Biomimetics最新文献

{"title":"Collagen Formulation in Xenogeneic Bone Substitutes Influences Cellular Responses in Periodontal Regeneration: An In Vitro Study.","authors":"Priscilla Pelaez-Cruz, Pia López Jornet, Eduardo Pons-Fuster","doi":"10.3390/biomimetics10090608","DOIUrl":"10.3390/biomimetics10090608","url":null,"abstract":"<p><strong>Background: </strong>Bone regeneration is a key therapeutic objective in periodontology, particularly in the treatment of alveolar defects caused by periodontal disease, dentoalveolar trauma, or surgical interventions. Among current regenerative strategies, collagen-enriched biomaterials have demonstrated an active role in modulating cellular behavior during bone repair. However, the specific effects of different collagen formulations on human dental pulp stem cells (hDPSCs) have not yet been fully characterized.</p><p><strong>Objective: </strong>To evaluate the impact of xenogeneic bone grafts with and without collagen-OsteoBiol<sup>®</sup> Gen-Os<sup>®</sup> (GO), OsteoBiol<sup>®</sup> GTO<sup>®</sup> (GTO), and Geistlich Bio-Oss<sup>®</sup> (BO)-on cell viability, adhesion, migration, osteogenic differentiation, and mineralization potential of hDPSCs, and to explore the molecular mechanisms underlying their effects.</p><p><strong>Methods: </strong>In vitro assays were conducted to assess viability (MTT and fluorescence staining), adhesion (SEM), migration (wound healing assay), and mineralization (Alizarin Red S staining). Gene expression analyses (RT-qPCR) were performed for adhesion/migration markers (<i>FN</i>, <i>SDF-1</i>, <i>COL1A1</i>), angiogenic/proliferation markers (<i>VEGF</i>, <i>FGF2</i>), and osteogenic differentiation markers (<i>RUNX2</i>, <i>ALP</i>, <i>COL1A1</i>).</p><p><strong>Results: </strong>GO showed a higher early expression of genes associated with adhesion, migration, angiogenesis (<i>FN</i>, <i>SDF-1</i>, <i>VEGF</i> and <i>FGF2</i>: <i>p</i> < 0.05; <i>COL1A1</i>: <i>p</i> < 0.01), and osteogenic differentiation (7 days: <i>COL1A1</i> and <i>ALP</i> (<i>p</i> < 0.001)); (14 days: <i>RUNX2</i>, <i>ALP</i>: <i>p</i> < 0.001; <i>COL1A1</i>: <i>p</i> < 0.05), indicating a sequential activation of molecular pathways and mineralization capacity comparable to the control group. GTO demonstrated the best biocompatibility, with significantly higher cell viability (<i>p</i> < 0.05), strong adhesion, and markedly increased mineralization at 21 days (<i>p</i> < 0.001), despite moderate early gene expression. BO showed reduced cell viability at 10 mg/mL (<i>p</i> < 0.05) and 20 mg/mL (<i>p</i> < 0.001), with mineralization levels similar to the control group.</p><p><strong>Conclusion: </strong>Collagen-based xenografts demonstrate favorable interactions with hDPSCs, enhancing viability and promoting osteogenic differentiation. Our findings suggest that beyond the presence of collagen, the specific formulation of these biomaterials may modulate their biological performance, highlighting the importance of material design in optimizing regenerative outcomes.</p><p><strong>Clinical significance: </strong>The formulation of collagen in xenogeneic bone substitutes may be a determining factor in enhancing periodontal regenerative outcomes by modulating the early cellular response and osteogenic activity in stem cell-based ","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 9","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Accuracy Lower-Limb Intent Recognition: A KPCA-ISSA-SVM Approach with sEMG-IMU Sensor Fusion.","authors":"Kaiyang Yin, Pengchao Hao, Huanli Zhao, Pengyu Lou, Yi Chen","doi":"10.3390/biomimetics10090609","DOIUrl":"10.3390/biomimetics10090609","url":null,"abstract":"<p><p>Accurately decoding human locomotion intention from physiological signals remains a significant hurdle for the seamless control of advanced rehabilitation devices like exoskeletons and intelligent prosthetics. Conventional recognition methods often falter, exhibiting limited accuracy and struggling to capture the complex, nonlinear dynamics inherent in biological data streams. Addressing these critical limitations, this study introduces a novel framework for lower-limb motion intent recognition, integrating Kernel Principal Component Analysis (KPCA) with a Support Vector Machine (SVM) optimized via an Improved Sparrow Search Algorithm (ISSA). Our approach commences by constructing a comprehensive high-dimensional feature space from synchronized surface electromyography (sEMG) and inertial measurement unit (IMU) data-a potent combination reflecting both muscle activation and limb kinematics. Critically, KPCA is employed for nonlinear dimensionality reduction; leveraging the power of kernel functions, it transcends the linear constraints of traditional PCA to extract low-dimensional principal components that retain significantly more discriminative information. Furthermore, the Sparrow Search Algorithm (SSA) undergoes three strategic enhancements: chaotic opposition-based learning for superior population diversity, adaptive dynamic weighting to adeptly balance exploration and exploitation, and hybrid mutation strategies to effectively mitigate premature convergence. This enhanced ISSA meticulously optimizes the SVM hyperparameters, ensuring robust classification performance. Experimental validation, conducted on a challenging 13-class lower-limb motion dataset, compellingly demonstrates the superiority of the proposed KPCA-ISSA-SVM architecture. It achieves a remarkable recognition accuracy of 95.35% offline and 93.3% online, substantially outperforming conventional PCA-SVM (91.85%) and standalone SVM (89.76%) benchmarks. This work provides a robust and significantly more accurate solution for intention perception in human-machine systems, paving the way for more intuitive and effective rehabilitation technologies by adeptly handling the nonlinear coupling characteristics of sEMG-IMU data and complex motion patterns.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 9","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid Cuckoo Search-Bees Algorithm with Memristive Chaotic Initialization for Cryptographically Strong S-Box Generation.","authors":"Sinem Akyol","doi":"10.3390/biomimetics10090610","DOIUrl":"10.3390/biomimetics10090610","url":null,"abstract":"<p><p>One of the essential parts of contemporary cryptographic systems is s-boxes (Substitution Boxes), which give encryption algorithms more complexity and resilience due to their nonlinear structure. In this study, we propose CSBA (Cuckoo Search-Bees Algorithm), a hybrid evolutionary method that combines the strengths of Cuckoo Search and Bees algorithms, to generate s-box structures with strong cryptographic properties. The initial population is generated with a high-diversity four-dimensional Memristive Lu chaotic map, taking advantage of the random yet deterministic nature of chaotic systems. This proposed method was designed with inspiration from biological systems. It was developed based on the foraging strategies of bees and the reproductive strategies of cuckoos. This nature-inspired structure enables an efficient scanning of the solution space. The resultant s-boxes' fitness was assessed using the nonlinearity value. These s-boxes were then optimized using the hybrid CSBA algorithm suggested in this paper as well as the Bees algorithm. The performance of the proposed approaches was measured using SAC, nonlinearity, BIC-SAC, BIC-NL, maximum difference distribution, and linear uniformity (LU) metrics. Compared to other studies in the literature that used metaheuristic algorithms to generate s-boxes, the proposed approach demonstrates good performance. In particular, the average value of 109.75 obtained for the nonlinearity metric demonstrates high success. Therefore, this study demonstrates that robust and reliable s-boxes can be generated for symmetric encryption algorithms using the developed metaheuristic algorithms.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 9","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired Approaches and Their Philosophical-Ethical Dimensions: A Narrative Review.","authors":"Louisa Estadieu, Julius Fenn, Michael Gorki, Philipp Höfele, Oliver Müller","doi":"10.3390/biomimetics10090602","DOIUrl":"10.3390/biomimetics10090602","url":null,"abstract":"<p><p>The environmental crisis demands transformative solutions on both technological and societal levels. Bioinspired approaches, which draw from the principles of natural systems, have emerged as a promising interdisciplinary framework to address these challenges. These approaches not only drive technological innovation but also provoke critical philosophical and ethical discourse, particularly in the field of biomimicry. Philosophical and ethical questions include: How can we ethically justify drawing inspiration from nature without exploiting it? How might a shift toward a bioinspired perspective alter our relationship with nature? How could a reorientation toward nature influence ethical frameworks and guide human behavior toward the environment? This narrative review systematically examines key philosophical and ethical perspectives within biomimicry, while focusing on potentials as well as limitations of these approaches to the environmental crisis. In doing so, it explores key perspectives such as \"biomimetic ethics\", the \"ontology of nature\", \"bioinclusivity\", and the \"naturalistic fallacy\".</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 9","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Concept for Bio-Agentic Visual Communication: Bridging Swarm Intelligence with Biological Analogues.","authors":"Bryan Starbuck, Hanlong Li, Bryan Cochran, Marc Weissburg, Bert Bras","doi":"10.3390/biomimetics10090605","DOIUrl":"10.3390/biomimetics10090605","url":null,"abstract":"<p><p>Biological swarms communicate through decentralized, adaptive behaviors shaped by local interactions, selective attention, and symbolic signaling. These principles of animal communication enable robust coordination without centralized control or persistent connectivity. This work presents a proof of concept that identifies, evaluates, and translates biological communication strategies into a generative visual language for unmanned aerial vehicle (UAV) swarm agents operating in radio-frequency (RF)-denied environments. Drawing from natural exemplars such as bee waggle dancing, white-tailed deer flagging, and peacock feather displays, we construct a configuration space that encodes visual messages through trajectories and LED patterns. A large language model (LLM), preconditioned using retrieval-augmented generation (RAG), serves as a generative translation layer that interprets perception data and produces symbolic UAV responses. Five test cases evaluate the system's ability to preserve and adapt signal meaning through within-modality fidelity (maintaining symbolic structure in the same modality) and cross-modal translation (transferring meaning across motion and light). Covariance and eigenvalue-decomposition analysis demonstrate that this bio-agentic approach supports clear, expressive, and decentralized communication, with motion-based signaling achieving near-perfect clarity and expressiveness (0.992, 1.000), while LED-only and multi-signal cases showed partial success, maintaining high expressiveness (~1.000) but with much lower clarity (≤0.298).</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 9","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Supervised Voice Denoising Network for Multi-Scenario Human-Robot Interaction.","authors":"Mu Li, Wenjin Xu, Chao Zeng, Ning Wang","doi":"10.3390/biomimetics10090603","DOIUrl":"10.3390/biomimetics10090603","url":null,"abstract":"<p><p>Human-robot interaction (HRI) via voice command has significantly advanced in recent years, with large Vision-Language-Action (VLA) models demonstrating particular promise in human-robot voice interaction. However, these systems still struggle with environmental noise contamination during voice interaction and lack a specialized denoising network for multi-speaker command isolation in an overlapping speech scenario. To overcome these challenges, we introduce a method to enhance voice command-based HRI in noisy environments, leveraging synthetic data and a self-supervised denoising network to enhance its real-world applicability. Our approach focuses on improving self-supervised network performance in denoising mixed-noise audio through training data scaling. Extensive experiments show our method outperforms existing approaches in simulation and achieves 7.5% higher accuracy than the state-of-the-art method in noisy real-world environments, enhancing voice-guided robot control.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 9","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Substrate Compliance on the Jumping Mechanism of the Tree Frog (<i>Polypedates dennys</i>).","authors":"Rui Zhou, Baowen Zhang, Zhouyi Wang, Zhendong Dai","doi":"10.3390/biomimetics10090604","DOIUrl":"10.3390/biomimetics10090604","url":null,"abstract":"<p><p>Animal locomotion in complex environments depends on the ability to adaptively regulate movement in response to substrate mechanics. Tree frogs (<i>Polypedates dennysi</i>), which combine jumping and adhesive capabilities, inhabit arboreal habitats with a wide range of compliant substrates. While previous studies have offered preliminary insights into their locomotion, the biomechanical mechanisms underlying their adaptability remain poorly characterized. In this study, we developed a stiffness-adjustable takeoff substrate supported by four springs, and combined it with a 3D motion capture system to analyze the jumping dynamics and kinematics of frogs across a broader range of compliant substrates. We found that energy recovery from the substrate was influenced by compliance. On the stiffest substrate, up to 50% of the stored energy was recovered during takeoff, whereas highly compliant substrates caused nonlinear damping, energy dissipation, and even takeoff failure. During takeoff, frogs generated peak normal forces up to 6 times their body weight and fore-aft forces up to 4.5 times their body weight. However, force generation showed limited adaptability to substrate mechanics, while takeoff velocity exhibited stronger adaptability to changes in compliance. These findings reveal a trade-off between substrate mechanics and jump performance. This work provides biomechanical insight into substrate preference and informs the design of bioinspired systems capable of efficient locomotion on compliant substrates.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 9","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic Dual-Sensing Bone Scaffolds: Characterization and In Vitro Evaluation Under Dynamic Culturing Conditions.","authors":"Damion T Dixon, Erika N Landree, Cheryl T Gomillion","doi":"10.3390/biomimetics10090598","DOIUrl":"10.3390/biomimetics10090598","url":null,"abstract":"<p><p>The regeneration of large segmental bone defects remains a significant challenge. While electrical stimulation has demonstrated the potential to accelerate bone healing, clinical translation has been hindered by the lack of safe, localized delivery methods. In this study, we present a novel strategy combining piezoelectric and electrically conductive polymers with allograft demineralized bones to create stimuli-responsive, biologically relevant scaffolds via pneumatic 3D printing. These scaffolds exhibit enhanced piezoelectric potential and tunable electrical properties, enabling both electrical and mechanical stimulation of cells (without external stimulators). Under dynamic culturing conditions (i.e., ultrasound stimulation), human bone marrow-derived mesenchymal stromal cells cultured on these scaffolds displayed significantly elevated osteogenic protein expression (i.e., alkaline phosphatase and osteocalcin) and mineralization (confirmed via xylenol orange mineral staining) after two weeks. This work introduces a bioinspired, printable ink in conjunction with a simple fabrication approach for creating dual-responsive scaffolds with high potential for functional bone tissue regeneration.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 9","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scalable Fabrication of Biomimetic Antibacterial Nanospikes on PMMA Films Using Atmospheric-Pressure Low-Temperature Plasma.","authors":"Masashi Yamamoto, Kentaro Tada, Ayumu Takada, Atsushi Sekiguchi","doi":"10.3390/biomimetics10090601","DOIUrl":"10.3390/biomimetics10090601","url":null,"abstract":"<p><p>Antibacterial surfaces inspired by biological micro- and nanostructures, such as those found on the wings of cicadas and dragonflies, have attracted interest due to their ability to inhibit bacterial adhesion and damage microbial membranes without relying on chemical agents. However, conventional fabrication techniques like photolithography or nanoimprinting are limited by substrate shape, size, and high operational costs. In this study, we developed a scalable method using atmospheric-pressure low-temperature plasma (APLTP) to fabricate sharp-edged nanospikes on solvent-cast polymethyl methacrylate (PMMA) films. The nanospikes were formed through plasma-induced modification of pores in the film, followed by annealing to control surface wettability while maintaining structural sharpness. Atomic force microscopy confirmed the formation of micro/nanostructures, and contact angle measurements revealed reversible hydrophilicity. Antibacterial performance was evaluated against <i>Escherichia coli</i> using ISO 22196 standards. While the film with only plasma treatment reduced bacterial colonies by 30%, the film annealed after plasma treatment achieved an antibacterial activity value greater than 5, with bacterial counts below the detection limit (<10 CFU). These findings demonstrate that APLTP offers a practical route for large-area fabrication of biomimetic antibacterial coatings on flexible polymer substrates, holding promise for future applications in healthcare, packaging, and public hygiene.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 9","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired Polyvinyl Alcohol-Based Foam Fabricated via Supercritical Carbon Dioxide Foaming for Atmospheric Water Harvesting.","authors":"Yingying Chen, Changjun Guo, Hao Wang, Jiabao Lu, Heng Xie, Ting Wu","doi":"10.3390/biomimetics10090599","DOIUrl":"10.3390/biomimetics10090599","url":null,"abstract":"<p><p>The intensifying freshwater crisis underscores the critical need for all-weather, low-energy atmospheric water harvesting technologies. Inspired by the scale-like protrusions and interconnected channels of Tillandsia leaves that enable efficient water capture and release, a polyvinyl alcohol-based foam featuring a three-dimensional porous structure is fabricated using the supercritical carbon dioxide foaming technology. Compared to the traditional freeze-drying method, this approach significantly reduces preparation energy consumption and shortens the production cycle. Lithium chloride integration endows the foam with exceptional moisture absorption capacity, reaching 300% of its weight. Leveraging graphene's outstanding photothermal conversion properties, the foam achieves a photothermal dehydration rate of 80.7% within 80 min under 1 Sun irradiation, demonstrating a rapid water release capacity. Furthermore, the polyvinyl alcohol-based foam exhibits no performance degradation after 60 cycles, indicating remarkable stability. This technology provides a scalable, low-cost, and all-climate-applicable solution for water-scarce regions.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 9","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}