R J Lennen, M A Jansen, D E Newby, L Marson, P A Henriksen","doi":"10.1155/2015/507909","DOIUrl":"10.1155/2015/507909","url":null,"abstract":"<p><p>Objectives. We investigated whether ultrasmall paramagnetic particles of iron oxide- (USPIO-) enhanced magnetic resonance imaging (MRI) can detect experimental chronic allograft damage in a murine renal allograft model. Materials and Methods. Two cohorts of mice underwent renal transplantation with either a syngeneic isograft or allograft kidney. MRI scanning was performed prior to and 48 hours after USPIO infusion using T2(∗)-weighted protocols. R2(∗) values were calculated to indicate the degree of USPIO uptake. Native kidneys and skeletal muscle were imaged as reference tissues and renal explants analysed by histology and electron microscopy. Results. R2(∗) values in the allograft group were higher compared to the isograft group when indexed to native kidney (median 1.24 (interquartile range: 1.12 to 1.36) versus 0.96 (0.92 to 1.04), P < 0.01). R2(∗) values were also higher in the allograft transplant when indexed to skeletal muscle (6.24 (5.63 to 13.51)) compared to native kidney (2.91 (1.11 to 6.46) P < 0.05). Increased R2(∗) signal in kidney allograft was associated with macrophage and iron staining on histology. USPIO were identified within tissue resident macrophages on electron microscopy. Conclusion. USPIO-enhanced MRI identifies macrophage. </p>","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2015 ","pages":"507909"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33166227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Folate Receptor Targeted Optical Contrast Agents for Intraoperative Molecular Imaging.","authors":"Elizabeth De Jesus,&nbsp;Jane J Keating,&nbsp;Sumith A Kularatne,&nbsp;Jack Jiang,&nbsp;Ryan Judy,&nbsp;Jarrod Predina,&nbsp;Shuming Nie,&nbsp;Philip Low,&nbsp;Sunil Singhal","doi":"10.1155/2015/469047","DOIUrl":"https://doi.org/10.1155/2015/469047","url":null,"abstract":"<p><p>Background. Intraoperative imaging can identify cancer cells in order to improve resection; thus fluorescent contrast agents have emerged. Our objective was to do a preclinical comparison of two fluorescent dyes, EC17 and OTL38, which both target folate receptor but have different fluorochromes. Materials. HeLa and KB cells lines were used for in vitro and in vivo comparisons of EC17 and OTL38 brightness, sensitivity, pharmacokinetics, and biodistribution. In vivo experiments were then performed in mice. Results. The peak excitation and emission wavelengths of EC17 and OTL38 were 470/520 nm and 774/794 nm, respectively. In vitro, OTL38 required increased incubation time compared to EC17 for maximum fluorescence; however, peak signal-to-background ratio (SBR) was 1.4-fold higher compared to EC17 within 60 minutes (p < 0.001). Additionally, the SBR for detecting smaller quantity of cells was improved with OTL38. In vivo, the mean improvement in SBR of tumors visualized using OTL38 compared to EC17 was 3.3 fold (range 1.48-5.43). Neither dye caused noticeable toxicity in animal studies. Conclusions. In preclinical testing, OTL38 appears to have superior sensitivity and brightness compared to EC17. This coincides with the accepted belief that near infrared (NIR) dyes tend to have less autofluorescence and scattering issues than visible wavelength fluorochromes. </p>","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2015 ","pages":"469047"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/469047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34278119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Initial Performance of Simultaneous SPECT-CT Imaging Using a Commercial Multi-Modality Preclinical Imaging System.","authors":"Dustin R Osborne,&nbsp;Derek W Austin","doi":"10.1155/2015/134768","DOIUrl":"https://doi.org/10.1155/2015/134768","url":null,"abstract":"<p><p>Multi-modality imaging provides coregistered PET-CT and SPECT-CT images; however such multi-modality workflows usually consist of sequential scans from the individual imaging components for each modality. This typical workflow may result in long scan times limiting throughput of the imaging system. Conversely, acquiring multi-modality data simultaneously may improve correlation and registration of images, improve temporal alignment of the acquired data, increase imaging throughput, and benefit the scanned subject by minimizing time under anesthetic. In this work, we demonstrate the feasibility and procedure for modifying a commercially available preclinical SPECT-CT platform to enable simultaneous SPECT-CT acquisition. We also evaluate the performance of simultaneous SPECT-CT tomographic imaging with this modified system. Performance was accessed using a (57)Co source and image quality was evaluated with (99m)Tc phantoms in a series of simultaneous SPECT-CT scans. </p>","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2015 ","pages":"134768"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/134768","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33880427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}