International journal of molecular imaging最新文献_第3页

^99mTc-Sestamibi/¹²³I Subtraction SPECT/CT in Parathyroid Scintigraphy: Is Additional Pinhole Imaging Useful? 减影SPECT/CT在甲状旁腺造影中的应用:额外的针孔成像有用吗?

International journal of molecular imaging Pub Date : 2017-01-01 Epub Date: 2017-10-18 DOI: 10.1155/2017/2712018

Virpi Tunninen, Pekka Varjo, Tomi Kauppinen, Anu Holm, Hannu Eskola, Marko Seppänen

{"title":"99mTc-Sestamibi/123I Subtraction SPECT/CT in Parathyroid Scintigraphy: Is Additional Pinhole Imaging Useful?","authors":"Virpi Tunninen, Pekka Varjo, Tomi Kauppinen, Anu Holm, Hannu Eskola, Marko Seppänen","doi":"10.1155/2017/2712018","DOIUrl":"https://doi.org/10.1155/2017/2712018","url":null,"abstract":"Objectives: This retrospective study evaluated whether the use of additional anterior 99mTc-sestamibi/123I pinhole imaging improves the outcome of 99mTc-sestamibi/123I subtraction SPECT/CT in parathyroid scintigraphy (PS).Materials and methods: PS using simultaneous dual-isotope subtraction methods and an acquisition protocol combining SPECT/CT and planar pinhole imaging was performed for 175 patients with primary or secondary hyperparathyroidism. All patients who proceeded to surgery with complete postsurgery laboratory findings were included in this study (n = 94). SPECT/CT images alone and combined with pinhole images were evaluated.Results: There were 111 enlarged parathyroid glands of which 104 and 108 glands were correctly visualized by SPECT/CT (seven false positives) or SPECT/CT with pinhole (three false positives), respectively. Both sensitivity and specificity were higher with combined SPECT/CT with pinhole than with SPECT/CT alone (97% versus 94% and 99% versus 98%, resp., not significant). The false-positive rate was 6% with SPECT/CT and decreased to 3% using combined SPECT/CT with pinhole.Conclusion: 99mTc-sestamibi/123I subtraction SPECT/CT is a highly sensitive and specific protocol for PS. The use of additional anterior pinhole imaging increases both sensitivity and specificity of PS, although this increase is not statistically significant.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2017 ","pages":"2712018"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35643794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Multimodal Microscopy for Skin Cancer Diagnosis and Therapy Guidance 多模态显微镜用于皮肤癌诊断和治疗指南

International journal of molecular imaging Pub Date : 2017-01-01 DOI: 10.4172/2155-9937.1000E105

N. Iftimia, M. Rajadhyaksha

{"title":"Multimodal Microscopy for Skin Cancer Diagnosis and Therapy Guidance","authors":"N. Iftimia, M. Rajadhyaksha","doi":"10.4172/2155-9937.1000E105","DOIUrl":"https://doi.org/10.4172/2155-9937.1000E105","url":null,"abstract":"Skin cancer is an increasing burden on people of all ages. Among various types of skin cancers, basal cell carcinomas (BCCs) have the highest occurrence. About 2.5 million new cases of BCCs are diagnosed every year in the USA and another 500,000 in Europe and Australia [1,2]. BCCs occur most commonly in middle-aged and older people, but, lately, skin cancers are increasingly affecting younger people, too [3]. Approximately 80% to 90% of the cases occur on the head-and-neck, including 65% on the face, in high-risk anatomical areas such as on or near the nose, eyes, ears or mouth. Although not fatal, BCCs can cause large-scale anatomical destruction, resulting in morbidity, physical disfigurement, loss of function (breathing, hearing, swallowing and vision) and psychological trauma. Quality of life thus becomes a significant issue for these patients. Consequently, Mohs surgery guided by frozen pathology is performed to precisely remove the cancer with minimal damage to the surrounding normal skin [4]. Because Mohs surgery is guided by frozen pathology, the procedure is very effective at completely removing cancer, with five-year cure rates of 97% to 99%. However, the preparation of frozen pathology is laborintensive and time-consuming, which results in the overall Mohs procedure being expensive. As incidence rates of skin cancer continue to increase, the number of physician visits and the number of Mohs surgeries in the USA nearly doubled during the last decade. Currently, an estimated 1.5 million surgeries are performed every year, with treatments costs exceeding $3 billion [5].","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"36 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77290385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual and Quantitative Assessment of a New Anisotropic Diffusion Filter (Statistical Transfer with Optimizing Noise and Edge Sensing) for Positron Emission Tomography 一种用于正电子发射断层扫描的新型各向异性扩散滤波器(具有优化噪声和边缘传感的统计传递)的视觉和定量评价

International journal of molecular imaging Pub Date : 2017-01-01 DOI: 10.4172/2155-9937.1000137

Hitoshi Iizuka, T. Kaneta, Matsuyoshi Ogawa, N. Motomura, T. Arisawa, Ayako Hino-Shishikura, Keisuke Yoshida, Tomio Inoue

{"title":"Visual and Quantitative Assessment of a New Anisotropic Diffusion Filter (Statistical Transfer with Optimizing Noise and Edge Sensing) for Positron Emission Tomography","authors":"Hitoshi Iizuka, T. Kaneta, Matsuyoshi Ogawa, N. Motomura, T. Arisawa, Ayako Hino-Shishikura, Keisuke Yoshida, Tomio Inoue","doi":"10.4172/2155-9937.1000137","DOIUrl":"https://doi.org/10.4172/2155-9937.1000137","url":null,"abstract":"Post-filtering with a Gaussian filter is commonly used to reduce noise in positron emission tomography (PET) images. However, its non-selective smoothing obscures the edges of lesions or organs. We compared the performance of a newly developed anisotropic diffusion filter called “Statistical Transfer with Optimizing Noise and Edge Sensing” (STONES) with that of the Gaussian filter for small lesions on PET images. We selected seven PET/computed tomography (CT) image slices of the lungs from three patients with multiple lung metastases. For each slice, the lesion detection rates by two physicians (A and B) were compared for Gaussian- and STONES-filtered PET images. The maximum standardized uptake (SUVmax) values of the detected lesions were also compared for non-, Gaussian-, and STONES-filtered images. Physician A detected 19 lesions in the Gaussian-filtered images and 23 lesions in the STONES-filtered images, while Physician B detected 14 lesions in the Gaussian-filtered images and 19 lesions in the STONES-filtered images. SUVmax for the STONES-filtered images was significantly higher and closer to that of the non-filtered images compared to those for the Gaussian-filtered images. STONES improved the detection rate and increased SUVmax in comparison with Gaussian filter. Thus, it should be more advantageous for the detection of small lesions with PET.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"76 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72686426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Antenna for Microwave Imaging Systems for Breast Cancer Detection 乳腺癌微波成像系统天线的研制

International journal of molecular imaging Pub Date : 2016-12-28 DOI: 10.4172/2155-9937.1000128

S. Al-habsi, Thuraiya ARuzaiqi, Khalid AlHadharami, S. Gopinathan

{"title":"Development of Antenna for Microwave Imaging Systems for Breast Cancer Detection","authors":"S. Al-habsi, Thuraiya ARuzaiqi, Khalid AlHadharami, S. Gopinathan","doi":"10.4172/2155-9937.1000128","DOIUrl":"https://doi.org/10.4172/2155-9937.1000128","url":null,"abstract":"Motivation: Breast cancer is a major health problem globally for women causing an appreciable percentage of the yearly female death. Microwave imaging is a promising method in biomedical applications such as breast cancer detection due to its good penetration property, non-ionizing and non-invasive nature which has the potential to be a complementary modality to standard mammography. In this paper, An UWB Microstrip-fed Vivaldi antenna for microwave imaging systems aimed for an early breast cancer detection is developed. \u0000Results: The Vivaldi antenna is designed to operate between 8.821 to 22.30 GHz with dimensions of 44.85 × 25.28 mm that permits good radiation within the frequency range. To achieve UWB performance, Taconic TLC-32 substrate which has relative permittivity of 3.2 has been used to simulate the antenna by using Antenna Magus Software. The simulation results show that the return loss is better than -10dB within the range of 7.143 GHz to 24.60 GHz with the maximum return loss of -37.56 dB at 18.39 GHz. However, due to difficulties in antenna fabrication at higher frequencies, a low frequency of about 2.4 GHz is considered. Antenna measurements presents good radiation pattern that suit medical imaging systems to detect breast tumors. The amount of reflection is also found to be minimum for the antenna design frequency (2.4 GHz) which appears to be -26.34 db.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"32 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78557152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Visualization of Inflammation at Early Stage of Lung Cancer in Xenografted Temporally Immunosuppression Rats by Ferrioxamine Magnetic Resonance Imaging 铁胺磁共振成像显示异种移植性颞叶免疫抑制大鼠早期肺癌炎症

International journal of molecular imaging Pub Date : 2016-12-15 DOI: 10.1155/2016/8434308

N. Dechsupa, C. Udomtanakunchai, Anan Udom-Utraracheva, Dutsadee Suttho, L. Pazart, P. Humbert, M. Garrigos, S. Mankhetkorn

{"title":"Visualization of Inflammation at Early Stage of Lung Cancer in Xenografted Temporally Immunosuppression Rats by Ferrioxamine Magnetic Resonance Imaging","authors":"N. Dechsupa, C. Udomtanakunchai, Anan Udom-Utraracheva, Dutsadee Suttho, L. Pazart, P. Humbert, M. Garrigos, S. Mankhetkorn","doi":"10.1155/2016/8434308","DOIUrl":"https://doi.org/10.1155/2016/8434308","url":null,"abstract":"Physiological responses such as chronic inflammation and angiogenesis could be used as biomarkers for early detection of cancer with noninvasive imaging modalities. The present study reports the application of magnetic resonance imaging instrument to image the binding of ferrioxamine with hemin that allows visualizing the chronic inflammation foci of lung tissue of immunocompromised rats xenografted using small cell lung carcinoma. A low concentration of ferrioxamine (0.05 ± 0.02 μM·kg−1 of rat weight) deposited on tissue outside the vasculature was found to diffuse across the capillary walls to the interstitial space and inflammation foci, which provided a clear enhancement of T1-weighted gradient-echo sequence images. Ferrioxamine imaging allowed the determination of inflammatory sites and their localization in 3D fat-suppressed maximum intensity projections. The smallest dimension of foci that can be clearly determined is about 0.1 mm3. In concomitant to the in vivo imaging, analysis of histological tissue section showed the development of inflammatory sites. This study provides evidence that medical imaging instrument such as MRI scanner allows researchers to correlate images taken with MRI with those using high-resolution microscopy. Moreover, ferrioxamine is a useful molecular probe for determining chronic inflammation particularly at the very early stages of cancer.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8434308","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64569075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding Lung Deposition of Alpha-1 Antitrypsin in Acute Experimental Mouse Lung Injury Model Using Fluorescence Microscopy 用荧光显微镜观察α -1抗胰蛋白酶在急性实验性小鼠肺损伤模型中的肺沉积

International journal of molecular imaging Pub Date : 2016-12-06 DOI: 10.1155/2016/5768312

Mengmeng Wang, Y. Zhan, Jianqing Chen, H. Rong, S. O’Neil, Brahma Ghosh, Vuong Nguyen, J. Owens, Xianfeng Li, Denise M O'Hara

{"title":"Understanding Lung Deposition of Alpha-1 Antitrypsin in Acute Experimental Mouse Lung Injury Model Using Fluorescence Microscopy","authors":"Mengmeng Wang, Y. Zhan, Jianqing Chen, H. Rong, S. O’Neil, Brahma Ghosh, Vuong Nguyen, J. Owens, Xianfeng Li, Denise M O'Hara","doi":"10.1155/2016/5768312","DOIUrl":"https://doi.org/10.1155/2016/5768312","url":null,"abstract":"Human plasma-derived α1-antitrypsin (AAT) delivered by intravenous infusion is used as augmentation therapy in patients with emphysema who have a genetic mutation resulting in deficiency of AAT. Inhalation is an alternative route of administration that can potentially increase the efficacy and convenience of treatment. This study was conducted to determine whether delivery to the lungs, initially via the intratracheal (IT) route of administration, would deliver efficacious levels of a recombinant AAT (rAAT) to the site of action in the lungs in mice. 125I-radiolabeled rAAT, fluorophore-conjugated rAAT (rAAT-Alexa488), and NE680 (neutrophil elastase 680, a silent fluorescent substrate of neutrophil elastase which fluoresces in the near-infrared range upon activation by neutrophil elastase) were used to characterize the pharmacokinetics and tissue distribution profile, distribution of rAAT within the lung, and efficacy of rAAT to inhibit neutrophil elastase at the site of action, respectively. The study has demonstrated that rAAT was able to gain access to locations where neutrophil elastase was localized. The histochemical quantification of rAAT activity relative to dose at the site of action provided here will improve confidence in predicting the human dose via the inhalation route.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/5768312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64438846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Kala-Azar is a Neglected Tropical Disease 黑热病是一种被忽视的热带病

International journal of molecular imaging Pub Date : 2016-11-16 DOI: 10.4172/2155-9937.1000i107

S. Bhattacharya, A. Dash, P. Sinha

引用次数: 0

Gynecomastia in a Young Male 年轻男性的男性乳房发育症

International journal of molecular imaging Pub Date : 2016-11-05 DOI: 10.4172/2155-9937.1000i106

S. Bhattacharya

引用次数: 1

Optimizing STORM Imaging Conditions for Identifying Single MoleculesUnder Cellular Auto-fluorescence Background 细胞自荧光背景下单分子识别的STORM成像条件优化

International journal of molecular imaging Pub Date : 2016-11-04 DOI: 10.4172/2155-9937.1000127

Bo Cao, Tszshan Ma, Gang Niu, Danni Chen, Jianjiang Hu, Chen Xu, Yanxiang Ni, Michael Q. Zhang, H. Niu

{"title":"Optimizing STORM Imaging Conditions for Identifying Single MoleculesUnder Cellular Auto-fluorescence Background","authors":"Bo Cao, Tszshan Ma, Gang Niu, Danni Chen, Jianjiang Hu, Chen Xu, Yanxiang Ni, Michael Q. Zhang, H. Niu","doi":"10.4172/2155-9937.1000127","DOIUrl":"https://doi.org/10.4172/2155-9937.1000127","url":null,"abstract":"Stochastic Optical Reconstruction Microscopy (STORM) imaging of fluorophore-labeled single molecules in biological samples is interfered by unavoidable cellular auto-fluorescence. This situation is improved by pairing fluorophores with activator dyes, which enhances fluorescence signals but restricts its application in biomedical studies. To address this issue, we optimized STORM imaging conditions for sparsely-distributing Alexa-647 samples simultaneously illuminated by a 641-nm excitation and a 405-nm reactivation lasers. We found that, compared to a frame frequency of 46 Hz or 85 Hz in STORM imaging, low frequency (20 Hz) resulted in a relatively high background fluorescence but had no obvious effect on specific signals of Alexa-647 in cell-free samples. In fixed human cells, high frequency (85 Hz) was superior in distinguishing sparse Alexa-647 fluorophores from cellular autofluorescence. Furthermore, a small false discovery rate was achieved with the use of moderate but not intensive powers of excitation and reactivation lasers. With the selected rather than original frame frequency and laser intensity, low fluorescence background and high detection efficiency of fluorophores were obtained for cell samples sparsely labeled with a range of Alexa-647 concentrations. Therefore, this study optimized STORM imaging conditions and promoted detection sensitivity and efficiency of single molecules in cells in an activator dye-independent way.","PeriodicalId":89157,"journal":{"name":"International journal of molecular imaging","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88227569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiochemical and Biological Evaluation of 99mTc-Labeling of Phthalic Acid Using 99mTc-Tricabonyl and 99mTc-Sn (II) As a Model for Potential Hazards Imaging 利用99mTc-Tricabonyl和99mTc-Sn (II)作为潜在危害成像模型的邻苯二甲酸99mtc标记的放射化学和生物学评价

International journal of molecular imaging Pub Date : 2016-10-28 DOI: 10.4172/2155-9937.1000126

M. Sanad, Saad Mm, Fouzy Asm, F. Marzook, Ibrahim It

引用次数: 6