鸭圆环病毒和新型鹅副粘病毒共同感染 SPF 鸭的致病性。

IF 2.5 2区 农林科学 Q1 VETERINARY SCIENCES
Avian Pathology Pub Date : 2025-02-01 Epub Date: 2024-08-22 DOI:10.1080/03079457.2024.2383231
Yudong Zhu, Qiong Wu, Mian Wu, Dalin He, Bingrong Wu, Mingtian Mao, Wentao Tang, Jiake Li, Caiqi Wang, Hui Zhao, Yafei Qin, Youxiang Diao, Yi Tang
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引用次数: 0

摘要

鸭圆环病毒(DuCV)是中国养鸭业中最常见的传染性病毒之一。鸭圆环病毒(DuCV)是我国养鸭业中最常见的传染性病毒之一,虽然临床症状各异,但常引起宿主免疫抑制,并导致其他病原体的继发感染。新型鹅副粘病毒(NGPV)主要感染鸭,导致鸭的短喙和侏儒综合症(SBDS)。然而,近年来鸭的感染率有所上升,与 DuCV 混合感染的现象也很普遍,导致临床发病率更加严重。然而,目前还没有系统的研究来评估是否存在混合感染。为了研究DuCV和NGPV混合感染对SPF鸭的协同致病性,建立了DuCV和NGPV混合感染与单一感染动物模型的对比实验。结果表明,DuCV 和 NGPV 共感染的鸭子短喙、侏儒和免疫抑制等临床症状更明显,靶器官组织损伤更严重,器官和泄殖腔拭子的病毒滴度与只感染一种病毒的 SPF 鸭相比更显著。结果表明,与单一病毒感染相比,DuCV 和 NGPV 共同感染可促进病毒复制,造成更严重的组织损伤和免疫抑制。本研究从致病性方面揭示了NGPV和DuCV联合感染具有协同致病作用,得出的结论不仅为后续NGPV和DuCV联合感染机制的研究明确了方向,也为免疫抑制性疾病和其他疾病的联合感染研究提供了科学依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathogenicity of duck circovirus and novel goose parvovirus co-infection in SPF ducks.

Duck circovirus (DuCV) is one of the most prevalent infectious viruses in the duck industry in China. Although the clinical signs vary, it often causes immunosuppression in the host and leads to secondary infection with other pathogens. Novel goose parvovirus (NGPV) mainly infects ducks and causes short beak and dwarfism syndrome in ducks. However, the incidence of infection in ducks has increased in recent years, and the phenomenon of mixed infection with DuCV is common, resulting in more severe clinical morbidity. However, there are no systematic studies evaluating the presence of mixed infections. In order to investigate the synergistic pathogenicity of DuCV and NGPV co-infection in SPF ducks, a comparative experiment using DuCV and NGPV co-infection and mono-infection bird models was established. The results showed that the clinical signs of short beak, dwarfism and immunosuppression were more obvious in DuCV and NGPV co-infected ducks; the tissue damage of target organs was more serious, and the viral titre in organs and cloacal swabs were more significant compared with those of SPF ducks infected with only one virus. The results indicated that co-infection with DuCV and NGPV could promote viral replication and cause more severe tissue damage and immunosuppression than single virus infection. The present study reveals that the co-infection of NGPV and DuCV has a synergistic pathogenic effect from the aspect of pathogenicity, and the conclusions drawn not only clarify the direction of the subsequent research on the mechanism of co-infection of NGPV and DuCV, but also provide a scientific basis for the research on the co-infection of immunosuppressive pathogens and other pathogens.

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来源期刊
Avian Pathology
Avian Pathology 农林科学-兽医学
CiteScore
4.50
自引率
10.70%
发文量
68
审稿时长
1 months
期刊介绍: Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.
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