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Laryngeal foreign body in the differential diagnosis of wheeze in early childhood 喉异物在幼儿喘息的鉴别诊断
Pediatric asthma, allergy & immunology Pub Date : 2003-05-25 DOI: 10.1089/088318703765068695
É. Oláh, A. Gerber, J. Wildhaber
{"title":"Laryngeal foreign body in the differential diagnosis of wheeze in early childhood","authors":"É. Oláh, A. Gerber, J. Wildhaber","doi":"10.1089/088318703765068695","DOIUrl":"https://doi.org/10.1089/088318703765068695","url":null,"abstract":"Wheeze is the major clinical sign of asthma. However, wheeze cannot be used as a unique diagnostic sign for asthma in young children. Most respiratory disease in early childhood is obstructive in nature and usually manifests with wheeze. This report presents three wheezy young children diagnosed with asthma and treated with inhaled steroids before the diagnosis of laryngeal foreign body was made. The importance of a carefully taken history and examination of every child presenting with wheeze in early childhood is discussed.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"7 1","pages":"101-104"},"PeriodicalIF":0.0,"publicationDate":"2003-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82444850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Efficacy and Safety of Extrafine Beclomethasone Dipropionate Aerosol Therapy in Children with Asthma: A Twelve-Week Placebo-Controlled Trial 二丙酸倍氯米松雾化治疗儿童哮喘的疗效和安全性:一项为期12周的安慰剂对照试验
Pediatric asthma, allergy & immunology Pub Date : 2003-03-01 DOI: 10.1089/088318703320910052
M. Ruff, S. Szefler, E. Meltzer, W. Berger
{"title":"Efficacy and Safety of Extrafine Beclomethasone Dipropionate Aerosol Therapy in Children with Asthma: A Twelve-Week Placebo-Controlled Trial","authors":"M. Ruff, S. Szefler, E. Meltzer, W. Berger","doi":"10.1089/088318703320910052","DOIUrl":"https://doi.org/10.1089/088318703320910052","url":null,"abstract":"This multicenter study investigated whether beclomethasone dipropionate in hydrofluoroalkane-134a propellant (HFA-BDP) is effective in controlling asthma in children at a total dose as low as 100 μg/d. A group of 319 children with mild to moderate asthma, ranging in age from 6 to 12 years, were randomly assigned to receive double-blind treatment with HFA-BDP, 50 μg twice daily; HFA-BDP, 100 μg twice daily; or HFA-placebo for 12 weeks. The Maxair™ Autohaler™ (3M Pharmaceuticals) inhalation device was used to facilitate medication delivery. Median compliance with study medication was 62.5% in the intent-to-treat population, and was lower in the HFA-BDP 200 μg/d group (55.8%) compared to the HFA-BDP 100 μg/d (67.0%) and placebo (66.0%) groups. Median compliance was 80.0% in the evaluable-for-efficacy population. Mean change from baseline at week 12 in forced expiratory volume in 1 second (FEV1) percent predicted was significantly greater than placebo in the HFA-BDP 100 μg/d group (p ≤ 0.01) but not the 200 μ...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"145 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83449183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Conversion rate of leukotriene C4 to Leukotriene E4 is decreased in children with asthma 哮喘患儿白三烯C4到白三烯E4的转化率降低
Pediatric asthma, allergy & immunology Pub Date : 2003-03-01 DOI: 10.1089/088318703320910098
M. Zaitsu, Y. Hamasaki, Kinji Honjo, K. Sasaki, S. Nishimura, M. Matsuo, I. Fujita, E. Ishii
{"title":"Conversion rate of leukotriene C4 to Leukotriene E4 is decreased in children with asthma","authors":"M. Zaitsu, Y. Hamasaki, Kinji Honjo, K. Sasaki, S. Nishimura, M. Matsuo, I. Fujita, E. Ishii","doi":"10.1089/088318703320910098","DOIUrl":"https://doi.org/10.1089/088318703320910098","url":null,"abstract":"Cysteinyl leukotrienes (cysLTs; LTC4, LTD4, and LTE4) are important mediators in asthma. LTC4 is metabolized to less active LTE4 via LTD4 by glutamyl transpeptidases and dipeptidases. The enzymatic conversion of LTC4 to LTE4 may be a regulatory mechanism in asthma. We examined the conversion rate of LTC4 to LTE4 in children it to asthma, and compared it to that in controls. After serum specimens from children with asthma were incubated with exogenous LTC4 for 30 minutes at 37°C, the levels of LTC4 and LTE4 were measured by high-performance liquid chromatography. Conversion rate of LTC4 to LTE4 was significantly lower in children with asthma (67.6 ± 4.8 LTE4 ng/mg of protein per minute) than controls (86.8 ± 4.4 LTE4 ng/mg of protein per minute). The result indicates that the conversion rate of LTC4 to LTE4 may contribute to the pathogenesis of childhood asthma.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"20 1","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91307330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Changes of Mite-Specific Immunoglobulin A and Transforming Growth Factor-β1 During Immunotherapy of Children with Dust Mite Allergy 螨特异性免疫球蛋白A和转化生长因子-β1在儿童尘螨过敏免疫治疗中的变化
Pediatric asthma, allergy & immunology Pub Date : 2003-03-01 DOI: 10.1089/088318703320910061
L. Wang, Yao-Hsu Yang, M. Tsai, B. Chiang
{"title":"The Changes of Mite-Specific Immunoglobulin A and Transforming Growth Factor-β1 During Immunotherapy of Children with Dust Mite Allergy","authors":"L. Wang, Yao-Hsu Yang, M. Tsai, B. Chiang","doi":"10.1089/088318703320910061","DOIUrl":"https://doi.org/10.1089/088318703320910061","url":null,"abstract":"Immunoglobulin A (IgA) is the most important immunoglobulin of the mucosa. It can protect the mucosal surface from invasion by foreign pathogens. However, only a few studies have mentioned the changes of allergen-specific IgA after immunotherapy in patients with bronchial asthma. In this study, we sought to investigate the levels of mite-specific IgA, IgE, and IgG4 as well as total IgE, IgG, IgA, and IgM, before and after immunotherapy. Serum levels of transforming growth factor β1 (TGF-β1), the major cytokine secreted by type 3 T helper (TH3) cell and a contributing factor for IgA isotype switch, was also assayed. A total of 19 patients were enrolled in this study. The serum levels of total IgG, IgA, and IgM were measured by rate nephelometry. Total IgE, Dermatophagoides pteronyssinus (Der-p), and Dermatophagoides farinae (Der-f)-specific IgE, and mite-specific IgG4 were determined with commercial radioallergosorbent test (RAST) system. Mite-specific IgA and TGF-β1 were measured by enzyme-linked immunoso...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"32 1","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78376819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular Interstitial Pneumonitis in Children: Response to Hydroxychloroquine Treatment in Two Cases 儿童细胞间质性肺炎:两例羟氯喹治疗的疗效
Pediatric asthma, allergy & immunology Pub Date : 2003-03-01 DOI: 10.1089/088318703320910106
P. Nikolaidou, E. Charocopos, G. Anagnostopoulos, D. Lazopoulou, M. Kairis, A. Lourida, K. Tzoumakas, T. Tsiligiannis
{"title":"Cellular Interstitial Pneumonitis in Children: Response to Hydroxychloroquine Treatment in Two Cases","authors":"P. Nikolaidou, E. Charocopos, G. Anagnostopoulos, D. Lazopoulou, M. Kairis, A. Lourida, K. Tzoumakas, T. Tsiligiannis","doi":"10.1089/088318703320910106","DOIUrl":"https://doi.org/10.1089/088318703320910106","url":null,"abstract":"We describe two children with biopsy confirmed cellular interstitial pneumonitis (CIP). The first child, a 5.5-year-old girl, presented at 3 years of age with respiratory distress and decreased exercise tolerance. Open-lung biopsy was consistent with CIP. She was initially treated with prednisolone. After 2 months hydroxychloroquine was begun because of lack of response to corticosteroid therapy, and the patient had a significant response within 1 month. The patient has been maintained successfully on continuous treatment with hydroxychloroquine only for more than 3 years since this treatment was started. The second patient, a 9-month-old boy presented with tachypnea, cough, and hemoglobin desaturation. After confirmation of the diagnosis by lung biopsy and initial failure of response to oral prednisolone, hydroxychloroquine was begun while steroids were discontinued, with a rapid improvement. Four months later, the infant remains asymptomatic, with normal auscultatory findings and oxygen saturation above...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"56 1","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78423095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
In My Opinion—Interview with the Expert 在我看来-采访专家
Pediatric asthma, allergy & immunology Pub Date : 2003-03-01 DOI: 10.1089/088318703322247651
D. Metcalfe
{"title":"In My Opinion—Interview with the Expert","authors":"D. Metcalfe","doi":"10.1089/088318703322247651","DOIUrl":"https://doi.org/10.1089/088318703322247651","url":null,"abstract":"A NDREW H. Liu, M.D., is the Training Program Director and an Associate Professor in Pediatric Allergy & Immunology at the National Jewish Medical & Research Center and the University of Colorado Health Sciences Center inDenver. He serves as the Pediatric Asthma & Allergy Consultant to the Health & Hospitals System for the City & County of Denver. In addition, he runs teaching clinics at National Jewish, Denver Health, and The Children's Hospital of Denver. Dr. Liu researches the immune development underlying asthma and allergies in young children, seeking early intervention strategies for therapy and prevention. He is an investigator for the National Institutes of Health (NIH) in several research programs in this field. These include a recent NIH Career Development Award on \"Endotoxin and Asthma Prevention in Young Children,\" and several NIH-funded intervention studies for childhood asthma: Childhood Asthma Management Program (CAMP); Childhood Asthma Prevention Study (CAPS); and Prevention of Early Asthma in Kids study (PEAK). Dr. Liu has written articles for such peer-reviewed journals as The Lancet, Journal of Allergy and Clinical Immunology, Journal of Experimental Medicine, and Proceedings of the National Academy of Sciences. He is a Fellow of the American Academy of Pediatrics and the American College of Allergy, Asthma, and Immunology, and a member of the American Academy of Allergy, Asthma, and Immunology and the American Association of Immunologists. Dr. Liu received his medical degree from the University of Massachusetts Medical School and completed his Internship and Residency in Pediatrics at the University of Colorado School of Medicine. He completed his Fellowships in Allergy & Immunology and in Clinical & Laboratory Immunology at the National Jewish Medical and Research Center.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"41 1","pages":"53-57"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77935970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual-Channel pH Probe Is Not Distinctive in Children with Respiratory Symptoms 双通道pH探针在呼吸道症状儿童中无特异性
Pediatric asthma, allergy & immunology Pub Date : 2003-03-01 DOI: 10.1089/088318703320910070
M. Glock, C. Woods, C. Toro, I. Hill, J. Georgitis
{"title":"Dual-Channel pH Probe Is Not Distinctive in Children with Respiratory Symptoms","authors":"M. Glock, C. Woods, C. Toro, I. Hill, J. Georgitis","doi":"10.1089/088318703320910070","DOIUrl":"https://doi.org/10.1089/088318703320910070","url":null,"abstract":"Gastroesophageal reflux is considered one of the etiologies for chronic respiratory and laryngeal symptoms in infants and children, yet the association has been difficult to prove. Dual-channel 24-hour pH probe studies have become more common in the evaluation of these children. To establish whether a significant correlation exists between pharyngeal acid exposure and chronic respiratory symptoms in children, 293 infants and children with and without respiratory symptoms underwent 24-hour double pH probe monitoring. Patients were divided into four groups based on the clinical indication for the study and the results of the distal sensor. Pharyngeal reflux episodes correlated positively (r = 0.54) with lower esophageal episodes but did not differentiate children with respiratory symptoms from those with nonrespiratory symptoms. There was an inverse relation between the number of pharyngeal reflux episodes (r = -0.14) and age, making the definition of abnormal pharyngeal reflux age dependent. The evaluation...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"76 1","pages":"23-30"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76898212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reflux and Respiration: The Search for Better Diagnostics 反流和呼吸:寻找更好的诊断方法
Pediatric asthma, allergy & immunology Pub Date : 2003-03-01 DOI: 10.1089/088318703320910124
S. Bharwani, J. Herbst
{"title":"Reflux and Respiration: The Search for Better Diagnostics","authors":"S. Bharwani, J. Herbst","doi":"10.1089/088318703320910124","DOIUrl":"https://doi.org/10.1089/088318703320910124","url":null,"abstract":"","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"11 1","pages":"59-61"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74581559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bronchial Responsiveness to Inhaled Nonisotonic Solutions in Children with Asthma with Exercise-Induced Broncho-Obstruction 运动性支气管梗阻哮喘患儿支气管对吸入非等渗溶液的反应性
Pediatric asthma, allergy & immunology Pub Date : 2003-03-01 DOI: 10.1089/088318703320910089
V. Cherginets, A. Cherginets
{"title":"Bronchial Responsiveness to Inhaled Nonisotonic Solutions in Children with Asthma with Exercise-Induced Broncho-Obstruction","authors":"V. Cherginets, A. Cherginets","doi":"10.1089/088318703320910089","DOIUrl":"https://doi.org/10.1089/088318703320910089","url":null,"abstract":"The purpose of the present study was to assess the relation between bronchial responsiveness (BR) to exercise and inhaled nonisotonic solutions in children with asthma with exercise-induced broncho-obstruction (EIB). We investigated BR to exercise, inhaled, ultrasonically nebulized 4.5% saline (HS), and distilled water (UNDW) by bronchoprovocation challenges in 41 children with asthma, 6 to 15 year olds, with documented EIB. Bronchial responsiveness, as measured by a decrease in pulmonary function with various stimuli, was noted in 36 (87.8%) of children when challenged by HS and only 6 (14.6%) with UNDW. A positive correlation was noted between bronchial responsiveness to exercise and HS (r = 0.34323; p 0.05). Bronchial responsiveness to HS, and not UNDW, may mimic the response to exercise in children with asthma with EIB. It is a possible that responsiveness to exercise may have similar with hypertonic and different f...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"124 1","pages":"31-38"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73757347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long QT Syndrome in Children with Asthma 哮喘患儿的长QT综合征
Pediatric asthma, allergy & immunology Pub Date : 2002-12-01 DOI: 10.1089/088318702320323127
R. Khoudary, S. Mcgeady
{"title":"Long QT Syndrome in Children with Asthma","authors":"R. Khoudary, S. Mcgeady","doi":"10.1089/088318702320323127","DOIUrl":"https://doi.org/10.1089/088318702320323127","url":null,"abstract":"Finding the long QT syndrome on electrocardiogram (ECG) in a patient with asthma presents a therapeutic dilemma. The treatment of choice for long QT syndrome is β-adrenergic blocker drugs that may aggravate bronchospasm. Conversely, the treatment of asthma with β-adrenergic agonists may cause arrhythmias in patients with long QT syndrome. We report our experience with three children with asthma with long QT syndrome. Patients with asthma with long QT syndrome under our direct care or on whom we have been consulted were treated with β-blocker drugs, and the effect on their asthma was observed. When required, β-agonists were administered, and the effects on cardiac rhythm were noted. All three patients developed status asthmaticus during a respiratory infection while receiving β-blocker therapy for 8–24 months. All received standard therapy for status asthmaticus with inhaled β-agonist and intravenous glucocorticoid, and one received intravenous theophylline. Only minor disturbances of cardiac rhythm were o...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"41 1","pages":"213-217"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80204188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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