Biogerontology最新文献_第9页

Plasma proteins as potential biomarkers of aging of single tissue and cell type. 血浆蛋白作为单一组织和细胞类型衰老的潜在生物标志物。

IF 4.5 4区医学

Biogerontology Pub Date : 2024-02-01 Epub Date: 2023-09-14 DOI: 10.1007/s10522-023-10065-8

Daigo Okada

{"title":"Plasma proteins as potential biomarkers of aging of single tissue and cell type.","authors":"Daigo Okada","doi":"10.1007/s10522-023-10065-8","DOIUrl":"10.1007/s10522-023-10065-8","url":null,"abstract":"Plasma proteins serve as biomarkers of aging and various age-related diseases. While a number of plasma proteins have been identified that increase or decrease with age, the interpretation of each protein is challenging. This is due to the nature of plasma, which is a mixture of factors secreted by many different tissues and cells. Therefore, the catalog of age-related proteins secreted by a single cell type in a single tissue would be useful for understanding tissue-specific aging patterns. In this study, the author addressed this challenge by integrative data mining of the Human Protein Atlas and the recently published result of large-scale aging proteomics research. Finally, we identified the 17 age-related proteins produced by a single tissue and a single cell type: MBL2 and HP in the liver (hepatocytes), SFTPC in the lung (type II alveolar cells), PRL and POMC in the pituitary (anterior cells), GCG, CUZD1 and CPA2 in the pancreas (pancreatic cells), MYBPC1 in skeletal muscle (myocytes), PTH in the parathyroid gland (glandular cells), LPO and AMY1A in the salivary gland (glandular cells), INSL3 in the male testis (Leydig cells), KLK3 and KLK4 in the male prostate (glandular cells), MPO and ACP5 in immune cells. This list of proteins would be potentially useful for understanding age-related changes in the plasma proteome and inter-tissue networks.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10224436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses. 在细胞衰老和其他应激反应中与 FOXO3 相关的微小 RNA。

IF 4.5 4区医学

Biogerontology Pub Date : 2024-02-01 Epub Date: 2023-08-30 DOI: 10.1007/s10522-023-10059-6

Yi-Sheng Khor, Pooi-Fong Wong

引用次数: 0

Role of sestrins in metabolic and aging-related diseases. 雌甾素在代谢和衰老相关疾病中的作用。

IF 4.5 4区医学

Biogerontology Pub Date : 2024-02-01 Epub Date: 2023-07-30 DOI: 10.1007/s10522-023-10053-y

Huan Fang, Xiaomin Shi, Juyi Wan, Xiaolin Zhong

引用次数: 0

Aging adipose tissue, insulin resistance, and type 2 diabetes. 衰老的脂肪组织、胰岛素抵抗和2型糖尿病。

IF 4.5 4区医学

Biogerontology Pub Date : 2024-02-01 Epub Date: 2023-09-19 DOI: 10.1007/s10522-023-10067-6

Yixuan Zhao, Rensong Yue

引用次数: 0

Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease. 槲皮素和达沙替尼，这两种治疗年龄相关心血管疾病的强效解毒剂。

IF 4.5 4区医学

Biogerontology Pub Date : 2024-02-01 Epub Date: 2023-09-25 DOI: 10.1007/s10522-023-10068-5

Mario Nieto, Mina Konigsberg, Alejandro Silva-Palacios

引用次数: 0

Application potential of senolytics in clinical treatment 衰老剂在临床治疗中的应用潜力

IF 4.5 4区医学

Biogerontology Pub Date : 2023-12-18 DOI: 10.1007/s10522-023-10084-5

Tiantian Li, Shiyuan Li, Kefeng Ma, Jinming Kong

{"title":"Application potential of senolytics in clinical treatment","authors":"Tiantian Li, Shiyuan Li, Kefeng Ma, Jinming Kong","doi":"10.1007/s10522-023-10084-5","DOIUrl":"https://doi.org/10.1007/s10522-023-10084-5","url":null,"abstract":"Of the factors studied in individual ageing, the accumulation of senescent cells has been considered as an essential cause of organ degeneration to eventually initiate age-related diseases. Cellular senescence is attributed to the accumulation of damage for an inducement in the activation of cell cycle inhibitory pathways, resulting the cell permanently withdraw from the cell proliferation cycle. Further, senescent cells will activate the inflammatory factor secretion pathway to promote the development of various age-related diseases. Senolytics, a small molecule compound, can delay disease development and extend mammalian lifespan. The evidence from multiple trials shows that the targeted killing of senescent cells has a significant clinical application for the treatment of age-related diseases. In addition, senolytics are also significant for the development of ageing research in solid organ transplantation, which can fully develop the potential of elderly organs and reduce the age gap between demand and supply. We conclude that the main characteristics of cellular senescence, the anti-ageing drug senolytics in the treatment of chronic diseases and organ transplantation, and the latest clinical progress of related researches in order to provide a theoretical basis for the prevention and treatment of ageing and related diseases.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138714587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telomere length and cancer risk: finding Goldilocks 端粒长度与癌症风险：寻找金发姑娘

IF 4.5 4区医学

Biogerontology Pub Date : 2023-12-18 DOI: 10.1007/s10522-023-10080-9

Sharon A. Savage

{"title":"Telomere length and cancer risk: finding Goldilocks","authors":"Sharon A. Savage","doi":"10.1007/s10522-023-10080-9","DOIUrl":"https://doi.org/10.1007/s10522-023-10080-9","url":null,"abstract":"Telomeres are the nucleoprotein complex at chromosome ends essential in genomic stability. Baseline telomere length (TL) is determined by rare and common germline genetic variants but shortens with age and is susceptible to certain environmental exposures. Cellular senescence or apoptosis are normally triggered when telomeres reach a critically short length, but cancer cells overcome these protective mechanisms and continue to divide despite chromosomal instability. Rare germline variants in telomere maintenance genes cause exceedingly short telomeres for age (< 1st percentile) and the telomere biology disorders, which are associated with elevated risks of bone marrow failure, myelodysplastic syndrome, acute myeloid leukemia, and squamous cell carcinoma of the head/neck and anogenital regions. Long telomeres due to rare germline variants in the same or different telomere maintenance genes are associated with elevated risks of other cancers, such as chronic lymphocytic leukemia or sarcoma. Early epidemiology studies of TL in the general population lacked reproducibility but new methods, including creation of a TL polygenic score using common variants, have found longer telomeres associated with excess risks of renal cell carcinoma, glioma, lung cancer, and others. It has become clear that when it comes to TL and cancer etiology, not too short, not too long, but “just right” telomeres are important in minimizing cancer risk.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138714537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How soon do metabolic alterations and oxidative distress precede the reduction of muscle mass and strength in Wistar rats in aging process? 在 Wistar 大鼠衰老过程中，肌肉质量和力量下降之前多久会出现新陈代谢改变和氧化损伤？

IF 4.5 4区医学

Biogerontology Pub Date : 2023-12-08 DOI: 10.1007/s10522-023-10078-3

Malu Cristina de Araújo Montoro Lima, Matheus Felipe Zazula, Luiz Fernando Martins, Stephanie Rubiane Carvalhal, Ana Tereza Bittencourt Guimarães, Luiz Claudio Fernandes, Katya Naliwaiko

引用次数: 0

Zbp1 gene: a modulator of multiple aging hallmarks as potential therapeutic target for age-related diseases. Zbp1基因：一种具有多种衰老特征的调节剂，是年龄相关疾病的潜在治疗靶点。

IF 4.5 4区医学

Biogerontology Pub Date : 2023-12-01 Epub Date: 2023-05-18 DOI: 10.1007/s10522-023-10039-w

Mehran Radak, Hossein Fallahi

{"title":"Zbp1 gene: a modulator of multiple aging hallmarks as potential therapeutic target for age-related diseases.","authors":"Mehran Radak, Hossein Fallahi","doi":"10.1007/s10522-023-10039-w","DOIUrl":"10.1007/s10522-023-10039-w","url":null,"abstract":"The Zbp1 gene has recently emerged as a potential therapeutic target for age-related diseases. Multiple studies have reported that Zbp1 plays a key role in regulating several aging hallmarks, including cellular senescence, chronic inflammation, DNA damage response, and mitochondrial dysfunction. Regarding cellular senescence, Zbp1 appears to regulate the onset and progression of senescence by controlling the expression of key markers such as p16INK4a and p21CIP1/WAF1. Similarly, evidence suggests that Zbp1 plays a role in regulating inflammation by promoting the production of pro-inflammatory cytokines, such as IL-6 and IL-1β, through activation of the NLRP3 inflammasome. Furthermore, Zbp1 seems to be involved in the DNA damage response, coordinating the cellular response to DNA damage by regulating the expression of genes such as p53 and ATM. Additionally, Zbp1 appears to regulate mitochondrial function, which is crucial for energy production and cellular homeostasis. Given the involvement of Zbp1 in multiple aging hallmarks, targeting this gene represents a potential strategy to prevent or treat age-related diseases. For example, inhibiting Zbp1 activity could be a promising approach to reduce cellular senescence and chronic inflammation, two critical hallmarks of aging associated with various age-related diseases. Similarly, modulating Zbp1 expression or activity could also improve DNA damage response and mitochondrial function, thus delaying or preventing the development of age-related diseases. Overall, the Zbp1 gene appears to be a promising therapeutic target for age-related diseases. In the current review, we have discussed the molecular mechanisms underlying the involvement of Zbp1 in aging hallmarks and proposed to develop effective strategies to target this gene for therapeutic purposes.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9479158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging impairs recovery from stress-induced depression in male rats possibly by alteration of microRNA-101 expression and Rac1/RhoA pathway in the prefrontal cortex. 衰老可能通过前额叶皮层微小RNA-101表达和Rac1/RhoA通路的改变，损害雄性大鼠从压力诱导的抑郁症中恢复。

IF 4.5 4区医学

Biogerontology Pub Date : 2023-12-01 Epub Date: 2023-08-29 DOI: 10.1007/s10522-023-10056-9

Arshad Ghaffari-Nasab, Gonja Javani, Gisou Mohaddes, Mohammad Reza Alipour

{"title":"Aging impairs recovery from stress-induced depression in male rats possibly by alteration of microRNA-101 expression and Rac1/RhoA pathway in the prefrontal cortex.","authors":"Arshad Ghaffari-Nasab, Gonja Javani, Gisou Mohaddes, Mohammad Reza Alipour","doi":"10.1007/s10522-023-10056-9","DOIUrl":"10.1007/s10522-023-10056-9","url":null,"abstract":"Along with altering brain responses to stress, aging may also impair recovery from depression symptoms. In the present study, we investigated depressive-like behaviors in young and aged rats and assayed the levels of microRNA-101 (miR-101), Rac1/RhoA, PSD-95, and GluR1 in the prefrontal cortex (PFC) after stress cessation and after a recovery period. Young (3 months old) and aged (22 months old) male Wistar rats were divided into six groups; Young control (YNG), young rats received chronic stress for four weeks (YNG + CS), young rats received chronic stress for four weeks followed by a 6-week recovery period (YNG + CS + REC), Aged control (AGED), aged rats received chronic stress for four weeks (AGED + CS), and aged rats received chronic stress for four weeks followed by a 6-week recovery period (AGED + CS + REC). Stress-induced depression, evaluated by the sucrose preference test (SPT) and forced swimming test (FST), was yet observed after the recovery period in aged but not in young rats, which were accompanied by unchanged levels of miR-101, Rac1/RhoA, GluR1, and PSD-95 in the PFC of aged rats. These data suggested that impaired synaptic plasticity of glutamatergic synapses via the miR-101/Rac1/RhoA pathway may contribute to the delayed behavioral recovery after stress exposure observed in aging animals.","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10103239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0