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The Influence of a Nose-Clip on Inhalation Therapy in Asthmatic Children 鼻夹对哮喘患儿吸入治疗的影响
Pediatric asthma, allergy & immunology Pub Date : 2003-09-01 DOI: 10.1089/088318703322247606
C. Gruber, M. Moenkhoff, J. Hamacher, U. Frey, F. Sennhauser, J. Wildhaber
{"title":"The Influence of a Nose-Clip on Inhalation Therapy in Asthmatic Children","authors":"C. Gruber, M. Moenkhoff, J. Hamacher, U. Frey, F. Sennhauser, J. Wildhaber","doi":"10.1089/088318703322247606","DOIUrl":"https://doi.org/10.1089/088318703322247606","url":null,"abstract":"In our study we investigated if wearing a nose-clip during inhalation therapy in asthmatic children changes breathing patterns and hence, influences aerosol delivery. Aerosol delivery was measured in 30 asthmatic children (age range 4-7 years) inhaling in random order with and without a nose-clip from both a pressurized metered-dose inhaler (pMDI) through a holding chamber and a nebulizer. Breathing patterns were measured using a pneumotachograph inserted between the delivery device and the patient. Aerosol delivery to the patient was measured on a filter inserted in the inspiratory limb of the system. Inspiratory volume and inspiratory flow were significantly higher when inhaling with a nose-clip from both a pMDI (p = 0.004; p = 0.025) and a nebulizer (p = 0.003; p = 0.038). Aerosol deposition on the inspiratory filter while inhaling from a nebulizer was significantly higher when wearing a nose-clip (p < 0.0005), but not while inhaling from a pMDI with holding chamber (p = 0.32). Aerosol delivery from a ...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"147 1","pages":"129-135"},"PeriodicalIF":0.0,"publicationDate":"2003-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75652231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Latex Sensitivity in Hematologic and Oncologic Non-Atopic Pediatric Patients 血液学和肿瘤学非特应性儿童患者乳胶敏感性
Pediatric asthma, allergy & immunology Pub Date : 2003-09-01 DOI: 10.1089/088318703322247589
I. Bostanci, Resul Yılmaz, Y. Dallar, G. Tanyer
{"title":"Latex Sensitivity in Hematologic and Oncologic Non-Atopic Pediatric Patients","authors":"I. Bostanci, Resul Yılmaz, Y. Dallar, G. Tanyer","doi":"10.1089/088318703322247589","DOIUrl":"https://doi.org/10.1089/088318703322247589","url":null,"abstract":"Allergic reactions to latex ranging from contact urticaria to severe anaphylaxis have been reported at increased frequency. These forms of hypersensitivity have affected a large group, including health care workers, workers in the latex industry, and children with spina bifida. This present study has been designed to assess the prevalence of allergic reactions to latex products in a group of pediatric patients with hematologic and oncologic disease. The prevalence of latex sensitization was found to be 20% (n = 6). Latex sensitization was related to the duration of disease (p = 0.05). Our data provide evidence that latex hypersensitivity can be detected in distinct clinical manifestations of those diseases in children. This is the first study that shows pediatric hematologic and oncologic patients have increased risk to latex sensitivity.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"4 1","pages":"117-120"},"PeriodicalIF":0.0,"publicationDate":"2003-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85287827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Exhaled carbon monoxide levels in children with bronchial asthma 支气管哮喘儿童呼出的一氧化碳水平
Pediatric asthma, allergy & immunology Pub Date : 2003-09-01 DOI: 10.1089/088318703322247633
Ozlem Yilmaz, F. Ozturk, A. Bakirtas, R. Cengizlier, I. Turktas
{"title":"Exhaled carbon monoxide levels in children with bronchial asthma","authors":"Ozlem Yilmaz, F. Ozturk, A. Bakirtas, R. Cengizlier, I. Turktas","doi":"10.1089/088318703322247633","DOIUrl":"https://doi.org/10.1089/088318703322247633","url":null,"abstract":"Exhaled carbon monoxide (eCO) has been proposed as a potential marker of oxidative stress in the asthmatic airways. This study was conducted to investigate eCO levels in different asthma groups in children. Exhaled CO was measured electrochemically in 117 asthmatic and 45 non-asthmatic, non-atopic healthy children between the ages of 6 to 16 years. Exhaled CO levels in viral associated wheeze were similar to healthy controls. However, all symptomatic patients with either persistent or seasonal asthma had higher eCO values (mean ± SD) (2.05 ± 0.9 parts per million (ppm) and 2.30 ± 0.8 ppm) as compared to controls (0.94 ± 0.5 ppm, p < 0.001, p < 0.001, respectively), viral associated wheeze (1.19 ± 0.4 ppm, p < 0.001, p < 0.001, respectively), and symptom-free seasonal asthmatics (1.45 ± 0.6 ppm, p < 0.01, p < 0.001, respectively). In symptom-free seasonal asthmatics eCO levels that were measured at the specific pollen season, were higher than the controls (p < 0.001) and the viral associated wheeze (p < 0....","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"9 1","pages":"155-162"},"PeriodicalIF":0.0,"publicationDate":"2003-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77370774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Occurrence of Convulsions after Administration of Theophylline in a Large Japanese Pediatric Population with Asthma 大量日本儿童哮喘患者服用茶碱后抽搐的发生
Pediatric asthma, allergy & immunology Pub Date : 2003-09-01 DOI: 10.1089/088318703322247642
H. Odajima, Y. Mizumoto, Yuhei Hamazaki, Hiroyasu Okahata, N. Oka, Tokihiko Fujino, N. Ohta, T. Sakai
{"title":"Occurrence of Convulsions after Administration of Theophylline in a Large Japanese Pediatric Population with Asthma","authors":"H. Odajima, Y. Mizumoto, Yuhei Hamazaki, Hiroyasu Okahata, N. Oka, Tokihiko Fujino, N. Ohta, T. Sakai","doi":"10.1089/088318703322247642","DOIUrl":"https://doi.org/10.1089/088318703322247642","url":null,"abstract":"The main objective of this study was to evaluate the incidence of convulsions in a large Japanese pediatric population (60,634 patients from 79 centers) treated with theophylline (T). Moreover, further details were obtained from the affected patients. Two sequential questionnaires were sent to centers in order to obtain data. The incidence rate of convulsions was 0.24% (127/54,066) in asthmatic patients treated with T vs. 0.36% (27/7,568) in asthmatic patients not treated with T (p = NS). Eight patients showed convulsions related to T treatment: this group included three infants≤1 year, high mean serum T concentration at the time of convulsion attack (16.7 ± 1.6 μg/mL), and high concomitant medication rate. The rate of recurrent convulsions after readministration of theophylline was higher for patients with epilepsy than for patients with febrile convulsions. In conclusion, the incidence of convulsions in pediatric patients was not affected by the use of theophylline as treatment for asthma. The low frequ...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"5 1","pages":"163-173"},"PeriodicalIF":0.0,"publicationDate":"2003-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83187283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Inhaled corticosteroids may be superior to systemic corticosteroids in children with moderate-to-severe acute asthma 对于患有中度至重度急性哮喘的儿童，吸入皮质类固醇可能优于全身皮质类固醇
Pediatric asthma, allergy & immunology Pub Date : 2003-09-01 DOI: 10.1089/088318703322247598
C. Macias, E. Felner, V. Gan
{"title":"Inhaled corticosteroids may be superior to systemic corticosteroids in children with moderate-to-severe acute asthma","authors":"C. Macias, E. Felner, V. Gan","doi":"10.1089/088318703322247598","DOIUrl":"https://doi.org/10.1089/088318703322247598","url":null,"abstract":"The objective of this study was to assess the efficacy of inhaled triamcinalone as compared to oral prednisone or intravenous methylprednisolone in the treatment of children with moderate-to-severe acute asthma. This prospective, randomized trial involved convenience sampling of children 6 years and older presenting to one of two pediatric emergency centers. Patients were randomized to receive inhaled, oral, or intravenous corticosteroids. Patients receiving inhaled corticosteroids (600 mcg of inhaled triamcinalone acetonide with inhaler and spacer) in the emergency center and discharged home, received 4 consecutive days of the same preparation (600 mcg TID for 1 day and 400 mcg TID for the next 3 days). Patients receiving either oral [prednisone 2 mg/kg (maximum 80 mg)] or intravenous corticosteroids [methylprednisolone 2 mg/kg (maximum 80 mg)] and discharged home received a 4-day course of the oral preparation [prednisone 1 mg/kg/day BID (maximum 40 mg/day)]. Of 135 children enrolled, 106 were discharge...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"86 1","pages":"121-128"},"PeriodicalIF":0.0,"publicationDate":"2003-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77105791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
The Positive Impact of a Disease Management Program on Asthma Morbidity in Inner-City Children 疾病管理项目对城市儿童哮喘发病率的积极影响
Pediatric asthma, allergy & immunology Pub Date : 2003-09-01 DOI: 10.1089/088318703322247624
R. Hasan, G. Zureikat, J. Camp, J. Duff, B. Nolan
{"title":"The Positive Impact of a Disease Management Program on Asthma Morbidity in Inner-City Children","authors":"R. Hasan, G. Zureikat, J. Camp, J. Duff, B. Nolan","doi":"10.1089/088318703322247624","DOIUrl":"https://doi.org/10.1089/088318703322247624","url":null,"abstract":"Objectives of this study were to investigate whether implementing an asthma disease management program that involves the interplay of a physician in an asthma clinic, and periodic home visits by non-physician members of this program, could reduce asthma morbidity in disadvantaged inner-city children with moderate to severe asthma. Records of 142 children (6 ± 4 years) enrolled into the program for at least one year were reviewed. Seventy-six (54%) were black, while 61 (43%) were white. No mortalities were observed during the period of study. There was a significant reduction in the number of hospital admissions: 1.2 ± 0.11 (mean ± SEM) vs. 0.5 ± 0.1 episodes (p < 0.05), length of stay on pediatric floors: 3.2 ± 0.5 vs. 1.4 ± 0.38 days (p < 0.05) and in the pediatric critical care unit: 0.8 ± 0.2 vs. 0.2 ± 0.09 days (p < 0.05) 1 year after enrollment into the program. There was also a reduction in the proportion of the number of missed school days (35% vs. 12%, p < 0.01) and days with restricted activities...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"297 1","pages":"147-153"},"PeriodicalIF":0.0,"publicationDate":"2003-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77098502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Small Airway Responsiveness to Exercise as an Objective Measure of Exercise-Induced Asthma in Children 儿童运动性哮喘小气道反应的客观测量
Pediatric asthma, allergy & immunology Pub Date : 2003-06-01 DOI: 10.1089/088318703765068668
R. Soferman, Z. Spirer, M. Topilsky
{"title":"Small Airway Responsiveness to Exercise as an Objective Measure of Exercise-Induced Asthma in Children","authors":"R. Soferman, Z. Spirer, M. Topilsky","doi":"10.1089/088318703765068668","DOIUrl":"https://doi.org/10.1089/088318703765068668","url":null,"abstract":"Exercise has been proposed as a useful challenge test for measuring bronchial hyper-responsiveness. The accepted diagnosis of exercise-induced asthma (EIA) is an end FEV1- change index of at least 10-20% post standard exercise. This preliminary study aimed to demonstrate the importance of the contribution of the small airways to the obstruction postexercise. Ninety-one asthmatic children aged 6-17 years, of whom 70 had clinical presentation of EIA, participated in this study. They were subdivided into three groups according to the percentage fall index of FEV1 post an exercise challenge. Thirty-nine children showed a reduction of 35 ± 12% in FEV1, and a reduction of 50%, 55%, and 54% in FEF25%, FEF50%, and FEF75%, respectively. Thirty-one had a reduction of 12 ± 5% in FEV1, and a reduction of 21%, 29%, and 33% in FEF25%, FEF50%, and FEF75%, respectively. Twenty-one asthmatic children without clinical EIA demonstrated a percentage fall index in FEV1 (2 ± 2%) and a mean percentage fall in FEF25%, FEF50%, an...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"14 1","pages":"77-84"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73947669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Is the Betalactoglobulin- and Ovalbumin-Induced In Vitro Production of Interferon-Gamma and Interleukin-4 Predictive for Atopy in the Neonate? A Prospective Cohort Study and a Review of the Literature β -乳球蛋白和卵清蛋白诱导的干扰素- γ和白细胞介素-4的体外生成是否预示着新生儿的特应性?前瞻性队列研究及文献综述
Pediatric asthma, allergy & immunology Pub Date : 2003-06-01 DOI: 10.1089/088318703765068677
S. Sopo, G. Federico, G. Zorzi, A. Pugliese, C. Fadda, A. Stabile
{"title":"Is the Betalactoglobulin- and Ovalbumin-Induced In Vitro Production of Interferon-Gamma and Interleukin-4 Predictive for Atopy in the Neonate? A Prospective Cohort Study and a Review of the Literature","authors":"S. Sopo, G. Federico, G. Zorzi, A. Pugliese, C. Fadda, A. Stabile","doi":"10.1089/088318703765068677","DOIUrl":"https://doi.org/10.1089/088318703765068677","url":null,"abstract":"Some studies suggest that a reduction of interferon-gamma (IFNγ), in vitro production by cord blood mononuclear cells (CBMC) could be considered as a marker of atopic predisposition. The aim of our study is to estimate the usefulness of testing interleukin-4 (IL4) and IFNγ in CBMC culture supernatants after stimulus with betalactoglobulin (BLG) and ovalbumin (OVA) in predicting atopic disease. The possible correlation between the in vitro production of IL4 and IFNγ and cord blood IgE levels was also investigated. Our sample consisted of 68 neonates; among them, 28 had no atopic family history (group 0), 21 had only one parent suffering from an atopic disease (group 1), and 19 had both parents (group 2). CBMC were stimulated in vitro by 100 μg of betalactoglobulin (BLG) or ovalbumin (OVA) for 24 or 48 h. IL4 and IFNγ in the culture supernatants and cord blood IgE levels were quantified by commercial kits. Detectable production of IL4, undetectable production of IFNγ , and cord blood IgE levels of ≥0.7 kU/L...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"9 1","pages":"85-96"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73689987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hidden Peanut Allergen as a Cause for Anaphylaxis 隐藏花生过敏原是过敏反应的原因
Pediatric asthma, allergy & immunology Pub Date : 2003-06-01 DOI: 10.1089/088318703765068686
W. Spiegel, R. Anolik, E. Jakabovics
{"title":"Hidden Peanut Allergen as a Cause for Anaphylaxis","authors":"W. Spiegel, R. Anolik, E. Jakabovics","doi":"10.1089/088318703765068686","DOIUrl":"https://doi.org/10.1089/088318703765068686","url":null,"abstract":"A 6-year-old boy known to be allergic to peanuts inadvertently ingested peanut in a processed food that he normally eats without problems. Further investigation revealed that this food contained a substantial amount of peanut that was not revealed on the label. It appears that the contamination occurred at the raw material supplier level. Peanut-allergic individuals may ingest peanut even with diligence in reading labels and should always be prepared to handle an allergic emergency.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"17 1","pages":"97-99"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89744993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IgE-Mediated Cow's Milk Allergy: Skin Prick Test Subtypes and Clinical Phenotypes Using Cow's Milk Hydrolysate Infant Formulas ige介导的牛奶过敏:使用牛奶水解婴儿配方奶粉的皮肤点刺试验亚型和临床表型
Pediatric asthma, allergy & immunology Pub Date : 2003-06-01 DOI: 10.1089/088318703765068659
C. Copenhaver, R. Schwartz, J. Halterman, K. Conn
{"title":"IgE-Mediated Cow's Milk Allergy: Skin Prick Test Subtypes and Clinical Phenotypes Using Cow's Milk Hydrolysate Infant Formulas","authors":"C. Copenhaver, R. Schwartz, J. Halterman, K. Conn","doi":"10.1089/088318703765068659","DOIUrl":"https://doi.org/10.1089/088318703765068659","url":null,"abstract":"In 1986, Hill (Australia) classified group 1 children with cow's milk allergy (CMA) as having rapid onset, IgE-mediated reactions. In 1989, Schwartz (Rochester, NY) subtyped group 1 children (n = 75) into 1A, 1B, and 1C based on skin prick tests (SPTs) to non-hydrolyzed (CM—Similac®) and hydrolyzed CM infant formulas (Good Start®—partially hydrolyzed; Nutramigen®—extensively hydrolyzed). Our objective was to test the hypothesis that SPT subtypes 1A, 1B, and 1C represent different clinical phenotypes. Children with group 1 CMA (n = 170) were evaluated between 1989 and 2000. Clinical data analyzed included SPT subtype, signs, and symptoms after CM ingestion, age of onset, presence of other atopic conditions, serum CM-specific IgE, total serum IgE, and follow-up SPTs. Compared to 1A (n = 82), 1B (n = 58), and 1C (n = 30) had higher rates (p < 0.001) of systemic reactions to CM, higher (p < 0.001) serum-specific IgEs to CM proteins (α-lactalbumin, β-lactoglobulin, casein), higher prevalences of recurrent whee...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"1 1","pages":"67-76"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90111224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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