肾上腺素检测和定量的最新进展：进展和临床应用。

IF 1.8 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

Bioanalysis Pub Date : 2025-07-01 Epub Date: 2025-08-12 DOI:10.1080/17576180.2025.2546283

Tijana Mutić, Aleksandar Mijajlović, Vesna Stanković, Sladjana Djurdjić, Filip Vlahović, Dalibor Stanković

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引用次数: 0

摘要

肾上腺素是应激和自主神经系统功能的重要生物标志物，在诊断和监测心血管疾病、内分泌疾病和神经退行性综合征等几种疾病中起着核心作用。传统的检测方法，包括气相色谱法、高效液相色谱法、质谱法和分光光度法，具有很高的灵敏度和特异性，但受仪器复杂、成本高和需要专业人员的限制。这些限制阻碍了它们在快速、即时护理或分散环境中的使用。本文综述了传统的和新兴的肾上腺素检测技术，重点介绍了最近生物传感平台的进展。基于纳米材料的电极修饰和先进的分子识别策略增强了电化学和光学传感器，提高了灵敏度、选择性和便携性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Latest developments in the detection and quantification of adrenaline: advances and clinical applications.

Adrenaline, a critical biomarker of stress and autonomic nervous system function, plays a central role in diagnosing and monitoring several medical conditions such as cardiovascular ailments, endocrine illnesses, and neurodegenerative syndromes. Traditional detection methods, including gas chromatography, high-performance liquid chromatography, mass spectrometry, and spectrophotometry, offer high sensitivity and specificity but are limited by complex instrumentation, high cost, and the need for specialized personnel. These constraints hinder their use in rapid, point-of-care, or decentralized settings. This review provides a thorough summary of conventional and emerging adrenaline detection technologies, focusing on recent biosensing platform advancements. Electrochemical and optical sensors enhanced by nanomaterial-based electrode modifications and advanced molecular recognition strategies have improved sensitivity, selectivity, and portability.

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来源期刊

Bioanalysis BIOCHEMICAL RESEARCH METHODS-CHEMISTRY, ANALYTICAL

CiteScore

3.30

自引率

16.70%

发文量

审稿时长

2 months

期刊介绍： Reliable data obtained from selective, sensitive and reproducible analysis of xenobiotics and biotics in biological samples is a fundamental and crucial part of every successful drug development program. The same principles can also apply to many other areas of research such as forensic science, toxicology and sports doping testing. The bioanalytical field incorporates sophisticated techniques linking sample preparation and advanced separations with MS and NMR detection systems, automation and robotics. Standards set by regulatory bodies regarding method development and validation increasingly define the boundaries between speed and quality. Bioanalysis is a progressive discipline for which the future holds many exciting opportunities to further reduce sample volumes, analysis cost and environmental impact, as well as to improve sensitivity, specificity, accuracy, efficiency, assay throughput, data quality, data handling and processing. The journal Bioanalysis focuses on the techniques and methods used for the detection or quantitative study of analytes in human or animal biological samples. Bioanalysis encourages the submission of articles describing forward-looking applications, including biosensors, microfluidics, miniaturized analytical devices, and new hyphenated and multi-dimensional techniques. Bioanalysis delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for the modern bioanalyst.