Avian Pathology最新文献

{"title":"Influence of biosecurity on the occurrence of various enteric viruses in broiler flocks.","authors":"Beatrice Grafl, Barbara Gaußmann, Ivana Bilic, Remco Folkertsma, Michael Hess","doi":"10.1080/03079457.2024.2377337","DOIUrl":"10.1080/03079457.2024.2377337","url":null,"abstract":"<p><strong>Research highlights: </strong>Detection timepoints and patterns indicate horizontal introduction of various enteric viruses.Flock infection profiles were very heterogeneous; no dominating virus profile.Broiler production was negatively affected by the number of enteric viruses detected.Common biosecurity measures had a significant negative effect on virus prevalence.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"50-61"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first report and biological characterization of <i>Avian Orthoavulavirus 16</i> in wild migratory waterfowl and domestic poultry in China reveal a potential threat to birds.","authors":"Yuxin Sha, Weiwen Yan, Xinxin Liu, Haoran Chai, Jianjun Chen, Hongjin Li, Mengjun Wang, Shanshan Jiang, Sijie Wang, Yongning Ren, Hongli Li, Yifei Liu, Tobias Stoeger, Abdul Wajid, Aleksandar Dodovski, Chao Gao, Claro N Mingala, Dmitry B Andreychuk, Renfu Yin","doi":"10.1080/03079457.2024.2373366","DOIUrl":"10.1080/03079457.2024.2373366","url":null,"abstract":"<p><strong>Research highlights: </strong>First confirmation of AOAV-16 in domestic and wild birds in China.AOAV-16 are low virulent viruses for chickens.Co-circulation/co-infection of AOAV-16 and H9N2 subtype AIV enhanced pathogenicity.Different intergenic sequences and recombination events exist within AOAV-16.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"40-49"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of liposomal hesperetin in broilers: prospects for improving performance, antioxidant potential, immunity, and resistance against <i>Listeria monocytogenes</i>.","authors":"Marwa I Abd El-Hamid, Rania M S El-Malt, Safaa I Khater, Abdelwahab A Abdelwarith, Tarek Khamis, Reham A Abd El-Wahab, Elsayed M Younis, Simon J Davies, Dalia Ibrahim Mohamed, Rania I Mohamed, Shimaa Zayed, Mahmoud A Abdelrahman, Doaa Ibrahim","doi":"10.1080/03079457.2024.2395357","DOIUrl":"10.1080/03079457.2024.2395357","url":null,"abstract":"<p><p>Liposomal encapsulated phytogenics, such as liposomal hesperetin, are considered novel substitutes for antibiotics in the broiler industry owing to their improved nutritional and therapeutic properties. Therefore, our key goal was to investigate liposomal hesperetin impact on broiler growth performance, health, antioxidant status, tight junction proteins (TJP), and resistance against <i>Listeria monocytogenes</i>. Four broiler groups were fed 0, 150, 250, or 400 mg/kg of liposomal hesperetin-supplemented diets and experimentally infected with <i>L. monocytogenes</i> strain. Herein, liposomal hesperetin, especially at higher concentrations, augmented broilers FCR with upregulation of genes encoding TJP (occludin, <i>JAM-2</i>, <i>MUC-2</i>), and antioxidant attributes (<i>GPX-1</i>, <i>SOD-1</i>, <i>CAT</i>, <i>HO-1</i>, <i>NQO1</i>, <i>COX2</i>), which reflect enhancing health and welfare of broilers. Muscle antioxidant biomarkers were enhanced; meanwhile, muscle MDA, ROS, and H₂O₂ levels were reduced in response to 400 mg/kg of liposomal hesperetin. Liposomal hesperetin fortification reduced <i>L. monocytogenes</i> loads and expression levels of its virulence-related genes (<i>flaA, hlyA,</i> and <i>ami</i>). Remarkably, histopathological alterations in intestinal and brain tissues of <i>L. monocytogenes</i>-infected broilers were restored post-inclusion at higher levels of liposomal hesperetin, which reflects increase of the birds' resistance to <i>L. monocytogenes</i> infection. Transcription levels of genes encoding cytokines/chemokines (<i>MyD88</i>, <i>AVBD6</i>, <i>CCL20</i>, <i>IL-1β</i>, <i>IL-18</i>), and autophagy (<i>Bcl-2</i>, <i>LC3</i>, <i>AMPK</i>, <i>AKT</i>, <i>CHOP</i>, <i>Bip</i>, <i>p62</i>, <i>XBP1</i>) were ameliorated following dietary liposomal hesperetin fortification, which suggests enhancement of the birds' immunity and health. Collectively, our research recommends liposomal hesperetin application in broiler diets owing to its promoting impact on growth performance, antioxidant status, immunity, health, and welfare besides its antibacterial, and antivirulence characteristics to fight against <i>L. monocytogenes</i>.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"120-148"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Meetings, WVPA Matters and Announcements.","authors":"","doi":"10.1080/03079457.2025.2431429","DOIUrl":"https://doi.org/10.1080/03079457.2025.2431429","url":null,"abstract":"","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":"54 1","pages":"158"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> antiviral activity of NanB bacterial sialidase against avian influenza H9N2 virus in MDCK cells.","authors":"Christian Marco Hadi Nugroho, Otto Sahat Martua Silaen, Ryan Septa Kurnia, Desak Gede Budi Krisnamurti, Muhammad Ade Putra, Agustin Indrawati, Okti Nadia Poetri, I Wayan Teguh Wibawan, Silvia Tri Widyaningtyas, Amin Soebandrio","doi":"10.1080/03079457.2024.2386315","DOIUrl":"10.1080/03079457.2024.2386315","url":null,"abstract":"<p><p>The avian influenza virus is an infectious agent that may cause global health problems in poultry and is potentially zoonotic. In the recent decades, bacterial-derived sialidases have been extensively studied for their ability to inhibit avian influenza virus infections. In this study, the antiviral activity of NanB sialidase from <i>Pasteurella multocida</i> was investigated through <i>in vitro</i> analysis using Madin-Darby canine kidney (MDCK) cells. NanB sialidase was purified from <i>P. multocida</i> to test its toxicity and its ability to hydrolyse its sialic acid receptors on MDCK cells. The H9N2 challenge virus was propagated in MDCK cells until cytopathic effects appeared. Antiviral activity of NanB sialidase was tested using MDCK cells, and then observed based on cell morphology, viral copy number, and expression of apoptosis-mediating genes. NanB sialidase effectively hydrolysed Neu5Acα(2,6)-Gal sialic acid at a dose of 129 mU/ml, while at 258 mU/ml, it caused toxicity to MDCK cells. Antiviral activity of sialidase was evident based on the significant decrease in viral copy number at all doses administered. The increase of p53 and caspase-3 expression was observed in infected cells without sialidase. Our study demonstrates the ability of NanB sialidase to inhibit H9N2 virus replication based on observations of sialic acid hydrolysis, reduction in viral copy number, and expression of apoptosis-related genes. The future application of sialidase may be considered as an antiviral strategy against avian influenza H9N2 virus infections. RESEARCH HIGHLIGHTSNanB sialidase effectively hydrolyses Neu5Acα(2,6)-Gal at a dose of 129 mU/ml.NanB sialidase from <i>Pasteurella multocida</i> can inhibit the entry of H9N2 virus into cells.NanB sialidase of <i>Pasteurella multocida</i> prevents infection-induced cell apoptosis.NanB sialidase reduces the H9N2 viral copy number in MDCK cells.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"96-107"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very virulent infectious bursal disease virus infection triggered microscopic changes, apoptosis, and inflammatory cytokines imbalance in chicken spleen and thymus.","authors":"Weiye Liu, Xuewei Huang","doi":"10.1080/03079457.2024.2380420","DOIUrl":"10.1080/03079457.2024.2380420","url":null,"abstract":"<p><p>Infectious bursal disease virus (IBDV) can cause a highly contagious disease, resulting in severe damage to the immune system that causes immunosuppression in young chickens. Both spleen and thymus are important immune organs, which play a key role in eliciting protective immune responses. However, the effects of very virulent IBDV (vvIBDV) strain LJ-5 infection on chicken spleen and thymus are still unknown. In the present study, 3-week-old specific pathogen-free chickens were infected with vvIBDV for 1-5 days. The vvIBDV infection significantly increased the spleen index and decreased the thymus index. Microscopic analysis indicated necrosis, depletion of the lymphoid cells, and complete loss of structural integrity in spleen and thymus. Ultrastructural analysis displayed mitochondrial and nuclear damage, including mitochondrial cristae breaks, and deformation of nuclear membrane in vvIBDV-infected spleen and thymus tissues. Cytokine levels increased in the spleen and thymus after IBDV infection, promoting inflammation and causing an inflammatory imbalance. Moreover, the mRNA expression of apoptosis-related genes was significantly upregulated in the vvIBDV-infected group compared to the control group. Meanwhile, the mRNA expression of mitochondrial dynamics was altered in the spleen and thymus of vvIBDV-infected chickens. These results suggested that vvIBDV infection triggers an imbalance of inflammatory cytokines, and apoptosis in the spleen and thymus, resulting in immune injury in chickens. This study provides basic data for the further study of vvIBDV pathogenesis.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"62-75"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A vaccine programme comprising GA08 (GI-27) and Mass (GI-1) strains prevents DMV1639 (GI-17) infectious bronchitis virus transmission among broiler chickens.","authors":"Sean K Brimer, Egil A J Fischer, Robert Beckstead, James White, Christophe Cazaban, Timea Tatár-Kis, Francisca C Velkers, John Elattrache, Arjan Stegeman","doi":"10.1080/03079457.2024.2383765","DOIUrl":"10.1080/03079457.2024.2383765","url":null,"abstract":"<p><p>Effective control of infectious bronchitis is a challenge in commercial poultry operations due to the high transmissibility of the virus. Although multiple IBV lineages are circulating in the United States, the DMV1639-type IBV strain (GI-17) is currently the major circulating variant, creating production losses in the poultry industry. This study aimed to test whether the combination of a GA08 (GI-27) and a Mass-type (GI-1) IB vaccines could significantly reduce the transmission of a DMV1639-type (GI-17) field IBV strain in 4-week-old commercial broilers. Half of the birds were directly challenged, whereas the other half of the groupmates were put in contact 24 hours later. Two replicates of the same study setup, including 10 directly challenged and 10 contact birds per group, were run. Transmission of the challenge virus was significantly reduced in vaccinates (<i>R</i> = 0.0), whereas all unvaccinated birds became infected (<i>R</i> = 9.6). Reduced transmission of the DMV1639 IB challenge virus by the combined vaccination programme in broiler chickens was also accompanied by clinical protection. These data are important because prevention of IBV transmission by vaccination will result in overall reduced viral replication and consequently in reduced likelihood of genetic changes that can lead to new variants. This is the first published evidence of the successful transmission control of a DMV1639 IBV strain in chickens.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"83-95"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Necrotic enteritis in chickens: a comprehensive review of vaccine advancements over the last two decades.","authors":"Mohammad Ali Shamshirgaran, Mehdi Golchin","doi":"10.1080/03079457.2024.2398028","DOIUrl":"10.1080/03079457.2024.2398028","url":null,"abstract":"<p><p><b>ABSTRACT</b>Necrotic enteritis (NE) is a severe gastrointestinal disease that poses a significant threat to poultry, leading to progressive deterioration of the small intestine, reduced performance, and increased mortality rates, causing economic losses in the poultry industry. The elimination of antimicrobial agents from chicken feed has imposed a need to explore alternative approaches for NE control, with vaccination emerging as a promising strategy to counteract the detrimental consequences associated with NE. This comprehensive review presents an overview of the extensive efforts made in NE vaccination from 2004 to 2023. The review focuses on the development and evaluation of vaccine candidates designed to combat NE. Rigorous evaluations were conducted in both experimental chickens and broiler chickens, the target population, to assess the vaccines' capacity to elicit an immune response and provide substantial protection against toxin challenges and experimental NE infections. The review encompasses the design of vaccine candidates, the antigens employed, <i>in vivo</i> immune responses, and the efficacy of these vaccines in protecting birds from experimental NE infection. This review contributes to the existing knowledge of NE vaccination strategies, offering valuable insights for future research and development in this field.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"1-26"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of infectious bursal disease and its associated risk factors in Ethiopia: a systematic review and meta-analysis.","authors":"Solomon Lulie Abey, Gashaw Getaneh Dagnaw, Anmaw Shite Abat, Asnakew Mulaw Berihun, Zewdu Seyoum Tarekegn, Takele Adugna, Abebe Belete Bitew","doi":"10.1080/03079457.2024.2393613","DOIUrl":"10.1080/03079457.2024.2393613","url":null,"abstract":"<p><p>The poultry population is an integral part of Ethiopia's Gross Domestic Product (GDP) but, due to various infectious diseases such as infectious bursal disease (IBD), the expected economic impact in the country remains limited. The status of the disease in Ethiopia is obscured; thus, a systematic review and meta-analysis were employed to estimate the overall pooled prevalence of IBD in Ethiopia. Meta-analysis was conducted to determine the effects of each identified risk factor, while meta-regression and sub-group analysis were employed to assess the relationship between study-level covariates and effect size. The pooled prevalence of IBD in Ethiopia was 69.4% (95% CI 30.7-96.2), while the pooled logit prevalence was 0.94 (95% CI: 0.68-1.20) with significant inter-study variance (<i>Q</i> test = 948.28, df = 43, <i>P</i> < 0.001; <i>τ</i>² = 0.71, <i>I</i>²= 95.47%). A small-study effect was detected in the regression-based Egger test (Prob > |<i>z</i>| < 0.0001). Significant variation was observed among different groups such as sex, age, breed, and type of farm of the chickens. The effect size for the study period from 2018 to 2021 was significantly lower by -0.204 compared to the study period from 2009 to 2015 (<i>P</i> < 0.0001. In conclusion, the IBD pooled prevalence estimate is high, even though the number of studies in the country is insufficient. The high prevalence of the disease requires prompt attention from all stakeholders in the sector to bring it under control through comprehensive disease prevention and control intervention strategies.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"108-119"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Meetings, WVPA Matters and Announcements.","authors":"","doi":"10.1080/03079457.2024.2412429","DOIUrl":"https://doi.org/10.1080/03079457.2024.2412429","url":null,"abstract":"","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":"53 6","pages":"540"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}