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sTNF-αRI levels in childhood asthma sTNF-αRI在儿童哮喘中的表达
Pediatric asthma, allergy & immunology Pub Date : 2002-01-01 DOI: 10.1089/088318702320323154
W. Shearer, M. Rais, J. M. Terán, S. Abramson, P. Brouwers, K. Evankovich, D. Glaze, L. Jefferson, D. Seilheimer, E. Smith, M. Wise, Bang‐Ning Lee, J. Reuben
{"title":"sTNF-αRI levels in childhood asthma","authors":"W. Shearer, M. Rais, J. M. Terán, S. Abramson, P. Brouwers, K. Evankovich, D. Glaze, L. Jefferson, D. Seilheimer, E. Smith, M. Wise, Bang‐Ning Lee, J. Reuben","doi":"10.1089/088318702320323154","DOIUrl":"https://doi.org/10.1089/088318702320323154","url":null,"abstract":"","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"45 1","pages":"233-234"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90782113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Celiac Disease and Risk of Atopy in Childhood 乳糜泻和儿童特应性反应的风险
Pediatric asthma, allergy & immunology Pub Date : 2001-06-01 DOI: 10.1089/088318701753436862
F. Cataldo, V. Marino, P. Stefano
{"title":"Celiac Disease and Risk of Atopy in Childhood","authors":"F. Cataldo, V. Marino, P. Stefano","doi":"10.1089/088318701753436862","DOIUrl":"https://doi.org/10.1089/088318701753436862","url":null,"abstract":"The object of this study is to determine whether celiac disease (CD) and atopic disorders are associated and whether atopy and gluten exposure are related. Ninety children (mean age of 9.3 years) being treated for CD were evaluated for a personal and family history of atopic diseases by a detailed questionnaire. In addition, study subjects had a peripheral blood eosinophil count, serum IgE, and skin prick tests for 10 common allergens. Ninety healthy children who attended pediatric well-child clinics or were admitted to the hospital for minor surgery served as age- and sex-matched controls. CD was excluded in the control group by clinical evaluation and by negative anti-gliadin (IgA and IgG) and anti-endomysium antibodies. In the children with CD, the age of onset of atopic disorders was compared with the age of diagnosis of CD. The prevalence of atopic disorders was compared in patients with CD who were submitted to gluten challenge or who had spontaneous challenges as teenagers by consuming gluten in their diet. No differences in the prevalence of atopic disorders was found in the group of children with CD compared to the healthy controls. The prevalence of atopic disorders did not increase with increasing age at diagnosis of CD and was not higher in children with CD who had gluten challenges. The conclusions were: CD and atopy are not associated in childhood celiac disease and atopic disorders are not related to gluten exposure. (Pediatr Asthma Allergy Immunol 2001;15[2]:77‐ 80.)","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"58 1","pages":"77-80"},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81448518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Beta-Chemokines in Nasal Secretions of Infants with Respiratory Syncytial Virus-Induced Respiratory Infections 呼吸道合胞病毒引起的呼吸道感染婴儿鼻分泌物中的β趋化因子
Pediatric asthma, allergy & immunology Pub Date : 2001-06-01 DOI: 10.1089/088318701753436880
R. Garofalo, B. Olszewska-Pazdrak, P. Ogra, R. Welliver
{"title":"Beta-Chemokines in Nasal Secretions of Infants with Respiratory Syncytial Virus-Induced Respiratory Infections","authors":"R. Garofalo, B. Olszewska-Pazdrak, P. Ogra, R. Welliver","doi":"10.1089/088318701753436880","DOIUrl":"https://doi.org/10.1089/088318701753436880","url":null,"abstract":"Immune mechanisms are believed to contribute to the pathogenesis of bronchiolitis, but the nature of the critical pathways is unknown. The purpose of this study was to determine if quantities of the beta-chemokines macrophage inflammatory protein 1 alpha (MIP1α), eotaxin, and regulated on expression, normal T-cell expressed and secreted (RANTES) were different among infants with various forms of illness due to respiratory syncytial virus (RSV) infection. Samples of nasopharyngeal secretions (NPS) were obtained from 56 infants and children less than 13 months of age with either upper respiratory illness (URI) alone (n = 25) or lower respiratory tract illness (n = 31) due to RSV infection. Seventeen asymptomatic infants served as controls. Quantities of chemokines in secretions were compared between groups using the t-test after logarithmic transformation of data. Quantities of all three chemokines were increased at the time of RSV infection regardless of whether wheezing was present. However, concentration...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"6 1","pages":"89-96"},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86557559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
In Vitro IgE Synthesis in Neonates with or without a Family History of Atopy 有或无特应性家族史新生儿的体外IgE合成
Pediatric asthma, allergy & immunology Pub Date : 2001-06-01 DOI: 10.1089/088318701753436899
S. Sopo, G. Federico, D. Parenti, M. C. Alecci, G. Zorzi, A. Stabile
{"title":"In Vitro IgE Synthesis in Neonates with or without a Family History of Atopy","authors":"S. Sopo, G. Federico, D. Parenti, M. C. Alecci, G. Zorzi, A. Stabile","doi":"10.1089/088318701753436899","DOIUrl":"https://doi.org/10.1089/088318701753436899","url":null,"abstract":"One highly desirable objective of preventive medicine is to find predictive markers that could identify neonates who are at risk of developing atopic diseases. However, no one laboratory test is sufficiently sensitive and specific to be used for this purpose. The objective of this study was to evaluate the use of an in vitro IgE synthesis by cord blood lymphocytes of neonates with or without a family history of atopy. Cord blood mononuclear cells (CBMC) of 11 neonates with a family history of atopy and 9 neonates without a family history of atopy were incubated for 48 hr with human recombinant IL4 (hrIL4) in Petri plates. Cord blood lymphocytes (nonadherent cells) were then washed and incubated for an additional 9 days with various stimuli. hrIL4, hrIL4 + human recombinant interferon-gamma (hrIFNg), hrIL4 + anti-IL4 antibody (ab), hrIL-4 + antiCD40 ab, hrIL4 + anti-CD40 ab + betalactoglobulin (BLG) hrIL4 + anti-IFNg ab. Unstimulated cultures were included as negative controls. IgE concentrations in sera w...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"53 1","pages":"97-105"},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75136881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic Granulomatous Disease 慢性肉芽肿病
Pediatric asthma, allergy & immunology Pub Date : 2001-06-01 DOI: 10.1089/088318701753436916
S. Sangwan, S. Sarkar
{"title":"Chronic Granulomatous Disease","authors":"S. Sangwan, S. Sarkar","doi":"10.1089/088318701753436916","DOIUrl":"https://doi.org/10.1089/088318701753436916","url":null,"abstract":"Chronic granulomatous disease is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. Immunodeficiencies are conditions in which the immune system is not able to protect the body from foreign invaders such as bacteria and fungi. Individuals with chronic granulomatous disease may have recurrent bacterial and fungal infections. People with this condition may also have areas of inflammation (granulomas) in various tissues that can result in damage to those tissues. The features of chronic granulomatous disease usually first appear in childhood, although some individuals do not show symptoms until later in life.","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"31 1","pages":"113-116"},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84202953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Respiratory Syncytial Virus: An Association with Severe Asthma Exacerbations in Children of All Ages 呼吸道合胞病毒:与所有年龄段儿童严重哮喘发作的关系
Pediatric asthma, allergy & immunology Pub Date : 2001-06-01 DOI: 10.1089/088318701753436853
Christopher A. Smith, R. Hodinka, T. F. Brown, C. Boardman, L. Bell, S. Starr, N. Pawlowski
{"title":"Respiratory Syncytial Virus: An Association with Severe Asthma Exacerbations in Children of All Ages","authors":"Christopher A. Smith, R. Hodinka, T. F. Brown, C. Boardman, L. Bell, S. Starr, N. Pawlowski","doi":"10.1089/088318701753436853","DOIUrl":"https://doi.org/10.1089/088318701753436853","url":null,"abstract":"Respiratory viruses are known to cause asthma exacerbations. There have been no previous studies in children looking at which viruses have the greatest capacity to induce an asthma exacerbation. This study attempts to identify viruses with the most asthmagenic properties. The objective of this study is to determine the prevalence of viral infections in children with asthma exacerbations, and to correlate specific viral infections with clinical severity. Nasopharyngeal and oropharyngeal swabs were collected for viral culture from 101 asthma patients presenting to the Children's Hospital of Philadelphia Emergency Department with an asthma exacerbation. Patients ranged in age from 3 years to 18 years. One hundred and one well asthmatics were recruited from the Allergy Clinic and Department of Pediatrics to serve as control patients. Control patients were enrolled within 2 weeks of study patients, and were matched by age, gender, and ethnic group. Viral isolates were correlated with the age, gender, ethnic gr...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"7 1","pages":"69-75"},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75058308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
New Mexico Public School Practices Regarding Use and Administration of Asthma Medications 新墨西哥州公立学校关于使用和管理哮喘药物的做法
Pediatric asthma, allergy & immunology Pub Date : 2001-03-01 DOI: 10.1089/088318701750314554
P. Marshik, M. Borrego, Elizabeth M. Baldonado, K. Baur, Geraldine H. Cipa, Lester C. George
{"title":"New Mexico Public School Practices Regarding Use and Administration of Asthma Medications","authors":"P. Marshik, M. Borrego, Elizabeth M. Baldonado, K. Baur, Geraldine H. Cipa, Lester C. George","doi":"10.1089/088318701750314554","DOIUrl":"https://doi.org/10.1089/088318701750314554","url":null,"abstract":"A survey was mailed to a randomly selected sample of New Mexico public school personnel to assess the existence of written school policies related to management of acute exacerbations, including the collection, storage, and administration of asthma medications. The survey also assessed the training and understanding of school staff members with respect to the management of an acute asthma exacerbation. Data analyses included comparisons between grade level (elementary, middle, and high schools) and urban versus rural schools categories. Survey response rate was 77.8%. Results indicated that 76.3% of public schools had written policies regarding the use of asthma medications. Over 99% of New Mexico public school children with asthma were allowed to take asthma medications to school. Forty-three percent of respondents had staff trained in the management of asthma exacerbations. Of the New Mexico public schools responding, 84% indicated interest in receiving further education on asthma management and inhaler...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"326 1","pages":"31-41"},"PeriodicalIF":0.0,"publicationDate":"2001-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76363639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
W. James Metzger, Jr., M.D. W. James Metzger, Jr.，医学博士
Pediatric asthma, allergy & immunology Pub Date : 2001-03-01 DOI: 10.1089/088318701750314518
P. Greenberger
{"title":"W. James Metzger, Jr., M.D.","authors":"P. Greenberger","doi":"10.1089/088318701750314518","DOIUrl":"https://doi.org/10.1089/088318701750314518","url":null,"abstract":"","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"214 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2001-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73575697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pilot Study of a Screening Questionnaire for Asthma 哮喘筛查问卷的初步研究
Pediatric asthma, allergy & immunology Pub Date : 2001-03-01 DOI: 10.1089/088318701750314536
M. Sockrider, S. Tortolero, L. K. Bartholomew, C. Markham, S. Abramson, Maria E. Fernandez, G. Parcel
{"title":"Pilot Study of a Screening Questionnaire for Asthma","authors":"M. Sockrider, S. Tortolero, L. K. Bartholomew, C. Markham, S. Abramson, Maria E. Fernandez, G. Parcel","doi":"10.1089/088318701750314536","DOIUrl":"https://doi.org/10.1089/088318701750314536","url":null,"abstract":"There is concern regarding the underdiagnosis and undertreatment of asthma in children. This pilot study was designed to determine the specificity, sensitivity, and feasibility of using a two-part (child + parent questionnaire) case finding tool (Video-guided Asthma Screening for Children-School Age, VASC-SA) to identify elementary school children with asthma. The child checklist includes two practice items and nine items asking about asthma symptoms and diagnosis. The items are visually cued using a 10-min videotape using split-screen vignettes, one corresponding to a no response (most children do not...) and one to a yes response (some children...). Three case definition algorithms were examined (all included inhaled medication, or current diagnosis, or wheeze with 0, 1, or 2 other symptoms). The VASC-SA was administered to English-speaking children in grades 1-4 from one school. All parents were sent a written asthma questionnaire. Positive screens were compared with diagnosis obtained from physician r...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"31 1","pages":"15-24"},"PeriodicalIF":0.0,"publicationDate":"2001-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73740235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Clinical Experience with Azelastine Nasal Spray in Children: Physician Survey of Case Reports 小儿使用氮唑elastine鼻喷雾剂的临床经验:病例报告的医师调查
Pediatric asthma, allergy & immunology Pub Date : 2001-03-01 DOI: 10.1089/088318701750314572
S. Fineman
{"title":"Clinical Experience with Azelastine Nasal Spray in Children: Physician Survey of Case Reports","authors":"S. Fineman","doi":"10.1089/088318701750314572","DOIUrl":"https://doi.org/10.1089/088318701750314572","url":null,"abstract":"Azelastine nasal spray, a topical second-generation antihistamine, was approved in the United States in 1996 for use in patients 12 years of age and older with seasonal allergic rhinitis. It was also recently approved for the treatment of seasonal allergic rhinitis in children 5–11 years of age. The efficacy and safety in children with allergic rhinitis has been demonstrated in 2 European double-blind, placebo-controlled, parallel-group trials. The objective of this study was to evaluate the clinical experience in the United States of a group of physicians treating patients <12 years of age with azelastine nasal spray. Three hundred physicians were sent a 1-page case report form which requested demographic characteristics, diagnosis of the rhinitis type, dosage and duration of therapy, assessment of symptom control, and any adverse drug reactions in these patients. Azelastine nasal spray was reported to be effective by the clinicians for the treatment of allergic rhinitis in children 5–11 years of age wit...","PeriodicalId":88951,"journal":{"name":"Pediatric asthma, allergy & immunology","volume":"119 1","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2001-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78580583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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