Pediatric asthma, allergy & immunology最新文献

Infantile Systemic Hyalinosis: A Case Report of Compromised Cellular and Humoral Branches of the Immune System Leading to Infections. 婴儿全身性透明质病：免疫系统细胞和体液分支受损导致感染的一例报告。

Pediatric asthma, allergy & immunology Pub Date : 2009-09-01 DOI: 10.1089/pai.2009.0011

Yana Klebanova, Christina Schwindt

{"title":"Infantile Systemic Hyalinosis: A Case Report of Compromised Cellular and Humoral Branches of the Immune System Leading to Infections.","authors":"Yana Klebanova, Christina Schwindt","doi":"10.1089/pai.2009.0011","DOIUrl":"10.1089/pai.2009.0011","url":null,"abstract":"Infantile systemic hyalinosis (ISH) is a rare disorder characterized by hyaline deposition in the skin as well as visceral organs. Though commonly associated with a protein losing enteropathy (PLE) and loss of immunoglobulins the profile of cellular and humoral branches of the immune system has not previously been described. We describe the immune system deficits in a case of ISH associated with PLE and infections. A history of multiple infections prompted an immunocompetency evaluation in a patient with ISH and PLE. Low immunoglobulin G (IgG), poorly protective pneumococcal titers, and nonresponse to Candida on lymphocyte transformation in the face of increasing infections lead to the diagnosis of a combined immunodeficiency. This is the first case report detailing quantitative and qualitative deficits of the humoral and cellular branches of the immune system in a patient with ISH. The understanding of the different aspects of this disease including the immune deficits impacts not only prognosis but also end-of-life decisions as well.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"22 3","pages":"127-130"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885719/pdf/nihms162992.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29068116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin Testing With Water Buffalo's Milk in Children With Cow's Milk Allergy. 对牛奶过敏的儿童用水牛奶进行皮肤试验。

Pediatric asthma, allergy & immunology Pub Date : 2009-09-01 DOI: 10.1089/pai.2009.0016

William J Sheehan, Andrea Gardynski, Wanda Phipatanakul

{"title":"Skin Testing With Water Buffalo's Milk in Children With Cow's Milk Allergy.","authors":"William J Sheehan, Andrea Gardynski, Wanda Phipatanakul","doi":"10.1089/pai.2009.0016","DOIUrl":"10.1089/pai.2009.0016","url":null,"abstract":"BACKGROUND: Cow's milk allergy is the most common food allergy in young children. In areas outside the United States, milk from other mammals has been studied as a possible and desirable alternative for children with cow's milk allergy. OBJECTIVES: We chose to further investigate water buffalo's milk as an alternative for cow's milk allergic children in the United States. METHODS: Children with cow's milk allergy were skin prick tested with water buffalo's milk. Additionally, subjects were followed clinically for 1 year after the test to determine how many of the subjects had persistent cow's milk allergy. RESULTS: In total, 30 children, age 8 months to 8 years, were skin prick tested to water buffalo's milk with 73% (22/30) having a positive test. All children with a negative water buffalo's milk skin test also had a negative cow's milk skin test. In follow-up, most (7 of 8) of the children with a negative skin prick test (SPT) to water buffalo's milk were found to have outgrown their cow's milk allergy. In comparison, all of the subjects with a positive skin test to water buffalo's milk had persistent cow's milk allergy. After adjusting for this, we determined that 96% (22/23) of the children with persistent cow's milk allergy were positive on skin testing to water buffalo's milk. CONCLUSIONS: In this population, the vast majority of children with persistent cow's milk allergy were positive on skin prick testing to water buffalo's milk. These results indicate that water buffalo's milk is unlikely to be a successful alternative for children with cow's milk allergy.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"22 3","pages":"121-125"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218082/pdf/nihms333464.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30269398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interview with the Expert 专家访谈

Pediatric asthma, allergy & immunology Pub Date : 2009-01-20 DOI: 10.1089/pai.2009.2104.opi

R. Steele

引用次数: 0

Cyclosporine Treatment of Intractable Colitis in Chronic Granulomatous Disease. 环孢素治疗慢性肉芽肿性顽固性结肠炎。

Pediatric asthma, allergy & immunology Pub Date : 2009-01-01 DOI: 10.1089/pai.2000.14.125

Wanda Phipatanakul, Jerry A Winkelstein, Alan M Lake

引用次数: 0

The Pro- and Anti-Inflammatory Cytokine Response to Exercise in Adolescent Swimmers. 青少年游泳运动员运动对促炎性和抗炎性细胞因子的影响。

Pediatric asthma, allergy & immunology Pub Date : 2009-01-01 DOI: 10.1089/pai.2009.0013

Lori D Wilson, Frank P Zaldivar, Christina D Schwindt, Dan M Cooper

{"title":"The Pro- and Anti-Inflammatory Cytokine Response to Exercise in Adolescent Swimmers.","authors":"Lori D Wilson, Frank P Zaldivar, Christina D Schwindt, Dan M Cooper","doi":"10.1089/pai.2009.0013","DOIUrl":"https://doi.org/10.1089/pai.2009.0013","url":null,"abstract":"Objective: Whether or not individuals with allergy and asthma experience different patterns of change in the balance of both pro- and anti-inflammatory mediators with acute exercise is not known. We hypothesized that adolescent swimmers with a clinical diagnosis of respiratory allergy would have an exaggerated proinflammatory response to laboratory exercise relative to a no-allergy comparison group.Methods: Adolescent swimmers (17 with clinical symptoms of respiratory allergy (CSRA) and 17 in comparison group) completed the American Thoracic Society (ATS) exercise challenge on cycle ergometer. Blood was collected at baseline and immediately post-exercise. All study tests were conducted at the Institute for Clinical Translational Science at the University of California, Irvine. Circulating cytokines, growth factors, and adhesion molecules were measured using ELISAs including transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), IL-6, IL-10, P-selectin, and immunoglobulin E (IgE).Results: There was a trend toward higher resting levels of TNF-α in the CSRA group (P = 0.076). Exercise induced a significant increase in P-selectin and TGF-β1 in both groups. TNF-α increased significantly (17%) in the comparison group (pre = 0.6, post = 0.7 pg/mL), but not in the CSRA group. IL-6 increased significantly in the CSRA group (pre = 0.7, post = 0.8 pg/mL), but not in the comparison group. Circulating levels of IL-4 and IL-10 were not altered immediately post-exercise in either group.Conclusions: A short bout of intense exercise increased inflammatory growth factors and adhesion molecules, namely TGF-β1 and P-selectin, both of which are known to be involved in allergic airway diseases. Differences in resting IL-6 and TNF-α and exercise alterations in these cytokines may also contribute to allergic disease in adolescent elite swimmers.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"22 3","pages":"95-100"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/pai.2009.0013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32830000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

In My Opinion—Interview with the Expert 在我看来-采访专家

Pediatric asthma, allergy & immunology Pub Date : 2006-12-01 DOI: 10.1089/pai.2006.19.195

M. Kiernan

引用次数: 0

In My Opinion—Interview with the Expert 在我看来-采访专家

Pediatric asthma, allergy & immunology Pub Date : 2005-06-01 DOI: 10.1089/pai.2005.18.51

W. Dolen

引用次数: 0

In My Opinion—Interview with the Expert 在我看来-采访专家

Pediatric asthma, allergy & immunology Pub Date : 2005-03-01 DOI: 10.1089/pai.2005.18.1

B. Smart

引用次数: 0

A Comparison of Cetirizine and Montelukast for Treating Childhood Perennial Allergic Rhinitis 西替利嗪与孟鲁司特治疗儿童常年性变应性鼻炎的比较

Pediatric asthma, allergy & immunology Pub Date : 2004-07-08 DOI: 10.1089/088318704322994958

J. Hsieh, K. Lue, D. Lai, Hai-Lun Sun, Yung-Hsiang Lin

引用次数: 22

The Use of Spatial Statistics to Identify Asthma Risk Factors in an Urban Community 利用空间统计识别城市社区哮喘危险因素

Pediatric asthma, allergy & immunology Pub Date : 2004-07-08 DOI: 10.1089/088318704322994895

V. F. Jones, P. Lawson, G. Robson, B. Buchanan, Tim E. Aldrich

引用次数: 17