CircITSN2-miR-17-5p/20a-5p/20b-5p-PD-L1 regulatory network is a potential molecular mechanism of PD-L1 gene involving in immune response to IBDV.

IF 2.5 2区农林科学 Q1 VETERINARY SCIENCES

Avian Pathology Pub Date : 2025-03-12 DOI:10.1080/03079457.2025.2470754

Yi Jiang, Yufei Tian, Jianwei Han, Xiangnan Wang, Rui Zhang, Xinxin Xu, Xiaoli Ma, Wei Zhang, Chaolai Man

引用次数: 0

Abstract

Research highlights: PD-L1 gene is correlated with IBDV immune response in chickens.PD-L1 is a key gene regulating the immune functions of the heart, lung, and proventriculus.CircITSN2-miR-17-5p/20a-5p/20b-5p-PD-L1 is a potential mechanism in IBDV immunity.

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摘要传染性法氏囊病病毒（IBDV）诱导的免疫抑制及其继发感染仍是家禽业亟待解决的严重问题。更令人担忧的是，IBDV 诱导免疫抑制的分子机制尚未完全清楚。本研究探讨了免疫检查点程序性细胞死亡-配体1（PD-L1）基因在IBDV减毒疫苗诱导的鸡免疫反应中的表达特征，并通过实时定量PCR（qRT-PCR）技术确定了PD-L1基因在体内的竞争性内源性RNA（ceRNA）调控机制。结果表明，PD-L1基因的表达与IBDV的免疫应答密切相关，并在免疫应答不同阶段的免疫相关组织中发挥重要的调控作用。研究发现miR-17家族成员（miR-17-5p、miR-20a-5p和miR-20b-5p）、circITSN2和PD-L1基因在体内表达水平存在显著的博弈关系，因此circITSN2-miR-17-5p/20a-5p/20b-5p-PD-L1网络是PD-L1在IBDV疫苗免疫应答中的潜在分子调控机制，而心脏（5 dpi）、胃窦（5 dpi）和肺（21 dpi）是关键组织。该研究为进一步研究IBDV诱导免疫抑制的分子机制提供了有价值的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Avian Pathology 农林科学-兽医学

CiteScore

4.50

自引率

10.70%

发文量

审稿时长

1 months

期刊介绍： Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.