Biomimetics最新文献_第4页

Multimodal Fusion Image Stabilization Algorithm for Bio-Inspired Flapping-Wing Aircraft. 仿生扑翼飞机多模态融合稳像算法。

IF 3.9 3区医学

Biomimetics Pub Date : 2025-07-07 DOI: 10.3390/biomimetics10070448

Zhikai Wang, Sen Wang, Yiwen Hu, Yangfan Zhou, Na Li, Xiaofeng Zhang

{"title":"Multimodal Fusion Image Stabilization Algorithm for Bio-Inspired Flapping-Wing Aircraft.","authors":"Zhikai Wang, Sen Wang, Yiwen Hu, Yangfan Zhou, Na Li, Xiaofeng Zhang","doi":"10.3390/biomimetics10070448","DOIUrl":"10.3390/biomimetics10070448","url":null,"abstract":"This paper presents FWStab, a specialized video stabilization dataset tailored for flapping-wing platforms. The dataset encompasses five typical flight scenarios, featuring 48 video clips with intense dynamic jitter. The corresponding Inertial Measurement Unit (IMU) sensor data are synchronously collected, which jointly provide reliable support for multimodal modeling. Based on this, to address the issue of poor image acquisition quality due to severe vibrations in aerial vehicles, this paper proposes a multi-modal signal fusion video stabilization framework. This framework effectively integrates image features and inertial sensor features to predict smooth and stable camera poses. During the video stabilization process, the true camera motion originally estimated based on sensors is warped to the smooth trajectory predicted by the network, thereby optimizing the inter-frame stability. This approach maintains the global rigidity of scene motion, avoids visual artifacts caused by traditional dense optical flow-based spatiotemporal warping, and rectifies rolling shutter-induced distortions. Furthermore, the network is trained in an unsupervised manner by leveraging a joint loss function that integrates camera pose smoothness and optical flow residuals. When coupled with a multi-stage training strategy, this framework demonstrates remarkable stabilization adaptability across a wide range of scenarios. The entire framework employs Long Short-Term Memory (LSTM) to model the temporal characteristics of camera trajectories, enabling high-precision prediction of smooth trajectories.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12292680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of Schizophrenia Using Feature Extraction from EEG Signals Based on Markov Transition Fields and Deep Learning. 基于马尔可夫过渡场和深度学习的脑电信号特征提取诊断精神分裂症。

IF 3.9 3区医学

Biomimetics Pub Date : 2025-07-07 DOI: 10.3390/biomimetics10070449

Alka Jalan, Deepti Mishra, Marisha, Manjari Gupta

{"title":"Diagnosis of Schizophrenia Using Feature Extraction from EEG Signals Based on Markov Transition Fields and Deep Learning.","authors":"Alka Jalan, Deepti Mishra, Marisha, Manjari Gupta","doi":"10.3390/biomimetics10070449","DOIUrl":"10.3390/biomimetics10070449","url":null,"abstract":"Diagnosing schizophrenia using Electroencephalograph (EEG) signals is a challenging task due to the subtle and overlapping differences between patients and healthy individuals. To overcome this difficulty, deep learning has shown strong potential, especially given its success in image recognition tasks. In many studies, one-dimensional EEG signals are transformed into two-dimensional representations to allow for image-based analysis. In this work, we have used the Markov Transition Field for converting EEG signals into two-dimensional images, capturing both the temporal patterns and statistical dynamics of the data. EEG signals are continuous time-series recordings from the brain, where the current state is often influenced by the immediately preceding state. This characteristic makes MTF particularly suitable for representing such data. After the transformation, a pre-trained VGG-16 model is employed to extract meaningful features from the images. The extracted features are then passed through two separate classification pipelines. The first uses a traditional machine learning model, Support Vector Machine, while the second follows a deep learning approach involving an autoencoder for feature selection and a neural network for final classification. The experiments were conducted using EEG data from the open-access Schizophrenia EEG database provided by MV Lomonosov Moscow State University. The proposed method achieved a highest classification accuracy of 98.51 percent and a recall of 100 percent across all folds using the deep learning pipeline. The Support Vector Machine pipeline also showed strong performance with a best accuracy of 96.28 percent and a recall of 97.89 percent. The proposed deep learning model represents a biomimetic approach to pattern recognition and decision-making.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12292799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Approach to Semantic Visual SLAM for Bionic Robots Based on Loop Closure Detection with Combinatorial Graph Entropy in Complex Dynamic Scenes. 基于组合图熵闭环检测的复杂动态场景仿生机器人语义视觉SLAM方法。

IF 3.9 3区医学

Biomimetics Pub Date : 2025-07-06 DOI: 10.3390/biomimetics10070446

Dazheng Wang, Jingwen Luo

{"title":"Approach to Semantic Visual SLAM for Bionic Robots Based on Loop Closure Detection with Combinatorial Graph Entropy in Complex Dynamic Scenes.","authors":"Dazheng Wang, Jingwen Luo","doi":"10.3390/biomimetics10070446","DOIUrl":"10.3390/biomimetics10070446","url":null,"abstract":"In complex dynamic environments, the performance of SLAM systems on bionic robots is susceptible to interference from dynamic objects or structural changes in the environment. To address this problem, we propose a semantic visual SLAM (vSLAM) algorithm based on loop closure detection with combinatorial graph entropy. First, in terms of the dynamic feature detection results of YOLOv8-seg, the feature points at the edges of the dynamic object are finely judged by calculating the mean absolute deviation (MAD) of the depth of the pixel points. Then, a high-quality keyframe selection strategy is constructed by combining the semantic information, the average coordinates of the semantic objects, and the degree of variation in the dense region of feature points. Subsequently, the unweighted and weighted graphs of keyframes are constructed according to the distribution of feature points, characterization points, and semantic information, and then a high-performance loop closure detection method based on combinatorial graph entropy is developed. The experimental results show that our loop closure detection approach exhibits higher precision and recall in real scenes compared to the bag-of-words (BoW) model. Compared with ORB-SLAM2, the absolute trajectory accuracy in high-dynamic sequences improved by an average of 97.01%, while the number of extracted keyframes decreased by an average of 61.20%.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12292993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Unilateral Jumping Structures of the Spotted Lanternfly, Lycorma delicatula (Hemiptera: Fulgoridae): A Highly Functional and Integrated Unit. 斑点灯笼蝇的单侧跳跃结构，Lycorma delicatula（半翅目：斑点灯笼蝇科）：一个高度功能性和整体性的单位。

IF 3.9 3区医学

Biomimetics Pub Date : 2025-07-06 DOI: 10.3390/biomimetics10070444

Xu Chen, Aiping Liang

{"title":"The Unilateral Jumping Structures of the Spotted Lanternfly, Lycorma delicatula (Hemiptera: Fulgoridae): A Highly Functional and Integrated Unit.","authors":"Xu Chen, Aiping Liang","doi":"10.3390/biomimetics10070444","DOIUrl":"10.3390/biomimetics10070444","url":null,"abstract":"Previous research on the jumping structures of insects with strong leaping abilities mainly focused on overall jumping mechanisms. Our study reveals that the unilateral jumping structures (UJSs) of L. delicatula has relative functional autonomy. The UJSs consist of three distinct but interconnected parts: (1) energy storage component: it comprises the pleural arch and trochanteral depressor muscles, with the deformation zone extending about two-thirds of the pleural arch from the V-notch to the U-notch; (2) coupling component: made up of the coxa and trochanter, it serves as a bridge between the energy and lever components, connecting them via protuberances and pivots; and (3) lever component: it encompasses the femur, tibia, and tarsus. A complete jumping action lasts from 2.4 ms to 4.6 ms. During a jump, the deformation length of the pleural arch is 0.96 ± 0.06 mm. The angles &ang;ct (angle between coxa and trochanter), &ang;fp (angle between femur and pleural arch), and &ang;ft (angle between femur and tibia) change by 57.42 ± 1.60, 101.40 ± 1.59, and 36.06 ± 2.41 degrees, respectively. In this study, we abstracted the jumping structures of L. delicatula and identified its critical components. The insights obtained from this study are anticipated to provide valuable inspiration for the design and fabrication of biomimetic jumping mechanisms.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sharpbelly Fish Optimization Algorithm: A Bio-Inspired Metaheuristic for Complex Engineering. sharphbelly Fish优化算法：一种生物启发的复杂工程元启发式算法。

IF 3.9 3区医学

Biomimetics Pub Date : 2025-07-05 DOI: 10.3390/biomimetics10070445

Jian Liu, Rong Wang, Yonghong Deng, Xiaona Huang, Zhibin Li

{"title":"Sharpbelly Fish Optimization Algorithm: A Bio-Inspired Metaheuristic for Complex Engineering.","authors":"Jian Liu, Rong Wang, Yonghong Deng, Xiaona Huang, Zhibin Li","doi":"10.3390/biomimetics10070445","DOIUrl":"10.3390/biomimetics10070445","url":null,"abstract":"This paper introduces a novel bio-inspired metaheuristic algorithm, named the sharpbelly fish optimizer (SFO), inspired by the collective ecological behaviors of the sharpbelly fish. The algorithm integrates four biologically motivated strategies-(1) fitness-driven fast swimming, (2) convergence-guided gathering, (3) stagnation-triggered dispersal, and (4) disturbance-induced escape-which synergistically enhance the balance between global exploration and local exploitation. To assess its performance, the proposed SFO is evaluated on the CEC2022 benchmark suite under various dimensions. The experimental results demonstrate that SFO consistently achieves competitive or superior optimization accuracy and convergence speed compared to seven state-of-the-art metaheuristic algorithms. Furthermore, the algorithm is applied to three classical constrained engineering design problems: pressure vessel, speed reducer, and gear train design. In these applications, SFO exhibits strong robustness and solution quality, validating its potential as a general-purpose optimization tool for complex real-world problems. These findings highlight SFO's effectiveness in tackling nonlinear, constrained, and multimodal optimization tasks, with promising applicability in diverse engineering scenarios.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12292082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Advances and Future Perspectives of Liver-on-a-Chip Platforms Incorporating Dynamic Fluid Flow. 结合动态流体流动的肝脏芯片平台的最新进展和未来展望。

IF 3.9 3区医学

Biomimetics Pub Date : 2025-07-04 DOI: 10.3390/biomimetics10070443

Jingyeong Yun, Tae-Joon Jeon, Sun Min Kim

{"title":"Current Advances and Future Perspectives of Liver-on-a-Chip Platforms Incorporating Dynamic Fluid Flow.","authors":"Jingyeong Yun, Tae-Joon Jeon, Sun Min Kim","doi":"10.3390/biomimetics10070443","DOIUrl":"10.3390/biomimetics10070443","url":null,"abstract":"The liver is a vital organ responsible for a broad range of metabolic functions, including glucose and lipid metabolism, detoxification, and protein synthesis. Its structural complexity, characterized by hexagonal hepatic lobules composed of diverse parenchymal and non-parenchymal cell types, supports its broad spectrum of physiological activities. Traditional in vitro liver models have contributed significantly to our understanding of hepatic biology and the development of therapies for liver-related diseases. However, static culture systems fail to replicate the dynamic in vivo microenvironment, particularly the continuous blood flow and shear stress that are critical for maintaining hepatocyte function and metabolic zonation. Recent advances in microphysiological systems (MPS) incorporating dynamic fluid flow have addressed these limitations by providing more physiologically relevant platforms for modeling liver function. These systems offer improved fidelity for applications in drug screening, toxicity testing, and disease modeling. Furthermore, the integration of liver MPS with other organ models in multi-organ-on-chip platforms has enabled the investigation of inter-organ crosstalk, enhancing the translational potential of in vitro systems. This review summarizes recent progress in the development of dynamic liver MPS, highlights their biomedical applications, and discusses future directions for creating more comprehensive and predictive in vitro models.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Binder Jetting 3D Printing of Biomass-Fungi Composite Materials: A Preliminary Experimental Study. 生物质-真菌复合材料粘结剂喷射3D打印的初步实验研究。

IF 3.9 3区医学

Biomimetics Pub Date : 2025-07-04 DOI: 10.3390/biomimetics10070441

Yeasir Mohammad Akib, Caleb Oliver Bedsole, Jackson Sanders, Harlie Warren, Zhijian Pei, Brian D Shaw

{"title":"Binder Jetting 3D Printing of Biomass-Fungi Composite Materials: A Preliminary Experimental Study.","authors":"Yeasir Mohammad Akib, Caleb Oliver Bedsole, Jackson Sanders, Harlie Warren, Zhijian Pei, Brian D Shaw","doi":"10.3390/biomimetics10070441","DOIUrl":"10.3390/biomimetics10070441","url":null,"abstract":"This paper reports on a preliminary experimental study on binder jetting 3D printing of biomass-fungi composite materials. Biomass-fungi composite materials have potential applications in the packaging, furniture, and construction industries. Biomass particles (prepared from agricultural residues) act as the substrate of the composite materials. The filamentous roots of fungi intertwine and bind biomass particles together. In this study, the biomass (hemp hurd) powders used had two distinct average particle sizes. The liquid binder used contained fungi (Trametes versicolor) cells. T-shaped samples were printed using a lab-designed binder jetting setup. Printed samples were kept inside an incubator oven for four days to allow fungi to grow. Afterward, loose biomass powder was removed from the T-shaped samples. The samples were then kept inside the incubator oven for eight more days to allow further fungal growth. The samples were subsequently placed in an oven at 120 °C for four hours to terminate all fungal activity in the samples. SEM micrographs were taken of the cross-sectional surfaces of the samples. The micrographs showed a significant presence of fungi hyphae inside the printed samples, providing evidence of the binding of biomass particles by the hyphae.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12292789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the Biological Functionality of Hydrogels Using Self-Assembling Peptides. 利用自组装肽增强水凝胶的生物功能。

IF 3.9 3区医学

Biomimetics Pub Date : 2025-07-04 DOI: 10.3390/biomimetics10070442

Woo Hyun Kwon, Kyoung Choi, Sang Jun Park, GeumByeol Park, Cho Young Park, Yoo Han Seo, Chun-Ho Kim, Jun Shik Choi

{"title":"Enhancing the Biological Functionality of Hydrogels Using Self-Assembling Peptides.","authors":"Woo Hyun Kwon, Kyoung Choi, Sang Jun Park, GeumByeol Park, Cho Young Park, Yoo Han Seo, Chun-Ho Kim, Jun Shik Choi","doi":"10.3390/biomimetics10070442","DOIUrl":"10.3390/biomimetics10070442","url":null,"abstract":"Hydrogels are ECM-mimicking three-dimensional (3D) networks that are widely used in biomedical applications; however, conventional natural and synthetic polymer-based hydrogels present limitations such as poor mechanical strength, limited bioactivity, and low reproducibility. Self-assembling peptides (SAPs) offer a promising alternative, as they can form micro- and nanostructured hydrogels through non-covalent interactions and allow precise control over their biofunctionality, mechanical properties, and responsiveness to biological cues. Through rational sequence design, SAPs can be engineered to exhibit tunable mechanical properties, controlled degradation rates, and multifunctionality, and can dynamically regulate assembly and degradation in response to specific stimuli such as pH, ionic strength, enzymatic cleavage, or temperature. Furthermore, SAPs have been successfully incorporated into conventional hydrogels to enhance cell adhesion, promote matrix remodeling, and provide a more physiologically relevant microenvironment. In this review, we summarize recent advances in SAP-based hydrogels, particularly focusing on their novel biofunctional properties such as anti-inflammatory, antimicrobial, and anticancer activities, as well as bioimaging capabilities, and discuss the mechanisms by which SAP hydrogels function in biological systems.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12292889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Enhanced Dynamic Model of a Spatial Parallel Mechanism Receiving Direct Constraints from the Base at Two Point-Contact Higher Kinematic Pairs. 两点接触高运动副空间并联机构直接受基约束的改进动力学模型。

IF 3.9 3区医学

Biomimetics Pub Date : 2025-07-03 DOI: 10.3390/biomimetics10070437

Chen Cheng, Xiaojing Yuan, Yenan Li

{"title":"An Enhanced Dynamic Model of a Spatial Parallel Mechanism Receiving Direct Constraints from the Base at Two Point-Contact Higher Kinematic Pairs.","authors":"Chen Cheng, Xiaojing Yuan, Yenan Li","doi":"10.3390/biomimetics10070437","DOIUrl":"10.3390/biomimetics10070437","url":null,"abstract":"In this paper, a biologically congruent parallel mechanism (PM) inspired by the masticatory system of human beings has been proposed to recreate complete chewing behaviours in three-dimensional space. The mechanism is featured by direct constraints from the base (DCFB) to its end effector at two higher kinematic pairs (HKPs), which greatly raise its topological complexity. Meanwhile, friction effects occur at HKPs and actuators, causing wear and then reducing motion accuracy. Regarding these, an inverse dynamic model that can raise the computational efficiency and the modelling fidelity is proposed, being prepared to be applied to realise accurate real-time motion and/or force control. In it, Euler parameters are employed to express the motions of the constrained end effector, and Newton-Euler's law is applied, which can conveniently incorporate friction effects at both HKPs and actuators into the dynamic model. Numerical results show that the time consumption of the model using Euler parameters is only approximately 23% of that of the model using Euler angles, and friction effects significantly increase the model's nonlinearity. Further, from the comparison between the models of the target PM and its counterpart free of DCFB, these constraints sharply raise the modelling complexity in terms of the transformation between Euler parameters and Euler angles in the end effector and the computational cost of inverse dynamics.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12292522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast and Fractionated: Correlation of Dose Attenuation and the Response of Human Cancer Cells in a New Anthropomorphic Brain Phantom. 快速与分步：在一个新的拟人化脑幻影中剂量衰减与人类癌细胞反应的相关性。

IF 3.9 3区医学

Biomimetics Pub Date : 2025-07-03 DOI: 10.3390/biomimetics10070440

Bernd Frerker, Elette Engels, Jason Paino, Vincent de Rover, John Paul Bustillo, Marie Wegner, Matthew Cameron, Stefan Fiedler, Daniel Häusermann, Guido Hildebrandt, Michael Lerch, Elisabeth Schültke

{"title":"Fast and Fractionated: Correlation of Dose Attenuation and the Response of Human Cancer Cells in a New Anthropomorphic Brain Phantom.","authors":"Bernd Frerker, Elette Engels, Jason Paino, Vincent de Rover, John Paul Bustillo, Marie Wegner, Matthew Cameron, Stefan Fiedler, Daniel Häusermann, Guido Hildebrandt, Michael Lerch, Elisabeth Schültke","doi":"10.3390/biomimetics10070440","DOIUrl":"10.3390/biomimetics10070440","url":null,"abstract":"The results of radiotherapy in patients with primary malignant brain tumors are extremely dissatisfactory: the overall survival after a diagnosis of glioblastoma is typically less than three years. The development of spatially fractionated radiotherapy techniques could help to improve this bleak prognosis. In order to develop technical equipment and organ-specific therapy plans, dosimetry studies as well as radiobiology studies are conducted. Although perfect spheres are considered optimal phantoms by physicists, this does not reflect the wide variety of head sizes and shapes in our patient community. Depth from surface and X-ray dose absorption by tissue between dose entry point and target, two key parameters in medical physics planning, are largely determined by the shape and thickness of the skull bone. We have, therefore, designed and produced a biomimetic tool to correlate measured technical dose and biological response in human cancer cells: a brain phantom, produced from tissue-equivalent materials. In a first pilot study, utilizing our phantom to correlate technical dose measurements and metabolic response to radiation in human cancer cell lines, we demonstrate why an anthropomorphic phantom is preferable over a simple spheroid phantom.","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 7","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12292920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0