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In Vivo and In Vitro Production of Interferon-γ in Pediatric Patients with Idiopathic Pulmonary Fibrosis 小儿特发性肺纤维化患者体内和体外干扰素γ的产生
Pediatric asthma, allergy & immunology Pub Date : 2004-07-08 DOI: 10.1089/088318704322994985
D. Rigante, S. Sopo, G. Federico, A. Stabile
{"title":"In Vivo and In Vitro Production of Interferon-γ in Pediatric Patients with Idiopathic Pulmonary Fibrosis","authors":"D. Rigante, S. Sopo, G. Federico, A. Stabile","doi":"10.1089/088318704322994985","DOIUrl":"https://doi.org/10.1089/088318704322994985","url":null,"abstract":"Idiopathic pulmonary fibrosis (IPF) is a very rare and progressive disease in the pediatric patients. Immunologic mechanisms are involved in IPF pathogenesis. The theory that inflammation may arise from an imbalance between Th1 and Th2 cells has focused attention on the Th1-type cytokine interferon-γ (IFN-γ). We have determined levels of IFN-γ in the serum and in the leukocyte culture medium of 2 pediatric patients displaying different IPF disease duration and severity. Peripheral blood mononuclear cells of the 2 patients have shown decreased production of IFN-γ after mitogen stimulus. This event might indicate considering the feasibility of IFN-γ administration. We conclude that IFN-γ evaluations might be performed in cases of pediatric IPF to potentially suggest substitutive therapy with this cytokine.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"3 1","pages":"87-92"},"PeriodicalIF":0.0,"publicationDate":"2004-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87395140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum sFas and sFas-Ligand Levels in Childhood Asthma 儿童哮喘血清sFas和sFas配体水平
Pediatric asthma, allergy & immunology Pub Date : 2004-07-08 DOI: 10.1089/0883187041269887
A. Ikinciogullari, F. Doğu, Gunseli Bozdoğan, Y. Eğin, I. Reisli, Dilek Gökdemir, E. Babacan
{"title":"Serum sFas and sFas-Ligand Levels in Childhood Asthma","authors":"A. Ikinciogullari, F. Doğu, Gunseli Bozdoğan, Y. Eğin, I. Reisli, Dilek Gökdemir, E. Babacan","doi":"10.1089/0883187041269887","DOIUrl":"https://doi.org/10.1089/0883187041269887","url":null,"abstract":"In recent years, an increasing number of observations has lent support to the concept that dysregulation of apoptosis may play a role in the development of airway inflammation in asthma. In the present study, serum sFas and soluble Fas ligand (sFasL) levels were measured by enzyme-linked immunosorbent assay (ELISA), during and 2 weeks after the treatment of the acute attack in 15 asthmatic children (range, 2–14 years; median, 5 years) to evaluate the possible role of the Fas-FasL system in asthmatic inflammation. Serum sFas levels of stable asthmatic patients were significantly higher than both the ones with acute attack and the controls (p < 0.001, p < 0.01, respectively). sFas levels were higher in nonatopic asthmatics, both in the acute and stable phases, than those of the atopics. sFasL levels during the acute attack were significantly higher than those of the controls (p < 0.05). sFasL levels of patients receiving inhaler corticosteroid (ICS) treatment were significantly higher than those of the pati...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"1 1","pages":"126-130"},"PeriodicalIF":0.0,"publicationDate":"2004-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88874273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Trial of an Asthma Education Program in an Inner-City Pediatric Emergency Department 市中心儿科急诊科哮喘教育项目的试验
Pediatric asthma, allergy & immunology Pub Date : 2004-07-08 DOI: 10.1089/0883187041269913
H. Farber, L. Oliveria
{"title":"Trial of an Asthma Education Program in an Inner-City Pediatric Emergency Department","authors":"H. Farber, L. Oliveria","doi":"10.1089/0883187041269913","DOIUrl":"https://doi.org/10.1089/0883187041269913","url":null,"abstract":"The objective of this study was to determine the effect of an asthma education and management intervention, offered as part of an emergency department (ED) visit, on functional severity, use of asthma controller medication, and risk of needing crisis care. Designed as a randomized, controlled clinical trial, Medicaid-insured children aged 2 years to 18 years were seen in an inner-city hospital ED for acute asthma. In the intervention group, the adult accompanying the child received basic asthma education, a written asthma management plan (illustrated by zones colored green, yellow, and red), and prescriptions for both quick-relief and long-term control medication as part of the ED visit. The control group received routine care. Functional severity of asthma was assessed at baseline and at 1 month after the intervention. Medicaid claims data were used to determine frequency of asthma medication dispensing and dates of hospital-based events (ED visits and hospital admissions) during the 6 months after the i...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"91 1","pages":"107-115"},"PeriodicalIF":0.0,"publicationDate":"2004-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91169778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Resolution of Selective Antibody Deficiency in a Child with a Lacunar Defect of Immune Recognition of Hemophilus influenzae 流感嗜血杆菌免疫识别腔隙性缺陷儿童选择性抗体缺乏的解决
Pediatric asthma, allergy & immunology Pub Date : 2004-07-08 DOI: 10.1089/088318704322994976
H. Gray, A. Knutsen
{"title":"Resolution of Selective Antibody Deficiency in a Child with a Lacunar Defect of Immune Recognition of Hemophilus influenzae","authors":"H. Gray, A. Knutsen","doi":"10.1089/088318704322994976","DOIUrl":"https://doi.org/10.1089/088318704322994976","url":null,"abstract":"A child who had Hemophilus influenzae type B (HiB) meningitis with a selective antibody deficiency to Hemophilus influenzae associated with decreased immunoglobulin-A (IgA) and IgG-2 levels is presented. Resolution of the immune deficiency was observed with normalization of serum immunoglobulin and IgG-2 levels at 2.5 years old, normal antibody responses to tetanus toxoid, and unconjugated pneumoccocal immunization, but persistent defect to conjugated HiB immunization until 7 years old.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"10 1","pages":"81-85"},"PeriodicalIF":0.0,"publicationDate":"2004-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87489799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exhaled Nitric Oxide in Airway Diseases of Children 呼出一氧化氮在儿童气道疾病中的作用
Pediatric asthma, allergy & immunology Pub Date : 2004-07-08 DOI: 10.1089/088318704322994921
C. Hung, Ming-Yung Lee, Kuender D Yang, Y. Tsai, D. Chu, Y. Yuh
{"title":"Exhaled Nitric Oxide in Airway Diseases of Children","authors":"C. Hung, Ming-Yung Lee, Kuender D Yang, Y. Tsai, D. Chu, Y. Yuh","doi":"10.1089/088318704322994921","DOIUrl":"https://doi.org/10.1089/088318704322994921","url":null,"abstract":"The measurement of exhaled nitric oxide (ENO) is a simple and noninvasive approach for assessing airway inflammation. The purpose of this study was to investigate whether ENO levels were different in children with various types of airway diseases. We recruited 100 consecutive patients with different airway diseases and 42 healthy control subjects for the study. Allergic asthmatic patients with high specific immunoglobulin E (IgE) level to Dermatophagoides pteronyssinus (Der p) tended to have the highest specific ENO levels (48.28 ± 16.63 ppb; n = 24). Perennial allergic rhinitis patients with high specific IgE level to Der p had intermediate levels of ENO (20.81 ± 9.56 ppb; n = 40). Patients with interstitial pneumonia induced by Mycoplasma pneumoniae (9.44 ± 3.97 ppb; n = 12) or with simple upper respiratory tract infections (10.51 ± 4.19 ppb; n = 24) had ENO levels similar to those of the healthy control subjects (8.80 ± 3.03 ppb; n = 42). Increased ENO in asthmatic patients and perennial allergic rhini...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"317 1","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2004-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77784562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction of Plasma Levels of Neurotrophins by Laughter in Patients with Atopic Dermatitis 笑声对特应性皮炎患者血浆神经营养因子水平的影响
Pediatric asthma, allergy & immunology Pub Date : 2004-07-08 DOI: 10.1089/0883187041269869
H. Kimata
{"title":"Reduction of Plasma Levels of Neurotrophins by Laughter in Patients with Atopic Dermatitis","authors":"H. Kimata","doi":"10.1089/0883187041269869","DOIUrl":"https://doi.org/10.1089/0883187041269869","url":null,"abstract":"Patients with atopic dermatitis (AD) are afflicted with a distressing, chronically relapsing, extremely pruritic eczema. The pruritus often produces stress in these patients. However, many \"triggers\" (i.e., sweating, xerosis, some allergens, etc.) are known to produce their itch. \"Stress\" is well-recognized as another \"trigger\" of their pruritus. In contrast, laughter reduces allergic responses. The effect of laughter on plasma neurotrophic levels caused by viewing humorous videos was studied in AD patients. The study was conducted using a cross-over design. Twenty-four patients with moderate AD (SCORAD index mean age 14 years, range 13–15 years) and 24 normal subjects (mean age 14 years, range 13–15 years) randomly viewed an 87-minute-long nonemotional weather information video and an 87-minute-long humorous video movie (Modern Times, featuring Charlie Chaplin). Just before and immediately after viewing each video, stress levels were measured using a one-item overall stress-rating scale. Simultaneously, ...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"52 1","pages":"131-135"},"PeriodicalIF":0.0,"publicationDate":"2004-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82689584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Remodeling: Is This the Appropriate Term? 重塑:这个词合适吗?
Pediatric asthma, allergy & immunology Pub Date : 2004-07-08 DOI: 10.1089/088318704322994886
M. Levine
{"title":"Remodeling: Is This the Appropriate Term?","authors":"M. Levine","doi":"10.1089/088318704322994886","DOIUrl":"https://doi.org/10.1089/088318704322994886","url":null,"abstract":"","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"62 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2004-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76612119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
There Is No Evidence of Difference in Polymorphisms in the IL-1 β-511 Promoter and IL-1Ra Gene Between Asthmatic and Healthy Groups 哮喘组与健康组IL-1 β-511启动子和IL-1Ra基因多态性无差异
Pediatric asthma, allergy & immunology Pub Date : 2004-07-08 DOI: 10.1089/088318704322994949
C. Hsieh, F. Tsai, W. Chow, ChiYu Wu, H. Kobayashi
{"title":"There Is No Evidence of Difference in Polymorphisms in the IL-1 β-511 Promoter and IL-1Ra Gene Between Asthmatic and Healthy Groups","authors":"C. Hsieh, F. Tsai, W. Chow, ChiYu Wu, H. Kobayashi","doi":"10.1089/088318704322994949","DOIUrl":"https://doi.org/10.1089/088318704322994949","url":null,"abstract":"Asthma is a chronic inflammatory disease of the airway. Both genetic and environmental factors are thought to be involved in the onset of the disease. We aimed to investigate if the interleukin-1β (IL-1β)-511 promoter and IL-1 receptor antagonist (IL-1Ra) gene polymorphisms could be used as markers of susceptibility to bronchial asthma in children. Children were divided into two groups: (1) bronchial asthma (n = 202) and (2) healthy control (n = 144). Polymorphisms for the IL-1β-511 promoter and IL-1Ra were detected by polymerase chain reaction. Genotypes and allelic frequencies for these polymorphisms in both groups were compared. The difference in the proportions of different IL-1β-511 promoter and IL-1Ra polymorphisms in both groups were not significant. Proportions of C homozygote/heterozygote/T homozygote for IL-1β-511 promoter were (1) 34.2/46.0/19.8% in the asthma group and (2) 33.3/48.6/18.1% in the control group. Alleles I/II/III/IV for IL-1Ra were (1) 91.8/7.7/0.5/0% in the asthma group and (2) ...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"28 1","pages":"53-57"},"PeriodicalIF":0.0,"publicationDate":"2004-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72782403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Bronchial Reactivity in Students from Moisture and Mold-Damaged Schools: Changes in Relation to Changes in Exposure 湿气和霉变学校学生支气管反应性:与暴露变化相关的变化
Pediatric asthma, allergy & immunology Pub Date : 2004-07-08 DOI: 10.1089/0883187041269878
J. Immonen, T. Taskinen, J. Pekkanen, M. Korppi
{"title":"Bronchial Reactivity in Students from Moisture and Mold-Damaged Schools: Changes in Relation to Changes in Exposure","authors":"J. Immonen, T. Taskinen, J. Pekkanen, M. Korppi","doi":"10.1089/0883187041269878","DOIUrl":"https://doi.org/10.1089/0883187041269878","url":null,"abstract":"There is epidemiological and preliminary clinical evidence that exposure to moisture and mold growth is associated with wheezing and asthma in children. Lung function and challenge tests may find obstructive changes in the airways before clinically evident symptoms. The aim of the study was to evaluate lung function and bronchial reactivity in school children in a follow-up setting, and relate them to changes in mold exposure over a 3-year observation period. We performed flow-volume spirometry and an exercise challenge test by outdoor free running 3 years apart to the same 139 students from moisture-problem and control schools. The subjects were classified into four exposure groups: exposure continued, eased, started, and no exposure. There were no significant differences in spirometry or in the exercise challenge test among the children in the four different exposure groups. However, there was a trend that, on average, bronchial reactivity increased when exposure started, and decreased when exposure eas...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"59 1","pages":"116-125"},"PeriodicalIF":0.0,"publicationDate":"2004-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90885748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Perinatal, Social, and Environmental Factors and the Risk for Childhood Asthma in a 10-Year Follow-Up 围产期、社会和环境因素与10年随访儿童哮喘风险的关系
Pediatric asthma, allergy & immunology Pub Date : 2004-07-08 DOI: 10.1089/0883187041269931
E. Roel, Å. Faresjö, O. Zetterström, T. Faresjö
{"title":"Perinatal, Social, and Environmental Factors and the Risk for Childhood Asthma in a 10-Year Follow-Up","authors":"E. Roel, Å. Faresjö, O. Zetterström, T. Faresjö","doi":"10.1089/0883187041269931","DOIUrl":"https://doi.org/10.1089/0883187041269931","url":null,"abstract":"The aim of this study was to investigate the relative importance of perinatal, social, and environmental factors in a birth cohort for the risk of developing asthma in a 10-year followup. A group of children (n = 144) with medically diagnosed asthma was matched to a control group of demographic twins (n = 144) from the same birth cohort and region. In a defined region in Sweden, children with a well-documented and medically confirmed asthma diagnosis were retrospectively identified and followed from birth up to the age of 10. Asthma diagnosis, perinatal and obstetric factors, and social data for both the case and control groups were collected through medical records at all health centers in primary care, privately practicing pediatricians, and the public pediatric clinic in the region. The parents of these children answered the standardized ISAAC postal questionnaire, with an overall response rate of 87%. Family history of asthma and allergic rhinitis and low birth weight indicated an increased asthma ris...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"5 1","pages":"136-145"},"PeriodicalIF":0.0,"publicationDate":"2004-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75975772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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