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CH50 and Its Use in the Allergist–Clinical Immunologist's Practice CH50及其在变态反应科-临床免疫学实践中的应用
Pediatric asthma, allergy & immunology Pub Date : 2002-12-01 DOI: 10.1089/088318702320323136
D. Reichmuth, D. Ledford
{"title":"CH50 and Its Use in the Allergist–Clinical Immunologist's Practice","authors":"D. Reichmuth, D. Ledford","doi":"10.1089/088318702320323136","DOIUrl":"https://doi.org/10.1089/088318702320323136","url":null,"abstract":"The CH50 reflects the ability of serum complement to lyse sheep red blood cells (RBCs); its value is the reciprocal of the dilution of serum to lyse 50% of antibody coated sheep RBCs. Reduction of the CH50 occurs when individual complement component(s) are deficient or consumed. The CH50 may be useful for a variety of medical specialties and is most helpful diagnostically when laboratory results are interpreted in the context of the history and physical exam. The primary utility of the CH50 in the practice of an allergist-immunologist is to screen for complement-deficiency associated immunodeficiency (primarily classic or terminal complement component deficiencies) and some vasculitides (usually immune-complex induced and/or small vessel vasculitis). Absent or significantly reduced individual complement components may result in recurrent sinopulmonary bacterial infections, Neisserial meningitis, or sepsis. A reduced CH50 in this situation warrants quantification and functional assays of individual complem...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"40 1","pages":"219-225"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85077055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Open-label trial of high-dose intravenous immunoglobulin in patients with severe asthma 大剂量静脉注射免疫球蛋白治疗严重哮喘的开放标签试验
Pediatric asthma, allergy & immunology Pub Date : 2002-12-01 DOI: 10.1089/088318702320323091
Sandra J. Downes, Jon E. Stahlman, I. Borras, L. Salmun, L. Schneider
{"title":"Open-label trial of high-dose intravenous immunoglobulin in patients with severe asthma","authors":"Sandra J. Downes, Jon E. Stahlman, I. Borras, L. Salmun, L. Schneider","doi":"10.1089/088318702320323091","DOIUrl":"https://doi.org/10.1089/088318702320323091","url":null,"abstract":"Anti-inflammatory corticosteroid therapy is highly effective, however, the long term adverse effects may be devastating for patients with severe asthma. Intravenous immunoglobulin (IVIG) is known to have immunomodulatory effects, and in a few clinical trials has been shown to have potential benefit as a steroid-sparing agent in asthma patients requiring high doses of corticosteroids. This study assessed the efficacy of high-dose IVIG in reducing the steroid requirement and subsequently improving the pulmonary function, symptomatology, and quality of life in patients with severe steroid-dependent asthma. Six immunocompetent, steroid-dependent patients were enrolled in an open-label trial of IVIG given as six monthly infusions of 2 g/kg per dose. Five patients completed the study. Of these, four showed a significant reduction in oral corticosteroid requirement while being treated with IVIG. The mean reduction was 10.1 mg/d (p = 0.02), which was an almost 50% decrease in corticosteroid requirement. Two patie...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"37 1","pages":"187-194"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89298923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are Mold-Specific Immunoglobulin G Antibodies in Schoolchildren a Marker of Exposure and Respiratory Disease? 学童霉菌特异性免疫球蛋白G抗体是暴露和呼吸道疾病的标志吗?
Pediatric asthma, allergy & immunology Pub Date : 2002-12-01 DOI: 10.1089/088318702320323118
J. Immonen, S. Laitinen, T. Taskinen, J. Pekkanen, A. Nevalainen, M. Korppi
{"title":"Are Mold-Specific Immunoglobulin G Antibodies in Schoolchildren a Marker of Exposure and Respiratory Disease?","authors":"J. Immonen, S. Laitinen, T. Taskinen, J. Pekkanen, A. Nevalainen, M. Korppi","doi":"10.1089/088318702320323118","DOIUrl":"https://doi.org/10.1089/088318702320323118","url":null,"abstract":"Based on experience received from occupational studies, immunoglobulin G (IgG) antibodies to molds have also been used as markers of exposure to molds in homes, schools, or other low-exposure environments. The purpose of the present study was to evaluate mold-specific IgG antibodies measured 3 years apart in children exposed to moisture and molds at school. In 1996, 212 primary school students with asthma, wheezing, or prolonged cough participated in a study, including clinical examination and mold-specific IgG determinations to 24 molds. In 1999, 144 students of the same cohort participated in an identical follow-up study; among them, mold-specific IgG was measured in 121 students. The schools they attended were investigated both technically and microbiologically at both phases of the study. No association was found between IgG antibodies to molds and exposure to moisture or molds in school in either year. Mold-specific IgG antibodies had no significant association with asthma or other long-term allergic...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"12 1","pages":"201-211"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84702011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Influence of the TH1/TH2 Paradigm: The Prevalence of Asthma and Allergic Diseases in Patients with Type 1 Diabetes in the United States TH1/TH2范式的影响:美国1型糖尿病患者哮喘和过敏性疾病的患病率
Pediatric asthma, allergy & immunology Pub Date : 2002-12-01 DOI: 10.1089/088318702320323109
Shih-wen Huang, J. Hitchcock
{"title":"Influence of the TH1/TH2 Paradigm: The Prevalence of Asthma and Allergic Diseases in Patients with Type 1 Diabetes in the United States","authors":"Shih-wen Huang, J. Hitchcock","doi":"10.1089/088318702320323109","DOIUrl":"https://doi.org/10.1089/088318702320323109","url":null,"abstract":"To test the TH1/TH2 paradigm, we determined the prevalence of asthma and allergic disorders (TH2-driven diseases) in children with type 1 diabetes (a TH1-driven disease) in the United States. The s...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"1 1","pages":"195-199"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84217588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Childhood Asthma as an Allergic Disease: Basis of Anti-Immunoglobulin E Therapy 儿童哮喘作为变应性疾病:抗免疫球蛋白E治疗的基础
Pediatric asthma, allergy & immunology Pub Date : 2002-06-01 DOI: 10.1089/08831870260093870
H. Milgrom
{"title":"Childhood Asthma as an Allergic Disease: Basis of Anti-Immunoglobulin E Therapy","authors":"H. Milgrom","doi":"10.1089/08831870260093870","DOIUrl":"https://doi.org/10.1089/08831870260093870","url":null,"abstract":"Asthma is a dynamic disorder of bronchial inflammation, tissue injury and repair, with resulting bronchoconstriction, bronchial hyperresponsiveness, and airway obstruction. Genetic predisposition, a decline in infections in early childhood, and exposure and sensitization to environmental allergens all appear to play a role in the pathogenesis of asthma. Elevated immunoglobulin E (IgE) in infancy is associated with onset of the disease later in childhood. Current management strategies for persistent childhood asthma recommend the use of antiinflammatory medications, particularly inhaled corticosteroids. A promising new treatment is based on the neutralization of free IgE by humanized monoclonal anti-IgE antibody (omalizumab).","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"03 1","pages":"153-162"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86266637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Uses of Erythrocyte Sedimentation Rate in Allergy/Immunology 红细胞沉降率在过敏/免疫学中的应用
Pediatric asthma, allergy & immunology Pub Date : 2002-06-01 DOI: 10.1089/08831870260093898
D. Reichmuth, D. Ledford
{"title":"Uses of Erythrocyte Sedimentation Rate in Allergy/Immunology","authors":"D. Reichmuth, D. Ledford","doi":"10.1089/08831870260093898","DOIUrl":"https://doi.org/10.1089/08831870260093898","url":null,"abstract":"The erythrocyte sedimentation rate (ESR), one of the original tests of modern medicine, is a relatively simple procedure that continues to be used in evaluating medical conditions. Its function in the allergist/clinical immunologist's practice is to assess patients with an unusual presentation of a normally encountered condition for an underlying disorder, e.g., a severe asthmatic with Churg Strauss syndrome. It is also used to identify potential etiologies of some disorders, such as vasculitis causing chronic urticaria. It is neither completely sensitive nor specific for diagnosing any disorder; thus, it is adjunctive to the history, physical exam, and other laboratory and radiological studies. The ESR does not have a role in assessing uncomplicated atopic conditions.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"1 1","pages":"167-171"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79619984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Left-handedness and Parental Psychopathology in the Course of Bronchial Asthma in Childhood 儿童支气管哮喘过程中左撇子与父母精神病理的关系
Pediatric asthma, allergy & immunology Pub Date : 2002-06-01 DOI: 10.1089/08831870260093861
G. Krommydas, K. Gourgoulianis, N. Angelopoulos, G. Andreou, P. Molyvdas
{"title":"Left-handedness and Parental Psychopathology in the Course of Bronchial Asthma in Childhood","authors":"G. Krommydas, K. Gourgoulianis, N. Angelopoulos, G. Andreou, P. Molyvdas","doi":"10.1089/08831870260093861","DOIUrl":"https://doi.org/10.1089/08831870260093861","url":null,"abstract":"Psychopathology in the family seems to have a role in the course of a child's asthma. The purpose of this study was to examine the possible impact of parental anxiety and depression on the course of asthma, as well as to examine the relationship between left-handedness and asthma in children. The International Study of Asthma and Allergy in Childhood (ISAAC), the Foulds and Bedford Inventory for Anxiety and Depression (DSSI/sAD), and the Edinburgh Left-handedness Inventory were administered to 70 families with asthmatic children 4-8 years old. One year later, the children's asthma was reevaluated using a brief questionnaire based on ISAAC. A sample of 70 families with nonasthmatic healthy children were used as controls. The majority of children in the study group had mild asthma. Allergic rhinitis was found in 31.4% and allergic dermatitis in 20% of the sample. The parents of the asthmatic children scored significantly higher in DSSI/sAD compared to parents of the controls. Maternal anxiety reached the le...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"25 1","pages":"145-152"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76949118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Diagnosis of human immunodeficiency virus infection in children 儿童人类免疫缺陷病毒感染的诊断
Pediatric asthma, allergy & immunology Pub Date : 2002-06-01 DOI: 10.1089/08831870260093843
E. Moylett, W. Shearer
{"title":"Diagnosis of human immunodeficiency virus infection in children","authors":"E. Moylett, W. Shearer","doi":"10.1089/08831870260093843","DOIUrl":"https://doi.org/10.1089/08831870260093843","url":null,"abstract":"Since the availability of specific virologic assays for the diagnosis of human immunodeficiency virus infection, the diagnosis of neonatal infection is more specific and confirmed at an earlier age. An early diagnosis of human immunodeficiency virus infection has important implications for the initiation of antiretroviral therapy. Whereas the diagnosis of this infection is primarily antibody-based prior to 18 months of age, the diagnosis at less than 18 months is virologically based.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"4 1","pages":"125-131"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90844507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Assessment of efficacy and systemic safety of a new chlorofluorocarbon-free formulation of inhaled beclomethasone dipropionate in asthmatic children 一种新的不含氯氟烃的吸入二丙酸倍氯米松配方对哮喘儿童的疗效和全身安全性评估
Pediatric asthma, allergy & immunology Pub Date : 2002-06-01 DOI: 10.1089/08831870260093852
T. L. Lee, L. Adler, G. McLaren, A. Rossetti, L. Cantini
{"title":"Assessment of efficacy and systemic safety of a new chlorofluorocarbon-free formulation of inhaled beclomethasone dipropionate in asthmatic children","authors":"T. L. Lee, L. Adler, G. McLaren, A. Rossetti, L. Cantini","doi":"10.1089/08831870260093852","DOIUrl":"https://doi.org/10.1089/08831870260093852","url":null,"abstract":"This study was undertaken with the objective to demonstrate clinical equivalence of a standard 400 μg/d dose of inhaled beclomethasone dipropionate (BDP) given via a new HFA-134a propellant (Chiesi Farmaceutici S.p.A., Parma, Italy), in two dose-units of 50 μg and 100 μg or with the conventional chlorofluorocarbon (CFC) (Becotide™, 50 μg unit dose, Allen & Hanburys, U.K.). A total of 218 children, ages 6-16, with mild to moderate persistent asthma in a stable phase, entered a 2-week run-in period and were then assigned to a 12-week treatment with one of the three treatment tests, following a double-blind, double-dummy (100 μg-dose strength as open arm), multicenter, parallel groups design. Two hundred seven patients entered the intent-to-treat (ITT) analysis and 181 completed the study period. The following efficacy variables were daily recorded by children on a diary card: morning and evening PEFR, number of daytime and nighttime asthma attacks, number of nocturnal awakenings because of asthma, symptoms'...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"29 1","pages":"133-143"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74047667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Intracranial Tumor Masquerading as Allergic Rhinitis 颅内肿瘤伪装成过敏性鼻炎
Pediatric asthma, allergy & immunology Pub Date : 2002-06-01 DOI: 10.1089/08831870260093889
K. Waibel, R. Katial
{"title":"Intracranial Tumor Masquerading as Allergic Rhinitis","authors":"K. Waibel, R. Katial","doi":"10.1089/08831870260093889","DOIUrl":"https://doi.org/10.1089/08831870260093889","url":null,"abstract":"Seasonal allergic rhinitis and perennial allergic rhinitis can present with rhinorrhea, congestion, and headache. Although headache is often attributed to allergic disease, it can be overlooked as a manifestation of other underlying processes. We present a case of intracranial calcifications that incidentally were found on sinus imaging. Subsequently the patient was diagnosed with a craniopharyngioma. Health care providers should be cautious about attributing prominent headache complaints to \"hay fever\" or \"sinus-related disease\" and consider other etiologies.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"136 1","pages":"163-166"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76438471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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