Avian Pathology最新文献

{"title":"Bart Rispens Research Award 2025 for the best paper published in Avian Pathology (volumes 52 and 53).","authors":"Sjaak de Wit, Damer P Blake","doi":"10.1080/03079457.2025.2503607","DOIUrl":"https://doi.org/10.1080/03079457.2025.2503607","url":null,"abstract":"","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"1-2"},"PeriodicalIF":2.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative meta-analysis of prevalence and molecular features of high-priority <i>Enterococcus faecium</i> and <i>E. faecalis</i> from the guts of food-producing and wild birds.","authors":"Idris Nasir Abdullahi, Islem Trabelsi","doi":"10.1080/03079457.2025.2485106","DOIUrl":"10.1080/03079457.2025.2485106","url":null,"abstract":"<p><strong>Research highlights: </strong>Vancomycin, ampicillin, and linezolid resistance in <i>E. faecium</i> and <i>E. faecalis</i> are considered high-priority public health concerns.This is a meta-analysis of high-priority <i>E. faecium</i> and <i>E. faecalis</i> from gut samples of birds.Food-producing birds had significantly higher frequency of priority <i>E. faecium</i> and <i>E. faecalis</i> than wild birds.Vancomycin resistance in <i>E. faecium</i> and <i>E. faecalis</i> exists more frequently than linezolid resistance.<i>E. faecium</i> has a higher capacity to acquire ampicillin and vancomycin resistance than <i>E. faecalis</i>.Genetically related human-adapted vancomycin- and linezolid-resistant strains were identified in food-producing and wild birds.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"1-15"},"PeriodicalIF":2.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of pulmonary arterial vascular cell dysfunction in pulmonary hypertension in broiler chickens.","authors":"Juan Chen, Chenxi Jiang, Xiaoqin Hu, Yun Zhang, Xiaona Gao, Xiaoquan Guo, Huibo Jin, Ying Zhang, Yirong Wu, Jing Liang, Pei Liu, Ping Liu","doi":"10.1080/03079457.2025.2480802","DOIUrl":"https://doi.org/10.1080/03079457.2025.2480802","url":null,"abstract":"<p><p>Broiler ascites syndrome is a common and complex disease in broiler farming, which severely impacts broiler growth performance and health and brings huge economic losses to the breeding industry. Hypoxia has been shown to be an important cause of this disease. Prolonged exposure of broiler chickens to a hypoxic environment induces pulmonary vasoconstriction, which leads to an increase in pulmonary artery pressure, triggering pulmonary artery remodelling and compensatory right ventricular hypertrophy, and ultimately ascites. Pulmonary artery remodelling is a process in which the vascular wall tissue structure and function undergo pathological changes after the pulmonary artery is stimulated by various injuries or hypoxia, including endothelial dysfunction, abnormal proliferation of pulmonary artery smooth muscle cells, vascular fibrosis, etc. When these cells are damaged or stimulated, they may undergo programmed cell death, an orderly and regulated mode of cell death that is important for maintaining the stability of the body's internal environment. It has been demonstrated that death modes such as apoptosis and autophagy are involved in the pathophysiologic process of pulmonary hypertension, but their specific molecular mechanisms are still unclear. In this review, we first describe the pathogenesis of broiler ascites, then describe the specific mechanism of dysfunction of pulmonary artery vascular cells in broiler ascites syndrome, and finally elaborate the progression of different programmed cell death in broiler pulmonary hypertension. This study aims to elucidate the specific mechanisms underlying the dysfunction of pulmonary artery vascular cells in broiler pulmonary hypertension, thereby enhancing our understanding of the pathogenesis of this syndrome.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"1-12"},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant auto-bioluminescent <i>Escherichia coli</i> to monitor the progression of <i>Escherichia coli</i> infection in the embryonated chicken eggs.","authors":"Mohamed Kamal Abdelhamid, Surya Paudel, Hammad Ur Rehman, Manolis Lyrakis, Ivana Bilic, Michael Hess, Claudia Hess","doi":"10.1080/03079457.2025.2477246","DOIUrl":"10.1080/03079457.2025.2477246","url":null,"abstract":"<p><strong>Research highlights: </strong>Bioluminescence imaging enabled real-time, noninvasive tracking of a bioluminescent APEC infection in embryonated chicken eggs over time.Bioluminescence signals showed contrasting patterns for dead and surviving embryos.The <i>ilux2</i>-APEC showed a higher luminoscore than <i>lux</i>ABCDE-APEC in inoculated embryonated chicken eggs.The <i>in ovo</i> bioluminescent signal from intact eggs effectively reflects the <i>ex ovo</i> signal following the take out of yolk and embryo.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular characterization and recombination analysis of <i>Gyrovirus homsa2</i> in chickens.","authors":"Zhibin Zhang, Weichi Li, Xin Xu, Dandan Li, Jun Ji, Lunguang Yao, Yingzuo Bi, Qingmei Xie","doi":"10.1080/03079457.2025.2494756","DOIUrl":"https://doi.org/10.1080/03079457.2025.2494756","url":null,"abstract":"<p><p><b>ABSTRACT</b>Gyrovirus homsa2 (GyVh2), originally identified in Tunisian children with diarrhea, was previously known as Gyrovirus 6. In this study, chickens from 36 poultry farms across four major poultry-producing provinces in China (Henan, Hubei, Anhui, and Jiangsu) were screened for GyVh2 using polymerase chain reaction (PCR) from 2022 to 2024. As a result, 12 farms positive for GyVh2 were detected and subsequently conducted whole-genome sequencing for GyVh2. The genomes of the 12 GyVh2 from positive farms were all 2,282 nucleotides (nt) in length. Sequence similarity analysis showed high similarity (94.87%-99.65%) among the obtained and reference GyVh2 strains with no significant determining of years or geographic distribution, but low similarity (48.99%-57.60%) with other Gyrovirus species (<i>Gyrovirus chickenanemia</i>, <i>Gyrovirus galga1</i>, <i>Gyrovirus galga2</i> and <i>Gyrovirus homsa1</i>). Phylogenetic analysis of the whole genome sequences of all 12 positive farms GyVh2 revealed that they formed a unique branch, clearly separated from other Gyrovirus species. Recombination analysis suggested that HN220604 (accession NO.: 9595.1) and HN221228 (accession NO.: 9596.1) may have originated from recombination with the human-derived GyVh2 strain (accession NO.: NC_022789.1). A hypervariable region (located at sites 140-152) and highly mutated sites at positions 149, 254 and 380 were identified in the capsid protein through amino acid mutation analysis. The observed association between GyVh2 cross-species transmission and complex mutations and recombination offers a basis for future studies on its molecular epidemiology and evolution.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"1-24"},"PeriodicalIF":2.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in lesion development of slow- and fast-growing meat-type chickens after experimental challenge with <i>Enterococcus cecorum</i>.","authors":"Amanda Rosenbaum, Silke Rautenschlein, Arne Jung","doi":"10.1080/03079457.2025.2485109","DOIUrl":"https://doi.org/10.1080/03079457.2025.2485109","url":null,"abstract":"<p><p>Field observations suggest genotype-associated differences in susceptibility to infection with <i>Enterococcus cecorum</i> (EC). We hypothesized that slow-growing (SG) chickens show less clinical signs and reduced lesions compared to fast-growing (FG) chickens after experimental challenge with EC. At 1-day post-hatch (dph), 97 FG and 97 SG chickens were randomly assigned to four groups: control, SG (CSG), control, FG (CFG), EC-inoculated, SG (ESG), and EC-inoculated, FG (EFG). After oral inoculation with 10⁷ colony forming units EC or mock inoculation with physiological saline, chickens were monitored for clinical signs and samples were collected weekly for further analysis via ELISA, real-time PCR, and flow cytometric analysis. The final necropsy of 40 chickens per group was carried out at 43/44 dph. Clinical signs and pathological findings were observed in a reduced number of chickens in group ESG compared to EFG. Extra-intestinal colonization with EC at 43/44 dph was significantly reduced in group ESG compared to EFG (<i>P</i> < 0.05). Circulating heterophils and monocytes were significantly increased in groups ESG and EFG compared to the control groups (<i>P</i> < 0.05). Additionally, circulating monocytes were increased and heterophil/lymphocyte (H/L) ratios were decreased in SG chickens compared to FG chickens. We may speculate that SG chickens were less affected by the EC-associated disease due to a more efficient innate immune response and may more vigorously control extra-intestinal colonization after translocation from the intestine. Overall, the use of slow-growing chickens may reduce the incidence of the EC-associated disease in meat-type chickens and therefore increase overall health performance.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An outbreak in week-old broiler chicks caused by a highly virulent and multidrug-resistant strain of <i>Salmonella</i> Gallinarum.","authors":"Eric Santos Oliveira, Letícia Cury Rocha Veloso Arantes, Gabryel Bernardo Vieira de Lima, Victória Veiga Alves, Michelle de Paula Gabardo, Bertram Brenig, Vasco Azevedo, Flávia Figueira Aburjaile, Oliveiro Caetano de Freitas Neto, Roselene Ecco","doi":"10.1080/03079457.2025.2480800","DOIUrl":"10.1080/03079457.2025.2480800","url":null,"abstract":"<p><strong>Research highlights: </strong><i>Salmonella</i> Gallinarum infection in chicks resulted in a mortality rate of 42%.Chicks had unusual lesions such as haemorrhagic enteritis and interstitial pneumonia.Whole genome analysis of the SG isolate revealed exclusive antimicrobial resistance genes.Higher number of exclusive virulence genes were related to severe fowl typhoid in chicks.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"1-7"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenicity and transmissibility differences in goose-originated subgenotype 3 duck Tembusu virus in goose embryos and 3-day-old goslings.","authors":"Ziqiao Zhao, Junhong Ke, Mengfan Liu, Zuoxin Chen, Shuwen Li, Wuque Wei, Kun Mei, Shujian Huang","doi":"10.1080/03079457.2024.2373365","DOIUrl":"10.1080/03079457.2024.2373365","url":null,"abstract":"<p><p>The Duck Tembusu virus (DTMUV) was first reported in China in 2010 and has since caused substantial economic losses in the poultry breeding industry. In the autumn of 2022, an outbreak of an infectious disease resembling DTMUV was reported in Guangdong Province, China, which caused significantly high mortality in goose embryos, and decreased egg production. This study identified one strain of the new subgenotype 3 of DTMUV, designated as DTMUV GDZQ2022, responsible for these effects. Comprehensive genomic sequencing of this strain was conducted to analyse its genetic variations. Additionally, the isolated and purified virus was inoculated into goose embryos and goslings to assess its pathogenicity. The GDZQ2022 genome displayed over 88% nucleotide homology with other DTMUV strains from China and Southeast Asia. Phylogenetic analysis of the E gene classified GDZQ2022 within the subgenotype 3 of DTMUV. Pathogenicity experiments on goose embryos and goslings showed that the GDZQ2022 strain induced typical clinical signs of DTMUV, particularly severe neurological manifestations. Although GDZQ2022 exhibited high virulence in goose embryos, its virulence in goslings was minimal, resulting in a low mortality rate. Pathological examinations detected significant histological lesions in the brains, livers, and spleens of the infected goslings. In conclusion, this study presents the first evidence of a novel DTMUV strain proliferating among young geese in China, underscoring the genetic diversity of DTMUV and contributing to our understanding of the pathogenicity of the subgenotype 3 Tembusu virus in goose embryos and goslings.<b>RESEARCH HIGHLIGHTS</b>Pathogenicity of subgenotype 3 duck Tembusu virus in goose embryos and goslings was shown for the first time.DTMUV GDZQ2022 strain is highly pathogenic in goose embryos.The virulence of the DTMUV GDZQ2022 strain in goslings is relatively mild.Infected goslings exhibit typical clinical manifestations, with a low mortality rate.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"175-184"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Meetings, WVPA Matters and Announcements.","authors":"","doi":"10.1080/03079457.2025.2456371","DOIUrl":"https://doi.org/10.1080/03079457.2025.2456371","url":null,"abstract":"","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":"54 2","pages":"265"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuing evolution of H5N1 highly pathogenic avian influenza viruses of clade 2.3.2.1a G2 genotype in domestic poultry of Bangladesh during 2018-2021.","authors":"Mohammed Nooruzzaman, Tanjin Tamanna Mumu, Ismail Hossain, Congriev Kumar Kabiraj, Jahan Ara Begum, Mohammad Mijanur Rahman, Md Zulfekar Ali, Mohammed Giasuddin, Jacqueline King, Diego G Diel, Emdadul Haque Chowdhury, Timm Harder, Mohammad Rafiqul Islam, Rokshana Parvin","doi":"10.1080/03079457.2024.2403427","DOIUrl":"10.1080/03079457.2024.2403427","url":null,"abstract":"<p><p>We characterized 15 H5N1 HPAI viruses from different small- and medium-scale poultry flocks across Bangladesh during 2018-2021 based on their complete genome sequences. The antigenic relatedness of H5N1 HPAI viruses from different timepoints was analysed. During 2020-2021, 42.11% of the flocks tested positive for at least one of the respiratory infections, with 15.79% showing influenza A virus, of which 8.77% tested positive for HPAIV H5N1. Co-infections with two to four pathogens were detected in 15.8% of flocks. Phylogeny and gene constellation analyses based on complete genome sequences of 15 HPAI viruses revealed the continuing circulation of H5 clade 2.3.2.1a genotype G2 viruses. In the HA protein of the study isolates, functionally meaningful mutations caused the loss of an N-linked glycosylation site (T156A), a modified antigenic site A (S141P), and a mutation in the receptor binding pocket (E193R/K). Consequently, antigenic analysis revealed a significant loss of cross-reactivity between viruses from different host species and periods. Most viruses displayed oseltamivir resistance markers at positions V96, I97, S227, and N275 (N1 numbering) of the NA protein. In addition, for the PB2, M1, and NS1 proteins, significant mutations were noticed that have been associated with polymerase activity and increased virulence for mammals in all study isolates. These results highlight the need for intensified genomic surveillance of HPAI circulating in poultry in Bangladesh and for establishing appropriate control measures to decrease the circulation of these viruses in poultry in the country.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"198-211"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}