Attention deficit and hyperactivity disorders最新文献

{"title":"Physiological substrates of executive functioning: a systematic review of the literature.","authors":"Bailey A Munro,&nbsp;Lisa L Weyandt,&nbsp;Lily E Hall,&nbsp;Danielle R Oster,&nbsp;Bergljot Gyda Gudmundsdottir,&nbsp;Benjamin G Kuhar","doi":"10.1007/s12402-017-0226-9","DOIUrl":"https://doi.org/10.1007/s12402-017-0226-9","url":null,"abstract":"<p><p>Executive function (EF) is a multifaceted construct that has been defined as a set of higher-order cognitive processes that allow for flexibility, self-regulation, strategic planning, and goal-directed behaviors. EFs have been studied in numerous clinical disorders using a variety of neuropsychological tasks and, more recently, neuroimaging techniques. The underlying physiological substrates of EF were historically attributed to the frontal lobes; however, recent studies suggest more widespread involvement of additional brain regions. The purpose of the present study was to conduct a systematic review (using PRISMA 2009 guidelines) of neuroimaging studies employing functional magnetic resonance imaging and diffusion tensor imaging methods investigating the physiological substrates of EFs in attention-deficit/hyperactivity disorder compared to other clinical groups and non-clinical participants. Research articles were retrieved using PsycINFO, PsycARTICLES, MEDLINE, and ScienceDirect, beginning February 2015 through May 2016. A total of 42 studies met eligibility. Of those 42 studies, 22 studies included clinical participants and 20 studies included non-clinical participants. Results revealed increased activation of the frontal brain region in the majority of non-clinical studies and approximately 50% of the clinical studies, albeit with some inconsistencies across subregions, tasks, and age groups. Implications, methodological limitations, and suggestions for future research are discussed.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"10 1","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-017-0226-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34846177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective Distress Associated with Adult ADHD: evaluation of a new self-report.","authors":"Rosetta Nicastro,&nbsp;Martin Desseilles,&nbsp;Paco Prada,&nbsp;Sébastien Weibel,&nbsp;Nader Perroud,&nbsp;Marianne Gex-Fabry","doi":"10.1007/s12402-017-0234-9","DOIUrl":"https://doi.org/10.1007/s12402-017-0234-9","url":null,"abstract":"<p><p>The current study aims at documenting the psychometric properties of the Subjective Distress Associated with Adult ADHD-Self-Report (SDAAA-SR), a newly developed instrument for the assessment of psychological suffering in ADHD adults. The SDAAA-SR was administered to 247 students and 142 ADHD adults. Factor structure, internal consistency, test-retest reliability, convergent validity and discriminant validity were assessed. Sensitivity to change was examined in a subsample of 25 ADHD patients who participated in a 1-year therapy. The initial pool of 62 items was reduced to 33 items distributed in a three-component structure. Internal consistency was excellent for the \"distress due to inattention/disorganization\" subscale and good for the \"distress due to hyperactivity/impulsivity\" and \"distress due to self-esteem deficit\" subscales. Test-retest reliability in a subsample of 98 students was substantial for all three subscales. ADHD patients scored significantly higher than students on distress due to \"inattention/disorganization\" and \"hyperactivity/impulsivity,\" but no difference was observed for \"self-esteem deficit.\" The components \"inattention/disorganization\" and \"hyperactivity/impulsivity\" displayed moderate to large correlations with the corresponding dimensions of the Adult Self-Report Scale for ADHD (ASRS-V1.1). Distress due to \"inattention/disorganization\" and \"self-esteem deficit\" was significantly associated with lower satisfaction with social behaviors (QFS, social functioning questionnaire) and quality of life (WHOQOL-BREF). Distress due to \"inattention/disorganization\" and \"self-esteem deficit\" significantly decreased after a 1-year therapy. The SDAAA-SR represents a reliable and valid measure of adult ADHD-associated distress, an important but often undocumented parameter in the clinical setting. Its use as an outcome variable in psychological interventions deserves further investigation.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"10 1","pages":"77-86"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-017-0234-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35078492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception in attention deficit hyperactivity disorder.","authors":"Anselm B M Fuermaier,&nbsp;Philippa Hüpen,&nbsp;Stefanie M De Vries,&nbsp;Morgana Müller,&nbsp;Francien M Kok,&nbsp;Janneke Koerts,&nbsp;Joost Heutink,&nbsp;Lara Tucha,&nbsp;Manfred Gerlach,&nbsp;Oliver Tucha","doi":"10.1007/s12402-017-0230-0","DOIUrl":"https://doi.org/10.1007/s12402-017-0230-0","url":null,"abstract":"<p><p>A large body of research demonstrated that individuals with attention deficit hyperactivity disorder (ADHD) suffer from various neuropsychological deficits. In contrast, less is known and only divergent evidence exists on perceptual functions of individuals with ADHD. This is problematic as neuropsychological and perceptual functions are closely interrelated and are often difficult to disentangle in behavioral assessments. This study presents the conduct and results of a systematic literature review on perceptual functions in children and adults with ADHD. This review considers studies using psychophysical methods (objective measurements) and self- and informant reports (subjective measurements). Results indicate that individuals with ADHD have altered perceptual functions in various domains as compared to typically developing individuals. Increased perceptual functions in individuals with ADHD were found with regard to olfactory detection thresholds, whereas reduced perceptual functions were evident for aspects of visual and speech perception. Moreover, individuals with ADHD were found to experience discomfort to sensory stimuli at a lower level than typically developing individuals. Alterations of perceptual functions in individuals with ADHD were shown to be moderated by various factors, such as pharmacological treatment, cognitive functions, and symptom severity. We conclude by giving implications for daily life functioning and clinical practice.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"10 1","pages":"21-47"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-017-0230-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34906848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging role of miRNA in attention deficit hyperactivity disorder: a systematic review.","authors":"Saurabh Srivastav,&nbsp;Susanne Walitza,&nbsp;Edna Grünblatt","doi":"10.1007/s12402-017-0232-y","DOIUrl":"https://doi.org/10.1007/s12402-017-0232-y","url":null,"abstract":"<p><p>Attention deficit hyperactivity disorder (ADHD) is a neuropsychiatric disorder whose aetiology still remains elusive. Nevertheless, evidence supports a high genetic contribution that interacts with environmental factors, also known to modulate epigenetic processes. These epigenetic modulators are a class of non-coding RNAs, microRNAs (miRNAs), known as post-transcriptional regulators, which have emerged as prospective players in neuropsychiatric disorders since they play a role in brain development, synapse formation, and the fine-tuning of genes underlying synaptic and memory formation. Here, we review the current literature following a systematic search up until August 2016. The keywords used were \"ADHD\", \"attention deficit hyperactivity disorder\", \"attention hyperactivity\" in combination with \"miRNA\" or \"microRNA\". A total of 9 studies out of 34 met inclusion criteria. The results provide preliminary information, shedding light on two important aspects. First, it depicts that miRNAs modulate expression of genes (BDNF, DAT1, HTR2C, HTR1B, SNAP-25) linked to ADHD aetiology. Dysregulation of miRNAs affects regulatory mechanisms of aforementioned genes, which may affect neurodevelopmental processes leading to alterations. Secondly, altered peripheral miRNA levels are observed in both ADHD animal model and humans, suggesting a notion of utilizing circulatory miRNA in disease diagnosis. Therefore, deciphering the role of miRNAs in ADHD seems a promising step in understanding its aetiology.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"10 1","pages":"49-63"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-017-0232-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34986678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of sexual dysfunctions and other sexual disorders in adults with attention-deficit/hyperactivity disorder compared to the general population.","authors":"D Bijlenga,&nbsp;J A Vroege,&nbsp;A J M Stammen,&nbsp;M Breuk,&nbsp;A M Boonstra,&nbsp;K van der Rhee,&nbsp;J J S Kooij","doi":"10.1007/s12402-017-0237-6","DOIUrl":"https://doi.org/10.1007/s12402-017-0237-6","url":null,"abstract":"<p><p>Attention-deficit/hyperactivity disorder (ADHD) is characterized by symptoms of inattention and/or hyperactivity and impulsivity that lead to dysfunctioning in daily life. One of the affected areas of life that has so far not been studied in ADHD is sexual functioning. The goal of this study was to assess prevalence of sexual dysfunctions and other sexual disorders among adults with ADHD. A total of n = 136 adult patients treated in a Dutch outpatient ADHD clinic filled out two questionnaires to screen for sexual dysfunctions and other sexual disorders. We compared the prevalence of sexual dysfunctions and other sexual disorders in our ADHD patient population to results from two large surveys among the general Dutch population. We found that 39% of the male and 43% of the female ADHD patients had symptoms of a sexual dysfunction, and 17% of the male and 5% of the female ADHD patients had symptoms of any other sexual disorder. Only one male patient had received a diagnosis of a sexual disorder at this clinic prior to study participation. In conclusion, sexual dysfunctions and other sexual disorders are highly prevalent in adults with ADHD. Screening for sexual disorders should be therefore standard procedure during diagnostic assessment.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"10 1","pages":"87-96"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-017-0237-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35338769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk of misdiagnosing posture weakness as hyperactivity in ADHD: a case study.","authors":"Carsten Vogt","doi":"10.1007/s12402-017-0221-1","DOIUrl":"https://doi.org/10.1007/s12402-017-0221-1","url":null,"abstract":"<p><p>Difficulties in sustaining posture can present with features associated with hyperactive behaviour listed in DSM-5 and ICD-10 classifications for ADHD. Information from a system measuring motor activity during a neurocognitive test (QbTest), occupational therapist reports and Conners rating scales are compared between cases with and without posture problems. Weakness in sustaining posture results in elevated activity measures during infrared motion analysis. Strong posture on the other hand appears to mitigate activity levels. Posture is an independent factor which requires consideration during the assessment of ADHD.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"9 4","pages":"239-251"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-017-0221-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34783169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4).","authors":"Joachim Hauser,&nbsp;Andreas Reissmann,&nbsp;Thomas-A Sontag,&nbsp;Oliver Tucha,&nbsp;Klaus W Lange","doi":"10.1007/s12402-017-0225-x","DOIUrl":"https://doi.org/10.1007/s12402-017-0225-x","url":null,"abstract":"<p><p>The aim of the present study was to assess the effects of the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4), which allows a depletion of noradrenergic terminals in a dose-dependent manner, on attention in rats as measured using the five-choice serial-reaction time task (5CSRTT). In addition, we investigated whether the effects of DSP4 treatment can be reversed by atomoxetine. Atomoxetine is a selective noradrenaline reuptake inhibitor and has been shown to be effective in the treatment of attention deficit hyperactivity disorder. Wistar rats were trained in the 5CSRTT and treated with one of the three doses of DSP4 (10, 20 or 50 mg/kg) or saline. Following DSP4 treatment, rats were injected with three doses of atomoxetine (0.1, 0.5 or 1 mg/kg) or saline and tested in the 5CSRTT. The treatment with DSP4 caused a reduction in activity and a decline of performance in parameters related to attention in the 5CSRTT. Whether or not these impairments are due to attention deficits or changes in explorative behaviour and activity remains to be investigated. The treatment with atomoxetine had no beneficial effect on the rats' performance regardless of the DSP4 treatment. The present findings support the role of noradrenaline in modulating attentional processes and call for future studies regarding the effects of atomoxetine on attention in rats.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"9 4","pages":"253-262"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-017-0225-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34812743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prepotent response inhibition and reaction times in children with attention deficit/hyperactivity disorder from a Caribbean community.","authors":"Giomar Jiménez-Figueroa,&nbsp;Carlos Ardila-Duarte,&nbsp;David A Pineda,&nbsp;Johan E Acosta-López,&nbsp;Martha L Cervantes-Henríquez,&nbsp;Wilmar Pineda-Alhucema,&nbsp;Jeimys Cervantes-Gutiérrez,&nbsp;Marisol Quintero-Ibarra,&nbsp;Manuel Sánchez-Rojas,&nbsp;Jorge I Vélez,&nbsp;Pedro J Puentes-Rozo","doi":"10.1007/s12402-017-0223-z","DOIUrl":"https://doi.org/10.1007/s12402-017-0223-z","url":null,"abstract":"<p><p>Impairment in inhibitory control has been postulated as an underlying hallmark of attention deficit/hyperactivity disorder (ADHD), which can be utilized as a quantitative trait for genetic studies. Here, we evaluate whether inhibitory control, measured by simple automatized prepotent response (PR) inhibition variables, is a robust discriminant function for the diagnosis of ADHD in children and can be used as an endophenotype for future genetic studies. One hundred fifty-two school children (30.9% female, 67.8% with ADHD) were recruited. The ADHD checklist was used as the screening tool, whilst the DSM-IV Mini International Neuropsychiatry Interview, neurologic interview and neurologic examination, and the WISC III FSIQ test were administered as the gold standard procedure to assert ADHD diagnosis. A Go/No-Go task using a naturalistic and automatized visual signal was administered. A linear multifactor model (MANOVA) was fitted to compare groups including ADHD status, age, and gender as multiple independent factors. Linear discriminant analysis and the receiver operating characteristic curve were used to assess the predictive performance of PR inhibition variables for ADHD diagnosis. We found that four variables of prepotent response reaction time- and prepotent response inhibition established statistically significant differences between children with and without ADHD. Furthermore, these variables generated a strong discriminant function with a total classification capability of 73, 84% specificity, 68% sensitivity, and 90% positive predictive value for ADHD diagnosis, which support reaction times as a candidate endophenotype that could potentially be used in future ADHD genetic research.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"9 4","pages":"199-211"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-017-0223-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34764890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4).","authors":"Joachim Hauser,&nbsp;Andreas Reissmann,&nbsp;Thomas-A Sontag,&nbsp;Oliver Tucha,&nbsp;Klaus W Lange","doi":"10.1007/s12402-017-0235-8","DOIUrl":"https://doi.org/10.1007/s12402-017-0235-8","url":null,"abstract":"","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"9 4","pages":"263"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-017-0235-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35172185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of self-mutilative behaviour with history of childhood trauma and adult ADHD symptoms in a sample of inpatients with alcohol use disorder.","authors":"Cuneyt Evren,&nbsp;Gokhan Umut,&nbsp;Bilge Evren","doi":"10.1007/s12402-017-0228-7","DOIUrl":"https://doi.org/10.1007/s12402-017-0228-7","url":null,"abstract":"<p><p>The aim of the present study was to evaluate relationship of self-mutilative behaviour (SMB) with the severity of childhood trauma and adult attention-deficit/hyperactivity disorder (ADHD) symptoms in a sample of inpatients with alcohol use disorder (AUD). Participants included 188 inpatients with AUD. Participants were evaluated with the Self-mutilative Behaviour Questionnaire, the Childhood Trauma Questionnaire (CTQ-28) and the Adult ADD/ADHD DSM-IV Based Diagnostic Screening and Rating Scale (Adult ADHD Scale). Among inpatients with AUD those who have a history of SMB constituted the SMB group (n = 57, 30.3%), and those without a history of SMB constituted the group without SMB (n = 131, 69.7%). Risk of high ADHD risk was 2.5 times higher among those with SMB. Adult ADHD Scale and CTQ-28 scores were also higher in the group with SMB. In the first backward logistic regression model, the severity of ADHD symptoms predicted the presence of SMB, together with the severity of childhood trauma, whereas in the second model, physical neglect and inattentive (IN) dimension of ADHD predicted the presence of SMB. These findings suggest that the higher severity of physical neglect and adult IN dimension of ADHD may be related to SMB among inpatients with AUD.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"9 4","pages":"231-238"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-017-0228-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34882762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}