Advances in physiotherapy最新文献

{"title":"Biomimetic properties and estimated in vivo distribution of chloroquine and hydroxy-chloroquine enantiomers.","authors":"Klara L Valko, Tong Zhang","doi":"10.5599/admet.929","DOIUrl":"10.5599/admet.929","url":null,"abstract":"<p><p>Chloroquine and hydroxy-chloroquine already established as anti-malarial and lupus drugs have recently gained renewed attention in the fight against the Covid-19 pandemic. Bio-mimetic HPLC methods have been used to measure the protein and phospholipid binding of the racemic mixtures of the drugs. The tissue binding and volume of distribution of the enantiomers have been estimated. The enantiomers can be separated using Chiralpak AGP HPLC columns. From the α-1-acid-glycoprotein (AGP) binding, the lung tissue binding can be estimated for the enantiomers. The drugs have a large volume of distribution, showed strong and stereoselective glycoprotein binding, medium-strong phospholipid-binding indicating only moderate phospholipidotic potential, hERG inhibition and promiscuous binding. The drug efficiency of the compounds was estimated to be greater than 2 % which indicates a high level of free biophase concentration relative to dose. The biomimetic properties of the compounds support the well-known tolerability of the drugs.</p>","PeriodicalId":87870,"journal":{"name":"Advances in physiotherapy","volume":"14 1","pages":"151-165"},"PeriodicalIF":3.4,"publicationDate":"2020-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91392454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Global Body Examination (GBE). A useful instrument for evaluation of respiration.","authors":"Svein Friis, Alice Kvåle, Stein Opjordsmoen, Berit H Bunkan","doi":"10.3109/14038196.2012.704943","DOIUrl":"10.3109/14038196.2012.704943","url":null,"abstract":"<p><p>BACKGROUND AND AIMS: Assessment of respiration is important in medicine and physical therapy. As respiration is multifaceted, we need several specific examination methods. The purpose of this study was to develop a method for examination of visible respiratory movements, by extracting from two examinations the items with best ability to discriminate among healthy controls, patients with pain disorders and patients with psychotic disorders. METHODS: Two physiotherapists independently examined 132 individuals (34 healthy persons, 32 with localized pain, 32 with widespread pain and 34 with psychoses). Items were assigned to subscales by explorative factor analysis. Internal consistency of subscales was examined with Cronbach's alpha. To examine validity, one-way analysis of variance and the area under the curve (AUC) were used. RESULTS: WE IDENTIFIED FOUR SUBSCALES: Tension, Position of Thorax, Basal respiration and Thoracic movements. Cronbach's alpha ranged from 0.75 to 0.86. The subscales' discriminating ability was excellent between healthy controls and patients, and fair between patients with localized pain and the two other patient groups. CONCLUSIONS: The respiration domain of the new Global Body Examination has 21 items, which comprise four subscales with high internal consistency and good ability to discriminate between healthy persons and patients with pain disorders or psychosis.</p>","PeriodicalId":87870,"journal":{"name":"Advances in physiotherapy","volume":"14 4","pages":"146-154"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/d4/PHY-14-146.PMC3518292.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31122584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences with CPAP treatment in patients with obstructive sleep apnea syndrome and obesity","authors":"M. Willman, H. Igelström, Cathrin Martin, P. Åsenlöf","doi":"10.3109/14038196.2012.704944","DOIUrl":"https://doi.org/10.3109/14038196.2012.704944","url":null,"abstract":"Objective: Continuous positive airway pressure (CPAP) is the first treatment of choice for obstructive sleep apnea syndrome (OSAS). However, adherence rates are low with no clear consensus on causes. Behavioral support strategies are needed, which is an evolving arena for physiotherapists within sleep medicine. The purpose of this study was to describe patients’ experiences of CPAP treatment in obese individuals with moderate to severe OSAS. Methods: A qualitative content analysis was employed. Fifteen participants were consecutively selected. Data were collected by semi-structured interviews. Results: Experiences were described and structured according to three themes: (1) coming to terms with wearing CPAP; (2) getting a new life; and (3) being restricted in everyday life. Conclusion: A focus on incentives for regular CPAP use is important when supporting the use of a device that has almost as many disadvantages as advantages. Positive and negative reinforcers may receive greater attention when tailoring behavioral support for initiation and maintenance of CPAP. The potential of involving spouses and significant others to reinforce self-management behaviors needs further studies.","PeriodicalId":87870,"journal":{"name":"Advances in physiotherapy","volume":"234 1","pages":"166 - 174"},"PeriodicalIF":0.0,"publicationDate":"2012-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14038196.2012.704944","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69372208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical reasoning in occupational health services for individuals with musculoskeletal and mental disorders","authors":"C. Wåhlin, K. Ekberg, B. Öberg","doi":"10.3109/14038196.2012.729609","DOIUrl":"https://doi.org/10.3109/14038196.2012.729609","url":null,"abstract":"Aims: To investigate whether there are associations between the professional assessment of a patient's main clinical problem and the patient's self-reported health among patients with musculoskeletal disorders and/or mental disorders. To investigate differences in self-reported health and work-related measures in patients who were recommended clinical versus work-related interventions. Method: A cross-sectional study, including a convenience sample of 210 patients, visiting occupational health service. Patients answered a questionnaire on demographic variables, dimensions of health, functioning, work ability and working conditions. Patients’ main clinical problem and type of intervention was classified by physiotherapists. Activity limitations were identified using the Patient-Specific Functional Scale. Findings: The main clinical problems were: medical/organic problems (39%), psychosocial problems (46%) and physical work-related problems (15%). The psychosocial group reported more problems in mental functioning and the medical/organic group had worse physical functioning. There were significant differences for the main clinical problem, educational level, work ability, social interaction skills and mobility in patients who were recommended clinical versus work-related interventions. Conclusions: There are associations between the professional biopsychosocial classification and the patient's self-reported health and functioning. Clinical reasoning may be improved by including systematic biopsychosocial assessment of specific health and working conditions, and activity limitations according to Patient-Specific Functional Scale.","PeriodicalId":87870,"journal":{"name":"Advances in physiotherapy","volume":"14 1","pages":"155 - 165"},"PeriodicalIF":0.0,"publicationDate":"2012-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14038196.2012.729609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69372439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reciprocal struggling in person transfer tasks – Caregivers’ experiences in dementia care","authors":"C. Thunborg, Petra von Heideken Wågert, A. Söderlund, E. Götell","doi":"10.3109/14038196.2012.725184","DOIUrl":"https://doi.org/10.3109/14038196.2012.725184","url":null,"abstract":"Purpose: This study describes caregivers’ experiences of person transfer situations involving people with dementia. Method: Qualitative focus group interviews were conducted with a total of 10 caregivers; two groups with five persons each, including two men and eight women. The resulting data were extracted and condensed into meaning units and codes using content analysis. Findings: One main theme was formulated that represents the caregivers’ experiences of person transfer situations involving people with dementia: “Reciprocal struggle in person transfer tasks”. Five categories were formulated: “Becoming familiar and making contact”, “Risking one's own body to protect the resident from injury”, “Focused yet aware of the surroundings”, “Identifying needs to facilitate the person transfer” and “Struggling to be understood”. Conclusion: Person transfer situations involving people with dementia are subject to sudden changes. The ongoing challenge is to ensure a dynamic approach that can be adapted to the needs of the person with dementia at any given time. There is a need for more studies within the field about care and rehabilitation among people with dementia. We suggest that assessment of person transfer situations involving people with dementia and their caregivers is an important issue for further investigation and physiotherapeutic interventions.","PeriodicalId":87870,"journal":{"name":"Advances in physiotherapy","volume":"14 1","pages":"175 - 182"},"PeriodicalIF":0.0,"publicationDate":"2012-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14038196.2012.725184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69372372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The concept of palpation of the shoulder – A basic element of physiotherapy practice: A focus group study with physiotherapists","authors":"Lisbeth Eriksson, L. Ekenberg, Anita Melander-Wikman","doi":"10.3109/14038196.2012.738244","DOIUrl":"https://doi.org/10.3109/14038196.2012.738244","url":null,"abstract":"Although palpation is frequently used in physiotherapy examinations, a limited amount of research has been done to clarify this concept. The aim of this study was to describe physiotherapists’ experiences of shoulder palpation with the intention of obtaining detailed descriptions of the concept of palpation. Three focus group interviews were conducted, including a total of seven physiotherapists who had experience of patients with shoulder disability built up over a long period. A qualitative content analysis of the interviews was carried out. The findings showed how palpation can be perceived as a skill that could be described from two different perspectives: Manual and technical palpation and Palpation being dependent on the relationship between the physiotherapist and the patient. Palpation requires time, and the knowledge and experience of palpating built up over time. We also found how the two “perspectives” of palpation were inseparable from each other. The ability to perform manual and technical palpation and the relationship between the physiotherapist and the patient can be considered an interactive learning situation where the physiotherapist and the patient develop mutual knowledge of the body.","PeriodicalId":87870,"journal":{"name":"Advances in physiotherapy","volume":"14 1","pages":"183 - 193"},"PeriodicalIF":0.0,"publicationDate":"2012-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14038196.2012.738244","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69372928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galvanic skin resistance (GSR) biofeedback in tension-type headache – Auditory, visual or combined feedback: Which is beneficial? A randomized controlled trial","authors":"Veena Bembalgi, K. Naik","doi":"10.3109/14038196.2012.693947","DOIUrl":"https://doi.org/10.3109/14038196.2012.693947","url":null,"abstract":"Abstract Background: The efficacy of electromyograph (EMG) biofeedback (BF) in the treatment of tension-type headaches (TTH) has been extensively studied, but very few studies have been done comparatively to study efficacy of galvanic skin resistance (GSR) BF. Moreover, no studies have reported the efficacy of isolated audio, visual and combined GSR BF in TTH. Objectives: The present study aimed at studying the efficacy of GSR BF using auditory, visual and combined feedback in patients with TTH. Design: Randomized, controlled study. Participants, settings: 143 subjects were recruited. Of these, 121 subjects (76 females and 45 males) were randomly assigned using the lottery method to four groups receiving auditory (n = 30), visual (n = 30), combined GSR BF (n = 30) and control group (n = 31), respectively. Intervention: Each subject (except control group) received 15 sessions of BF for 30 min each in an isolated room in the physiotherapy outpatient department. The control group received only medication prescribed by their physician. No blinding was followed. Outcome measures: Pain variables, consumption of analgesics and 36-item Short Form health survey (SF-36) quality-of-life scores were recorded at baseline and 6 months after therapy. Results: Repeated-measures analysis of variance at baseline and 6 months showed significant differences in frequency (p = 0.01), duration (p < 0.001) and intensity (p < 0.001) in the GSRav group with insignificant differences in the control group except intensity (p < 0.001). All four groups showed significant improvement in total, physical and mental SF-36 scores after 6 months except mental score in the control group (p = 0.06). An insignificant drop in analgesic usage was seen in all groups after 6 months. Conclusion: All three forms of GSR were effective in treatment of TTH and improving the quality of life of TTH patients. Combined GSR BF seems to have slightly more effectiveness compared with isolated auditory or visual feedback.","PeriodicalId":87870,"journal":{"name":"Advances in physiotherapy","volume":"14 1","pages":"123 - 131"},"PeriodicalIF":0.0,"publicationDate":"2012-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14038196.2012.693947","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69406125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further methodological development of the Test Instrument for Profile of Physical Ability (TIPPA) designed for patients with long-term musculoskeletal pain","authors":"Minaj Missaghi-Wedefalk, M. Lindh, Christina U M Schön-Ohlsson, C. Willén","doi":"10.3109/14038196.2012.694907","DOIUrl":"https://doi.org/10.3109/14038196.2012.694907","url":null,"abstract":"Abstract In a heterogeneous group of patients with long-term musculoskeletal pain (LMP), there is a need for a short test to assess physical ability. The Test Instrument for Profile of Physical Ability (TIPPA) includes observed physical ability and pain behaviour as well as the individual's self-assessment of his or her ability and experience of exertion. The relation between these four dimensions of the individual is made visible in a profile. The aim of this study was to investigate the inter-rater reliability of pain behaviour, to reconstruct the limits for the grades in the nine physical activities and to investigate the test–retest reliability of these reconstructed grades. The results showed that the percentual agreement between the two physiotherapists who observed LMP patients (n = 7) was 100% for seven of the activities and 86% for the two remaining activities. The reconstruction of the grading system was based on the results of healthy persons (n = 48) and LMP patients (n = 658) performing the nine physical activities. For test–retest of the reconstructed grading system in a patient group (n = 13), no disagreement was found between occasions but a systematic disagreement was found in one activity. This study confirms that the TIPPA instrument is reliable and the grading system discriminates between healthy persons and LMP patients.","PeriodicalId":87870,"journal":{"name":"Advances in physiotherapy","volume":"14 1","pages":"106 - 97"},"PeriodicalIF":0.0,"publicationDate":"2012-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14038196.2012.694907","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69372079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revised version of a comprehensive hand book for gait analysis","authors":"C. Häger","doi":"10.3109/14038196.2012.686518","DOIUrl":"https://doi.org/10.3109/14038196.2012.686518","url":null,"abstract":"","PeriodicalId":87870,"journal":{"name":"Advances in physiotherapy","volume":"14 1","pages":"140 - 140"},"PeriodicalIF":0.0,"publicationDate":"2012-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14038196.2012.686518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69405790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observations of four children with severe cerebral palsy using a novel dynamic platform. A case report","authors":"Ylva Dalén, M. Sääf, S. Nyrén, E. Mattsson, Y. Haglund‐Åkerlind, B. Klefbeck","doi":"10.3109/14038196.2012.693948","DOIUrl":"https://doi.org/10.3109/14038196.2012.693948","url":null,"abstract":"Abstract The aim was to evaluate effects on bone mineral content (BMC) in children with severe cerebral palsy (CP) standing on a self-controlled dynamic platform (vibrations, jumps and rotation), assess reactions expressed and record negative effects. An experimental design was used. Four children with severe CP participated. Two children used the platform for 8–9 months while two children were controls (period I). After 1 year, the former users were controls (period II). Dual-energy X-ray absorptiometry was performed. Children in period I (Child 1/Child 2) were exposed to whole body vibration for 330/394 min on 28/25 occasions and showed a percentage change in BMC values at the lumbar spine of +35/+23% (versus controls, Child 3/Child 4, −9/+7%), left legs −9/ −12% (vs. −2/ −12%) and right legs +61/+34% (vs. −18/+10%). Children in period II (Child 3/Child 4) were exposed for 524/635 min on 57/64 occasions. The corresponding percentage change in BMC values at the lumbar spine was +10/+10% (+21/+5%), left legs +26/+22% (0/+5%) and right legs +26/+17% (+15/ −1%). The children's reactions were perceived positive. No negative effects were recorded. Standing on a self-controlled dynamic platform may be an enjoyable method to increase BMC in children with severe CP.","PeriodicalId":87870,"journal":{"name":"Advances in physiotherapy","volume":"14 1","pages":"132 - 139"},"PeriodicalIF":0.0,"publicationDate":"2012-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14038196.2012.693948","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69371973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}