Avian Pathology最新文献

{"title":"Investigation of dietary eubiotic supplementation on the growth performance and gut health parameters in broiler chicks challenged with <i>Eimeria</i> spp.: a pilot study.","authors":"Tilemachos Mantzios, Dimitrios Galamatis, Ioanna Stylianaki, Ioannis Panitsidis, Konstantinos Kiskinis, Elias Papadopoulos, Ilias Giannenas, Vasilios Tsiouris","doi":"10.1080/03079457.2025.2523883","DOIUrl":"10.1080/03079457.2025.2523883","url":null,"abstract":"<p><strong>Research highlights: </strong>Dietary supplementation with phytogenic and prebiotic blend (PPB) effectively mitigated <i>Eimeria</i> spp. infection in broilers.PPB and salinomycin reduced oocyst excretion.Oocyst excretion was highest in the infected group.PPB was as effective as salinomycin.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"762-774"},"PeriodicalIF":2.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High pathogenicity avian influenza H5N1 clade 2.3.4.4b natural infection in captive Humboldt penguins (<i>Spheniscus humboldti</i>).","authors":"Audra-Lynne D Schlachter, Natalia Furman, Alexander M P Byrne, Scott M Reid, Sarah Jayne Smith, Daniel Maskell, Benjamin C Mollett, Jacob Peers-Dent, Marco Falchieri, Alex Schock, Ashley C Banyard, Ian H Brown, Alex Núñez","doi":"10.1080/03079457.2025.2513338","DOIUrl":"10.1080/03079457.2025.2513338","url":null,"abstract":"<p><strong>Research highlights: </strong>Natural HPAIV H5N1 infection causes mortality and pathology in Humboldt penguins.Molecular analysis identified the aetiology as a novel H5N1 clade 2.3.4.4b genotype.Immunohistochemical analysis demonstrated infection of endothelial cells, macrophages and reticular cells in lymphoid tissue.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"701-711"},"PeriodicalIF":2.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New method for early detection of gut health issues in broilers.","authors":"Kirsten van Hees, Reinier van Velzen, Joost Thijssen, Lucas Hofmans, Remco Dijkman, Richard Ducatelle, Robert Jan Molenaar","doi":"10.1080/03079457.2025.2521354","DOIUrl":"10.1080/03079457.2025.2521354","url":null,"abstract":"<p><strong>Research highlights: </strong>Flocks differ in levels for <i>Lactobacillales</i>, <i>Lachnospiraceae</i> and <i>Ruminococcaceae</i>.Gut Damage Ratio differs between broilers with or without gut health problems.Results of both assays in 21-day-old broilers relate significantly to slaughter weight.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"753-761"},"PeriodicalIF":2.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fowl adenoviruses (FAdVs) in Iran between 2020 and 2022: the first comprehensive phylogenetic study.","authors":"Ali Hojabr Rajeoni, Hossein Hosseini, Hamideh Najafi, Arash Ghalyanchilangeroudi","doi":"10.1080/03079457.2025.2520361","DOIUrl":"10.1080/03079457.2025.2520361","url":null,"abstract":"<p><p>Inclusion body hepatitis (IBH) outbreaks have been reported globally over the past two decades, predominantly affecting broiler flocks and resulting in significant economic losses due to increased mortality and diminished production performance. In Iran, fowl adenovirus (FAdV) infections have been circulating for several years, with recurrent reports of clinical cases suggesting IBH and hepatitis-hydropericardium syndrome (HHS) in commercial poultry operations. In response to these concerns, the present study was conducted to comprehensively characterize circulating FAdV strains in Iranian poultry farms over a 3-year period. A total of 200 pooled liver samples were collected from 200 broiler flocks that exhibited clinical signs consistent with IBH/HHS. Partial amplification and sequencing of the hexon gene were performed to detect and genotype the FAdV strains. The phylogenetic analysis assigned 66.32% of the detected strains to FAdV-D, 16.32% to FAdV-C, 11.22% to FAdV-E, and 6.12% to FAdV-B. Notably, this investigation provided the first genomic evidence of FAdV serotype 5 in Iran. Within the FAdV-C group, both serotypes 4 and 10 were identified. Additionally, serotype 6, closely related (98% nucleotide identity) to a Chinese reference strain, was reported for the first time in Iran. Given the high diversity of FAdV serotypes, continued vaccination of broiler breeders, using vaccines that cover the strains circulating in the country, is recommended. Monitoring broilers and broiler breeders remain essential for effective disease control and prevention.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"743-752"},"PeriodicalIF":2.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study of causes of mortality in Danish commercial laying hens in non-cage housing systems.","authors":"Vibe Pedersen Butler-Lund, Ida Cecilie Naundrup Thøfner, Frederik Stig Scharling, Liza Rosenbaum Nielsen, Jens Peter Christensen","doi":"10.1080/03079457.2025.2527120","DOIUrl":"10.1080/03079457.2025.2527120","url":null,"abstract":"<p><strong>Research highlights: </strong>Five causes of mortality accounted for 71.1% of total mortality of laying hens.Non-infectious causes of mortality (63.9%) more prevalent than infectious (37.6%).Risk periods were inconclusive due to flock variation.Egg binding can cause mortality, and may be linked to above normal body condition.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"775-791"},"PeriodicalIF":2.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deletion of genes encoding anti-inflammatory proteins in <i>Salmonella</i> Pullorum: impact on persistence and virulence in <i>Gallus gallus domesticus</i>.","authors":"Letícia Cury Rocha Veloso Arantes, Victória Veiga Alves, Eric Santos Oliveira, Maira Dos Santos Carneiro Lacerda, Marcelo Coelho Lopes, Larissa Moreira Gonçalves, Nelson Rodrigo da Silva Martins, Roselene Ecco, Flávia Figueira Aburjaile, Mauro de Mesquita Souza Saraiva, Angelo Berchieri Júnior, Oliveiro Caetano de Freitas Neto","doi":"10.1080/03079457.2025.2516564","DOIUrl":"10.1080/03079457.2025.2516564","url":null,"abstract":"<p><strong>Research highlights: </strong>Deleting a<i>vrA</i>, <i>gtgA</i>, <i>pipA</i>, and <i>sseL</i> genes did not affect serovar Pullorum (SP) persistence.The absence of <i>avrA</i> and <i>gtgA</i> increased tissue damage associated with inflammation.SP mutants lacking anti-inflammatory proteins had reduced survival in host tissues.SP Δ<i>gtgA</i> caused liver and spleen lesions resembling those observed in <i>S</i>. Gallinarum (SG) infection.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"725-733"},"PeriodicalIF":2.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulatory effects of <i>Ascaridia galli</i> excretory-secretory products, including extracellular vesicles, on host immune cell function.","authors":"Chanaka Premathilaka, Anna Sophia Feix, Konstantinos Papanikolaou, Rikke Kjærup, Aneta Andronowska, Suranga Kodithuwakku, Alireza Fazeli, Tina S Dalgaard","doi":"10.1080/03079457.2025.2528838","DOIUrl":"10.1080/03079457.2025.2528838","url":null,"abstract":"<p><p>Gastrointestinal nematode infections, particularly <i>Ascaridia galli (A. galli)</i>, pose challenges to the poultry industry especially in free-range chickens. These nematodes employ sophisticated immunomodulation strategies to evade host immune defences, allowing them to establish chronic infections. Excretory-secretory (ES) products, including extracellular vesicles (EVs), play a pivotal role in host-parasite communication. Thus, this study aimed to investigate the immunomodulatory properties of nematode-derived ES/EVs, and evaluate the impact of ivermectin (IVM) on these interactions <i>in vitro</i>. Adult <i>A. galli</i> worms were collected from the jejunum of infected chickens and cultured <i>in vitro</i> with or without IVM treatment. ES products were collected, and EVs were enriched using size-exclusion chromatography. T-cell proliferation and macrophage activation assays were performed to assess the immunomodulatory effects of ES/EVs. <i>A. galli</i>-derived ES products suppressed T-cell activation (CD25+CD57+ cells) and reduced blast transformation in both CD4+ and CD8+ T-cells (<i>P</i><i> </i>< 0.05). Furthermore, ES promoted TLR4-induced macrophage NO production, changed macrophage-activated surface phenotype, and inhibited macrophage phagocytosis in high concentration but promoted it in low concentration (<i>P</i><i> </i>< 0.05). Additionally, <i>A. galli</i>-derived EVs were detected in culture supernatants, and this EV secretion was decreased with the IVM treatment (<i>P</i><i> </i>< 0.05). Fourier-transform infrared spectroscopy confirmed IVM treatment altered EV cargo composition. Finally, the EVs influenced cytokine profiles of activated macrophages, decreasing pro-inflammatory cytokine gene expression (IL-1β and IL-8, <i>P</i><i> </i>< 0.05) which may mirror immune evasion <i>in vivo</i>. In summary, this study highlights immunomodulatory mechanisms of <i>A. galli</i> ES/EVs and provides fundamental information for developing diagnostic and therapeutic strategies targeting nematode ES products including EVs.RESEARCH HIGHLIGHTSExcretory-secretory (ES) products, including extracellular vesicles (EVs), demonstrated immunomodulatory properties.<i>A. galli</i> ES suppressed T-cell activation, proliferation, and macrophage phagocytosis.<i>A. galli</i> ES, including EVs, may help in evading the host immune system.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"792-809"},"PeriodicalIF":2.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of YbdO in regulating acid resistance and biofilm formation in avian pathogenic <i>Escherichia coli</i>.","authors":"Lumin Yu, Linan Xu, Yuzhong Zhao, Xiangpeng Yang, Junfei Ma, Bin Ye, Xinglin Zhang","doi":"10.1080/03079457.2025.2514210","DOIUrl":"10.1080/03079457.2025.2514210","url":null,"abstract":"<p><strong>Research highlights: </strong>YbdO increases biofilm formation and acid resistance.YbdO upregulates the transcription levels of the biofilm-associated genes <i>bcsE</i>, <i>csgD</i>, <i>pgaA</i>, <i>wcaD</i>, <i>fimH</i>, and <i>flhD.</i>YbdO activates the expression of acid stress-associated genes <i>hdeA</i> and <i>yqgB.</i>YbdO contributes to improving the adaptability of APEC to environmental stresses.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"712-724"},"PeriodicalIF":2.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast muscle myopathies: twists and turns in modern broilers.","authors":"Elizabeth S Greene, Sunoh Che, Francesca Soglia, Tomohito Iwasaki, Takafumi Watanabe, Takeshi Kawasaki, Leonardo Susta, Massimiliano Petracci, Colin Scanes, Sami Dridi","doi":"10.1080/03079457.2025.2533454","DOIUrl":"10.1080/03079457.2025.2533454","url":null,"abstract":"<p><p>Although poultry meat production supports the livelihood and provides food security for billions of people worldwide, it is facing substantial challenges. The emergence of broiler breast myopathies (white striping, woody breast, spaghetti meat) at large scale is one of the most significant economic and welfare challenges that menace poultry production sustainability and for which there is currently no effective prevention, due to its unknown aetiologies. Here, by inviting and gathering several experts with diverse, but complementary disciplines, the objective of the present review is to highlight the current progress and knowledge on these myopathies. Five sections are presented, describing in detail the history and geographic occurrence of these breast myopathies, their macroscopic morphologies and microscopic characteristics, their putative aetiologies and causes as well as their underlying molecular mechanisms, and potential strategies and solutions. The is review summarizes both descriptive and functional mechanistic studies, highlights the complexity of these myopathies and the kinship between broiler genome, nutrition, and management, and outlines some of the promising molecular signatures. It aims to offer new fundamental frameworks for future investigations.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"669-692"},"PeriodicalIF":2.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative pathogenesis of aerosol-induced colibacillosis reveals greater susceptibility in broiler chicks compared to layer chicks, with systemic clearance of bacteria but persistence in the bursa of Fabricius.","authors":"Hammad Ur Rehman, Surya Paudel, Claudia Hess, Dieter Liebhart, Ivana Bilic, Michael Hess, Mohamed Kamal Abdelhamid","doi":"10.1080/03079457.2025.2536331","DOIUrl":"10.1080/03079457.2025.2536331","url":null,"abstract":"<p><strong>Research highlights: </strong>Broiler birds as compared to layers are more susceptible to avian colibacillosis.An aerosol challenge using an <i>ilux2</i>-APEC effectively evaluates disease pathogenesis.The <i>ilux2</i>-APEC persistently colonized the bursa of Fabricius after aerosol exposure.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"810-822"},"PeriodicalIF":2.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}