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An LC-MS/MS method for the determination of Lifitegrast in human plasma and tear and its application in the pharmacokinetic study 一种测定人血浆和泪液中利福司特含量的 LC-MS/MS 方法及其在药代动力学研究中的应用
IF 1.8 4区 医学
Bioanalysis Pub Date : 2024-06-06 DOI: 10.1080/17576180.2024.2344345
Cai Juan, Wen Qi, Yang Min, Boping Wei, Weixun Lv, Xingxiang Lv, Xiaorong He, Ke Xiao, Daiguo Zhao
{"title":"An LC-MS/MS method for the determination of Lifitegrast in human plasma and tear and its application in the pharmacokinetic study","authors":"Cai Juan, Wen Qi, Yang Min, Boping Wei, Weixun Lv, Xingxiang Lv, Xiaorong He, Ke Xiao, Daiguo Zhao","doi":"10.1080/17576180.2024.2344345","DOIUrl":"https://doi.org/10.1080/17576180.2024.2344345","url":null,"abstract":"","PeriodicalId":8797,"journal":{"name":"Bioanalysis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141378984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inclusion of dilution quality control samples in quantitative LC-MS bioanalysis 在 LC-MS 生物定量分析中加入稀释质量控制样本
IF 1.8 4区 医学
Bioanalysis Pub Date : 2024-06-06 DOI: 10.1080/17576180.2024.2352253
Wenkui Li, Yunlin Fu, Franck Picard
{"title":"Inclusion of dilution quality control samples in quantitative LC-MS bioanalysis","authors":"Wenkui Li, Yunlin Fu, Franck Picard","doi":"10.1080/17576180.2024.2352253","DOIUrl":"https://doi.org/10.1080/17576180.2024.2352253","url":null,"abstract":"","PeriodicalId":8797,"journal":{"name":"Bioanalysis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141377305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The synergy of nucleic acid amplification and miniaturized systems in enhancing liquid biopsy applications. 核酸扩增和微型化系统在提高液体活检应用方面的协同作用。
IF 1.9 4区 医学
Bioanalysis Pub Date : 2024-06-02 Epub Date: 2024-02-21 DOI: 10.4155/bio-2023-0238
Ngoc Nguyen, Toi Vo Van, Trieu Nguyen
{"title":"The synergy of nucleic acid amplification and miniaturized systems in enhancing liquid biopsy applications.","authors":"Ngoc Nguyen, Toi Vo Van, Trieu Nguyen","doi":"10.4155/bio-2023-0238","DOIUrl":"10.4155/bio-2023-0238","url":null,"abstract":"","PeriodicalId":8797,"journal":{"name":"Bioanalysis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139911965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
16th GCC Closed Forum: ICH M10 implementation; NGS, qPCR/dPCR, flow cytometry validation; tissue biomarkers; IS response; immunogenicity harmonization; bioanalytical industry status. 第 16 届海湾合作委员会闭门论坛：ICH M10 实施；NGS、qPCR/dPCR、流式细胞仪验证；组织生物标志物；IS 响应；免疫原性协调；生物分析行业现状。
IF 1.9 4区 医学
Bioanalysis Pub Date : 2024-06-02 Epub Date: 2024-06-12 DOI: 10.1080/17576180.2024.2342691
Jennifer Zimmer, Amanda Hays, Todd Lester, Manisha Diaz, Eric Thomas, Mark O'Dell, Elizabeth Hyer, Shabnam Tangri, Naveen Dakappagari, Moucun Yuan, Amy Lavelle, Shane Karnik, Aihua Liu, Bin Xu, Kurt Sales, Shashank Gorityala, Gregory Reynolds, Tim Sangster, Dean Franckaert, Iain Love, Vimal Patel, Martin Roberge, Jenny Lin, Erik Jerks, Tao Xu, Wei Garofolo, Sankeetha Nadarajah, Robert Kernstock, Dawn Dufield, David Ambrose, Dominic Warrino, Marsha Luna, Chantal Di Marco, Ariana Tudoroniu, Adriana Iordachescu, Mitesh Sanghvi, Hollie Barton, Michael Brown, Brian Hoffpauir, Agostinho Rocha, Kelly Dong, Jim Yamashita
{"title":"16<sup>th</sup> GCC Closed Forum: ICH M10 implementation; NGS, qPCR/dPCR, flow cytometry validation; tissue biomarkers; IS response; immunogenicity harmonization; bioanalytical industry status.","authors":"Jennifer Zimmer, Amanda Hays, Todd Lester, Manisha Diaz, Eric Thomas, Mark O'Dell, Elizabeth Hyer, Shabnam Tangri, Naveen Dakappagari, Moucun Yuan, Amy Lavelle, Shane Karnik, Aihua Liu, Bin Xu, Kurt Sales, Shashank Gorityala, Gregory Reynolds, Tim Sangster, Dean Franckaert, Iain Love, Vimal Patel, Martin Roberge, Jenny Lin, Erik Jerks, Tao Xu, Wei Garofolo, Sankeetha Nadarajah, Robert Kernstock, Dawn Dufield, David Ambrose, Dominic Warrino, Marsha Luna, Chantal Di Marco, Ariana Tudoroniu, Adriana Iordachescu, Mitesh Sanghvi, Hollie Barton, Michael Brown, Brian Hoffpauir, Agostinho Rocha, Kelly Dong, Jim Yamashita","doi":"10.1080/17576180.2024.2342691","DOIUrl":"10.1080/17576180.2024.2342691","url":null,"abstract":"<p><p>The 16th GCC Closed Forum was held in Orlando, FL, USA, on 23 June 2023. Representatives from international bioanalytical Contract Research Organizations were in attendance in order to discuss scientific and regulatory issues specific to bioanalysis. The issues discussed at the meeting included: IS response, flow cytometry, changes to the bioanalytical industry, NGS assays, biomarker assay for tissues, dPCR validation, immunogenicity harmonization and ICH M10 implementation. Conclusions and consensus from discussions of these topics are included in this article.</p>","PeriodicalId":8797,"journal":{"name":"Bioanalysis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous estimation of rutin and donepezil through RP-HPLC: implication in pharmaceutical and biological samples. 通过 RP-HPLC 同时估算芦丁和多奈哌齐：对药物和生物样品的影响
IF 1.9 4区 医学
Bioanalysis Pub Date : 2024-06-02 Epub Date: 2024-07-16 DOI: 10.1080/17576180.2024.2344395
Rafquat Rana, Keerti Mishra, Shourya Tripathi, Animesh Kumar Gupta, Amrendra Kumar Tiwari, Pavan Kumar Yadav, Abhiram Kumar, Jvus Chakradhar, Sanjay Singh, Sonia Verma, Pooja Yadav, Manish K Chourasia
{"title":"Simultaneous estimation of rutin and donepezil through RP-HPLC: implication in pharmaceutical and biological samples.","authors":"Rafquat Rana, Keerti Mishra, Shourya Tripathi, Animesh Kumar Gupta, Amrendra Kumar Tiwari, Pavan Kumar Yadav, Abhiram Kumar, Jvus Chakradhar, Sanjay Singh, Sonia Verma, Pooja Yadav, Manish K Chourasia","doi":"10.1080/17576180.2024.2344395","DOIUrl":"10.1080/17576180.2024.2344395","url":null,"abstract":"<p><p><b>Aim:</b> A HPLC method was developed and validated for the novel combination of rutin (RN) and donepezil (DNP). <b>Materials & methods:</b> RN and DNP were simultaneously eluted through a C18 column (Ø 150 × 4.6 mm) with a 60:40 v/v ratio of 0.1% formic acid aqueous solution to methanol at 0.5 ml/min. <b>Results:</b> The purposed method was found linear, selective, reproducible, accurate and precise with percent RSD less than 2. The limit of quantification for RN and DNP was found 3.66 and 3.25 μg/ml, respectively. <b>Conclusion:</b> Validated as per the ICH guidelines, the developed method efficiently quantified RN and DNP co-loaded in DQAsomes (121 nm) estimating matrix effect, release profile, entrapment efficiency, loading efficiency and <i>in vivo</i> plasma kinetics.</p>","PeriodicalId":8797,"journal":{"name":"Bioanalysis","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuberculosis diagnosis versus GeneXpert ® MTB/RIF formats 结核病诊断与 GeneXpert ® MTB/RIF 格式的比较
IF 1.8 4区 医学
Bioanalysis Pub Date : 2024-05-22 DOI: 10.1080/17576180.2024.2349423
Anish Khan, Nisha Khan, Raj Singh
{"title":"Tuberculosis diagnosis versus GeneXpert\u0000 ®\u0000 MTB/RIF formats","authors":"Anish Khan, Nisha Khan, Raj Singh","doi":"10.1080/17576180.2024.2349423","DOIUrl":"https://doi.org/10.1080/17576180.2024.2349423","url":null,"abstract":"","PeriodicalId":8797,"journal":{"name":"Bioanalysis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141109492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GC-NPD analysis of topiramate in capillary dried plasma: assessing chemical dependency pharmacotherapy 毛细管干燥血浆中托吡酯的 GC-NPD 分析：评估化学依赖性药物疗法
IF 1.8 4区 医学
Bioanalysis Pub Date : 2024-05-20 DOI: 10.1080/17576180.2024.2348938
Isabela Ritter Ott, Debora Renata Macali Oliveira, A.P.C. Grando, Klaus Vogel Frohlich, M. Perassolo, Rafael Linden, M. V. Antunes
{"title":"GC-NPD analysis of topiramate in capillary dried plasma: assessing chemical dependency pharmacotherapy","authors":"Isabela Ritter Ott, Debora Renata Macali Oliveira, A.P.C. Grando, Klaus Vogel Frohlich, M. Perassolo, Rafael Linden, M. V. Antunes","doi":"10.1080/17576180.2024.2348938","DOIUrl":"https://doi.org/10.1080/17576180.2024.2348938","url":null,"abstract":"","PeriodicalId":8797,"journal":{"name":"Bioanalysis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141120666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Observations from a decade of oligonucleotide bioanalysis by LC-MS. 通过 LC-MS 进行寡核苷酸生物分析的十年观察。
IF 1.8 4区 医学
Bioanalysis Pub Date : 2024-04-18 DOI: 10.4155/bio-2024-0007
Matthew Ewles, A. Ledvina, Brendan Powers, C. E. Thomas
{"title":"Observations from a decade of oligonucleotide bioanalysis by LC-MS.","authors":"Matthew Ewles, A. Ledvina, Brendan Powers, C. E. Thomas","doi":"10.4155/bio-2024-0007","DOIUrl":"https://doi.org/10.4155/bio-2024-0007","url":null,"abstract":"There is a growing need for efficient bioanalysis of oligonucleotide therapeutics. This broad class of molecules presents numerous challenges relative to traditional small molecule therapeutics. Methodologies including ligand-binding assays or polymerase chain reaction may be fit-for-purpose in many instances, but liquid chromatography coupled to mass spectrometry (LC-MS) often delivers the best balance of sensitivity and selectivity. Over the last decade, we have engaged with many such molecules and derived insights into challenges and solutions. Herein, we provide four case studies illustrating challenges we have encountered. These issues include low or variable analyte recovery, poor resolution from related species, chromatographic abnormalities or challenging sensitivity. We present a summary of considerations, based on these experiences, to assist others working in the area.","PeriodicalId":8797,"journal":{"name":"Bioanalysis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140687311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BiSim Tool: a binding simulation tool to aid and simplify ligand-binding assay design and development. BiSim 工具：用于辅助和简化配体结合检测设计和开发的结合模拟工具。
IF 1.8 4区 医学
Bioanalysis Pub Date : 2024-04-17 DOI: 10.4155/bio-2023-0242
Lien Dejager, Sophia Banton, Patricia Marques, Gabriela Rinikova, Sabrina Lory, Elizabeth S Hickford, Carole Martin-Hamka, Mark Penney, Sasker Grootjans
{"title":"BiSim Tool: a binding simulation tool to aid and simplify ligand-binding assay design and development.","authors":"Lien Dejager, Sophia Banton, Patricia Marques, Gabriela Rinikova, Sabrina Lory, Elizabeth S Hickford, Carole Martin-Hamka, Mark Penney, Sasker Grootjans","doi":"10.4155/bio-2023-0242","DOIUrl":"https://doi.org/10.4155/bio-2023-0242","url":null,"abstract":"Ligand-binding assays (LBAs) rely on the reversible, noncovalent binding between the analyte of interest and the assay reagents, and understanding their dynamic equilibrium is key to building robust LBA methods. Although the dynamic interplay of free and bound fractions can be calculated using mathematical models, these are not routinely applied. This approach is costly in terms of both assay development time and reagents, and can result in an under-exploration of the possible parameter combinations. Therefore, we have created a user-friendly simulation tool to facilitate LBA development (the BiSim Tool). We describe the models driving the mathematical simulations and the main features of our software solution by means of case studies, illustrating the tool's value in drug development. To support drug development for all patients worldwide, the BiSim Tool is now available as an open-source code project and as a free web-based tool at https://proteinbindingsimulation.shinyapps.io/BiSim-ProteinBindingSimulation [1].","PeriodicalId":8797,"journal":{"name":"Bioanalysis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of matrix effect in quantitative LC-MS bioanalysis. 评估液相色谱-质谱生物定量分析中的基质效应。
IF 1.8 4区 医学
Bioanalysis Pub Date : 2024-04-05 DOI: 10.4155/bio-2024-0047
Yunlin Fu, Wenkui Li, Franck Picard
{"title":"Assessment of matrix effect in quantitative LC-MS bioanalysis.","authors":"Yunlin Fu, Wenkui Li, Franck Picard","doi":"10.4155/bio-2024-0047","DOIUrl":"https://doi.org/10.4155/bio-2024-0047","url":null,"abstract":"","PeriodicalId":8797,"journal":{"name":"Bioanalysis","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140736424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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