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Basic Pulmonary Function Testing in Children 儿童基本肺功能检测
Pediatric asthma, allergy & immunology Pub Date : 2003-12-01 DOI: 10.1089/088318703322751264
L. Inselman
{"title":"Basic Pulmonary Function Testing in Children","authors":"L. Inselman","doi":"10.1089/088318703322751264","DOIUrl":"https://doi.org/10.1089/088318703322751264","url":null,"abstract":"Pulmonary function testing helps in the evaluation of respiratory disorders in children. Although it does not provide a specific diagnosis or etiology, it can identify abnormalities in lung volumes, airflow, diffusion, respiratory endurance, and respiratory muscle strength. Pulmonary exercise testing can help differentiate pulmonary from cardiac disease with exercise, detect the presence of ventilatory and/or cardiac limitation with exercise, and measure the degree of physical fitness. These studies have a role in the research of lung disorders in children because changes in lung function with age and alterations in lung growth secondary to acute and chronic disease can be identified.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"2 1","pages":"193-213"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82448563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Raj Padman, M.D., and Laura S. Inselman, M.D. Raj Padman，医学博士和Laura S. Inselman，医学博士
Pediatric asthma, allergy & immunology Pub Date : 2003-12-01 DOI: 10.1089/088318703322751246
B. Hilman
{"title":"Raj Padman, M.D., and Laura S. Inselman, M.D.","authors":"B. Hilman","doi":"10.1089/088318703322751246","DOIUrl":"https://doi.org/10.1089/088318703322751246","url":null,"abstract":"","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"150 1","pages":"185-186"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80077058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible Beneficial Effect of Chest Physical Therapy in Hospitalized Asthmatic Children 住院哮喘患儿胸部物理治疗可能产生的有益效果
Pediatric asthma, allergy & immunology Pub Date : 2003-12-01 DOI: 10.1089/088318703322751345
R. Samransamruajkit, T. Chin, Anchalee Yuengsrigul, T. Newton, E. Nussbaum
{"title":"Possible Beneficial Effect of Chest Physical Therapy in Hospitalized Asthmatic Children","authors":"R. Samransamruajkit, T. Chin, Anchalee Yuengsrigul, T. Newton, E. Nussbaum","doi":"10.1089/088318703322751345","DOIUrl":"https://doi.org/10.1089/088318703322751345","url":null,"abstract":"Patients with acute asthma often demonstrate impaired clearance of secretions from large and small airways. However, chest physical therapy is not generally recommended for acute asthma. Flutter VRP1 is a hand-held device approved by the Federal Drug Administration in the United States for patients with cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) to promote mucus clearance. The purpose of this study is to determine whether the addition of chest physical therapy such as the Flutter VRP1 device has any effect on pediatric patients hospitalized with acute asthma in an open label, prospective, randomized-controlled clinical trial. Forty-five children between 6 and 16 years of age who were admitted to a tertiary care children's hospital in a large metropolitan area with uncomplicated acute asthma were enrolled in the study. Of these, 20 were randomized to receive the Flutter treatment in addition to the standard therapy for acute asthma upon hospitalization and compared with 20 who re...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"16 1","pages":"295-303"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78011007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Tuberculin Skin Testing and Interpretation in Children 儿童结核菌素皮肤试验及解释
Pediatric asthma, allergy & immunology Pub Date : 2003-12-01 DOI: 10.1089/088318703322751282
L. Inselman
{"title":"Tuberculin Skin Testing and Interpretation in Children","authors":"L. Inselman","doi":"10.1089/088318703322751282","DOIUrl":"https://doi.org/10.1089/088318703322751282","url":null,"abstract":"Tuberculosis is the most frequently occurring infectious disease in the world. The tuberculin skin test using 5 TU of purified protein derivative (PPD) applied by the Mantoux technique remains the primary method of identifying children infected with Mycobacterium tuberculosis or Mycobacterium bovis. PPD is injected intradermally, and induration is measured 48-72 hours after application. Interpretation of the skin test reaction depends on the age of the child and presence or absence of risk factors for acquisition of tuberculosis, irrespective of previous immunization with bacille Calmette-Guerin (BCG). False-positive and false-negative skin test reactions can occur. Following identification of a positive tuberculin skin test reaction, a complete history, physical examination, chest radiographs, and laboratory studies are necessary to determine the appropriate chemotherapeutic agents to treat tuberculosis infection or disease. Epidemiologic investigation of the child's contact with active tuberculosis is v...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"45 1","pages":"225-235"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85596560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The Wheezing Infant: A Challenge in Evaluation and Diagnosis 喘息婴儿:评估和诊断的挑战
Pediatric asthma, allergy & immunology Pub Date : 2003-12-01 DOI: 10.1089/088318703322751291
B. Hilman, R. Amaro-Galvez
{"title":"The Wheezing Infant: A Challenge in Evaluation and Diagnosis","authors":"B. Hilman, R. Amaro-Galvez","doi":"10.1089/088318703322751291","DOIUrl":"https://doi.org/10.1089/088318703322751291","url":null,"abstract":"The evaluation of the wheezing infant is a common clinical problem. Initially it is important to differentiate wheezing from \"noisy breathing\" due to stridor. By definition, wheezing is a prolonged or continuous musical adventitial lung sound of varying intensity due to the obstruction of the intrathoracic airways. In contrast, stridor is a high-pitched, loud respiratory sound caused by oscillations of narrowed large extrathoracic airways. Specific diagnostic criteria for asthma in infancy are not well-defined. Since wheezing is often associated with viral respiratory infections in infants, it is difficult to distinguish an initial episode of asthma triggered by a viral respiratory infection from acute viral bronchiolitis. The history is one of the most important components of the evaluation of the wheezing infant. Birth history, age of onset, history of maternal smoking, atopy, and clinical circumstances associated with the wheezing episodes may suggest a diagnosis other than asthma. Congenital anomalies...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"60 1","pages":"237-246"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78131495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Exercise-induced Vocal Cord Dysfunction Presenting as Asthma in Pediatric Patients: Toxicity of Inappropriate Inhaled Corticosteroids and the Role of Exercise Laryngoscopy 运动性声带功能障碍在儿童患者中表现为哮喘:不适当吸入皮质类固醇的毒性和运动喉镜检查的作用
Pediatric asthma, allergy & immunology Pub Date : 2003-12-01 DOI: 10.1089/088318703322751273
R. Heinle, A. Linton, A. Chidekel
{"title":"Exercise-induced Vocal Cord Dysfunction Presenting as Asthma in Pediatric Patients: Toxicity of Inappropriate Inhaled Corticosteroids and the Role of Exercise Laryngoscopy","authors":"R. Heinle, A. Linton, A. Chidekel","doi":"10.1089/088318703322751273","DOIUrl":"https://doi.org/10.1089/088318703322751273","url":null,"abstract":"Chevalier Jackson, M.D., noted, and it is often reiterated, that \"not all that wheezes is asthma.\" This is often the case in pediatric patients in whom there is a broad differential diagnosis for chronic respiratory symptoms. Children and adolescents with chronic respiratory symptoms require thoughtful and complete evaluation to avoid misdiagnosis with the potential for harm due to inappropriate medical therapy. This is particularly true of patients with vocal cord dysfunction, which is a common mimic of asthma. In this report, we present the case of an adolescent female athlete with exercise-induced vocal cord dysfunction misdiagnosed as asthma. Significant adrenal suppression resulted due to high doses of inhaled corticosteroids. The diagnosis of exercise-induced vocal cord dysfunction was confirmed by performing a flexible laryngoscopy during a maximal cardiopulmonary exercise test. We review our experience with a technique of combined exercise testing and real-time flexible laryngoscopy in athletes wi...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"45 1","pages":"215-224"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73721216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
The Efficacy of Azelastine in the Prophylaxis of Acute Upper Respiratory Tract Infections 氮唑elastine预防急性上呼吸道感染的疗效观察
Pediatric asthma, allergy & immunology Pub Date : 2003-12-01 DOI: 10.1089/088318703322751327
M. Simon
{"title":"The Efficacy of Azelastine in the Prophylaxis of Acute Upper Respiratory Tract Infections","authors":"M. Simon","doi":"10.1089/088318703322751327","DOIUrl":"https://doi.org/10.1089/088318703322751327","url":null,"abstract":"Azelastine is a potent and selective second-generation histamine H 1 receptor antagonist. It also effectively down regulates expression of the intracellular adhesion molecule-1 (ICAM1) receptor, which plays an important role in human rhinovirus, Coxsackie type A viruses, adenovirus type 5, human parainfluenza virus type 2 and 3, and respiratory syncytial virus mucosal attachment as well as mobilization of immune effector cells. Therapies aimed at reducing ICAM-1 expression should reduce episodes of viral airway infection. This study shows that azelastine prophylaxis may reduce the occurrence of Upper Respiratory Infections (URIs), otitis media, sinusitis, and pharyngitis in otherwise healthy children. (Pediatr Asthma Allergy Immunol 2003;16[4]:275‐ 282.)","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"16 1","pages":"275-282"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80013709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Comparison of the Systemic Effects of Fluticasone Propionate and Triamcinolone Acetonide Administered in Equipotent Doses in Children with Asthma 丙酸氟替卡松与曲安奈德等效剂量对哮喘患儿全身疗效的比较
Pediatric asthma, allergy & immunology Pub Date : 2003-12-01 DOI: 10.1089/088318703322751336
H. Raissy, H. Wright, M. Crowley, P. Marshik, Angel Colon-Semidy, H. Kelly
{"title":"Comparison of the Systemic Effects of Fluticasone Propionate and Triamcinolone Acetonide Administered in Equipotent Doses in Children with Asthma","authors":"H. Raissy, H. Wright, M. Crowley, P. Marshik, Angel Colon-Semidy, H. Kelly","doi":"10.1089/088318703322751336","DOIUrl":"https://doi.org/10.1089/088318703322751336","url":null,"abstract":"Equal efficacious doses of the inhaled corticosteroids can result in significant differences in systemic effects due to differences in their pharmacokinetic profile. The purpose of this study was to evaluate a model to compare systemic activity of inhaled corticosteroids given in topically equipotent doses in children. Systemic effects were measured by 24-hour urinary free cortisol (UFC) and a.m. and p.m. serum osteocalcin. Efficacy was monitored by a.m. and p.m. exhaled nitric oxide (eNO) and a.m. peak expiratory flow (PEF). Twenty-one children, 6-16 years old on inhaled corticosteroids at ≥400 μg/day beclomethasone dipropionate (BDP) equivalent were placed on BDP for a 2-week, open-label, run-in, baseline period. Patients were then randomized into a double-blind, double-dummy, crossover trial for two 3-week periods of equipotent doses of fluticasone propionate (FP) or triamcinolone acetonide (TAA) as defined by the NHLBI Expert Panel Report 2. At the end of baseline and each treatment phase patients wer...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"19 1","pages":"283-293"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82736205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Once-Daily Cetirizine Is Safe and Effective for Children with Allergic Rhinitis with and without Intermittent Asthma 每日一次西替利嗪对伴有或不伴有间歇性哮喘的变应性鼻炎儿童安全有效
Pediatric asthma, allergy & immunology Pub Date : 2003-12-01 DOI: 10.1089/088318703322751318
A. Segal, E. Meltzer, R. Lockey, B. Prenner, D. Q. Mitchell, D. Tinkelman, D. Hewlett, D. Chapman, B. Kramer
{"title":"Once-Daily Cetirizine Is Safe and Effective for Children with Allergic Rhinitis with and without Intermittent Asthma","authors":"A. Segal, E. Meltzer, R. Lockey, B. Prenner, D. Q. Mitchell, D. Tinkelman, D. Hewlett, D. Chapman, B. Kramer","doi":"10.1089/088318703322751318","DOIUrl":"https://doi.org/10.1089/088318703322751318","url":null,"abstract":"The prevalence of seasonal allergic rhinitis among 1 to 12 year olds is between 10% and 20%. Cetirizine is a selective, once-daily H1 antagonist approved for the treatment of seasonal allergic rhinitis, perennial allergic rhinitis, and chronic idiopathic urticaria in adults and children 2 years and older, and was recently approved for the treatment of perennial allergic rhinitis and chronic urticaria in children down to 6 months of age. This randomized, multicenter, double-blind, placebo-controlled study enrolled 172 children with seasonal allergic rhinitis, including a large subgroup with concomitant asthma. Cetirizine syrup or placebo were administered for 2 weeks. Cetirizine 10 mg once daily provided significant relief from symptoms of seasonal allergic rhinitis, both in children with and without concomitant asthma. Among subjects with asthma, the frequency and severity of asthma symptoms were similar between the cetirizine and placebo groups. Cetirizine caused no adverse effects on pulmonary function ...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"10 1","pages":"265-274"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87183837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Cystic Fibrosis Masquerading as Asthma and Bronchitis in Young Adults 囊性纤维化伪装成哮喘和支气管炎的年轻人
Pediatric asthma, allergy & immunology Pub Date : 2003-12-01 DOI: 10.1089/088318703322751363
F. Hiller
{"title":"Cystic Fibrosis Masquerading as Asthma and Bronchitis in Young Adults","authors":"F. Hiller","doi":"10.1089/088318703322751363","DOIUrl":"https://doi.org/10.1089/088318703322751363","url":null,"abstract":"The report describes 2 adult patients with unusual presentations of undiagnosed cystic fibrosis. Both were young women with children. They are examples of the difficulty in recognition of diseases in patients who are outside of the usual conceptual framework of understanding for this uncommon disease.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"11 1","pages":"319-324"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76632262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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