Avian Pathology最新文献

{"title":"The relativity analysis of hypoxia inducible factor-1α in pulmonary arterial hypertension (ascites syndrome) in broilers: a review.","authors":"Weile Fang, Enqi Wang, Pei Liu, Xiaona Gao, Xiaolu Hou, Guoliang Hu, Guyue Li, Juan Cheng, Chenxi Jiang, Linjie Yan, Cong Wu, Zheng Xu, Ping Liu","doi":"10.1080/03079457.2024.2358882","DOIUrl":"10.1080/03079457.2024.2358882","url":null,"abstract":"<p><p>Ascites syndrome (AS) in broiler chickens, also known as pulmonary arterial hypertension (PAH), is a significant disease in the poultry industry. It is a nutritional metabolic disease that is closely associated with hypoxia-inducible factors and rapid growth. The rise in pulmonary artery pressure is a crucial characteristic of AS and is instrumental in its development. Hypoxia-inducible factor 1α (HIF-1α) is an active subunit of a key transcription factor in the oxygen-sensing pathway. HIF-1α plays a vital role in oxygen homeostasis and the development of pulmonary hypertension. Studying the effects of HIF-1α on pulmonary hypertension in humans or mammals, as well as ascites in broilers, can help us understand the pathogenesis of AS. Therefore, this review aims to (1) summarize the mechanism of HIF-1α in the development of pulmonary hypertension, (2) provide theoretical significance in explaining the mechanism of HIF-1α in the development of pulmonary arterial hypertension (ascites syndrome) in broilers, and (3) establish the correlation between HIF-1α and pulmonary arterial hypertension (ascites syndrome) in broilers. HIGHLIGHTSExplains the hypoxic mechanism of HIF-1α.Linking HIF-1α to pulmonary hypertension in broilers.Explains the role of microRNAs in pulmonary arterial hypertension in broilers.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"441-450"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Galleria mellonella</i> larvae as an alternative model to determine the pathogenicity of avian pathogenic <i>Escherichia coli</i>.","authors":"Elisar Camilotti, Thales Quedi Furian, Karen Apellanis Borges, Oscar Fernando Ortiz Granados, Gabriela Zottis Chitolina, Thaína de Brites Weber, Daniela Tonini da Rocha, Vladimir Pinheiro do Nascimento, Hamilton Luiz de Souza Moraes, Carlos Tadeu Pippi Salle","doi":"10.1080/03079457.2024.2365932","DOIUrl":"10.1080/03079457.2024.2365932","url":null,"abstract":"<p><strong>Research highlights: </strong><i>Galleria mellonella</i> larvae are a viable model for determining APEC pathogenicity.Larval disease score is the main variable for determining APEC pathogenicity.Response variables should be evaluated up to 24 h post-inoculation.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"507-519"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141282913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and molecular characterization of chicken parvovirus and chicken megrivirus in layer breeders affected by intestinal dilatation syndrome.","authors":"Luis Fabian N Nuñez, Ruy D Chacón, Antonio Charlys da Costa, Silvana H Santander-Parra, Rafael da Costa Pereira Innocentini, Christian J Sánchez-Llatas, Pablo Cea-Callejo, Stefhany Valdeiglesias Ichillumpa, Claudete S Astolfi Ferreira, Lilian Rose Marques de Sá, Antonio J Piantino Ferreira","doi":"10.1080/03079457.2024.2372486","DOIUrl":"10.1080/03079457.2024.2372486","url":null,"abstract":"<p><strong>Research highlights: </strong>IDS presented pathognomonic dilatation of the jejunum up to Meckel's diverticulum.IDS caused weight loss, decreased egg production, and increased culling and mortality.Chicken parvovirus (ChPV) was consistently detected through PCR assays.Chicken megrivirus (ChMV) was consistently detected through viral metagenomics.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"520-532"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral vaccination of young broilers with a live <i>Salmonella</i> Typhimurium vaccine reduces caecal and internal organ colonization following a <i>Salmonella</i> Infantis challenge in a seeder-bird model.","authors":"Venessa Eeckhaut, Nathalie Van Rysselberghe, Serge Verbanck, Richard Ducatelle, Filip Van Immerseel","doi":"10.1080/03079457.2024.2362223","DOIUrl":"10.1080/03079457.2024.2362223","url":null,"abstract":"<p><p>Poultry products are an important source of foodborne <i>Salmonella</i> infections in humans. Amongst these, the prevalence of <i>S.</i> Infantis is rising. In this study, the protection efficacy of an authorized live-attenuated <i>S.</i> Typhimurium vaccine against <i>S.</i> Infantis, was examined using a seeder-bird model in broilers. Vaccinated birds displayed a significantly lower colonization of <i>S.</i> Infantis bacteria in the caeca compared to the non-vaccinated counterparts (<i>P</i> = 0.017), with no significant differences observed in the spleen among the groups, three days post-infection. Thirty-two days post-infection, the disparity in average <i>S.</i> Infantis concentration between all-vaccinated and non-vaccinated birds was significant in both caeca (<i>P</i> = 0.0003) and spleen (<i>P</i> = 0.0002). Interestingly, a third group, consisting of seeder birds that were not vaccinated but housed with vaccinated penmates, exhibited significantly lower <i>S</i>. Infantis levels in both caeca (<i>P</i> = 0.0014) and spleen (<i>P</i> < 0.0001) compared to the non-vaccinated group. These findings underscore the potential of a live-attenuated <i>S.</i> Typhimurium vaccine administered to 2-day-old chicks in conferring protection against <i>S.</i> Infantis in broilers up to slaughter age.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"492-498"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141173929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary inclusion of phytase and stimbiotic decreases mortality and lameness in a wire ramp challenge model in broilers.","authors":"Elizabeth S Greene, Alison Ramser, Robert Wideman, Mike Bedford, Sami Dridi","doi":"10.1080/03079457.2024.2359592","DOIUrl":"10.1080/03079457.2024.2359592","url":null,"abstract":"<p><strong>Research highlights: </strong>Wire ramp model reproducibly induced lameness/BCO in broilers.Treatments did not affect growth, but phytase with stimbiotic significantly reduced BCO.Phytase increased circulating inositol, and wire flooring decreased bone inositol.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"474-491"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141074564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of <i>Bacillus subtilis</i> probiotic in preventing necrotic enteritis in broilers: a systematic review and meta-analysis.","authors":"Shweta Ghimire, Keshab Subedi, Xinwen Zhang, Changqing Wu","doi":"10.1080/03079457.2024.2359596","DOIUrl":"10.1080/03079457.2024.2359596","url":null,"abstract":"<p><p>Probiotics can enhance broiler chicken health by improving intestinal microbiota, potentially replacing antibiotics. They protect against bacterial diseases like necrotic enteritis (NE) in poultry. Understanding their role is crucial for managing bacterial diseases, including NE. This study conducted a meta-analysis to assess the effects of <i>Bacillus subtilis</i> probiotic supplementation on feed conversion ratio (FCR), NE lesion score, and mortality. Additionally, a systematic review analysed gut microbiota changes in broilers challenged with <i>Clostridium perfringens</i> with or without the probiotic supplementation. Effect sizes from the studies were estimated in terms of standardized mean difference (SMD). Random effect models were fitted to estimate the pooled effect size and 95% confidence interval (CI) of the pooled effect size between the control [probiotic-free + <i>C. perfringens</i>] and the treatment [<i>Bacillus subtilis</i> supplemented + <i>C. perfringens</i>] groups. Overall variance was computed by heterogeneity (Q). The meta-analysis showed that <i>Bacillus subtilis</i> probiotic supplementation significantly improved FCR and reduced NE lesion score but had no effect on mortality rates. The estimated overall effects of probiotic supplementation on FCR, NE lesion score and mortality percentage in terms of SMD were -0.91 (CI = -1.34, -0.49; <i>P</i> < 0.001*); -0.67 (CI = -1.11, -0.22; <i>P</i> = 0.006*), and -0.32 (CI = -0.70, 0.06; <i>P</i> = 0.08), respectively. Heterogeneity analysis indicated significant variations across studies for FCR (Q = 69.66; <i>P</i> < 0.001*) and NE lesion score (Q = 42.35; <i>P</i> < 0.001*) while heterogeneity was not significant for mortality (Q = 2.72; <i>P</i> = 0.74). <i>Bacillus subtilis</i> probiotic supplementation enriched specific gut microbiota including <i>Streptococcus, Butyricicoccus, Faecalibacterium, and Ruminococcus</i>. These microbiotas were found to upregulate expression of various genes such as TJ proteins occluding, ZO-1, junctional adhesion 2 (JAM2), interferon gamma, IL12-β and transforming growth factor-β4. Moreover, downregulated mucin-2 expression was involved in restoring the intestinal physical barrier, reducing intestinal inflammation, and recovering the physiological functions of damaged intestines. These findings highlight the potential benefits of probiotic supplementation in poultry management, particularly in combating bacterial diseases and promoting intestinal health.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"451-466"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and genetic characterization of chicken astrovirus and avian nephritis virus from hatchery to farm.","authors":"Elena Grego, Luigi Bertolotti, Barbara Colitti, Maria Cristina Stella, Angela Maria Catania, Carlo Castellina","doi":"10.1080/03079457.2024.2365249","DOIUrl":"10.1080/03079457.2024.2365249","url":null,"abstract":"<p><strong>Research highlights: </strong>Identified the role of the hatchery in astrovirus transmission.Sequenced the avian nephritis virus complete genome.Investigated tissue distribution of astrovirus from egg to chicks.Demonstrated co-infection of ANV/CAstV.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"499-506"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic characterization of infectious bursal disease virus in Argentina provides evidence of the recent transcontinental spread of Chinese genotype A2dB1b.","authors":"Gonzalo Tomás, Claudia Techera, Ana Marandino, Valeria Olivera, Joaquín Williman, Yanina Panzera, Ruben Pérez, Ariel Vagnozzi","doi":"10.1080/03079457.2024.2355918","DOIUrl":"10.1080/03079457.2024.2355918","url":null,"abstract":"<p><p>The infectious bursal disease virus (IBDV) is a significant pathogen affecting the poultry industry worldwide. Its epidemiological history has been marked by the emergence of strains with different antigenic, pathogenic, and genetic features, some of which have shown notable spread potential. The A2dB1b genotype, also known as novel variant, has become widespread and gained increased relevance in IBDV epidemiology. This genotype was described in China in the 2010s and rapidly spread in Asia and Africa. The present study describes the circulation of the A2dB1b genotype in Argentina. Applying a next-generation sequencing approach, we obtained the complete coding sequence of 18 Argentine viruses. The high level of genomic homogeneity observed amongst these viruses, their monophyletic clustering in both partial and complete segments A and B derived phylogenies, and their close relatedness to some Chinese strains suggest that a unique transcontinental spread event from China to Argentina occurred recently. The apparent success of the A2dB1b genotype spreading throughout Asia, Africa, and South America may partially be due to specific amino acid characteristics. Novel residues in the hypervariable region of VP2 may help A2dB1b IBDVs evade the protection elicited by the applied commercial vaccines. Our findings underscore the importance of continuous characterization of field samples and evaluation of the control measures currently applied to fight against this specific IBDV genotype.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"430-438"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interference between <i>Escherichia coli</i> genotypes from the <i>E. coli</i> peritonitis syndrome given simultaneously to productive SPF White Leghorn hens by intratracheal inoculation.","authors":"W J M Landman, J H H van Eck, A E Heuvelink","doi":"10.1080/03079457.2024.2334683","DOIUrl":"10.1080/03079457.2024.2334683","url":null,"abstract":"<p><p>The purpose of the present study was to examine if potentiation of mortality occurred after simultaneous administration of several <i>Escherichia coli</i> genotypes, each capable of inducing the <i>E. coli</i> peritonitis syndrome, in comparison with single genotype application. Five groups of productive specified pathogen free White Leghorn hens were housed in isolators. Groups 1-4 consisted of 32 hens each, group 5 of 10 hens. At 32 weeks of age all groups were inoculated intratracheally. Groups 1 and 2 were inoculated with a mix of four <i>E. coli</i> genotypes and groups 3 and 4 with a mix of four other genotypes. Groups 1 and 3 were given 1 median lethal dose (LD₅₀) of each genotype per hen and groups 2 and 4 had a dose of 0.1 LD₅₀ per genotype per hen; group 5 was mock inoculated. The experiment ended one week after inoculations. In Group 5, no mortality occurred and gross lesions were absent at <i>post-mortem</i> examination. Mortality in groups 1 and 3 was 84% and 81%, respectively; in groups 2 and 4 59% and 66%, respectively. Although mortality in groups 1 and 3 exceeded the expected 50%, this could not be due to potentiation as cluster analysis of reisolates showed that in individual hens only one genotype was found, indicating interference between <i>E. coli</i> genotypes. In groups all four or only two genotypes were recovered, showing that not all genotypes will induce colibacillosis in all experimental groups. Therefore, broad protection can be best assessed by challenging with various single genotypes.<b>RESEARCH HIGHLIGHTS</b> All four or only two <i>E. coli</i> genotypes were found in groups of hens given mixes of four genotypes.In contrast, only one genotype was found in individual hens.<i>E. coli</i> genotypes interfere with each other in hens after given as a mix.Interference is likely based on a random process.Broad protection can best be assessed by challenging with single genotypes.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"359-367"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avian Diseases 68.2 Table of Contents.","authors":"","doi":"10.1080/03079457.2024.2389684","DOIUrl":"https://doi.org/10.1080/03079457.2024.2389684","url":null,"abstract":"","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":"53 5","pages":"440"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}